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71. 发明申请

WO1995018146A1 SUBSTITUTED GLYCEROL 审中-公开
标题翻译：取代的甘油
公开(公告)号：WO1995018146A1
公开(公告)日：1995-07-06
申请号：PCT/EP1994004329
申请日：1994-12-28
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , THIRRING, Klaus
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , BAHR, Georges, Michel
IPC分类号： C07K09/00
CPC分类号： C07K9/005 , A61K38/00
摘要： The invention concerns 3-O-[N-acetylmuramyl-L-lysyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-gl ycerol of formula (I) in free form or salt form, a process for its preparation by deprotection, and its use as a pharmaceutical, particularly as an immunomodulating agent.
摘要翻译：本发明涉及游离形式或盐形式的式（I）的3-O- [N-乙酰胞壁酰-L-赖氨酰-D-异谷氨酰基] -1,2-二-O-棕榈酰基-sn-gl ycerol，其脱保护制剂及其作为药物的用途，特别是作为免疫调节剂。

72. 发明申请

WO1995006077A2 POLYMERIC MATRICES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：聚合物基质及其在药物组合物中的应用
公开(公告)号：WO1995006077A2
公开(公告)日：1995-03-02
申请号：PCT/EP1994002833
申请日：1994-08-26
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGELLSCHAFT M.B.H. , ACEMOGLU, Murat , BANTLE, Siegfried , BODMER, David , CAMMISULI, Salvatore , HIESTAND, Peter , NIMMERFALL, Fritz , STOLL, Georg
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGELLSCHAFT M.B.H.
IPC分类号： C08G64/02
CPC分类号： C08G64/183 , A61K9/1647 , A61K9/204 , A61K9/5031 , A61K38/2013 , A61K38/204 , A61K38/31 , C08G64/0208 , C08G64/34 , Y02A50/401 , Y10S514/825 , Y10S514/885 , Y10S514/903 , Y10S514/953 , Y10S514/964
摘要： This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylenecarbonate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF alpha , e.g., certain autoimmune and inflammatory conditions, as well as septic shock.
摘要翻译：本发明提供包含聚合物基质，特别是包含IL-6作为活性成分的聚合物基质的药物组合物。还提供特定的新型聚（碳酸亚乙酯）聚合物作为用于在含有药理活性化合物的持续释放组合物中作为基质材料的一般用途，以及使用IL-6用于治疗由IL-1和/或TNFα介导的病症的方法，例如，某些自身免疫和炎症状况以及败血性休克。

73. 发明申请

WO1992020215A1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的改善或有关
公开(公告)号：WO1992020215A1
公开(公告)日：1992-11-26
申请号：PCT/EP1992001035
申请日：1992-05-11
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , KOOL, Arnoldus, Johannes , VAN-VUURE-RIETVELD, Elizabeth, Mariette , JARL-SUNESSON, Carin, Ingegärd
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： A01H01/02
CPC分类号： A01H1/02 , A01H5/08
摘要： A method of preparing fertile, diploid eggplants including a trait found naturally in species of the family Solanaceae, such as reduced susceptibility to the fungal disease caused by Verticillium and/or Fusarium, said trait(s) not being found naturally in eggplants which comprises: i) irradiating a Solanaceae protoplast donor having a desired trait with an irradiating dose sufficient to cause fragmentation of the chromosomes of the donor protoplast, ii) fusing said irradiated donor protoplast with an eggplant protoplast serving as an acceptor wherein the donor protoplast and the acceptor protoplast are derived from different explant types and, iii) regenerating the fused protoplasts obtained to mature plants. Also fertile, diploid eggplants comprising desirable traits found naturally in species of the family Solanaceae other than egg plants.
摘要翻译：一种制备可育的二倍体茄子的方法，其包括茄科科属物种天然存在的性状，例如对由轮枝孢属和/或镰刀菌引起的真菌病的易感性降低，所述性状在茄子中天然存在，其特征包括： i）用足以引起供体原生质体染色体碎裂的照射剂量照射具有所需性状的茄科植物原生质体供体，ii）将所述被照射的供体原生质体与用作受体的茄子原生质体融合，其中供体原生质体和受体原生质体衍生自不同的外植体类型，以及iii）将获得的融合原生质体再生成熟植物。还有肥沃的二倍体茄子，其包含理想的性状，其天然存在于茄科以外的茄科的物种中。

74. 发明申请

WO1992002543A1 NOVEL IMMUNOSUPPRESSANT PEPTIDES 审中-公开
标题翻译：新型免疫抑制剂
公开(公告)号：WO1992002543A1
公开(公告)日：1992-02-20
申请号：PCT/EP1991001420
申请日：1991-07-29
申请人： CYTEL CORPORATION , SANDOZ LTD. , SANDOZ-PATENT-GMBH , GAETA, Federico, C., A. , POWELL, Michael, F. , GREY, Howard, M. , SETTE, Alessandro, D. , ARRHENIUS, Thomas, S.
发明人： CYTEL CORPORATION , SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： C07K07/06
CPC分类号： C07K7/08 , A61K38/00 , C07K14/005 , C12N2760/16022
摘要： Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptides are of 4-25 amino acid residues in length, and have a core binding region comprising, in the direction from the N- to the C- terminus, a hydrophobic L-amino acid or amino acid mimetic, a spacer sequence of 2-6 residues and a Thr or Thr mimetic. At least one residue is a D-amino acid or an amino acid mimetic. The compositions may be used to treat diseases associated with particular Dr alleles, including autoimmune diseases such as rheumatoid arthritis.
摘要翻译：提供了结合感兴趣的MHC分子并抑制T细胞活化的肽组合物。所述肽的长度为4-25个氨基酸残基，并且具有核心结合区，其在从N-至C-末端的方向上包含疏水性L-氨基酸或氨基酸模拟物，间隔序列为2 -6个残基和一个Thr或Thr模拟物。至少一个残基是D-氨基酸或氨基酸模拟物。组合物可用于治疗与特定的Dr等位基因相关的疾病，包括自身免疫性疾病如类风湿性关节炎。

75. 发明申请

WO1997012040A1 GENE THERAPY WITH MODIFIED p65 PROTEINS 审中-公开
标题翻译：用改良的p65蛋白进行基因治疗
公开(公告)号：WO1997012040A1
公开(公告)日：1997-04-03
申请号：PCT/EP1996004216
申请日：1996-09-26
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , ANRATHER, Josef , BACH, Fritz, B. , WINKLER, Hans
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0368 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： A method to render mammalian, particularly endothelial cells less susceptible to platelet- and leukocyte-mediated injury and inflammation is described, comprising genetically modifying the cells by inserting DNA encoding a transdominant inhibitor of a Re1A (p65) protein, and expression functional inhibitor in the modified cells under cellular activating conditions, whereby Re1A (i.e. NF kappa B) transactivation of genes is suppressed, and corresponding proteins and DNA therefor. The method, which can be carried out in vivo, ex vivo or in vitro, has use in allogeneic or xenogeneic transplantation as well as to treat systemic or local inflammatory conditions.
摘要翻译：描述了使哺乳动物，特别是对血小板和白细胞介导的损伤和炎症不敏感的内皮细胞的方法，包括通过将编码Re1A（p65）蛋白的跨主导抑制剂的DNA和表达功能抑制剂插入到基因修饰细胞中细胞激活条件下的修饰细胞，从而抑制基因的Re1A（即NFκB）反式激活，以及相应的蛋白质和DNA。该方法可以在体内，离体或体外进行，可用于同种异体移植或异种移植，也可用于治疗全身或局部炎性病症。

76. 发明申请

WO1996040910A1 HUMAN GROWTH FACTORS, NUCLEOTIDE SEQUENCE ENCODING GROWTH FACTORS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：人类生长因子，核苷酸序列编码生长因子及其使用方法
公开(公告)号：WO1996040910A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002455
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , VAN DEN BERG, David, John
IPC分类号： C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： This invention provides novel human growth factor polypeptides, nucleotides encoding the growth factor polypeptides, and uses for the growth factor polypeptides and polynucleotides.
摘要翻译：本发明提供了新的人生长因子多肽，编码生长因子多肽的核苷酸，以及生长因子多肽和多核苷酸的用途。

77. 发明申请

WO1996037233A1 POLYMYXIN CONJUGATES 审中-公开
标题翻译：聚甲基丙烯酸
公开(公告)号：WO1996037233A1
公开(公告)日：1996-11-28
申请号：PCT/EP1996002256
申请日：1996-05-24
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , KAPA, Prasad, Koteswara , KARDASH, Gleb , KUCEROVY, Andrew , LAKE, Philip , MATTNER, Paul, Gerard , PETTER, Russell, C. , PRASHAD, Mahavir , SHARMA, Sushill
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： Water-soluble polymyxin B/dextran conjugates (or salts thereof) having anti-endotoxin activity greater than unconjugated polymyxin B. They can be prepared by reacting polymyxin B or a salt thereof with dextran in an aqueous medium at a pH of from about 9.3 to about 10 and a temperature of from about 30 DEG to about 35 DEG C.
摘要翻译：具有大于未缀合的多粘菌素B的抗内毒素活性的水溶性多粘菌素B /葡聚糖缀合物（或其盐）。它们可以通过使多粘菌素B或其盐与葡聚糖在水性介质中反应制备，pH为约9.3〜约10℃，温度为约30℃至约35℃。

78. 发明申请

WO1996005150A1 CEMENT ACCELERATING ADMIXTURE 审中-公开
标题翻译：水泥加速粘合剂
公开(公告)号：WO1996005150A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003132
申请日：1995-08-07
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , LEIKAUF, Bernhard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C04B28/02
CPC分类号： C04B28/02 , C04B2103/10 , C04B2111/00146 , C04B14/303 , C04B22/082 , C04B22/124 , C04B24/2641 , C04B40/0039 , C04B22/148 , C04B24/122
摘要： An accelerating admixture for use with sprayable cementitious compositions such as shotcrete comprises a mixture of (a) amorphous aluminium hydroxide and/or aluminium hydroxysulphate, and (b) at least one amine, preferably an alkanolamine. In a preferred embodiment, the admixture also comprises an aqueous dispersion of at least one polymer which comprises pendant carboxylic moieties.
摘要翻译：与喷雾混凝土可喷涂水泥质组合物一起使用的加速混合物包括（a）无定形氢氧化铝和/或羟基硫酸铝的混合物，和（b）至少一种胺，优选链烷醇胺。在优选的实施方案中，混合物还包含至少一种包含羧酸部分的聚合物的水性分散体。

79. 发明申请

WO1996004785A1 LONG TERM XENOGENEIC MYELOID AND LYMPHOID CELL PRODUCTION IN CHIMERIC IMMUNOCOMPROMISED ANIMALS 审中-公开
标题翻译：长期免疫免疫动物中的长期XENOGENEIC MYELOID和LYMPHOID细胞生产
公开(公告)号：WO1996004785A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003198
申请日：1995-08-11
申请人： SANDOZ LTD. , SYSTEMIX INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
发明人： SANDOZ LTD. , SYSTEMIX INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , CHEN, Benjamin, P. , FRASER, Christopher, C.
IPC分类号： A01K67/027
CPC分类号： G01N33/56977 , A01K67/0271
摘要： Immunocompromised mammalian hosts are subcutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human fetal thymic fragment at the same site. Grafts contain cell populations expressing CD4 and CD8, CD19 or CD33, CD14 and CD15, all of which also express the HLA type of the fetal bone/spleen. T-cells derived from progenitors in the fetal bone/spleen contain both mature single positive CD4+CD8-, CD8+CD4- as well as a high percentage of immature double positive CD4+CD8+ populations.
摘要翻译：将免疫受损的哺乳动物宿主皮下植入人胎儿骨与脾的组合。当在同一位点提供同种异体的人胎儿胸腺胸腺片段时，嵌合动物可以在体内产生人B细胞，骨髓细胞和T细胞长达9个月。移植物包含表达CD4和CD8，CD19或CD33，CD14和CD15的细胞群体，所有这些细胞群体也表达胎儿骨/脾脏的HLA型。来自胎儿骨/脾脏祖细胞的T细胞既含有成熟的单一阳性CD4 + CD8-，CD8 + CD4-以及高比例的未成熟双阳性CD4 + CD8 +群体。

80. 发明申请

WO1995011306A1 ANTI-MICROBIAL PROTEINS 审中-公开
标题翻译：抗微生物蛋白
公开(公告)号：WO1995011306A1
公开(公告)日：1995-04-27
申请号：PCT/EP1994003449
申请日：1994-10-20
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , KRAGH, Karsten, Matthias , MIKKELSEN, Jorn, Dalgaard , NIELSEN, Klaus, Kristian
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/82
CPC分类号： C12N15/8282 , A01N65/08 , C07K14/415
摘要： An anti-microbial protein comprising a peptide having the amino acid sequence: AA1-AA2-AA3-Cys-AA5-AA6-AA7-AA8-AA9-Cys-AA11-AA12-AA13-AA14-Cys-Cys-AA17-AA18-AA19-AA20-AA21-Cys-AA23-AA24-AA25-AA26-AA27-AA28-Cys-AA30. An anti-microbial protein having the sequence depicted in any one of SEQ ID Nos. 1-3. Recombinant DNA encoding such proteins. A vector comprising such DNA which is expressible in plants and which is linked to a plant operable promoter and terminator. Plants transformed with such recombinant DNA; the progeny of such plants which contain the DNA stably incorporated and hereditable in a Mendelian manner, and/or the seeds of such plants or such progeny.
摘要翻译：包含具有氨基酸序列的肽的抗微生物蛋白质：AA1-AA2-AA3-Cys-AA5-AA6-AA7-AA8-AA9-Cys-AA11-AA12-AA13-AA14-Cys-Cys-AA17-AA18- AA19-AA20-AA21-CYS-AA23-AA24-AA25-AA26-AA27-AA28-CYS-AA30。具有SEQ ID No.3-1中任一项所示序列的抗微生物蛋白质。编码这种蛋白质的重组DNA。包含这样的DNA的载体，其在植物中可表达并与植物可操作的启动子和终止子连接。用这种重组DNA转化的植物; 这些植物的后代含有以孟德尔方式稳定掺入和遗传的DNA，和/或这种植物或其后代的种子。

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