专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US08420368B2 Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof 有权
公开(公告)号：US08420368B2
公开(公告)日：2013-04-16
申请号：US13371082
申请日：2012-02-10
申请人： Erno Pungor , Charles Hague , Zhi Chen
发明人： Erno Pungor , Charles Hague , Zhi Chen
IPC分类号： C12N9/14
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.

72. 发明申请

US20100075971A1 SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 审中-公开
标题翻译：用于治疗癌症和其他疾病的替代吡啶衍生物
公开(公告)号：US20100075971A1
公开(公告)日：2010-03-25
申请号：US12628735
申请日：2009-12-01
申请人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
发明人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
IPC分类号： A61K31/4412 , C07D211/74 , C07D405/12 , C07D401/12 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/4433 , A61K31/4709 , A61K31/4439 , A61K31/4545 , A61K31/5377
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

73. 发明授权

US07384947B2 Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译：用于治疗高增殖性疾病的融合的三环杂环
公开(公告)号：US07384947B2
公开(公告)日：2008-06-10
申请号：US11512032
申请日：2006-08-28
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
IPC分类号： A61K31/497 , A61K31/4355 , A61K31/4436 , A61K31/443 , A61K31/427
CPC分类号： C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要： This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译：本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。

74. 发明申请

US20060287387A1 Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译：用于治疗高增殖性疾病的融合的三环杂环
公开(公告)号：US20060287387A1
公开(公告)日：2006-12-21
申请号：US11512032
申请日：2006-08-28
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
IPC分类号： A61K31/381 , A61K31/343
CPC分类号： C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要： This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译：本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。

75. 发明授权

US07144937B2 Adhesion promoters for sealants 失效
标题翻译：密封剂的粘合促进剂
公开(公告)号：US07144937B2
公开(公告)日：2006-12-05
申请号：US10718233
申请日：2003-11-19
申请人： Jerome M. Klosowski , Gary Wentworth , Zhi Chen , Stephen Semlow , Stephen O'Rourke , Kimberly L. Stefanisin , John English
发明人： Jerome M. Klosowski , Gary Wentworth , Zhi Chen , Stephen Semlow , Stephen O'Rourke , Kimberly L. Stefanisin , John English
IPC分类号： C08K5/09 , C08K5/34 , C08K5/101 , C08K5/12
CPC分类号： C08K5/34922 , C08K5/10 , C08K5/101 , C08K5/109 , C08L21/00 , C08L59/00 , C08L79/02 , Y10T156/10 , C08L2666/14 , C08L2666/16
摘要： A sealant composition comprising a sealant, an adhesive resin, and a long chain ester, particularly dimerate and trimerate esters, is capable of unexpected adhesion to substrates such as ceramic substrates (e.g., concrete), glass substrates, metal substrates such as metal flat stock materials, polymeric substrates including substrates comprising natural and/or synthetic rubbers and substrates comprising thermoplastic polymeric materials, particularly for use in sealing around bathroom fixtures, in storage areas, vents, plumbing lines, flooring, wheel wells, and the like.
摘要翻译：包含密封剂，粘合剂树脂和长链酯，特别是二聚和三聚酯的密封剂组合物能够意外地粘附到诸如陶瓷基底（例如混凝土），玻璃基底，金属基底如金属扁平材料材料，包括天然和/或合成橡胶的基材的聚合物基材和包含热塑性聚合物材料的基材，特别是用于密封卫生间固定装置，储存区域，通风口，管线，地板，轮井等中的基材。

76. 发明授权

US5989144A Oscillatory roller transmission 失效
标题翻译：振荡辊传动
公开(公告)号：US5989144A
公开(公告)日：1999-11-23
申请号：US828889
申请日：1997-03-31
申请人： Zhi Chen , Bo Chen , Shixian Chen
发明人： Zhi Chen , Bo Chen , Shixian Chen
IPC分类号： F16H1/32
CPC分类号： F16H1/32 , F16H25/06
摘要： A transmission apparatus comprising a wave actuator having a wave-actuating disk mounted on an eccentric body through a rolling bearing; an oscillatory roller gear having Zh number of oscillatory rollers assembled in Zh radial slots of an oscillatory roller carrier, and a stationary gear with Zg number of inner teeth, where Zg=Zh.+-.1. The wave actuator pushes the oscillatory rollers to move radially. The oscillatory rollers roll along the inner surface of the stationary gear, driving the oscillatory roller carrier to rotate, thereby transmitting movement and power. Any one of the three components: the wave actuator, the oscillatory roller gear, and the stationary gear, can be chosen as a fixed component; the other two then form a speed-reducing or a speed-increasing transmission. When none of the components are fixed, they form a two-in/one-out differential transmission.
摘要翻译：一种传动装置，包括具有通过滚动轴承安装在偏心体上的波浪致动盘的波浪致动器; 具有组合在振动辊载体的Zh径向槽中的Zh个摆动辊的摆动辊齿轮和Zg数为内齿的固定齿轮，其中Zg = Zh +/- 1。波形执行器推动振荡辊径向移动。振荡辊沿着静止齿轮的内表面滚动，驱动振荡辊架旋转，从而传递运动和动力。三个组件中的任何一个：波形致动器，振荡辊齿轮和固定齿轮，可以选择为固定部件; 另外两个则形成减速或增速传输。当没有一个组件固定时，它们形成一个二进一出差分传输。

77. 发明授权

US09567571B2 Hepatitis B virus mutant, mutant amplification kit and use thereof 有权
标题翻译：乙型肝炎病毒突变体，突变型扩增试剂盒及其用途
公开(公告)号：US09567571B2
公开(公告)日：2017-02-14
申请号：US14360931
申请日：2012-02-14
申请人： Zhi Chen
发明人： Zhi Chen
IPC分类号： C12N7/00 , C12P19/34 , C12Q1/70
CPC分类号： C12N7/00 , C12N2710/00021 , C12N2730/10121 , C12P19/34 , C12Q1/706 , C12Q2600/156
摘要： The present invention relates to the field of biotechnology, and discloses a hepatitis B virus mutant, a mutant amplification kit and use thereof. The HBV mutant of the invention takes place mutation of the hepatitis B virus mutant in genome sequence No. 216 and/or 285, the mutation occurred at position 216 is that base T mutates to C, the mutation occurred at position 285 is that base G mutates to A. The two mutations are closely related to the inflammation aggravation of the hepatitis B. The invention further provides a HBV mutant amplification kit to detect the above mutation, the usage of the kit and its application, therefore offering help for the clinical early diagnosis and intervention of severe hepatitis B, and providing references for further studying the functional changes caused by HBV gene mutation.
摘要翻译：本发明涉及生物技术领域，并公开了乙型肝炎病毒突变体，突变型扩增试剂盒及其应用。本发明的HBV突变体在基因组序列216和/或285中发生乙型肝炎病毒突变体的突变，在位置216发生的突变是基因T突变为C，位置285处的突变是基G 突变为A.两种突变与乙型肝炎的炎症加重密切相关。本发明还提供了用于检测上述突变的HBV突变扩增试剂盒，该试剂盒的用途及其应用，因此为临床早期提供了帮助诊断和干预重型乙型肝炎，为进一步研究HBV基因突变引起的功能变化提供依据。

78. 发明申请

US20150370473A1 USING A SYMBOL RECOGNITION ENGINE 审中-公开
标题翻译：使用符号识别引擎
公开(公告)号：US20150370473A1
公开(公告)日：2015-12-24
申请号：US14410361
申请日：2012-06-27
申请人： Zhigang Chen , Yong Li , Yunjian Zou , Zhi Chen
发明人： Zhigang Chen , Yong Li , Yunjian Zou , Zhi Chen
IPC分类号： G06F3/0488 , G06F1/16
CPC分类号： G06F3/04883 , G06F1/1626 , G06F1/1637 , G06F3/04886
摘要： A method comprises receiving signals indicative of receipt of a dynamic input by a touch-sensitive transducer, the dynamic input defining a path on the touch-sensitive transducer, at least a first portion of the path being within a first region of the touch-sensitive transducer. The method further comprises determining if a second portion of the path of the dynamic input is within a second region of the touch-sensitive transducer, in response to determining that the second portion path of the dynamic input is within the second region of the display, using a symbol recognition engine to identify a command based on the path of the dynamic input, and causing an action to be performed based on the identified command.
摘要翻译：一种方法包括接收指示由触敏传感器接收动态输入的信号，所述动态输入限定所述触敏传感器上的路径，所述路径的至少第一部分在所述触摸敏感的第一区域内传感器。响应于确定动态输入的第二部分路径在显示器的第二区域内，该方法还包括确定动态输入的路径的第二部分是否在触敏传感器的第二区域内，使用符号识别引擎基于动态输入的路径来识别命令，并且基于所识别的命令使得执行动作。

79. 发明申请

US20150284690A1 HEPATITIS B VIRUS MUTANT, MUTANT AMPLIFICATION KIT AND USE THEREOF 有权
标题翻译：乙型肝炎病毒突变体，突变体扩增试剂盒及其用途
公开(公告)号：US20150284690A1
公开(公告)日：2015-10-08
申请号：US14360931
申请日：2012-02-14
申请人： Zhi Chen
发明人： Zhi Chen
IPC分类号： C12N7/00 , C12Q1/70 , C12P19/34
CPC分类号： C12N7/00 , C12N2710/00021 , C12N2730/10121 , C12P19/34 , C12Q1/706 , C12Q2600/156
摘要： The present invention relates to the field of biotechnology, and discloses a hepatitis B virus mutant, a mutant amplification kit and use thereof. The HBV mutant of the invention takes place mutation of the hepatitis B virus mutant in genome sequence No. 216 and/or 285, the mutation occurred at position 216 is that base T mutates to C, the mutation occurred at position 285 is that base G mutates to A. The two mutations are closely related to the inflammation aggravation of the hepatitis B. The invention further provides a HBV mutant amplification kit to detect the above mutation, the usage of the kit and its application, therefore offering help for the clinical early diagnosis and intervention of severe hepatitis B, and providing references for further studying the functional changes caused by HBV gene mutation.
摘要翻译：本发明涉及生物技术领域，并公开了乙型肝炎病毒突变体，突变型扩增试剂盒及其应用。本发明的HBV突变体在基因组序列216和/或285中发生乙型肝炎病毒突变体的突变，在位置216发生的突变是基因T突变为C，位置285处的突变是基G 突变为A.两种突变与乙型肝炎的炎症加重密切相关。本发明还提供了用于检测上述突变的HBV突变扩增试剂盒，该试剂盒的用途及其应用，因此为临床早期提供了帮助诊断和干预重型乙型肝炎，为进一步研究HBV基因突变引起的功能变化提供依据。

80. 发明授权

US08912246B2 Crosslinkable curing super-branched polyester and cured product and preparation method thereof 有权
标题翻译：可交联固化超支化聚酯和固化产物及其制备方法
公开(公告)号：US08912246B2
公开(公告)日：2014-12-16
申请号：US13885399
申请日：2010-11-15
申请人： Mingdong Yu , Zhi Chen
发明人： Mingdong Yu , Zhi Chen
IPC分类号： C08G61/04 , C08G63/06 , C08G83/00 , C08G63/664 , C08G63/91
CPC分类号： C08G63/664 , C08G63/06 , C08G63/912 , C08G83/005
摘要： A crosslinkable curing super-branched polyester and the cured product and the preparation method thereof are disclosed. The super-branched polyester has high refractive index and comprises a compound represented by the following structural formula (I). In the formula (I), HBP is the backbone of the super-branched polyester; both a and b are positive integers; the sum of a and b is less than or equal to n; n is more than or equal to 10 and less than 80. In the super-branched polyester, A is represented by formula (II) and N is represented by formula (III), wherein R is methyl or hydrogen atom; the mole ratio of N relative to the total mole of A and N is more than 30 mol %, and the ratio of the total mole of A and N relative to the product of the total mole of HBP backbone and n is more than 0.5 and less than or equal to 1.
摘要翻译：公开了一种可交联固化的超支化聚酯和固化产物及其制备方法。超支化聚酯具有高折射率，并且包含由以下结构式（I）表示的化合物。在式（I）中，HBP是超支化聚酯的主链; a和b都是正整数; a和b的和小于或等于n; 在超支化聚酯中，A由式（II）表示，N由式（III）表示，其中R是甲基或氢原子; N相对于A和N的总摩尔数的摩尔比大于30mol％，A和N的总摩尔数相对于HBP主链和n的总摩尔数的乘积的比率大于0.5，小于或等于1。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式