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    • 73. 发明授权
    • Indole derivative for treating overproduction of dihydrotestosterone
    • 用于治疗二氢睾酮过量产生的吲哚衍生物
    • US5760040A
    • 1998-06-02
    • US714079
    • 1997-05-05
    • Kiyoshi YoshidaTadashi KurimotoMineo TakeiHiroki Sato
    • Kiyoshi YoshidaTadashi KurimotoMineo TakeiHiroki Sato
    • C07D209/12A61K31/405A61K31/495C07D403/10
    • C07D209/12
    • The present invention relates to an indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical containing the derivative or the salt: ##STR1## wherein R.sup.1 represents lower alkyl; R.sup.2 represents hydrogen or phenyl which may be substituted by at least one lower alkyl, lower alkoxy or a halogen atom; R.sup.3 represents hydrogen, lower alkyl, lower alkoxy, or phenylalkyloxy which may be substituted by halogen or lower alkyl; R.sup.4 represents hydrogen, lower alkyl or lower alkoxy; R.sup.5 represents hydrogen or lower alkyl; and n represents an integer of 1 to 5. This compound has the effects of both blocking .alpha..sub.1 -adrenergic receptors and inhibiting testosterone 5.alpha.-reductases, and is useful as a remedy and/or a preventive for diseases caused by dihydrotestosterone overproduction, such as prostatic hypertrophy, and diseases accompanying the same, such as urination disorder, male pattern alopecia, acne, and so forth.
    • PCT No.PCT / JP95 / 00599 Sec。 371日期:1997年5月5日 102(e)日期1997年5月5日PCT提交1995年3月29日PCT公布。 第WO95 / 26955号公报 日期:1995年10月12日本发明涉及式(1)表示的吲哚衍生物或其盐,以及含有该衍生物或其盐的药物:其中R1表示低级烷基; R2代表氢或可被至少一个低级烷基,低级烷氧基或卤原子取代的苯基; R 3表示可被卤素或低级烷基取代的氢,低级烷基,低级烷氧基或苯基烷氧基; R4代表氢,低级烷基或低级烷氧基; R5代表氢或低级烷基; 并且n表示1至5的整数。该化合物具有阻断α1-肾上腺素能受体和抑制睾酮5α-还原酶的作用,并且可用作二氢睾酮过量产生引起的疾病的补救和/或预防,例如 作为前列腺肥大,以及伴随的疾病,例如排尿障碍,男性脱发,痤疮等。
    • 76. 发明授权
    • Tiltable steering shaft assembly for automotive vehicles
    • 用于汽车的倾斜转向轴总成
    • US4538478A
    • 1985-09-03
    • US591807
    • 1984-03-21
    • Hiroki SatoShuhei ToyodaYuji YokoyaHakumi Ishii
    • Hiroki SatoShuhei ToyodaYuji YokoyaHakumi Ishii
    • B62D1/18B62D1/183B62D1/184
    • B62D1/184B62D1/183Y10T74/20714
    • A fastening device for a tiltable steering shaft assembly of the type in which when shifted into a remote position upwardly from a pre-selected angular position, the steering wheel is automatically returned to the pre-selected angular position and locked at the same position only by depression of the steering wheel. The fastening device comprises a first manual lever arranged to release lock of the fastening device for permitting upward movement of the steering wheel to the remote position, and a second manual lever arranged to readjust the pre-selected angular position of the steering wheel in accordance with a user's physique, in which the first manual lever is cooperable with the second manual lever in operation of the latter to carry out readjustment of the pre-selected angular position of the steering wheel in a simple manner.
    • 一种用于可倾斜转向轴组件的紧固装置,其中当从预选角度位置向上移动到远程位置时,方向盘自动返回到预选角位置,并且仅通过 方向盘凹陷。 紧固装置包括第一手动杆,其布置成释放紧固装置的锁定,以允许方向盘向上移动到远程位置;以及第二手动杆,其布置成根据下述方式重新调整方向盘的预先选定的角位置 用户的身体状态,其中第一手动杆与第二手动杆配合操作,以便操作者以简单的方式对方向盘的预选角位置进行重新调整。