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72. 发明专利

CA2268847A1 SUBSTITUTED OXIMES DERIVATIVES USEFUL AS NEUROKININ ANTAGONISTS 未知
公开(公告)号：CA2268847A1
公开(公告)日：1998-05-07
申请号：CA2268847
申请日：1997-10-28
申请人： SCHERING CORP
发明人： SHANKAR BANDARPALLE B
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/501 , A61P1/00 , A61P11/00 , A61P19/02 , A61P25/04 , A61P25/06 , A61P29/00 , A61P43/00 , C07D211/52 , C07D211/58 , C07D211/76 , C07D295/13 , C07D295/185 , C07D333/22 , C07D401/04 , C07D401/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D405/06 , A61K31/40
摘要： The compounds (a, b, c, d, e, f, g, h, i, j, k or l) are disclosed for use as neurokinin antagonists.

73. 发明专利

FI963817A0 未知
公开(公告)号：FI963817A0
公开(公告)日：1996-09-25
申请号：FI963817
申请日：1996-09-25
申请人： SCHERING CORP
发明人： KIRKUP MICHAEL P , DUGAR SUNDEEP , SHANKAR BANDARPALLE B
IPC分类号： A61K31/395 , A61K31/397 , A61P3/06 , A61P9/10 , C07B53/00 , C07C227/32 , C07C229/34 , C07C311/06 , C07C311/19 , C07C311/37 , C07C319/20 , C07C323/62 , C07D205/08 , C07D
摘要： Substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar1 is R3-substituted aryl; Ar2 is R4-substituted aryl; Ar3 is R5-substituted aryl; Y and Z are independently -CH2-, -CH(lower alkyl)- or -C(dilower alkyl)-; A is -O-, -S-, -S(O)- or -S(O)2-; R1 is -OR6, -O(CO)R6, -O(CO)OR9 or -O(CO)NR6R7; R2 is hydrogen, lower alkyl or aryl; or R1 and R2 together are =O; q is 1, 2 or 3; p is 0, 1,2, 3 or 4; R5 is 1-3 substitutes independently selected from -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR9, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO2-lower alkyl, -NR6SO2-aryl, -CONR6R7, -COR6, -SO2NR6R7, S(O)0-2-alkyl, S(O)0-2-aryl, -O(CH2)1-10-COOR6, -O(CH2)0-10CONR6R7, o-halogeno, m-halogeno, o-lower alkyl, m-lower alkyl, -(lower alkylene)-COOR6 and -CH=CH-COOR6; R3 and R4 are 1-3 substituents independently selected from R5, hydrogen, p-lower alkyl, aryl, -NO2, CF3 and p-halogeno; R6, R7 and R8 are hydrogen, lower alkyl, aryl or aryl-substituted lower alkyl; and R9 is lower alkyl, aryl or aryl-substituted lower alkyl; are disclosed, as well as a method of lowering serum cholesterol by administering said compounds, pharmaceutical compositions containing them, the combination of a substituted azetidinone and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis, novel intermediates and methods for preparing said intermediates.

74. 发明专利

CZ9302136A3 DIINDOLEPYRROLBENZODIAZOCINES, PROCESS OF THEIR PREPARATION AND USE, AND A PHARMACEUTICAL MIXTURE BASED THEREON 未知
公开(公告)号：CZ9302136A3
公开(公告)日：1994-05-18
申请号：CS213693
申请日：1992-04-09
申请人： SCHERING CORP
发明人： MCCOMBIE STUART W , SHANKAR BANDARPALLE B , KIRKUP MICHAEL P
IPC分类号： A61K31/55 , A61P17/00 , A61P35/00 , C07D20060101 , C07D498/22 , C07H19/044 , C07H19/04
CPC分类号： C07D498/22 , C07H19/044

75. 发明专利

CZ213693A3 DIINDOLEPYRROLBENZODIAZOCINES, PROCESS OF THEIR PREPARATION AND USE, AND A PHARMACEUTICAL MIXTURE BASED THEREON 未知
公开(公告)号：CZ213693A3
公开(公告)日：1994-05-18
申请号：CS213693
申请日：1992-04-09
申请人： SCHERING CORP
发明人： MCCOMBIE STUART W , SHANKAR BANDARPALLE B , KIRKUP MICHAEL P
IPC分类号： A61K31/55 , A61P17/00 , A61P35/00 , C07D20060101 , C07D498/22 , C07H19/044 , C07H19/04

76. 发明专利

FI934461A0 未知
公开(公告)号：FI934461A0
公开(公告)日：1993-10-11
申请号：FI934461
申请日：1993-10-11
申请人： SCHERING CORP
发明人： MCCOMBIE STUART W , SHANKAR BANDARPALLE B , KIRKUP MICHAEL P
IPC分类号： A61K31/55 , A61P17/00 , A61P35/00 , C07D20060101 , C07D498/22 , C07H19/044

77. 发明专利

NO933611D0 未知
公开(公告)号：NO933611D0
公开(公告)日：1993-10-08
申请号：NO933611
申请日：1993-10-08
申请人： SCHERING CORP
发明人： MCCOMBIE STUART W , SHANKAR BANDARPALLE B , KIRKUP MICHAEL P
IPC分类号： A61K31/55 , A61P17/00 , A61P35/00 , C07D20060101 , C07D498/22 , C07H19/044 , C07D

78. 发明专利

BRPI0707152A2 未知
公开(公告)号：BRPI0707152A2
公开(公告)日：2011-04-19
申请号：BRPI0707152
申请日：2007-01-16
申请人： SCHERING CORP
发明人： YU WENSHENG , TONG LING , CHEN LEI , KOZLOWSKI JOSEPH A , LAVEY BRIAN J , SHIH NENG-YANG , MADISON VINCENT S , ZHOU GUOWEI , ORTH PETER , GUO ZHUYAN , WONG MICHAEL K C , YANG DE-YI , KIM SEONG HEON , SHANKAR BANDARPALLE B , SIDDIQUI ARSHAD M , ROSNER KRISTIN E , DAI CHAOYANG , POPOVICI-MULLER JANETA , GIRIJAVALLABHAN VINAY M , LI DANSU , RIZVI RAZIA , MICULA ANETA S , FELTZ ROBERT
IPC分类号： C07D401/14 , A61K31/4166 , A61P35/00 , C07D403/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

79. 发明专利

ZA200806074B Compounds for the treatment of inflammatory disorders 未知
公开(公告)号：ZA200806074B
公开(公告)日：2009-05-27
申请号：ZA200806074
申请日：2008-07-11
申请人： SCHERING CORP
发明人： WENSHENG YU , LING TONG , LEI CHEN , KOZLOWSKI JOSEPH A , LAVEY BRIAN J , NENG-YANG SHIH , MADISON VINCENT S , GUOWEI ZHOU , PETER ORTH , ZHUYAN GUO , WONG MICHAEL K C , DE-YI YANG , SEONG-HEON KIM , SHANKAR BANDARPALLE B , ARSHAD SIDDIQUI M , ROSNER KRISTIN E , CHAOYANG DAI , JANETA POPOVICI-MULLER , GIRIJAVALLABHAN VINAY M , DANSU LI , RAZIA RIZVI , MICULA ANETA S , ROBERT FELTZ
IPC分类号： A61K20090101 , A61P20090101 , C07D20090101
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

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