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71. 发明授权

US08126539B2 Method and apparatus for monitoring T-wave alternans 有权
标题翻译：用于监测T波交替的方法和装置
公开(公告)号：US08126539B2
公开(公告)日：2012-02-28
申请号：US11871405
申请日：2007-10-12
申请人： Xiaohong Zhou , Jeffrey M. Gillberg
发明人： Xiaohong Zhou , Jeffrey M. Gillberg
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/021 , A61N1/3702
摘要： An implantable medical device and associated method assess T-wave alternans by sensing a cardiac electrogram (EGM) signal and selecting a pair of consecutive T-wave signals from the EGM signal. A first amplitude and a second amplitude from each of the consecutive T-wave signals are determined. The differences between the first amplitudes and the second amplitudes of the consecutive T-wave signal pairs are used to compute a T-wave alternans metric.
摘要翻译：可植入医疗装置和相关方法通过感测心电图（EGM）信号和从EGM信号中选择一对连续的T波信号来评估T波交替。确定来自每个连续T波信号的第一幅度和第二幅度。使用连续T波信号对的第一幅度和第二幅度之间的差异来计算T波交替量度。

72. 发明申请

US20110245700A1 DETECTION OF T-WAVE ALTERNANS PHASE REVERSAL FOR ARRHYTHMIA PREDICTION AND SUDDEN CARDIAC DEATH RISK STRATIFICATION 有权
标题翻译： T-WAVE ALTERNANS相关检测ARRHYTHMIA预测和SUDDEN CARDIAC死亡风险分析
公开(公告)号：US20110245700A1
公开(公告)日：2011-10-06
申请号：US12749753
申请日：2010-03-30
申请人： Raja N. Ghanem , Xiaohong Zhou
发明人： Raja N. Ghanem , Xiaohong Zhou
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7264 , A61B5/7275 , A61N1/36507 , G06F19/00
摘要： An implantable medical device and associated method for classifying a patient's risk for arrhythmias by sensing a cardiac electrogram (EGM) signal and selecting a first pair of T-wave signals and a second pair of T-wave signals. A first difference between the two T-wave signals of the first pair is compared to a second difference between the two T-wave signals of the second pair. A T-wave alternans phase reversal is detected in response to comparing the first difference and the second difference, and the patient's arrhythmia risk is classified in response to detecting the phase reversal.
摘要翻译：一种用于通过感测心电图（EGM）信号和选择第一对T波信号和第二对T波信号来分类患者心律失常风险的可植入医疗装置和相关方法。将第一对的两个T波信号之间的第一个差异与第二对的两个T波信号之间的第二个差值进行比较。响应于比较第一个差异和第二个差异，检测到T波交替相位逆转，并且响应于检测相位反转来分类患者的心律失常风险。

73. 发明申请

US20080200769A1 IMPLANTABLE MEDICAL DEVICE HAVING OPTICAL FIBER FOR SENSING ELECTRICAL ACTIVITY 有权
标题翻译：具有用于传感电活动的光纤的可植入医疗装置
公开(公告)号：US20080200769A1
公开(公告)日：2008-08-21
申请号：US11676128
申请日：2007-02-16
申请人： VINOD SHARMA , Xiaohong Zhou
发明人： VINOD SHARMA , Xiaohong Zhou
IPC分类号： A61N5/06
CPC分类号： A61B5/0071 , A61B5/0084 , A61B5/0452
摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.
摘要翻译：一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

74. 发明申请

US20080177068A1 QUINAZOLE DERIVATIVES 审中-公开
标题翻译：喹唑啉衍生物
公开(公告)号：US20080177068A1
公开(公告)日：2008-07-24
申请号：US11939244
申请日：2007-11-13
申请人： Wenlin Huang , Xiaohong Zhou
发明人： Wenlin Huang , Xiaohong Zhou
IPC分类号： C07D239/94
CPC分类号： C07D239/94
摘要： The present invention relates to quinazoline derivatives represented by general formula (I): wherein X, Y, Z, R1, R2, R3, and R4 are as defined herein. The invention also relates to a method of preparing these compounds, and use of these compounds for inhibiting tumor growth.
摘要翻译：本发明涉及由通式（I）表示的喹唑啉衍生物：其中X，Y，Z，R 1，R 2，R 3， >和R 4'如本文所定义。本发明还涉及制备这些化合物的方法，以及这些化合物用于抑制肿瘤生长的用途。

75. 发明授权

US07221979B2 Methods and apparatus for the regulation of hormone release 有权
标题翻译：用于调节激素释放的方法和装置
公开(公告)号：US07221979B2
公开(公告)日：2007-05-22
申请号：US10426610
申请日：2003-04-30
申请人： Xiaohong Zhou , Thomas J. Mullen , Gary W. King , Michael R. S. Hill
发明人： Xiaohong Zhou , Thomas J. Mullen , Gary W. King , Michael R. S. Hill
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7–L2 and the associated neural fibers within a region of the T7–L2 dermatomes
摘要翻译：提供了一种通过激素调节进行矫正治疗的方法和装置。通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维

76. 发明授权

US07142928B2 Field stimulation about a discontinuity of the myocardium to capture the heart at reduced pacing thresholds 失效
公开(公告)号：US07142928B2
公开(公告)日：2006-11-28
申请号：US10308302
申请日：2002-12-03
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0587 , A61N1/0573
摘要： Improved pacing thresholds for capturing the heart are achieved by forming a discontinuity in the cardiac tissue of the heart chamber, disposing a pacing electrode at a distance exceeding a space constant of the cardiac tissue from the discontinuity in the cardiac tissue, and applying a stimulus of a first polarity at an energy insufficient to cause the directly stimulated tissue adjacent to the pacing electrode to propagate a depolarization wave through the cardiac tissue mass of the heart chamber but sufficient to induce a transmembrane potential change at the tissue adjacent to the discontinuity that results in a propagated wave front. Thus, pacing energy is advantageously reduced.

77. 发明授权

US07027856B2 Method for determining a metric of non-sustained arrhythmia occurrence for use in arrhythmia prediction and automatic adjustment of arrhythmia detection parameters 失效
标题翻译：确定用于心律失常预测和心律失常检测参数自动调整的非持续性心律失常发生度量的方法
公开(公告)号：US07027856B2
公开(公告)日：2006-04-11
申请号：US10261316
申请日：2002-09-30
申请人： Xiaohong Zhou , Bruce D. Gunderson , Walter H. Olson , Robert W. Stadler
发明人： Xiaohong Zhou , Bruce D. Gunderson , Walter H. Olson , Robert W. Stadler
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61N1/3956
摘要： An implantable medical device and associated method are provided for detecting non-sustained arrhythmias and determining a metric of non-sustained arrhythmias. The metric may be used for predicting the occurrence of a sustained arrhythmia or for automatically adjusting the parameters used for detecting a sustained arrhythmia.
摘要翻译：提供可植入医疗装置和相关方法用于检测非持续性心律失常并确定非持续性心律失常的度量。该度量可以用于预测持续性心律失常的发生或用于自动调整用于检测持续性心律失常的参数。

78. 发明申请

US20050177135A1 Delivery of a sympatholytic cardiovascular agent to the central nervous system to counter heart failure and pathologies associated with heart failure 有权
标题翻译：向中枢神经系统递送交感神经心血管药物以对抗心力衰竭和与心力衰竭相关的病理
公开(公告)号：US20050177135A1
公开(公告)日：2005-08-11
申请号：US10773965
申请日：2004-02-06
申请人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
发明人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
IPC分类号： A61B5/02 , A61M5/142 , A61M5/168 , A61M5/172 , A61N1/39 , A61K9/22
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms and otherwise treat heart failure (HF) and pathologies associated with HF. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with HF (or pathologies associated with HF) and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist, e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine.
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解症状，另外治疗与HF有关的心力衰竭（HF）和病理学。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与HF相关的生理学参数（或与HF相关的病理学）和触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂组成的组之一，例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫西康定，甲基多巴，甲苯噻嗪，胍法辛，美托咪定，美托咪定和右美托咪定。

79. 发明授权

US06175236B1 Method for acquiring spatially and spectrally selective MR images 失效
标题翻译：用于获取空间和频谱选择性MR图像的方法
公开(公告)号：US06175236B1
公开(公告)日：2001-01-16
申请号：US09047822
申请日：1998-03-25
申请人： Xiaohong Zhou , Matthew A. Bernstein
发明人： Xiaohong Zhou , Matthew A. Bernstein
IPC分类号： G01V300
CPC分类号： G01R33/446 , G01R33/5613
摘要： A method for acquiring spatially and spectrally selective MR images by means of an MR imaging system includes the step of selecting an SPSP pulse sequence, comprising a succession of RF sub-pulses and an oscillatory gradient magnetic field, which is disposed to select a slice through a subject. The method further includes measuring specified parameters of a perturbation magnetic field associated with the imaging system, and deriving an expression for the perturbation field from respective measured parameters and from the oscillatory gradient magnetic field. A specified ideal frequency modulation function, associated with the SPSP sequence, is disposed to offset the slice to a particular spatially localized region of the subject. The SPSP pulse sequence is modified by adjusting the frequency modulation function in specified corresponding relationship with the expression. The modified SPSP pulse sequence is then applied to the subject to excite a selected spectral species in the spatially localized region, while substantially reducing signal intensity loss resulting from the perturbation magnetic field.
摘要翻译：用于通过MR成像系统获取空间和频谱选择性MR图像的方法包括选择包括一系列RF子脉冲和振荡梯度磁场的SPSP脉冲序列的步骤，其被设置为选择切片通过课程。该方法还包括测量与成像系统相关联的扰动磁场的指定参数，以及从相应的测量参数和振荡梯度磁场导出扰动场的表达式。设置与SPSP序列相关联的指定的理想频率调制功能，以将切片偏移到对象的特定空间局部区域。通过调整与规定的对应关系的频率调制函数来修改SPSP脉冲序列。然后将经修改的SPSP脉冲序列应用于受试者以激发空间局部区域中的选定光谱物种，同时显着降低由扰动磁场引起的信号强度损失。

80. 发明授权

US10595813B2 Method and apparatus for monitoring cardiac and respiratory conditions using acoustic sounds 有权
公开(公告)号：US10595813B2
公开(公告)日：2020-03-24
申请号：US13456346
申请日：2012-04-26
申请人： Zhendong Song , Xiaohong Zhou
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61B5/02 , A61B7/00 , A61N1/362 , A61N1/365 , A61B5/08 , A61B5/0205
摘要： A medical device system and associated method discriminate respiratory and cardiac conditions using respiratory sounds. A sensing module acquires a first signal and a second signal, at least the second signal acquired from an acoustic transducer. A processor is configured to receive the first signal and to control the sensing module to acquire the second acoustic signal in response to a change in the first signal. The processor discriminates between a cardiac condition and a respiratory condition as a cause of the change in the first signal in response to the second acoustic signal.

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