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71. 发明申请

US20180022074A1 Composite Materials with Multilayer Laminate Facing 审中-公开
公开(公告)号：US20180022074A1
公开(公告)日：2018-01-25
申请号：US14185655
申请日：2014-02-20
申请人： Thomas Miller , Timothy Johnson
发明人： Thomas Miller , Timothy Johnson
IPC分类号： B32B27/12 , B32B7/12 , B32B5/02
CPC分类号： B32B27/12 , B32B5/022 , B32B7/12 , B32B2607/00
摘要： A composite board with a multilayer laminated facer is presented having a nonwoven, a first polymer layer, and a second polymer layer. The laminate may be printed on the nonwoven, on the upper surface of the first polymer layer or inverted printed on the backside of an applied film. A number of configurations for the polymer layers are disclosed. The laminate may include exposed fibers on the lower surface or the nonwoven may be saturated. A removable peel-ply may be included. By controlling the placement and thickness of the polymer layers it is possible to tailor additive in the polymers such as colorants, opacifiers, UV stabilizers, and fire retardants to improve quality and reduce costs. In an alternate embodiment of the present invention, a first polymer layer is applied to the topside of the nonwoven and the second polymer is laminated to the first polymer layer as a preformed film. The laminated facer is thermally or adhesively bonded to the composite board.

72. 发明授权

US09505196B2 Laminate facing for fiber reinforced materials and composite materials formed therefrom 有权
标题翻译：面向纤维增强材料的层压板和由其形成的复合材料
公开(公告)号：US09505196B2
公开(公告)日：2016-11-29
申请号：US13851662
申请日：2013-03-27
申请人： Thomas Miller
发明人： Thomas Miller
IPC分类号： B32B5/02 , B32B5/06 , B32B7/04 , B32B7/08 , B32B7/12 , B32B7/14 , B32B15/08 , B32B15/09 , B32B27/12 , B32B27/32 , B32B27/36 , B32B27/40 , B32B27/42
CPC分类号： B32B27/12 , B32B5/02 , B32B5/024 , B32B5/06 , B32B7/04 , B32B7/045 , B32B7/08 , B32B7/12 , B32B7/14 , B32B15/08 , B32B15/09 , B32B27/32 , B32B27/322 , B32B27/36 , B32B27/40 , B32B27/42 , B32B2255/10 , B32B2255/205 , B32B2260/021 , B32B2260/046 , B32B2262/0253 , B32B2262/0276 , B32B2262/101 , B32B2305/07 , B32B2305/073 , B32B2305/08 , B32B2323/04 , B32B2323/10 , B32B2327/06 , B32B2367/00 , B32B2375/00 , B32B2419/00 , B32B2607/00 , Y10T428/23914 , Y10T428/249923 , Y10T428/266 , Y10T428/269 , Y10T428/27 , Y10T428/31565 , Y10T428/31681 , Y10T428/31786 , Y10T428/31797 , Y10T442/2861 , Y10T442/3862 , Y10T442/675
摘要： The present invention provides a laminate material having a polyester film and a layer of polyester fibers cohesively bonded thereto. Generally, a metal layer deposited at least one surface of the laminate. The invention may also include a glass reinforced polymer layer formed on the laminated facer where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. The laminate may further include a second polymer layer having a thickness joined to the fiber layer and/or a layer of hot melt adhesive applied to the polyester fibers. Also presented is a composite material having a polyester film, a layer of polyester fibers bonded to the second polymer layer; a second polymer layer joined to the polyester film; and a glass reinforced polymer layer formed on the laminated facer, where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer.
摘要翻译：本发明提供了一种具有聚酯膜和与内聚合的聚酯纤维层的层压材料。通常，沉积层压体的至少一个表面的金属层。本发明还可以包括形成在层压面上的玻璃增强聚合物层，其中玻璃增强聚合物层的聚合物与层压面的非织造织物混合。层压材料还可以包括具有连接到纤维层的厚度的第二聚合物层和/或施加到聚酯纤维上的热熔粘合剂层。还提出了具有聚酯膜，与第二聚合物层结合的聚酯纤维层的复合材料; 连接到聚酯膜的第二聚合物层; 以及形成在层压面上的玻璃增强聚合物层，其中玻璃增强聚合物层的聚合物与层压面的非织造织物混合。

73. 发明申请

US20150193839A1 METHOD AND SYSTEM FOR DONATING TO THIRD-PARTY BENEFICIARIES 审中-公开
标题翻译：用于第三方受益人的方法和系统
公开(公告)号：US20150193839A1
公开(公告)日：2015-07-09
申请号：US14592647
申请日：2015-01-08
申请人： Richard Masino , Jesse Porter , Thomas Miller
发明人： Richard Masino , Jesse Porter , Thomas Miller
IPC分类号： G06Q30/02 , G06Q40/00
CPC分类号： G06Q30/0279 , G06Q40/00
摘要： The present invention relates to a network based, third-party beneficiary donation system, and in particular to systems and methods that allow a merchant to provide a choice to participating consumer(s) in the form of donations to third party beneficiaries based on consumer purchases wherein the consumer chooses their third party beneficiary from a merchant curated list or customer self-generated list and independently determines the percentage amount of the donation or selects a pre-determined amount. In this manner, consumers are provided with an option to purchase products from the authorized merchant knowing that the product purchases may result in a specified donation to a customer selected third-party beneficiary or multiple customer selected third party beneficiaries on a per product or per order basis. Third party beneficiaries are generally intended to be charities or causes but are not required to have tax-exempt status.
摘要翻译：本发明涉及一种基于网络的第三方受益人捐赠系统，特别涉及允许商家以基于消费者购买向第三方受益人提供捐赠形式的参与消费者的选择的系统和方法其中消费者从商家策划名单或客户自行列表中选择其第三方受益人，并独立地确定捐赠的百分比数量或选择预定金额。以这种方式，向消费者提供从授权商家购买产品的选项，知道产品购买可以导致对每个产品或每个订单的客户选择的第三方受益人或多个客户选择的第三方受益人的指定捐赠基础。第三方受益人通常是为了慈善或事业，但不需要享有免税地位。

74. 发明授权

US08871796B2 Diaryl ether derivatives as notch sparing gamma secretase inhibitors 有权
标题翻译：二芳基醚衍生物作为缺口保留的γ分泌酶抑制剂
公开(公告)号：US08871796B2
公开(公告)日：2014-10-28
申请号：US13501628
申请日：2010-10-05
申请人： William Colby Brown , Jason Brubaker , Christian Fischer , Richard W. Heidebrecht , John T. Hendrix , Elizabeth H. Kelley , Rachel N. MacCoss , Joey L. Methot , Thomas Miller , Karin M. Otte , Phieng Siliphaivanh , Thomas Reger , Peter D. Williams , Catherine M. Wiscount
发明人： William Colby Brown , Jason Brubaker , Christian Fischer , Richard W. Heidebrecht , John T. Hendrix , Elizabeth H. Kelley , Rachel N. MacCoss , Joey L. Methot , Thomas Miller , Karin M. Otte , Phieng Siliphaivanh , Thomas Reger , Peter D. Williams , Catherine M. Wiscount
IPC分类号： A61K31/415 , C07D401/00 , C07D421/00 , C07D405/10 , C07D413/12 , C07D409/12 , C07D417/12 , C07D231/22 , C07D413/14 , C07D491/113 , C07D405/12 , C07D401/04 , C07D405/14 , C07D401/12
CPC分类号： C07D231/22 , C07D231/20 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/113
摘要： The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明包括一类新的二芳基醚衍生物，其抑制通过推定的γ-分泌酶处理APP，同时保留Notch信号通路，因此可用于治疗或预防阿尔茨海默病而不发展Notch抑制介导的胃肠道问题。还包括药物组合物和使用方法。

75. 发明授权

US08801681B2 Medical device 有权
标题翻译：医疗装置
公开(公告)号：US08801681B2
公开(公告)日：2014-08-12
申请号：US11255492
申请日：2005-10-21
申请人： A. Bartholomew Flick , Gregg Silver , Thomas Miller
发明人： A. Bartholomew Flick , Gregg Silver , Thomas Miller
IPC分类号： A61F13/00 , A61F13/36 , A61F13/02
CPC分类号： A61F13/00063 , A61F13/022 , A61F13/36 , A61F2013/00119 , A61F2013/00251 , A61F2013/00327 , A61F2013/00553 , A61F2013/00578 , A61F2013/00604 , A61F2013/0074 , A61F2013/00859 , A61F2013/0091 , A61F2013/00936
摘要： A medical device for example a wound dressing having antibacterial and optionally, antifungal properties, are provided together with methods for making the device. An exemplary dressing includes a layer of silver-containing fabric, (optionally) a layer of absorbent material, and (optionally) a layer of flexible air-permeable and/or water-impermeable material. The dressing can be used for prophylactic and therapeutic care and treatment of skin infections and surface wounds (including surgical incisions), as a packing material, and as a swab for surface cleaning.
摘要翻译：提供具有抗细菌和任选的抗真菌性质的伤口敷料的医疗装置与制造该装置的方法一起提供。示例性敷料包括一层含银织物（任选地）一层吸收材料，和（任选地）一层柔性透气和/或不透水材料。敷料可用于预防和治疗护理和治疗皮肤感染和表面伤口（包括手术切口），作为包装材料，以及用于表面清洁的拭子。

76. 发明授权

US08701498B2 Device for determining material properties 有权
标题翻译：用于确定材料性质的装置
公开(公告)号：US08701498B2
公开(公告)日：2014-04-22
申请号：US13538628
申请日：2012-06-29
申请人： Itai Einav , Pierre Rognon , Thomas Miller
发明人： Itai Einav , Pierre Rognon , Thomas Miller
IPC分类号： G01B5/30 , G01B7/16 , G01L1/00 , G01N3/00
CPC分类号： G01B5/30 , G01N3/24 , G01N11/10 , G01N2203/0284
摘要： A device for determining material properties includes a bottom panel extending from a first end to a second end of the device, for supporting a material to be tested. A closed loop flexible wall extends upwardly from the panel and is in operational engagement with a flexible wall idle means towards the first end of the device and a flexible wall driving means in spaced relation with the flexible wall idle means. The flexible wall driving means causes movement of the closed loop flexible wall along a predetermined closed loop path. The flexible wall driving means and the means of driving it are arranged at a position outside of a material containment area of the device.
摘要翻译：用于确定材料性质的装置包括从装置的第一端延伸到第二端的底板，用于支撑待测材料。闭环柔性壁从面板向上延伸并且朝向装置的第一端与柔性壁空闲装置可操作地接合，以及与柔性壁空闲装置间隔开的柔性壁驱动装置。柔性壁驱动装置使得闭环柔性壁沿预定的闭环路径移动。柔性壁驱动装置和驱动装置布置在设备的材料容纳区域外部的位置。

77. 发明申请

US20120160146A1 FAIRLEAD LATCH DEVICE 有权
标题翻译： FAIRLEAD锁定装置
公开(公告)号：US20120160146A1
公开(公告)日：2012-06-28
申请号：US13335832
申请日：2011-12-22
申请人： Thomas Miller , Charlie O'Rourke
发明人： Thomas Miller , Charlie O'Rourke
IPC分类号： B63B21/18
CPC分类号： B63B21/10 , B63B21/18 , B63B21/50
摘要： A self-aligning fairlead latch device is provided for guiding and securing an anchor chain between an offshore structure and an anchor. The fairlead latch device includes a latch housing pivotally mounted to a fairlead housing. The latch housing includes one or more latches for securing the anchor chain in place. The fairlead latch device further includes an upper retainer component that is coupled to an upper support structure and a lower support structure. The coupling of the upper retainer component to the support structures allow the fairlead latch device to be relocated by lifting of the device from the support structures.
摘要翻译：提供了一种自对准的会话闩锁装置，用于在海上结构和锚之间引导和固定锚链。通道闩锁装置包括可枢转地安装到整流罩壳体上的闩锁壳体。闩锁壳体包括用于将锚链固定在适当位置的一个或多个闩锁。所述通道闩锁装置还包括联接到上支撑结构和下支撑结构的上保持器部件。上部保持器部件与支撑结构的联接允许通过从支撑结构提升装置来将导轨闩锁装置重新定位。

78. 发明授权

US07834026B2 Spirocyclic compounds 有权
标题翻译：螺环化合物
公开(公告)号：US07834026B2
公开(公告)日：2010-11-16
申请号：US12085396
申请日：2006-11-17
申请人： Scott C. Berk , Joshua Close , Christopher Hamblett , Richard W. Heidebrecht , Solomon D. Kattar , Laura T. Kliman , Dawn M. Mampreian , Joey L. Methot , Thomas Miller , David L. Sloman , Matthew G. Stanton , Paul Tempest , Anna A. Zabierek
发明人： Scott C. Berk , Joshua Close , Christopher Hamblett , Richard W. Heidebrecht , Solomon D. Kattar , Laura T. Kliman , Dawn M. Mampreian , Joey L. Methot , Thomas Miller , David L. Sloman , Matthew G. Stanton , Paul Tempest , Anna A. Zabierek
IPC分类号： A01N43/42 , A01N43/12 , A01N43/26 , A61K31/44 , A61K31/34 , A61K31/335 , C07D237/00 , C07D239/00 , C07D241/00 , C07D491/10 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D497/20 , C07D311/96 , C07D313/06 , C07D313/20 , C07D315/00
CPC分类号： C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D498/10
摘要： The present invention relates to a novel class of substituted spirocyclic compounds, represented by the following structural Formula: I Wherein A, B and D are independently selected from CR12, NR1a, C(O) and O; E is selected from a bond, CR12, NR1a, C(O) and O; wherein at least one of A, B, D or E is CR12; and provided that when A is O, then E is not O; G is CR12; R is selected from NH2 and OH; These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing termin differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及由下列结构式表示的新一类取代的螺环化合物：其中A，B和D独立地选自CR12，NR1a，C（O）和O; E选自键，CR12，NR1a，C（O）和O; 其中A，B，D或E中的至少一个为CR 12; 并且条件是当A为O时，则E不为O; G是CR12; R选自NH 2和OH; 这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经退行性疾病本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内产生治疗有效量的这些化合物。

79. 发明申请

US20090221669A1 Disubstituted Aniline Compounds 有权
标题翻译：二取代苯胺化合物
公开(公告)号：US20090221669A1
公开(公告)日：2009-09-03
申请号：US12226628
申请日：2007-04-20
申请人： Richard Heidebrecht , Joey Methot , Dawn Mampreian , Thomas Miller , Phieng Siliphaivanh
发明人： Richard Heidebrecht , Joey Methot , Dawn Mampreian , Thomas Miller , Phieng Siliphaivanh
IPC分类号： A61K31/24 , C07C229/54 , C07D333/06 , A61K31/381 , A61P35/00
CPC分类号： C07D333/20 , C07C229/60 , C07C237/04 , C07C237/40
摘要： The present invention relates to a novel class of disubstituted aniline compounds. These compounds can inhibit hi-stone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及一类新的二取代苯胺化合物。这些化合物可以抑制高山脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统疾病（CNS），例如神经退行性疾病本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。

80. 发明申请

US20090105264A1 Substituted Nicotinamide Compounds 审中-公开
标题翻译：取代的烟酰胺化合物
公开(公告)号：US20090105264A1
公开(公告)日：2009-04-23
申请号：US12084272
申请日：2006-10-30
申请人： Christopher Hamblett , Dawn M. Mampreian , Joey L. Methot , Thomas Miller , David L. Sloman , Matthew G. Stanton , Kevin Wilson
发明人： Christopher Hamblett , Dawn M. Mampreian , Joey L. Methot , Thomas Miller , David L. Sloman , Matthew G. Stanton , Kevin Wilson
IPC分类号： A61K31/496 , C07D401/04 , C07D241/36 , A61P35/00 , C07D409/14 , A61K31/497
CPC分类号： C07D213/56 , C07D239/28 , C07D401/12 , C07D487/08
摘要： The present invention relates to a novel class of substituted nicotinamides. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及一类新型的取代烟酰胺。这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经退行性疾病本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。

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