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71. 发明授权

EP2797641B1 FUNCTIONALIZATION OF BIOMATERIALS TO CONTROL REGENERATION AND INFLAMMATION RESPONSES 无效
公开(公告)号：EP2797641B1
公开(公告)日：2019-07-10
申请号：EP12862472.3
申请日：2012-12-31
申请人： Trustees Of Tufts College
发明人： LLAMAS, Jabier Gallego , KAPLAN, David L. , PANILAITIS, Bruce
IPC分类号： A61L27/22 , A61L27/26 , A61L27/40 , A61L27/56 , A61L27/50

72. 发明授权

EP2629836B1 SILK FIBROIN-BASED MICRONEEDLES AND METHODS OF MAKING THE SAME 有权
公开(公告)号：EP2629836B1
公开(公告)日：2018-09-12
申请号：EP11835053.7
申请日：2011-10-19
申请人： Trustees of Tufts College
发明人： KAPLAN, David L. , TSIORIS, Konstantinos , OMENETTO, Fiorenzo G. , PRITCHARD, Eleanor M.
IPC分类号： A61M37/00 , A61M5/158 , A61L27/58 , A61K9/00 , A61K9/70 , A61L27/00 , A61B17/20 , A61L31/12
CPC分类号： A61L31/125 , A61B17/205 , A61K9/0021 , A61L31/047 , A61L31/16 , A61M5/158 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

73. 发明公开

EP3328438A1 POLYPEPTIDE MONOLITHS 审中-实审
公开(公告)号：EP3328438A1
公开(公告)日：2018-06-06
申请号：EP16831335.1
申请日：2016-07-28
申请人： Trustees of Tufts College
发明人： OMENETTO, Fiorenzo G. , KAPLAN, David L. , MARELLI, Benedetto , LI, Chunmei
IPC分类号： A61K47/32 , A61K47/42 , A61L27/14 , A61L27/22
CPC分类号： A61L27/56 , A61K9/5052 , A61L27/227 , A61L27/46 , A61L27/54 , A61L2300/62
摘要： The present application relates to amphiphilic polypeptide materials, methods for making and using the same. Provided amphiphilic polypeptide materials are water-based and manufactured using all aqueous processing. Provided materials exhibit a capacity to encapsulate and store biologically active molecules or macromolecules. Such biologically active molecules or macromolecules retain their structure and the biological activity so that these biologically active molecules or macromolecules are not materially degraded, reduced, and/or inhibited by processing steps or exposure. Provided materials possess unique mechanical and structural properties, including size, density, moldability and machinability.

74. 发明授权

EP2129772B1 TISSUE-ENGINEERED SILK ORGANS 有权
标题翻译：组织工程丝织品
公开(公告)号：EP2129772B1
公开(公告)日：2016-07-27
申请号：EP08730804.5
申请日：2008-02-27
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： KAPLAN, David L. , OMENETTO, Fiorenzo , MARCHANT, Jeffrey , PANJWANI, Noorjahan , LAWRENCE, Brian
IPC分类号： C12N5/00 , A61L27/38
CPC分类号： A61L27/3604 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3839 , A61L27/3891 , A61L27/56 , A61L2300/412 , C12N5/0068 , C12N5/0621 , C12N2533/50 , G01N33/5044
摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.

75. 发明公开

EP2970411A2 LOW MOLECULAR WEIGHT SILK COMPOSITIONS AND STABILIZING SILK COMPOSITIONS 有权
标题翻译：低分子组织成分和稳定SILK组合物
公开(公告)号：EP2970411A2
公开(公告)日：2016-01-20
申请号：EP14763730.0
申请日：2014-03-14
申请人： Trustees of Tufts College
发明人： KAPLAN, David L. , KLUGE, Jonathan A. , OMENETTO, Fiorenzo G.
IPC分类号： C07K14/435
CPC分类号： A61K47/42 , A61K9/08 , A61K9/19 , A61K38/1825 , A61L27/3604 , B01J20/24 , C07H21/02 , C07K14/43518 , C07K14/43586 , C07K14/503 , C07K2319/00
摘要： The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition.

76. 发明公开

EP2776079A1 INJECTABLE SILK FIBROIN FOAMS AND USES THEREOF 有权
标题翻译：国际志愿人员培训基金会
公开(公告)号：EP2776079A1
公开(公告)日：2014-09-17
申请号：EP12846855.0
申请日：2012-11-09
申请人： Trustees of Tufts College
发明人： LEISK, Gary G. , LO, Tim Jia-Ching , LI, Lei , BELLAS, Evangelia , KAPLAN, David L.
IPC分类号： A61L27/22 , A61L27/14 , A61L27/40 , C12N5/0789
摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
摘要翻译：本文提供的发明涉及用于修复或增加受试者中的组织的组合物，方法，递送装置和试剂盒。本文所述的组合物可以是可注射的，使得它们可以以微创程序（例如通过注射）置于待治疗的组织中。在一些实施方案中，本文所述的组合物包含压缩的丝素蛋白基质，其可以在注射到组织中时膨胀并且将其初始膨胀体积保持在组织中一段时间。组合物可以用作填充剂来代替组织空隙，例如用于组织修复和/或增加，或作为支架以支持组织再生和/或重建。在一些实施方案中，本文所述的组合物可用于软组织修复或增强。

77. 发明公开

EP2699266A1 COMPOSITIONS AND METHODS FOR STABILIZATION OF ACTIVE AGENTS 有权
标题翻译：组合物和稳定剂的方法
公开(公告)号：EP2699266A1
公开(公告)日：2014-02-26
申请号：EP12774253.4
申请日：2012-04-23
申请人： Trustees of Tufts College
发明人： KAPLAN, David L. , OMENETTO, Fiorenzo
IPC分类号： A61K47/42 , A61K39/12 , A61J1/00 , B82Y5/00 , A61K35/76 , A61K39/00 , A61M5/00
CPC分类号： A61K39/20 , A61K9/0019 , A61K9/06 , A61K9/146 , A61K9/19 , A61K9/5026 , A61K9/5063 , A61K9/7007 , A61K38/00 , A61K39/0015 , A61K39/02 , A61K39/04 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/12 , A61K39/165 , A61K47/42 , A61K47/46 , A61K2039/5252 , A61K2039/5254 , A61K2039/6031 , A61K2039/622 , A61K2039/64 , A61K2039/70 , B82Y5/00 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234 , Y02A50/388 , Y02A50/39 , Y02A50/466 , Y02A50/484
摘要： Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.

78. 发明公开

EP2457087A2 ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS 审中-公开
标题翻译：完全蛋白质现有和植入式生物降解反射器的
公开(公告)号：EP2457087A2
公开(公告)日：2012-05-30
申请号：EP10823765.2
申请日：2010-07-20
申请人： Tufts University/Trustees of Tufts College
发明人： OMENETTO, Fiorenzo , KAPLAN, David L.
IPC分类号： G01N33/48 , G01N33/68 , A61B5/00
CPC分类号： A61B5/0059 , A61K49/0004 , A61L27/227
摘要： The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy. Such device can be used as a label-free, biocompatible, bioresorbable, implantable device for various applications ranging from medical imaging/diagnostics, drug/therapeutic delivery, to food chain safety and environmental monitoring.

79. 发明公开

EP2396276A2 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS 有权
标题翻译： NANOPRÄGUNGVON SEIDENFIBROINSTRUKTURENFÜRBIOMEDIZINISCHE UND BIOPHOTONISCHE ANWENDUNGEN
公开(公告)号：EP2396276A2
公开(公告)日：2011-12-21
申请号：EP10770086.6
申请日：2010-02-12
申请人： Trustees Of Tufts College
发明人： AMSDEN, Jason J. , KAPLAN, David L. , OMENETTO, Fiorenzo
IPC分类号： B82B3/00 , B29C59/02 , B29D7/01
CPC分类号： A61K9/7007 , A61K9/70 , A61K41/00 , A61K47/42 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , G01N21/4788 , G01N21/774 , G01N2021/7776 , G02B5/1809 , G02B5/1847 , G02B6/02061 , G02B6/1225 , G02B6/262 , G03F7/0002 , Y10T428/24479
摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
摘要翻译：本发明提供了一种基于光子纳米压印丝素蛋白的材料及其制备方法，其包括用光子纳米尺度图案压花丝素蛋白基膜。此外，本发明提供了通过局部降低丝膜的玻璃化转变温度，可以在室温下将丝素蛋白基膜纳米压印的方法。这种纳米压印工艺增加了高通量，并且提高了将丝基光子学结合到生物医学和其它光学器件中的潜力。

80. 发明公开

EP2129772A2 TISSUE-ENGINEERED SILK ORGANS 有权
标题翻译：组织工程丝织品
公开(公告)号：EP2129772A2
公开(公告)日：2009-12-09
申请号：EP08730804.5
申请日：2008-02-27
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： KAPLAN, David L. , OMENETTO, Fiorenzo , MARCHANT, Jeffrey , PANJWANI, Noorjahan , LAWRENCE, Brian
IPC分类号： C12N5/06 , A61L27/38
CPC分类号： A61L27/3604 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3839 , A61L27/3891 , A61L27/56 , A61L2300/412 , C12N5/0068 , C12N5/0621 , C12N2533/50 , G01N33/5044
摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
摘要翻译：本发明涉及薄片组织层，其包含含有组织特异性细胞的开槽丝素蛋白基质。丝素蛋白底物提供了控制和培养细胞和细胞外基质发育的极好手段。许多薄层组织层可用于创建组织工程器官，如组织工程角膜。组织工程器官是非免疫原性和生物相容性的。

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