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71. 发明授权

US08293486B2 Functionalization of silk material by avidin-biotin interaction 有权
标题翻译：丝素材料通过抗生物素蛋白 - 生物素相互作用进行功能化
公开(公告)号：US08293486B2
公开(公告)日：2012-10-23
申请号：US13381687
申请日：2010-07-20
申请人： David L. Kaplan , Xiaoqin Wang , Monica A. Serban
发明人： David L. Kaplan , Xiaoqin Wang , Monica A. Serban
IPC分类号： G01N33/53 , C07K1/00
CPC分类号： C07K14/43586 , A61K47/64 , A61K47/6903 , A61K47/6921
摘要： The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.
摘要翻译：本发明提供通过抗生物素蛋白和生物素之间的特异性相互作用将丝素蛋白与活性剂连接的组合物和方法，提供了基于丝的蛋白质生物材料的功能化。抗生物素蛋白或生物素修饰的丝是用于与多种相应连接的活性剂如抗体和生长因子进行功能化的生物材料平台。可以通过本发明的方法制备各种功能性丝绸材料，例如丝素水凝胶，丝微/纳米颗粒和丝膜。本发明的功能化策略相对容易，快速和可行，因此在许多生物医学应用中是有用的。

72. 发明申请

US20120195967A1 SILK-BASED DRUG DELIVERY SYSTEM 有权
标题翻译：基于SILK的药物递送系统
公开(公告)号：US20120195967A1
公开(公告)日：2012-08-02
申请号：US13443264
申请日：2012-04-10
申请人： David L. Kaplan , Lorenz Meinel
发明人： David L. Kaplan , Lorenz Meinel
IPC分类号： A61K47/42 , A61K31/7088 , A61K9/38 , A61K39/395 , A61K9/00 , A61K9/14 , A61K38/02 , A61K38/14
CPC分类号： A61K47/42 , A61K9/0002 , A61K9/7007 , A61K38/17 , A61K47/46
摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.
摘要翻译：本发明提供了新颖的持续释放的基于丝的递送系统。本发明还提供了生产这种制剂的方法。通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。然后对该文章进行处理，以改变其构象。构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

73. 发明申请

US20120159857A1 REMOVABLE TAILGATE GAP COVER 有权
标题翻译：可拆卸的TAILGATE GAP盖
公开(公告)号：US20120159857A1
公开(公告)日：2012-06-28
申请号：US13328375
申请日：2011-12-16
申请人： David L. Kaplan
发明人： David L. Kaplan
IPC分类号： B60J9/00
CPC分类号： B62D33/0273
摘要： A removable tailgate gap cover for preventing ingress of debris in a tailgate gap. The gap cover comprises an elongated cover plate having a top surface, a bottom surface, two longitudinal edges and an elongated support bar having an upper end and a lower end, wherein the upper end is fixedly attached to and substantially centrally aligned with the lengthwise direction of the bottom surface. The elongated support bar comprises a magnetic attaching means disposed along the lower end of the elongated support bar for attaching the gap cover to the floor of the end portion of the truck bed.
摘要翻译：可拆卸的后挡板间隙盖，用于防止尾门间隙中的碎屑进入。间隙盖包括具有顶表面，底表面，两个纵向边缘和具有上端和下端的细长支撑杆的细长盖板，其中上端固定地附接到基本上与长度方向对齐的底面。细长的支撑杆包括沿着细长支撑杆的下端设置的磁性附接装置，用于将间隙盖附接到卡车车厢底部的底部。

74. 发明申请

US20120129255A1 FUNCTIONALIZATION OF SILK MATERIAL BY AVIDIN-BIOTIN INTERACTION 有权
标题翻译：通过AVIDIN-BIOTIN相互作用对丝素材料的功能化
公开(公告)号：US20120129255A1
公开(公告)日：2012-05-24
申请号：US13381687
申请日：2010-07-20
申请人： David L. Kaplan , Xiaoqin Wang , Monica A. Serban
发明人： David L. Kaplan , Xiaoqin Wang , Monica A. Serban
IPC分类号： C07K19/00 , C12N5/0783
CPC分类号： C07K14/43586 , A61K47/64 , A61K47/6903 , A61K47/6921
摘要： The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.
摘要翻译：本发明提供通过抗生物素蛋白和生物素之间的特异性相互作用将丝素蛋白与活性剂连接的组合物和方法，提供了基于丝的蛋白质生物材料的功能化。抗生物素蛋白或生物素修饰的丝是用于与多种相应连接的活性剂如抗体和生长因子进行功能化的生物材料平台。可以通过本发明的方法制备各种功能性丝绸材料，例如丝素水凝胶，丝微/纳米颗粒和丝膜。本发明的功能化策略相对容易，快速和可行，因此在许多生物医学应用中是有用的。

75. 发明申请

US20120123519A1 TUBULAR SILK COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：管状丝素组合物及其使用方法
公开(公告)号：US20120123519A1
公开(公告)日：2012-05-17
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： A61F2/82 , B29C41/14 , B32B1/08
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
摘要翻译：描述的是管状丝素蛋白组合物及其制造和使用的方法。如本文所述的管状组合物可以在高爆裂强度的范围内制备，可以容易地在内径范围内制备，可以用官能部分衍生化，并且可以在适合于特定用途的渗透性范围内制备。在一个方面，管状组合物可用于修复或更换受损或患病的血管，包括但不限于小于约6mm的血管。

76. 发明授权

US08178656B2 Silk-based drug delivery system 有权
标题翻译：丝绸药物输送系统
公开(公告)号：US08178656B2
公开(公告)日：2012-05-15
申请号：US11628930
申请日：2005-06-13
申请人： David L. Kaplan , Meinel Lorenz
发明人： David L. Kaplan , Meinel Lorenz
IPC分类号： A61K38/17 , A61K9/22
CPC分类号： A61K47/42 , A61K9/0002 , A61K9/7007 , A61K38/17 , A61K47/46
摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.
摘要翻译：本发明提供了新颖的持续释放的基于丝的递送系统。本发明还提供了生产这种制剂的方法。通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。然后对该文章进行处理，以改变其构象。构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

77. 发明授权

US08071722B2 Silk biomaterials and methods of use thereof 有权
标题翻译：丝素生物材料及其使用方法
公开(公告)号：US08071722B2
公开(公告)日：2011-12-06
申请号：US12688014
申请日：2010-01-15
申请人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

78. 发明申请

US20100196447A1 SILK BIOMATERIALS AND METHODS OF USE THEREOF 有权
标题翻译：丝状生物材料及其使用方法
公开(公告)号：US20100196447A1
公开(公告)日：2010-08-05
申请号：US12688014
申请日：2010-01-15
申请人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61K9/70 , A61K31/56 , A61K38/30 , A61K38/16 , A61K31/715 , A61K47/42 , A61P17/02
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

79. 发明申请

US20100096763A1 BIOPOLYMER OPTOFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：生物聚合物光致变色器件及其制造方法
公开(公告)号：US20100096763A1
公开(公告)日：2010-04-22
申请号：US12513423
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
摘要翻译：一种制备生物聚合物光流体装置的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将生物聚合物基质溶液浇铸在基材上，将通道模具嵌入生物聚合物基质溶液中，干燥生物聚合物基质固化生物聚合物光流体装置的解决方案，以及提取嵌入式通道模具以在凝固的生物聚合物光流体装置中提供流体通道。根据另一方面，提供了由生物聚合物制成并且在其中具有用于输送流体的通道的光流体装置。

80. 发明申请

US20100068740A1 MICROFLUIDIC DEVICE WITH A CYLINDRICAL MICROCHANNEL AND A METHOD FOR FABRICATING SAME 审中-公开
标题翻译：具有圆柱微通道的微流体装置及其制造方法
公开(公告)号：US20100068740A1
公开(公告)日：2010-03-18
申请号：US12513416
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Hannah Perry
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Hannah Perry
IPC分类号： C12M1/34 , B29C39/02 , C12Q1/02 , C12Q1/28 , C12Q1/54 , C12Q1/34
CPC分类号： B29D11/0074 , B01L3/502707 , B01L2300/0816 , B01L2300/12 , B01L2300/163 , B29C39/02 , B81B2201/058 , B81B2201/06 , B81C1/00071 , G01J3/02 , G01J3/0237 , G01J3/0256 , G01J3/06 , G01J3/10 , G01J3/1804 , G01J3/42 , G01N33/54386 , G01N2021/0346
摘要： A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body.
摘要翻译：制造具有至少一个圆柱形微通道的微流体装置的方法包括提供基底，将未固化的聚合物基质溶液浇铸到基底上，将细长棒嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体，并提取细长杆以在凝固体中形成圆柱形微通道。在另一个实施例中，该方法包括在微流体装置的表面上形成光学特征。还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，所述圆柱形微通道的直径在约40μm至250μm之间，包括端点在内。提供额外的微流体装置，其用作光流体光谱仪。光流体光谱仪包括聚合物体，集成在聚合物主体内的衍射光栅，以及聚合物主体上的衍射光栅后面的圆柱形微通道。

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