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71. 发明授权

US09039684B2 Power regulated medical underskin irradiation treatment system for manual movement 有权
标题翻译：用于手动运动的电力医疗下冲辐射治疗系统
公开(公告)号：US09039684B2
公开(公告)日：2015-05-26
申请号：US11443143
申请日：2006-05-30
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61B18/24 , A61B18/20 , A61B18/00
CPC分类号： A61B18/24 , A61B18/20 , A61B2017/00075 , A61B2018/00196 , A61B2018/00636
摘要： A system and method for controllably releasing radiation in percutaneous radiation treatment is provided. In a preferred embodiment, a laser is coupled to an optical fiber that is inserted below the skin or into a vascular lumen to a predetermined point. The fiber is connected to a source of electromagnetic radiation such as a laser, non-coherent radiation source, high power laser diode, LED, and an ultrasonic source. Radiation is then delivered to the treatment site while the fiber is simultaneously drawn out to the entry point. The fiber is manually withdrawn and during this time the radiation is administered in a manner appropriate for the vein being treating in regards to power or energy level. To maintain a constant proper energy density, the speed of withdrawal is measured and sent to a controlling mechanism. The controlling mechanism modifies the power emitted, pulse length or pulse rate to ensure that the vein or tissue receives a consistent dose of energy during manual withdrawal. In one preferred embodiment, an imaging device provides the controlling device with position and time information so that speed information from fiber or catheter surface textural properties or based on one or more bar code like markings. In another preferred embodiment, additional information is collected, such as vein diameter prior to treatment, position of the distal end of the fiber, and/or impact measurements such as vibration or temperature during treatment, and the controlling mechanism adjusts output power or pulse rate in response to measurements to maintain a desired power density at all position during the manual withdrawal.
摘要翻译：提供了一种用于在经皮放射治疗中可控地释放放射线的系统和方法。在优选实施例中，激光器被耦合到插入到皮肤下面或者到血管腔中到达预定点的光纤。光纤连接到电磁辐射源，例如激光，非相干辐射源，大功率激光二极管，LED和超声波源。然后将辐射递送到治疗部位，同时将纤维同时拉出到入口点。纤维被手动取出，并且在此期间以适合于功率或能量水平处理的静脉的方式施用辐射。为了保持恒定的适当的能量密度，测量提取速度并将其发送到控制机制。控制机制改变发射功率，脉冲长度或脉率，以确保静脉或组织在手动取出时能够接受一致的能量。在一个优选实施例中，成像装置为控制装置提供位置和时间信息，使得来自纤维或导管表面纹理属性的速度信息或基于一个或多个条形码标记。在另一个优选实施例中，收集附加信息，例如治疗前的静脉直径，纤维远端的位置和/或治疗期间的冲击测量例如振动或温度，并且控制机构调节输出功率或脉率响应于在手动取出期间在所有位置处保持期望的功率密度的测量。

72. 发明授权

US08985121B2 Method and device for valve repair 有权
标题翻译：阀门维修方法和装置
公开(公告)号：US08985121B2
公开(公告)日：2015-03-24
申请号：US13102830
申请日：2011-05-06
申请人： Enrique Ferracani , Wolfgang Neuberger
发明人： Enrique Ferracani , Wolfgang Neuberger
IPC分类号： A61B19/00 , A61B18/24 , A61B18/00
CPC分类号： A61B18/24 , A61B2018/00029 , A61B2018/00982
摘要： A method and a device for minimally invasive treatment of diseased deep and superficial venous valves are disclosed. Treatment seeks to repair/rejuvenate dysfunctional valve by reducing the circumference of dilated valve rings and by restoring their original shape and function using laser energy to make physical suture points and shrink collagen in selected points. Real time monitoring is by angioscopic view and endovenous echographic control. In a preferred embodiment, system comprises a specific catheter-like device for endovenous insertion that allows for real time view of energy emission and venous surface to be corrected. Catheter flexibility is such that viewing angle and direct energy emission can be oriented properly. Catheter can comprise channels for irrigation or for interchange of laser fibers according to desired irradiation pattern. A preferred embodiment of catheter device also comprises cuffs for temporary occlusion, by inflation and deflation. In preferred embodiments, 1470 nm, 1550 nm or 1900 nm laser energy is applied. This treatment can be applied to venous valves of the deep venous system, as well as valves of the sapheno-femoral junction, terminal valve and pre-terminal valve.
摘要翻译：公开了用于微创治疗患病深部和浅静脉瓣的方法和装置。治疗旨在通过减小扩张瓣环的周长并通过使用激光能量恢复其原始形状和功能来修复/恢复功能失调的瓣膜，以在选定的点产生物理缝合点和收缩胶原蛋白。实时监测是通过血管镜观察和静态回波控制。在优选实施例中，系统包括用于静脉内插入的特定导管状装置，其允许实时观察要校正的能量排出和静脉表面。导管的灵活性使得视角和直接能量发射可以适当地定向。导管可以包括根据所需照射模式进行冲洗或激光纤维交换的通道。导管装置的优选实施例还包括用于暂时闭塞的袖口，通过充气和放气。在优选实施例中，施加1470nm，1550nm或1900nm的激光能量。这种治疗可以应用于深静脉系统的静脉瓣膜，以及隐静脉股关节，终端阀和前端阀的阀门。

73. 发明申请

US20130035684A1 Laser Treatment of Tissues at Wavelengths above 1330 nm 审中-公开
标题翻译：波长在1330nm以上的组织的激光处理
公开(公告)号：US20130035684A1
公开(公告)日：2013-02-07
申请号：US13197975
申请日：2011-08-04
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B90/361 , A61B2018/207 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N5/06 , A61N2005/067
摘要： A medical laser system is disclosed for ablation/resection/coagulation of unwanted tissue, including parenchymal lung resection to facilitate/accelerate growth/wound healing. System comprises laser energy sources and conveying means, optical fiber. A diode laser source emits above 1330 nm, at least 50 Watts, through an optical fiber onto target tissue. Wavelength, 1340 nm is preferred. Wavelength ranges 1330-1390 nm and 1450-1550 nm, are also useful. Additionally a wavelength, between 800-1100 nm, can be used. Wavelength differences maximize beam quality. Two radiation sources emit simultaneously from fiber's distal end. One emits at ˜1320 nm and the other emits at ˜1340 nm or ˜1360 nm with maximum total output power of 60 W or larger. Preferably, the ratio of the power levels is fixed at 1:1.5 and output power is the sum of individual lasers. High beam quality and power density system combines emissions from a diode laser and a fiber laser.
摘要翻译：公开了用于消融/切除/凝结不想要的组织的医疗激光系统，包括实质性肺切除术以促进/加速生长/伤口愈合。系统包括激光能源和输送装置，光纤。二极管激光源通过光纤在目标组织上发射1330nm以上，至少50瓦特。波长1340nm是优选的。波长范围1330-1390nm和1450-1550nm也是有用的。此外，可以使用在800-1100nm之间的波长。波长差异最大化光束质量。两个辐射源同时从纤维的远端排出。一个以〜1320nm发射，另一个发射在〜1340nm或〜1360nm，最大总输出功率为60W或更大。优选地，功率电平的比率固定为1：1.5，输出功率是各个激光器的总和。高光束质量和功率密度系统结合二极管激光器和光纤激光器的发射。

74. 发明申请

US20120283619A1 MINIMALLY INVASIVE CONTRACEPTION METHOD AND DEVICE 审中-公开
标题翻译：最小的入侵收缩方法和设备
公开(公告)号：US20120283619A1
公开(公告)日：2012-11-08
申请号：US13101873
申请日：2011-05-05
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61B18/20
CPC分类号： A61B18/22 , A61B18/24 , A61B2018/00559 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00982 , A61B2090/378 , A61B2218/001
摘要： Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.
摘要翻译：作为永久避孕方法，提出了微创治疗哺乳动物雌激素输卵管或输精管输精管的微创方法和装置。在优选实施例中，用于男性和女性消毒的医疗装置包括在约980nm至约1950nm之间的一个或多个预选波长操作的激光辐射源，优选980nm，1470nm和1950nm中的至少一个; 具有径向或圆柱形辐射发射尖端的处理波导; 查看范围; 和温度传感器。在另一个优选实施例中，对于男性和女性的微创永久避孕方法包括以下步骤：在体腔内引入至少一个治疗波导; 将治疗波导定位在体腔内; 照射; 并重复同伴体腔中的手术以抑制受精。在另一个实施例中，流体在手术之后，之前或期间被输注和/或提取，以增强激光能量吸收并提高激光治疗的效率。

75. 发明申请

US20110224660A1 Diode Laser Induced Vapor/Plasma Mediated Medical Procedures and Device 有权
标题翻译：二极管激光诱导蒸气/等离子体介导的医疗程序和装置
公开(公告)号：US20110224660A1
公开(公告)日：2011-09-15
申请号：US12629313
申请日：2009-12-02
申请人： Wolfgang Neuberger , Walter Cecchetti
发明人： Wolfgang Neuberger , Walter Cecchetti
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B18/042 , A61B2018/263 , A61N1/44
摘要： An improved method and device for safe and efficient medical applications is provided. In a preferred embodiment, based on using the inherent benefits of laser diodes (such as efficient power generation from a reliable and compact solid state device), plasmas and high energy vapors are produced for medical applications with power levels and power densities sufficient to treat medical indications and avoid the creation of extensive damage zones. Transmissions means in different configurations are used to achieve a high power density, which is able to initiate plasma and high-energy vapor at the tip. Once a sparkless plasma and high energy vapor bubbles are formed, it is often found that it will also absorb other wavelengths in addition to the one that initiated it. As a consequence, other wavelengths more efficiently generated by diodes or diode pumped lasers may be added into the beam in order to improve treatment efficiency. For example, the 1470 nm wavelength can be used to produces sparkler-less plasma bubbles, together with the 980 nm wavelength to produce tissue vaporization and an excellent haemostasis effect. Once plasma and or high-energy vapors are in place, radiation from this zone determine tissue effects. In another embodiment, high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally it can be applied in combination with another wavelength with medium absorption in water such as 980 nm. In another embodiment a concentric double core fiber is used, in which the ignition radiation is guided in near single mode, inner core and the radiation used to maintain and enhance the pulse is guided into the surrounding second outer core.
摘要翻译：提供了一种用于安全有效的医疗应用的改进方法和装置。在优选实施例中，基于使用激光二极管的固有优点（例如来自可靠和紧凑的固态器件的有效发电），为医疗应用产生等离子体和高能蒸气，其功率水平和功率密度足以治疗医疗适应症，避免造成广泛的伤害区。传输意味着不同的配置用于实现高功率密度，其能够启动尖端处的等离子体和高能蒸气。一旦形成了无火花等离子体和高能量蒸汽气泡，经常发现除了引发它之外，它也将吸收其它波长。因此，为了提高处理效率，可以将更多由二极管或二极管泵浦激光器产生的其它波长添加到光束中。例如，1470nm波长可用于产生无闪蒸的等离子体气泡，以及980nm波长以产生组织蒸发和良好的止血效果。一旦等离子体和/或高能量蒸气就位，来自该区域的辐射决定了组织的影响。在另一个实施例中，使用高峰值功率脉冲辐射。优选1470nm，1940nm或1550nm的波长。此外，它可以与另外一种在水中具有介质吸收的波长（例如980nm）结合使用。在另一个实施例中，使用同心双芯纤维，其中点火辐射在近单模模式内引导，并且用于维持和增强脉冲的辐射被引导到周围的第二外核中。

76. 发明申请

US20110082410A1 Method for Reducing Pain during Photodynamic Therapy 审中-公开
标题翻译：光动力治疗期间减轻疼痛的方法
公开(公告)号：US20110082410A1
公开(公告)日：2011-04-07
申请号：US12896551
申请日：2010-10-01
申请人： Albrecht Volker , Wolfgang Neuberger
发明人： Albrecht Volker , Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B18/203 , A61B2017/00172 , A61B2018/00452 , A61B2018/00476
摘要： The present invention provides a method for application of photodynamic therapy which results in a reduction of pain experienced by a patient during treatment. An irradiation pattern of short pulses is applied to a treatment site. The same total energy dosage and light intensity parameters for a specific application, as known in the state of the art is used, but the radiation is applied in a series of short pulses. In a preferred embodiment, radiation is applied with about 350 millisecond pulses, and each pulse is separated by about 100 to 500 millisecond intervals. Application of radiation in pulses rather than continuous wave application reduces pain during treatment without sacrificing the therapeutic effect.
摘要翻译：本发明提供了一种应用光动力疗法的方法，其导致患者在治疗期间经历的疼痛减轻。将短脉冲的照射图案施加到治疗部位。使用如现有技术中已知的具体应用的相同的总能量剂量和光强度参数，但是以一系列短脉冲施加辐射。在优选实施例中，以大约350毫秒的脉冲施加辐射，并且每个脉冲被隔开大约100到500毫秒的间隔。辐射在脉冲而不是连续波应用中的应用减少治疗期间的疼痛而不牺牲治疗效果。

77. 发明申请

US20110060388A1 DEVICE AND METHOD FOR VESSEL TREATMENT 有权
公开(公告)号：US20110060388A1
公开(公告)日：2011-03-10
申请号：US12877721
申请日：2010-09-08
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B90/36 , A61N2005/063 , A61N2005/0659
摘要： A device and method for restoring functionality of blood vessels are disclosed. Laser energy is accurately and precisely applied in order to restore vessel functionality. This is accomplished by a controlled, reliable and specific shrinkage and/or strengthening of the vessel structure. Laser radiation is transported in a controlled manner via an optical fiber to the site where energy is needed. Laser wavelength is chosen according to the required penetration depth in tissue. It has been found that a wavelength that is essentially absorbed within less than a millimeter of the actual dimensions of the vessel walls thickness works best. In a preferred embodiment, wavelength of approximately 1470 nm is used. A mini-endoscope is preferably used to control the process by visual inspection from the inside of the vessel. Other means such as ultrasound, echography, Positron Emission Tomography (PET), Computed Tomography (CT) and Optical Coherence Tomography (OCT), or other imaging means can also be combined to control the procedure. Full 360° radial emission, i.e., delivery of laser radiation perpendicularly or fairly inclined relative to the veins axis, is beneficial, and is accomplished by means of a radial emitting fiber. In another preferred embodiment, a 360 degree radiation pattern can be achieved by using a twister or side-emitting fiber, along with rotational and sweeping movements, to apply energy in an even, more-controlled, and guided manner. Valve function is restored to recover whole vein functionality, avoiding the need of closing it. In a preferred embodiment, energy is applied from the outside of the vessel, by inserting a device through the skin and tissue. In another preferred embodiment, specific radiation absorbers (and/or scattering enhancers) can be located at suitable positions inside the vessel wall or near the tissue to be treated, thus radiation can then selectively target tagged locations. Vessel function is restored preserving its structure, using a minimally invasive treatment. A wide range of vessel diameters are effectively treated. Vessels include veins, arteries and fistulas. Specifically, when treating veins, valvular incompetence is accurately and precisely treated, thus rendering a safe, versatile and fast procedure with reduced recurrence possibilities.

78. 发明申请

US20100179525A1 ENDOLUMINAL LASER ABLATION DEVICE AND METHOD FIR TREATING VEINS 审中-公开
标题翻译：内镜激光治疗装置和方法FIR治疗病毒
公开(公告)号：US20100179525A1
公开(公告)日：2010-07-15
申请号：US12731525
申请日：2010-03-25
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B18/18
CPC分类号： A61B18/245 , A61B17/22012 , A61B18/24 , A61B2018/2272
摘要： An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.
摘要翻译：提供了一种改进的方法和装置，用于安全有效的低功率密度腔内治疗静脉功能不全。一个这样的装置通过具有锥形尖端的光纤端部径向地发射脉冲或连续的能量，用于360°径向发射。在一些实施例中，锥形反射表面与发射尖端相对并面对发射尖端，以通过反射径向方向上任何设计或残余的向前传输的能量来增强径向发射效率。其他设备包括密封在保护性辐射透明盖内的平坦发射面。另外的实施例包括间隔/定中心机构，以使静止壁与径向等距离发射。激光辐射以波长和功率传输，使得其基本上完全被血管壁吸收，以充分损伤血管内皮，从而实现血管闭合。因为能量基本上完全被吸收在血管壁内，所以可以基本上避免沿着血管治疗区域的局部麻醉剂的需要。

79. 发明申请

US20090131499A1 PHOTODYNAMIC THERAPY FOR SKIN RELATED PROBLEMS 审中-公开
标题翻译：皮肤相关问题的光化疗法
公开(公告)号：US20090131499A1
公开(公告)日：2009-05-21
申请号：US12271708
申请日：2008-11-14
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61K31/407
CPC分类号： A61K41/0071
摘要： PhotoDynamic Therapy method is used to treat problems associated with pilosebaceous units including acne and other skin conditions. At least one liposomal-formulated, hydrophobic photosensitizer, such as a dihydro- or tetrahydro-porphyrin, is topically applied to acne affected regions, and is allowed to penetrate the hair follicle before being irradiated with a suitable wavelength of light energy overlapping the absorption spectrum of the selected photosensitizer. The photoactivated agent initiates a cytotoxic effect in the sebaceous gland, reducing excess oil production and destroying bacterial growth in the follicle thus subsiding inflammatory action. Scarring of the skin is minimized and the skin heals faster due to collagen cell stimulation.
摘要翻译： PhotoDynamic Therapy方法用于治疗与皮脂腺单位相关的问题，包括痤疮和其他皮肤病症。将至少一种脂质体配制的疏水性光敏剂，例如二氢或四氢卟啉，局部施用于痤疮受影响的区域，并且在用合适的波长的能量与吸收光谱重叠之前，允许穿透毛囊的所选光敏剂。光活化剂在皮脂腺中引发细胞毒性作用，减少多余的油产生并破坏卵泡中的细菌生长，从而消除炎症反应。由于胶原细胞刺激，皮肤的疤痕被最小化，皮肤愈合愈快。

80. 发明申请

US20080275432A1 Photodynamic foam composition and sclerosis treatment 审中-公开
标题翻译：光动力泡沫组合物和硬化症治疗
公开(公告)号：US20080275432A1
公开(公告)日：2008-11-06
申请号：US11800400
申请日：2007-05-04
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61B6/00 , A61K31/407 , A61K47/26
CPC分类号： A61K31/407 , A61K41/0042 , A61K41/0071 , A61K49/00 , A61N5/062 , A61N2005/0602
摘要： A photodynamic composition and a method for in vivo photonic treatments that is minimally invasive, versatile and precise are described. The invention allows for photonic treatments with only minimal insertions into the area of treatment, often a single one. The invention may be used with a standard insertion component making the system inexpensive and easy for doctors to use. The invention has applications in several areas of treatment. In vivo treatment of aesthetic skin blemishes such as varicose veins can be performed with minimal external effects. A predetermined amount of a photodynamic composition, as a foam, is injected into the vein or structure of concern. The composition is a sclerosis foam including a photosensitizer. By external compression, where applicable, the photodynamic composition is forced to remain in the vein or structure. After a predetermined time, radiation of appropriate wavelength from a light source is delivered directly to the vascular structure. Among the key benefits of the present invention are the elimination of targeted varicose veins, without need for anesthesia along the length of the vein; no edema; no skin reaction; and tactile appreciation.
摘要翻译：描述了光动力学组合物和微创，多功能和精确的体内光子处理方法。本发明允许光子治疗，只有最少的插入到治疗区域，通常是单一治疗。本发明可以与标准的插入部件一起使用，使得该系统便于医生使用。本发明在几个治疗领域都有应用。美容皮肤瑕疵如静脉曲张的体内治疗可以以最小的外部作用进行。将预定量的作为泡沫的光动力学组合物注入到关注的静脉或结构中。该组合物是包含光敏剂的硬化泡沫。通过外部压缩，如果适用，光动力学组合物被迫保持在静脉或结构中。在预定时间之后，从光源的适当波长的辐射直接传送到血管结构。本发明的主要优点之一是消除目标静脉曲张，而不需要沿着静脉的长度麻醉; 无水肿; 无皮肤反应; 和触觉欣赏。

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