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71. 发明申请

WO1990006949A2 PEPTIDE DERIVATIVES 审中-公开
标题翻译：肽衍生物
公开(公告)号：WO1990006949A2
公开(公告)日：1990-06-28
申请号：PCT/EP1989001448
申请日：1989-11-30
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ AG , SANDOZ-PATENT-GMBH
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ AG , SANDOZ-PATENT-GMBH , ALBERT, Rainer , KRENNING, Eric, P. , LAMBERTS, Steven, W., J. , PLESS, Janos
IPC分类号： C07K07/26
CPC分类号： C07K14/6555 , A61K38/00
摘要： Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.

72. 发明申请

WO1990006753A2 CANCER TREATMENT 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO1990006753A2
公开(公告)日：1990-06-28
申请号：PCT/EP1989001543
申请日：1989-12-14
申请人： SANDOZ AG , BROWNELL, Judith
发明人： SANDOZ AG
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： Low molecular weight quinoline derivatives, in free form or in pharmaceutically acceptable salt form are useful in reducing the spread or growth of secondary cancer cells associated with treatment of a primar cancer tumor, e.g. perioperative treatment of primary operable cancer tumors, and in treating meningiomas.

73. 发明申请

WO1990003962A1 PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-HEPT-6-ENOIC AND -HEPTANOIC ACIDS AND DERIVATIVES AND INTERMEDIATES THEREOF 审中-公开
标题翻译：制备7-取代的六羟基-6-羟基和己二酸及其衍生物的方法及其中间体
公开(公告)号：WO1990003962A1
公开(公告)日：1990-04-19
申请号：PCT/EP1989001201
申请日：1989-10-11
申请人： SANDOZ AG
发明人： SANDOZ AG , CHEN, Kau-Ming , KAPA, Prasad, Koteswara , LEE, George, T. , REPIC, Oljan , HESS, Petr , CREVOISIER, Michel
IPC分类号： C07C69/732
CPC分类号： C07D233/64 , C07C51/367 , C07C59/48 , C07C223/02 , C07D209/12 , C07D209/24 , C07C59/46 , C07C59/11 , C07C59/115 , C07C59/56
摘要： A novel process for the preparation of compounds of formula (I), wherein X is -CH2CH2- or -CH=CH-; R1 is an ester group inert to the reaction conditions; and R is an organic radical having groups which are inert under reducing conditions, by stereoselective reduction of a corresponding compound of formula (II), wherein R, R1 and X are as defined above and one of Z1 and Z2 is oxygen and the other is hydroxy and hydrogen, is disclosed. The process may also be applied to the preparation of compounds of formula (Iu), wherein u is triphenylmethyl (trityl) and Ru is allyl or a radical forming an ester inert under the reaction conditions, which are intermediates in the preparation of some of the compounds of formula (I). A specific embodiment of the above inventive concept is illustrated with the preparation of the compound of formula (Ia) in racemic or optically pure form; in free acid, salt, ester or δ-lactone, i.e. internal ester, form. The compounds of formula (I) are pharmaceuticals, especially antiatherosclerotic, antihyperlipidemic and antihypercholesterolemic agents.

74. 发明申请

WO1990000896A1 USE OF BENZO(g)QUINOLINES IN TREATMENT OF NICOTINE ADDICTION 审中-公开
标题翻译：使用苯并（g）喹诺酮治疗非甾体类药物
公开(公告)号：WO1990000896A1
公开(公告)日：1990-02-08
申请号：PCT/EP1989000814
申请日：1989-07-13
申请人： SANDOZ-PATENT-GMBH , SANDOZ AG
发明人： SANDOZ-PATENT-GMBH , SANDOZ AG , GOGERTY, John, Harry
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： Benzo(g)quinolines of formula (I), wherein the rings A and B are trans-fused and wherein R1 and R2 are each independently hydrogen, hydroxy or methoxy, with the proviso that R1 and R2 may not both be hydrogen; R3 is hydrogen or C1-4 alkyl; R¿4¿ is -COOH, -CH¿2?OR5, -CH2CN, -CON(R6)R7, -CH2SR8, -NHSO2N(R9)R10 or -NHCON(R9)R10, R5 is hydrogen or C1-3 alkyl, R6 is hydrogen or C1-3 alkyl and R7 is hydrogen, C1-3 alkyl, phenyl or pyridyl, said phenyl or pyridyl being optionally substituted by halogen, methyl or methoxy or R6 and R7 together are -(CH2)4-, -(CH2)5- or -(CH2)2-O-(CH2)2-, R8 is C1-4 alkyl or pyridyl, said pyridyl being optionally substituted by halogen, methyl or methoxy, and R9 and R10 are each independently hydrogen or C1-3 alkyl or together are -(CH2)4- or -(CH2)5-, are useful for the treatment of nicotine addiction.

75. 发明申请

WO1988002756A2 PEPTIDE DERIVATIVES 审中-公开
标题翻译：肽衍生物
公开(公告)号：WO1988002756A2
公开(公告)日：1988-04-21
申请号：PCT/EP1987000593
申请日：1987-10-12
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ AG , SANDOZ-PATENT-GMBH
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ AG , SANDOZ-PATENT-GMBH
IPC分类号： C07K09/00
CPC分类号： C07K9/00 , C07K1/1077 , Y02P20/55
摘要： Sugar derivative of a biologically active peptide, which derivative has a prolonged duration of action when compared to the non-sugar modified peptide, and contains at least on one of the amino acid units a sugar residue which is attached to an amino group thereof by a coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation product of a carboxyl group containing sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond.
摘要翻译：生物活性肽的糖衍生物，与未修饰的糖肽相比，该衍生物具有延长的作用持续时间，并且含有至少一个氨基酸单元的糖残基，其通过除直接N-糖苷键以外的偶联而与所述单元的氨基连接，此外，当其为含有羧基的糖和肽的缩合产物时，的8个氨基酸单元，通过不同于与酰胺直接键合的偶联。

76. 发明申请

WO1987006144A1 PLANAR THERAPEUTIC SYSTEM, PROCESS FOR ITS PRODUCTION AND ITS UTILIZATION 审中-公开
标题翻译：平面治疗系统及其生产过程及其应用
公开(公告)号：WO1987006144A1
公开(公告)日：1987-10-22
申请号：PCT/DE1987000174
申请日：1987-04-16
申请人： LOHMANN GMBH & CO. KG. , SANDOZ AG , WOLTER, Karin , HERRMANN, Fritz , HOFFMANN, Hans, Rainer , SIMON, Günter , KISSEL, Thomas , REINHARDT, Joerg
发明人： LOHMANN GMBH & CO. KG. , SANDOZ AG
IPC分类号： A61M37/00
CPC分类号： A61K9/703 , A45D34/00 , A45D44/00 , A61K8/0208 , A61K9/7061 , A61K9/7084 , A61K9/7092 , A61Q19/00
摘要： Planar therapeutic system with a flexible backing layer (3), one or several active ingredient stores (5), one or several pressure-sensitive adhesive layers (4) and possibly a separable protective layer for the skin-contact surface of the planar therapeutic system, whereby the skin-contact surface of the therapeutic system is a skin-contact layer which is provided with one or several non-adhesive active ingredient dispensing sections (2) and one or several skin-adhering sections (1), possibly containing another active ingredient. A process for producing the planar system is described as well as the use of the latter for the local or systemic transdermal material administration in the fields of human or veterinary medicine or cosmetics.
摘要翻译：具有柔性背衬层（3），一个或多个活性成分存储（5），一个或多个压敏粘合剂层（4）和可能的用于平面治疗系统的皮肤接触表面的可分离保护层的平面治疗系统由此，治疗系统的皮肤接触表面是皮肤接触层，其设置有一个或多个非粘性活性成分分配部分（2）和一个或多个皮肤粘附部分（1），可能含有另一活性成分成分。描述了用于制备平面系统的方法以及后者用于在人或兽医学或化妆品领域中局部或全身透皮材料施用的用途。

77. 发明申请

WO1986007054A1 IMIDAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF 审中-公开
标题翻译：咪唑啉酮及其衍生物的咪唑类似物
公开(公告)号：WO1986007054A1
公开(公告)日：1986-12-04
申请号：PCT/EP1986000297
申请日：1986-05-16
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ AG
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ AG , WAREING, James, Richard
IPC分类号： C07D233/64
CPC分类号： C07D233/64 , C07F7/1804 , C07F9/6506
摘要： Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

78. 发明申请

WO1986004080A1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的改善或有关
公开(公告)号：WO1986004080A1
公开(公告)日：1986-07-17
申请号：PCT/EP1985000745
申请日：1985-12-23
申请人： SANDOZ AG , AUERBACH, Günther , KOCH, Werner , MATZINGER, Peter , STEIGER, Jürg , VON TOBEL, Hans, Rudolf
发明人： SANDOZ AG
IPC分类号： C09B62/002
CPC分类号： C09B62/4413 , C09B62/02
摘要： New water-soluble, fibre-reactive compounds correspond to formula (I) in which the symbols are as defined in Claim 1, provided that a compound of formula (I) contains at least one of the following groups: (a) hydroxy groups, (b) ether groupings, (c) carbonyl groups, (d) carboxy groups, which group(s) is (are) in the compounds of formula (II) and/or in R. These compounds are prepared in conventional manner by condensation of a compound Qa-Hal with an appropriate starting compound containing a primary or secondary amine group. The compounds of formula (I) are suitable as fibre-reactive dyes for dyeing or printing hydroxy group or nitrogen containing organic substrates, especially cotton. The preferred dyeing temperature is in the cold-dyeing range. The dyeings and prints obtained have good general fastness properties and are stable to any oxidative influences.
摘要翻译：新的水溶性纤维反应性化合物对应于式（I），其中符号如权利要求1中所定义，条件是式（I）化合物含有至少一种以下基团：（a）羟基，（b）醚基团，（c）羰基，（d）羧基，这些基团在式（II）和/或R中的化合物中是（即）。这些化合物以常规方式通过缩合的化合物Qa-Hal与具有伯胺或仲胺基团的合适的起始化合物反应。式（I）化合物适用于染色或印刷羟基或含氮有机基质，特别是棉花的纤维活性染料。优选的染色温度为冷染色范围。获得的染色和印花具有良好的一般牢度性能，并且对任何氧化影响都是稳定的。

79. 发明申请

WO1986003488A1 INDENE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF 审中-公开
标题翻译：梅洛酮及其衍生物的衍生物类似物
公开(公告)号：WO1986003488A1
公开(公告)日：1986-06-19
申请号：PCT/EP1985000653
申请日：1985-11-29
申请人： SANDOZ AG
发明人： SANDOZ AG , KATHAWALA, Faizulla, G. , WATTANASIN, Sompong
IPC分类号： C07C69/738
CPC分类号： C07D309/30 , C07C17/2632 , C07C45/00 , C07C47/24 , C07C47/57 , C07C25/22
摘要： Compounds of formula (I), wherein R is hydrogen or primary or secondary C1-6alkyl, R1 is primary or secondary C1-6alkyl or R and R1 together are (CH2)m or (Z)-CH2-CH=CH-CH2- wherein m is 2, 3, 4, 5 or 6, Ro is C1-6alkyl, C3-7cycloalkyl or ring A (II) each or R2 and R4 is independently hydrogen, C1-4alkyl, C1-4alkoxy (except t-butoxy), trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, each of R3 and R5 is independently hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R6 is hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, with the proviso that there may only be one each of trifluoromethyl, phenoxy or benzyloxy on each of the phenyl and indene rings X is -(CH2)n - or - (CH2)qCH=CH(CH2)q- wherein n is 1, 2 or 3 and both q's are 0 or one is 0 and the other is 1, and Z is (III) wherein Q is (IV) wherein each R7 is the same primary or secondary C1-6alkyl or together they represent -(CH2)2-, -(CH2)3-, R10 is hydrogen or C1-3alkyl, with the proviso that Q may be other than (V) only when X is -CH=CH- or -CH2-CH=CH- and/or R10 is C1-3alkyl, in free acid form, or in the form of an ester or -lactone thereof or in salt form as appropriate, which are indicated for use as hypolipoproteinemic and anti-atherosclerotic agents.
摘要翻译：式（I）化合物，其中R是氢或伯或仲C 1-6烷基，R 1是伯或仲C 1-6烷基或R和R 1一起是（CH 2）m或（Z）-CH 2 -CH = CH-CH 2 - 其中m为2,3,4,5或6，Ro为C 1-6烷基，C 3-7环烷基或环A（II）或R 2和R 4独立地为氢，C 1-4烷基，C 1-4烷氧基（除了叔丁氧基）三氟甲基，氟，氯，苯氧基或苄氧基，R3和R5各自独立地是氢，C1-3烷基，C1-3烷氧基，三氟甲基，氟，氯，苯氧基或苄氧基，R6是氢，C1-2烷基，C1-2烷氧基，氟或氯，条件是每个苯基和茚环中只有一个三氟甲基，苯氧基或苄氧基，X是 - （CH 2）n - 或 - （CH 2）q CH = CH（CH 2）q-，其中 n为1,2或3，q为0或1为0，另一个为1，Z为（III）其中Q为（Ⅳ），其中每个R 7为相同的伯或仲C 1-6烷基或一起代表 - （CH 2）2 - ， - （CH 2）3 - ，R 10是氢或C 1-3烷基，条件是或者以酯或内酯的形式，当X是-CH = CH-或-CH 2 -CH = CH-和/或R 10是C 1-3烷基时，Q可以不同于（V）或适当的盐形式，其被指示用作低脂蛋白血症和抗动脉粥样硬化剂。

80. 发明申请

WO1985005124A1 HUMAN T-CELL GROWTH FACTOR 审中-公开
标题翻译：人类T细胞生长因子
公开(公告)号：WO1985005124A1
公开(公告)日：1985-11-21
申请号：PCT/EP1985000194
申请日：1985-05-02
申请人： SANDOZ AG
发明人： SANDOZ AG , CLARK, Steven, C.
IPC分类号： C12N15/00
CPC分类号： C07K14/55 , C12N15/70
摘要： The mRNA of a distinct human T-Cell Growth Factor concentrated from a plasma source lead to the production and cloning of its cDNA and the elucidation of its sequence and that of the mature protein. Transfer vectors for production of such T-Cell Growth Factor are disclosed along with useful intermediate expression products.

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