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71. 发明授权

US07879009B1 Variable opening delivery system for intervertebral disc therapies 有权
标题翻译：用于椎间盘治疗的可变开放输送系统
公开(公告)号：US07879009B1
公开(公告)日：2011-02-01
申请号：US12696153
申请日：2010-01-29
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61M5/178 , A61M29/00 , A61B1/32
CPC分类号： A61B1/32 , A61B17/0218 , A61B17/34 , A61B17/3439 , A61B2017/00261 , A61B2017/00473 , A61B2017/0256 , A61M5/158 , A61M2025/0024
摘要： The disclosure is directed to a needle system configured to enlarge an access path in a patient without further cutting into the tissue of the patient so as to reduce recovery time and trauma to the patient. Also provided are methods of using the needle system provided.
摘要翻译：本公开涉及一种被配置成在患者体内扩大进入路径而不进一步切入患者组织的针系统，以减少对患者的恢复时间和创伤。还提供了使用提供的针系统的方法。

72. 发明申请

US20080208198A1 Osteochondral Implant Procedure and Device 有权
标题翻译：骨软骨植入物程序和装置
公开(公告)号：US20080208198A1
公开(公告)日：2008-08-28
申请号：US11680318
申请日：2007-02-28
申请人： Jeffrey H. Nycz , Keith M. Kinnane , Susan J. Drapeau , Daniel Shimko , Jeetendra Bharadwaj
发明人： Jeffrey H. Nycz , Keith M. Kinnane , Susan J. Drapeau , Daniel Shimko , Jeetendra Bharadwaj
IPC分类号： A61B17/58
CPC分类号： A61B17/1764 , A61B2017/00946
摘要： A surgical procedure according to which a slotted film is positioned over an area of a bone to be milled; and a portion of a milling assembly is inserted in the defect, with another portion of the assembly extending through one of the slots so that the slot can be used as a guide to mill the bone.
摘要翻译：一种外科手术，根据该手术，开槽的薄膜位于要碾磨的骨的区域上; 并且铣削组件的一部分插入缺陷中，组件的另一部分延伸穿过其中一个槽，使得该槽可以用作铣削骨的引导件。

73. 发明申请

US20080031914A1 Flowable biomaterial composition 审中-公开
标题翻译：可流动的生物材料组成
公开(公告)号：US20080031914A1
公开(公告)日：2008-02-07
申请号：US11497837
申请日：2006-08-02
申请人： Susan J. Drapeau , Kathy L. Chamness
发明人： Susan J. Drapeau , Kathy L. Chamness
IPC分类号： A61F2/02 , A61K33/42
CPC分类号： C08L5/04 , A61L27/46 , C08L5/00 , C08L89/06 , C08L2666/02
摘要： A putty form biomaterial composition made of a collagen scaffold and ceramic granule having improved flowable yet cohesive characteristics through the addition of, either individually or in some combination, polyhydroxy compounds, a liquid polyhydroxy compound ester, a liquid solution of solid polyhydroxy compound, a liquid solution of solid polyhydroxy compound ester to allow for use in surgical bone repair is presented. Specific polyhydroxy compounds, including polyethylene glycol polymers (PEG), PPO/PEO block co-polymers (i.e., a poloxamer NF grade), and the polysaccharides alginate and chitosan may be utilized.
摘要翻译：由胶原支架和陶瓷颗粒制成的油灰形式的生物材料组合物，通过单独地或以某种组合的方式加入多羟基化合物，液体多羟基化合物酯，固体多羟基化合物的液体溶液，液体提出了固体多羟基化合物酯溶液用于手术骨修复。可以使用特定的多羟基化合物，包括聚乙二醇聚合物（PEG），PPO / PEO嵌段共聚物（即泊洛沙姆NF级）和多糖藻酸盐和壳聚糖。

74. 发明授权

US09125902B2 Methods for treating an intervertebral disc using local analgesics 有权
标题翻译：使用局部镇痛药治疗椎间盘的方法
公开(公告)号：US09125902B2
公开(公告)日：2015-09-08
申请号：US12695888
申请日：2010-01-28
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61K31/30 , A61K31/4168 , A61K47/32 , A61K9/00 , A61K47/34
CPC分类号： A61K31/4168 , A61K9/0024 , A61K47/34
摘要： Effective methods of treating back pain from an intervertebral disc are provided. The methods of treatment include administering an immediate release analgesic at or near the intervertebral disc; administering a bulking agent or sealing agent within the intervertebral disc; and administering a sustained release analgesic within the intervertebral disc, wherein the sustained release analgesic releases the analgesic over a period of at least one day.
摘要翻译：提供了从椎间盘治疗背痛的有效方法。治疗方法包括在椎间盘处或附近施用立即释放止痛剂; 在椎间盘内施用填充剂或密封剂; 以及在椎间盘内施用持续释放止痛剂，其中持续释放止痛剂在至少一天的时间段内释放止痛剂。

75. 发明授权

US09101606B2 Bone delivery system having a therapeutic agent 有权
标题翻译：具有治疗剂的骨递送系统
公开(公告)号：US09101606B2
公开(公告)日：2015-08-11
申请号：US13450573
申请日：2012-04-19
申请人： Susan J. Drapeau , Guobao Wei
发明人： Susan J. Drapeau , Guobao Wei
IPC分类号： A61F2/28 , A61F2/02 , A61F13/00 , A61K38/39 , A61K31/722 , A61K33/38 , A61K35/32 , A61L27/14 , A61L27/36 , A61L27/54 , A61K38/18
CPC分类号： A61L27/365 , A61K31/722 , A61K33/38 , A61K35/32 , A61K38/18 , A61K38/39 , A61L27/14 , A61L27/3608 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/418 , A61L2400/04 , A61L2430/02 , A61K2300/00
摘要： A covering for delivering a therapeutic agent to a surgical site is provided. The covering may include a single or multi-compartment structure configured to at least partially retain the therapeutic agent until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the therapeutic agent to the surgical site. In some embodiments, the covering comprises an antimicrobial agent, a hemostatic agent, an anti-inflammatory agent, and/or a growth factor.
摘要翻译：提供了用于将治疗剂递送到外科手术部位的覆盖物。覆盖物可以包括构造成至少部分地保持治疗剂的单室或多隔室结构，直到覆盖物被放置在手术部位。放置时，覆盖物可以促进治疗剂转移到手术部位。在一些实施方案中，覆盖物包含抗微生物剂，止血剂，抗炎剂和/或生长因子。

76. 发明授权

US08734387B2 Expansion device for treatment of black triangle disease and method 有权
标题翻译：用于治疗黑三角病的扩张装置及方法
公开(公告)号：US08734387B2
公开(公告)日：2014-05-27
申请号：US13349747
申请日：2012-01-13
申请人： Susan J. Drapeau , Daniel A. Shimko , Kip Roberts , Kelly B. Emerton
发明人： Susan J. Drapeau , Daniel A. Shimko , Kip Roberts , Kelly B. Emerton
IPC分类号： A61M29/00 , A61C19/06
CPC分类号： A61C19/063
摘要： An expansion device includes an inflatable balloon moveable from an unexpanded configuration to an expanded configuration configured to pass through soft tissue between two adjacent teeth of a patient when in the unexpanded configuration. The an expansion device also includes an inflation tube having one end connected to the inflatable balloon and another end serving as an entry port for an inflation fluid. The inflatable balloon has a triangular shape when in the expanded configuration.
摘要翻译：膨胀装置包括可膨胀的气囊，其可从未膨胀构型移动到扩张构型，所述膨胀构型构造成当处于未膨胀构型时穿过患者的两个相邻牙齿之间的软组织。膨胀装置还包括充气管，其一端连接到可膨胀气囊，另一端用作膨胀流体的入口。膨胀气囊处于膨胀构型时具有三角形形状。

77. 发明申请

US20130287817A1 FLOWABLE IMPLANT WITH CROSSLINKABLE SURFACE MEMBRANE 有权
标题翻译：具有可交换表面膜的可流动的植入物
公开(公告)号：US20130287817A1
公开(公告)日：2013-10-31
申请号：US13458286
申请日：2012-04-27
申请人： Susan J. Drapeau , Daniel A. Shimko
发明人： Susan J. Drapeau , Daniel A. Shimko
IPC分类号： A61K47/36 , A61K38/17 , A61K31/7088 , A61K35/00 , A61K31/047 , A61P19/08 , A61K9/00 , A61K38/19 , A61K35/28 , A61K38/48 , A61K38/21 , A61K38/18 , A61K31/56
CPC分类号： A61K35/28 , A61K38/1709 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/29 , A61K38/30 , A61K38/4886 , A61L27/46 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02 , C08L5/04
摘要： A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.
摘要翻译：提供了一种用于骨缺损以促进骨生长的可流动的生物医学植入物。可流动的生物医学植入物包括载体基质，其包括可生物降解的多糖和陶瓷材料。通过将交联剂施加到与陶瓷材料混合的可生物降解的多糖中，可以在载体基体的表面一体形成不渗透膜。

78. 发明授权

US08524253B2 Bone regeneration device 有权
标题翻译：骨再生装置
公开(公告)号：US08524253B2
公开(公告)日：2013-09-03
申请号：US12323093
申请日：2008-11-25
申请人： Keith Matthew Kinnane , Susan J. Drapeau
发明人： Keith Matthew Kinnane , Susan J. Drapeau
IPC分类号： A61K9/00
CPC分类号： A61L27/3604 , A61K38/00 , A61L27/3608 , A61L27/365 , A61L27/38 , A61L2430/02 , A61L2430/40
摘要： This invention is directed to a bone regeneration device including fascia and demineralized bone matrix mixed at a temperature not exceeding about 40° C. and lyophilized into the bone regeneration device, methods of preparing such a bone regeneration device and methods of treating bone defects using such a bone regeneration device.
摘要翻译：本发明涉及一种骨再生装置，其包括在不超过约40℃的温度下混合的筋膜和软化骨基质，并冻干至骨再生装置中，制备这种骨再生装置的方法和使用这种治疗骨缺损的方法骨再生装置。

79. 发明申请

US20130195805A1 MODIFICATION OF REACTIVITY OF BONE CONSTRUCTS 有权
标题翻译：骨骼结构的反应性修改
公开(公告)号：US20130195805A1
公开(公告)日：2013-08-01
申请号：US13361339
申请日：2012-01-30
申请人： Guobao Wei , Susan J. Drapeau
发明人： Guobao Wei , Susan J. Drapeau
IPC分类号： A61K35/32 , A61P19/00 , A61K35/28 , A61K35/12 , A61K38/46
CPC分类号： A61K35/28 , A61K35/32 , A61L27/3608 , A61L27/3683 , A61L27/3821 , A61L27/3834 , A61L27/50 , A61L2300/414 , A61L2430/02
摘要： A method of enhancing the binding of growth factors and cell cultures to a demineralized allograft bone material which includes applying ex vivo an effective quantity of an ionic force change agent to at least a portion of the surface of a demineralized allograft bone material to produce a binding-sensitized demineralized allograft bone material and implanting the binding-sensitized demineralized allograft bone material into a host bone. The ionic force change agent may include at least one of enzymes, pressure, chemicals, heat, sheer force, oxygen plasma, supercritical nitrogen, supercritical carbon, supercritical water or a combination thereof. A molecule, a cell culture, or a combination thereof is administered to the binding-sensitized demineralized allograft bone material.
摘要翻译：增强生长因子和细胞培养物与软化的同种异体移植骨材料的结合的方法，其包括向体内施用有效量的离子力变化剂至少部分脱矿质的同种异体移植骨材料的表面以产生结合敏化的脱矿质同种异体移植骨材料并将结合致敏的脱矿质同种异体移植骨材料植入宿主骨中。离子力变化剂可以包括酶，压力，化学物质，热量，剪切力，氧等离子体，超临界氮，超临界碳，超临界水或其组合中的至少一种。将一种分子，细胞培养物或其组合施用于结合致敏的脱矿质同种异体移植骨材料。

80. 发明申请

US20130190891A1 BONE DELIVERY SYSTEM 有权
标题翻译：骨输送系统
公开(公告)号：US20130190891A1
公开(公告)日：2013-07-25
申请号：US13355064
申请日：2012-01-20
申请人： Susan J. Drapeau , Guobao Wei
发明人： Susan J. Drapeau , Guobao Wei
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30075 , A61F2002/30462 , A61F2002/30467 , A61F2002/30588 , A61F2002/30677 , A61F2002/30909 , A61F2002/3096
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be formed of polymers for providing extended shelf life and/or increased moisture and radiation resistance, and may include a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a biocompatible material and is suitable for a variety of procedure specific uses.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可由用于提供延长的保质期和/或增加的耐湿和耐辐射性的聚合物形成，并且可以包括能够至少部分保留其中提供的物质的单室或多室结构，直到覆盖物被置于手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。在各种实施方案中，覆盖物可以由生物相容性材料形成，并且适用于各种程序特定用途。

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