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71. 发明专利

MXPA06008829A METODO DE FABRICAR 7-(4-BROMOBUTOXI)-3,4-DIHIDROCARBOESTIRILO. 未知
公开(公告)号：MXPA06008829A
公开(公告)日：2007-04-25
申请号：MXPA06008829
申请日：2005-02-07
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION , HILDESHEIM JEAN , BERLIN ALISA
IPC分类号： C07D215/22 , A61K31/4706 , C07D215/227
摘要： La invencion comprende sintetizar 7-(4-bromobutoxi)-3,4-dihidrocarboestirilo mezclando 7-hidroxi-tetrahidroquinolinona, dibromobutano, y por lo menos una base para formar una mezcla de la reaccion; calentar la mezcla de la reaccion; enfriar la mezcla de la reaccion; y aislar el 7-(4-bromobutoxi)-3,4-dihidrocarboestirilo desde la mezcla de la reaccion. La invencion tambien comprende utilizar catalizadores de transferencia de fase durante la reaccion.

72. 发明专利

DE60304175T2 未知
公开(公告)号：DE60304175T2
公开(公告)日：2007-03-15
申请号：DE60304175
申请日：2003-04-29
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION , NISNEVICH GENNADY , RUKHMAN IGOR , KAFTANOV JULIA
IPC分类号： C07D401/10 , C07D403/10
摘要： Losartan is prepared by acid catalyzed cleavage of a triarylmethyl group from a triarylmethyl-substituted losartan derivative in a diluent comprising liquid ketone. The reaction mixture is basified and liquid ketone is evaporated from the mixture leaving a residue from which a triarylmethyl alcohol and losartan are each obtained in high yield and high purity. In addition, losartan potassium is prepared by a process that is more convenient that those previously known in the art in which losartan is contacted with potassium ions in substantially pure liquid alcohol and losartan potassium is precipitated from the alcohol.

73. 发明专利

AT340793T 未知
公开(公告)号：AT340793T
公开(公告)日：2006-10-15
申请号：AT03764805
申请日：2003-07-16
申请人： TEVA PHARMA
发明人： NISNEVICH GENNADY , RUKHMAN IGOR , PERTSIKOV BORIS , KAFTANOV JULIA , DOLITZKY BEN-ZION
IPC分类号： C07D403/10
摘要： Provided is a novel synthesis of irbesartan employing a phase transfer catalyst. Also provided is irbesartan having a fine particle size.

74. 发明专利

AT335743T 未知
公开(公告)号：AT335743T
公开(公告)日：2006-09-15
申请号：AT03809127
申请日：2003-10-16
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION , LIFSHITZ IGOR
IPC分类号： C07D473/00 , C07D473/18
摘要： Provided is a method of reducing excess residual process solvents, especially excess residual process alcohol (e.g. isopropanol), in valacyclovir hydrochloride to about 1000 ppm (weight) or less by contacting valacyclovir hydrochloride having excess residual process alcohol with moist gas.

75. 发明专利

SI1474417T1 Postopek za pripravo lozartana in kalijevega lozartana 未知
公开(公告)号：SI1474417T1
公开(公告)日：2006-08-31
申请号：SI200330282
申请日：2003-04-29
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION , NISNEVICH GENNADY , RUKHMAN IGOR , KAFTANOV JULIA
IPC分类号： C07D401/00

76. 发明专利

YU30203A KRISTALNA VENLAFAKSIN BAZA I NOVI POLIMORFI VENLAFAKSIN HIDROHLORIDA, POSTUPCI ZA NJEGOVO PRIPREMANJE 未知
公开(公告)号：YU30203A
公开(公告)日：2006-08-17
申请号：YUP30203
申请日：2001-10-19
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION , ARONHIME JUDITH , WEIZEL SCHLOMIT , NISNEVISH GENADY
IPC分类号： A61P25/24 , A61K31/137 , C07C209/84 , C07C213/08 , C07C213/10 , C07C215/42 , C07C217/60 , C07C217/74
摘要： Predmetni pronalazak odnosi se na novi esencijalno čist venlafaksin i postupak za njegovo pripremanje. Predmetni pronalazak takođe se odnosi na nove solvatne oblike venlafaksin hlorovodonika i postupak za njegovo pripremanje. Dalje, predmetni pronalazak obezbeđuje novi postupak za pripremanje venlafaksin hlorovodonika iz venlafaksina; postupak sadrži korake: i) pripremanje mešavine venlafaksina sa acetonom; i ii) izlaganje mešavine gasovitoj hlorovodoničnoj kiselini.[The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochoric acid.

77. 发明专利

CA2594022A1 PROCESS FOR PRODUCING POLYPEPTIDE MIXTURES USING HYDROGENOLYSIS 未知
公开(公告)号：CA2594022A1
公开(公告)日：2006-08-10
申请号：CA2594022
申请日：2006-01-20
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION
IPC分类号： A61K31/74
摘要： The subject invention provides for a process for making a mixture of acetate salts of polypeptides, each of which consisting of glutamic acid, alanine, tyrosine and lysine, wherein the mixture has a desired peak molecular weight, comprising: a) polymerizing N-carboxyanhydrides of tyrosine, alanine, gamma-benzyl glutamate and trifluoroacetyllysine with an initiator in an amount of 0.01% to 20% by weight for a suitable period of time and at a suitable temperature to form a mixture of protected polypeptides, which mixture of polypeptides in unprotected form having a first peak molecular weight; b) removing the benzyl protecting group from the mixture of protected polypeptides by contacting the polypeptides with a hydrogenolysis catalyst and hydrogen to produce a mixture of trifluoroacetyl protected polypeptides, which mixture of polypeptides in unprotected form having the first peak molecular weight; c) removing the trifluoroacetyl protecting group from the trifluoroacetyl protected polypeptides by contacting the polypeptides with an organic base solution to form a mixture of polypeptides, which mixtures of polypeptides in unprotected form having the first peak molecular weight; d) removing the free trifluoroacetyl groups and low molecular weight impurities by ultrafiltration to obtain the mixture of polypeptides each of which consisting of glutamic acid, alanine, tyrosine and lysine; and e) contacting the mixture of polypeptides each of which consisting of glutamic acid, alanine, tyrosine and lysine with an aqueous solution of acetic acid to form the mixture of acetate salts of polypeptides each of which consisting of glutamic acid, alanine, tyrosine and lysine and having the desired peak molecular weight.

78. 发明专利

ZA200401268B Crystalline forms of valacyclovir hydrochloride 未知
公开(公告)号：ZA200401268B
公开(公告)日：2006-05-31
申请号：ZA200401268
申请日：2002-09-06
申请人： TEVA PHARMA
发明人： WIZEL SHLOMIT , ARONHIME JUDITH , NIDDAM-HILDESHEIM VALERIE , DOLITZKY BEN-ZION , ETINGER MARINA Y , YUZEFOVICH MICHAEL , NISNEVISH GENNADY A , PERTISKOV BORIS , TISHIN BORIS , BLASBERGER DINA
IPC分类号： C07D20060101

79. 发明专利

AT321039T 未知
公开(公告)号：AT321039T
公开(公告)日：2006-04-15
申请号：AT03726536
申请日：2003-04-29
申请人： TEVA PHARMA
发明人： DOLITZKY BEN-ZION , NISNEVICH GENNADY , RUKHMAN IGOR , KAFTANOV JULIA
IPC分类号： C07D403/10 , C07D401/10
摘要： Losartan is prepared by acid catalyzed cleavage of a triarylmethyl group from a triarylmethyl-substituted losartan derivative in a diluent comprising liquid ketone. The reaction mixture is basified and liquid ketone is evaporated from the mixture leaving a residue from which a triarylmethyl alcohol and losartan are each obtained in high yield and high purity. In addition, losartan potassium is prepared by a process that is more convenient that those previously known in the art in which losartan is contacted with potassium ions in substantially pure liquid alcohol and losartan potassium is precipitated from the alcohol.

80. 发明专利

YU79402A ZOLPIDEM HEMITARTRAT 未知
公开(公告)号：YU79402A
公开(公告)日：2006-03-03
申请号：YUP79402
申请日：2001-04-24
申请人： TEVA PHARMA
发明人： ARONHIME JUDITH , DOLITZKY BEN-ZION , KORDOVA MARCO , LEONOV DAVID , MESZAROS-SOS ERZEBET , SALYI SZABOLES , SCHWARTZ ANCHEL , SZABO CSABA , ZAVUROV SHLOMO
IPC分类号： A61K31/437 , A61K31/44 , A61P25/08 , A61P25/20 , A61P25/22 , A61P43/00 , C07D471/04
摘要： Predmetni pronalazak obezbedjuje nove polimorfe zolpidem hemitartrata i pripremanje polimorfa.[The present invention provides for novel polymorphs of zolpidem hemitartrate and the preparation of the polymorphs.

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