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    • 74. 发明申请
    • PRIMER AND PROBE FOR DETECTION OF MYCOBACTERIUM AVIUM AND METHOD FOR DETECTION OF MYCOBACTERIUM AVIUM BY USING THE PRIMER OR PROBE
    • 用于检测MYCOBACTERIUM AVIUM的检测和检测方法和使用PRIMER或PROBE检测MYCOBACTERIUM AVIUM的方法
    • US20100291555A1
    • 2010-11-18
    • US12519141
    • 2007-11-16
    • Tomokazu Ishikawa
    • Tomokazu Ishikawa
    • C12Q1/68C07H21/04C12N9/00
    • C12Q1/689C12Q1/6853C12Q1/6858C12Q2600/158C12Q2600/16G01N2333/35
    • The object of the present invention is to provide a novel primer for use in the detection of Mycobacterium avium (M. avium), and a method for detection of M. avium conveniently, rapidly and with high precision by using the primer. More specifically, disclosed are an oligonucleotide which comprises a part or an entire of the nucleotide sequence selected from SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, SEQ ID NO:42, SEQ ID NO:130, SEQ ID NO:131, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135 and SEQ ID NO:136, or a part or an entire of the sequence complementary to the nucleotide sequence, and which is capable of hybridizing with the nucleotide sequence for a Mycobacterium avium gene; a primer and a probe for use in the detection of M. avium, which comprises the oligonucleotide; and a method for detection of M. avium using the primer and/or probe.
    • 本发明的目的是提供一种用于检测鸟分枝杆菌(鸟分枝杆菌)的新型引物,以及通过使用引物,快速且高精度地检测鸟分枝杆菌的方法。 更具体地,公开了包含选自SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:3,SEQ ID NO:4,SEQ ID NO:5, SEQ ID NO:37,SEQ ID NO:38,SEQ ID NO:39,SEQ ID NO:40,SEQ ID NO:41,SEQ ID NO:42,SEQ ID NO:130,SEQ ID NO:131, NO:132,SEQ ID NO:133,SEQ ID NO:134,SEQ ID NO:135和SEQ ID NO:136,或与核苷酸序列互补的部分或全部序列,并且能够与 鸟分枝杆菌基因的核苷酸序列; 用于检测鸟分枝杆菌的引物和探针,其包含寡核苷酸; 以及使用引物和/或探针检测鸟分枝杆菌的方法。
    • 75. 发明申请
    • Primer and Probe for Use in Detection of Mycobacterium Kansasii and Method for Detection of Mycobacterium Kansasii Using the Same
    • 用于检测堪萨斯分枝杆菌的引物和探针及使用其的堪萨斯分枝杆菌检测方法
    • US20090298057A1
    • 2009-12-03
    • US11920234
    • 2006-05-11
    • Tomokazu Ishikawa
    • Tomokazu Ishikawa
    • C12Q1/68C07H21/04G01N27/26
    • C12Q1/04C12Q1/689G01N33/56922G01N2333/35
    • The present invention discloses an oligonucleotide which comprises a part or the entire sequence of the nucleotide sequence depicted in SEQ ID NO: 1, 2, 3 or 4, or a part or the entire sequence of a nucleotide sequence complementary to the nucleotide sequence, wherein the oligonucleotide is capable of hybridizing with the nucleotide sequence of Mycobacterium kansasii; a primer and a probe for use in the detection of Mycobacterium kansasii comprising the oligonucleotide; and a method for detecting Mycobacterium kansasii using the primer and/or probe.The method for detecting Mycobacterium kansasii enables the detection of M. kansasii more rapidly and with higher accuracy compared with a conventional bacterium identification method performed by culture examination on a bacterium. Further, the method can exclude any false positive result for the diagnosis and can also detect and diagnose M. kansasii with higher accuracy compared with a diagnosis method performed by PCR using a conventional primer and/or probe. Still further, the method can quantify a M. kansasii cell.
    • 本发明公开了一种寡核苷酸,其包含SEQ ID NO:1,2,3或4所示核苷酸序列的一部分或全部序列,或与该核苷酸序列互补的核苷酸序列的一部分或全部序列,其中 寡核苷酸能够与堪萨斯分枝杆菌的核苷酸序列杂交; 用于检测包含寡核苷酸的堪萨斯分枝杆菌的引物和探针; 以及使用引物和/或探针检测堪萨斯分枝杆菌的方法。 与通过细菌培养检查进行的常规细菌鉴定方法相比,用于检测堪萨斯分枝杆菌的方法能够更快速地和更准确地检测堪萨斯州。 此外,与通过使用常规的引物和/或探针的PCR进行的诊断方法相比,该方法可以排除诊断中的任何假阳性结果,并且还可以以更高的精度检测和诊断堪萨斯堪萨斯州堪萨斯州。 此外,该方法可以量化堪萨斯统计学(Kansasii)细胞。
    • 76. 发明申请
    • Primer and Probe for Detection of Mycobacterium Intracellulare, and Method for Detection of Mycobacterium Intracellulare by Using the Primer and Probe
    • 用于检测分支杆菌分枝杆菌的引物和探针,以及使用引物和探针检测分支杆菌的分枝杆菌的方法
    • US20090275026A1
    • 2009-11-05
    • US12298525
    • 2007-04-27
    • Tomokazu Ishikawa
    • Tomokazu Ishikawa
    • C12Q1/68C07H21/04
    • C12Q1/689
    • The present invention discloses an oligonucleotide which comprises a part or the entire sequence of the nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8, or a part or the entire sequence of a sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8, wherein the oligonucleotide is capable of hybridizing with a nucleotide sequence of Mycobacterium intracellulare gene; a primer or a probe for the detection of M. intracellulare, which comprises the aforementioned oligonucleotide; and a method for detection of M. intracellulare using the aforementioned primer and/or the probe.According to the detection method of the present invention, any false-positive result in diagnosis can be eliminated and detection or diagnosis of M. intracellulare can be carried out with higher accuracy, more preciseness, and more specifically compared to a conventional diagnostic method employing a cell culture assay or a PCR assay. The method also enables to quantify a microbial cell.
    • 本发明公开了包含SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:3,SEQ ID NO:4,SEQ ID NO:5所示核苷酸序列的部分或全部序列的寡核苷酸, SEQ ID NO:6,SEQ ID NO:7或SEQ ID NO:8,或与SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO所示的核苷酸序列互补的序列的部分或全部序列 3,SEQ ID NO:4,SEQ ID NO:5,SEQ ID NO:6,SEQ ID NO:7或SEQ ID NO:8,其中所述寡核苷酸能够与胞内分枝杆菌基因的核苷酸序列杂交; 用于检测胞内分枝杆菌的引物或探针,其包含上述寡核苷酸; 以及使用上述引物和/或探针检测胞内分枝杆菌的方法。 根据本发明的检测方法,可以消除诊断中的任何假阳性结果,并且可以以更高的精度,更精确的方式进行胞内分枝杆菌的检测或诊断,并且更具体地与使用 细胞培养测定或PCR测定。 该方法还能够定量微生物细胞。
    • 79. 发明申请
    • Switched reluctance motor
    • 开关磁阻电机
    • US20080278010A1
    • 2008-11-13
    • US12081928
    • 2008-04-23
    • Tomokazu IshikawaMasayuki NashikiYuuichirou Itou
    • Tomokazu IshikawaMasayuki NashikiYuuichirou Itou
    • H02K19/02
    • H02K19/103
    • A switched reluctance motor has a rotor and a stator. The stator has first and second stator magnetic pole groups sequentially placed in an axial direction of the rotor. First and second stator magnetic poles in each group are alternately arranged on a same circumference. The first stator magnetic poles are placed every electrical angle 2π and reversely magnetized to each other. The second stator magnetic poles are placed every electrical angle 2π and reversely magnetized to each other. The first magnetic pole is apart from the second magnetic pole by electrical angle π. Each stator magnetic pole in the first stator magnetic pole group is apart from that in the second magnetic pole group by electrical angle π/2 in the circumferential direction.
    • 开关磁阻电动机具有转子和定子。 定子具有顺序地设置在转子的轴向上的第一和第二定子磁极组。 每组中的第一和第二定子磁极交替地布置在相同的圆周上。 每个电角度2pi放置第一个定子磁极,并相互磁化。 第二定子磁极每个电角度2pi放置并彼此反向磁化。 第一磁极通过电角度pi与第二磁极分开。 第一定子磁极组中的每个定子磁极与第二磁极组中的每个定子磁极在圆周方向上以电角度π/ 2分开。
    • 80. 发明授权
    • Compiler, compiler apparatus and compilation method
    • 编译器,编译器和编译方法
    • US07284241B2
    • 2007-10-16
    • US10630705
    • 2003-07-31
    • Taketo HeishiToshiyuki SakataHajime OgawaRyoko MiyachiShuji MiyasakaTomokazu Ishikawa
    • Taketo HeishiToshiyuki SakataHajime OgawaRyoko MiyachiShuji MiyasakaTomokazu Ishikawa
    • G06F9/45
    • G06F8/443G06F8/425G06F8/427G06F8/4441
    • An operator definition file 102 and the like included in a source program 101 and a compiler 100 that translates the source program 101 into a machine language program 105 are provided. The operator definition file 102 includes definitions of various fixed point type operators by class definitions. The compiler 100 can generate effectively advanced and specific instructions that a processor executes and make improvements through expanding functions and the like without repeating frequently upgrading of the version of the compiler itself. The compiler 100 is made up of an intermediate code generation unit 121 that generates intermediate codes, a machine language instruction substitution unit 122 that substitutes the intermediate codes referring to classes defined by the operator definition file 102 with machine language instructions and an optimization unit 130 that performs optimization targeting the intermediate codes including the substituted machine language instructions.
    • 提供包括在源程序101中的操作者定义文件102等以及将源程序101转换为机器语言程序105的编译器100。 操作者定义文件102包括通过类定义的各种定点类型操作符的定义。 编译器100可以生成有效的高级特定指令,处理器执行并通过扩展功能等进行改进,而不会重复频繁升级编译器本身的版本。 编译器100由生成中间代码的中间代码生成单元121构成,机器语言指令替换单元122,其使用机器语言指令代替参考由操作者定义文件102定义的类别的中间代码和优化单元130, 执行针对包括替代机器语言指令的中间代码的优化。