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71. 发明授权

US07045119B2 Delivery of diazepam through an inhalation route 失效
标题翻译：通过吸入路线递送地西泮
公开(公告)号：US07045119B2
公开(公告)日：2006-05-16
申请号：US10792001
申请日：2004-03-03
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/5513 , Y10S514/958
摘要： The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising diazepam to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol
摘要翻译：本发明涉及通过吸入途径递送用于治疗焦虑症和这种病症症状的化合物。具体地说，它涉及含有用于吸入治疗的气溶胶。在本发明的方法方面，通过吸入途径向患者施用地西泮。该方法包括：a）加热包含地西泮以形成蒸气的组合物; 和b）允许蒸气冷却，由此形成少于药物降解产物的5％的凝结气雾剂。在本发明的试剂盒方面，提供了用于通过吸入途径递送地西泮的试剂盒，其包括：a）地西泮组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置

72. 发明授权

US07018620B2 Delivery of beta-blockers through an inhalation route 失效
标题翻译：通过吸入途径递送β受体阻滞剂
公开(公告)号：US07018620B2
公开(公告)日：2006-03-28
申请号：US10775583
申请日：2004-02-09
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route. Specifically, it relates to aerosols containing atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a composition of atenolol, pindolol, esmolol, propranolol, or metoprolol, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔。具体地说，它涉及用于吸入治疗的含有阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的气溶胶。在本发明的方法方面，通过吸入途径向患者施用阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔。该方法包括：a）加热阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的组合物以形成蒸气; 和b）允许蒸气冷却，由此形成包含具有小于5％药物降解产物的颗粒的凝结气溶胶。在本发明的试剂盒方面，提供了用于通过吸入途径输送阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的试剂盒，其包括：a）阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔组合物的薄涂层以及b）用于将所述薄涂层分配为冷凝气溶胶的装置。

73. 发明授权

US06884408B2 Delivery of diphenhydramine through an inhalation route 失效
标题翻译：通过吸入路线递送苯海拉明
公开(公告)号：US06884408B2
公开(公告)日：2005-04-26
申请号：US10153311
申请日：2002-05-21
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4418 , A61K31/4525 , A61K31/4545 , A61K31/46 , A61K31/473 , A61K31/48 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/505 , A61K31/519 , A61K31/53 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/5517 , A61K45/00 , A61K47/48 , A61M11/00 , A61P15/10 , A61P21/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/32 , A61P29/00 , A61P31/04 , A61P37/08 , A61P43/00 , C07D471/04 , C07D487/04 , F24V30/00 , A61K9/14
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antihistamines through an inhalation route. Specifically, it relates to aerosols containing diphenhydramine that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of diphenhydramine. In a method aspect of the present invention, diphenhydramine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of diphenhydramine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering diphenhydramine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of diphenhydramine; and, b) a device that forms a diphenhydramine containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送抗组胺剂。具体地说，它涉及用于吸入治疗的含有苯海拉明的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的苯海拉明的颗粒。在本发明的方法方面，苯海拉明通过吸入途径递送至哺乳动物。该方法包括：a）加热组合物，其中组合物包含至少5重量％的苯海拉明，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于将苯海拉姆通过吸入途径递送至哺乳动物的试剂盒，其包含：a）包含至少5重量％的苯海拉明的组合物; 和b）从组合物形成含有苯海拉明的气溶胶的装置，用于哺乳动物的吸入。

74. 发明授权

US06780399B2 Delivery of stimulants through an inhalation route 失效
标题翻译：通过吸入路线输送兴奋剂
公开(公告)号：US06780399B2
公开(公告)日：2004-08-24
申请号：US10150268
申请日：2002-05-15
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing ephedrine or fenfluramine that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of ephedrine or fenfluramine. In a method aspect of the present invention, one of ephedrine or fenfluramine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of ephedrine or fenfluramine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering ephedrine or fenfluramine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of ephedrine or fenfluramine; and, b) a device that forms an ephedrine or fenfluramine containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送兴奋剂。具体来说，它涉及用于吸入治疗的含有麻黄素或芬氟拉明的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的麻黄碱或芬氟拉明的颗粒。在本发明的方法方面，将麻黄素或芬氟拉明中的一种通过吸入途径递送至哺乳动物。该方法包括：a）加热组合物，其中组合物包含至少5重量％的麻黄碱或芬氟拉明，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径向哺乳动物递送麻黄素或芬氟拉明的试剂盒，其包含：a）包含至少5重量％的麻黄碱或芬氟拉明的组合物; 和b）从所述组合物形成含有气溶胶的麻黄素或芬氟拉明用于哺乳动物吸入的装置。

75. 发明授权

US06740308B2 Delivery of antihistamines through an inhalation route 有权
标题翻译：通过吸入途径递送抗组胺药
公开(公告)号：US06740308B2
公开(公告)日：2004-05-25
申请号：US10153831
申请日：2002-05-21
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antihistamines through an inhalation route. Specifically, it relates to aerosols containing antihistamines that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antihistamine. In a method aspect of the present invention, an antihistamine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antihistamine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antihistamine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antihistamine; and, b) a device that forms an antihistamine containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送抗组胺剂。具体地说，它涉及用于吸入治疗的含有抗组胺剂的气溶胶。在本发明的组合物方面，气雾剂包含包含至少5重量％抗组胺剂的颗粒。在本发明的方法方面，通过吸入途径将抗组胺药递送至哺乳动物。该方法包括：a）加热组合物，其中所述组合物包含至少5重量％的抗组胺剂，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径将抗组胺药物递送至哺乳动物的试剂盒，其包括：a）包含至少5重量％抗组胺剂的组合物; 和b）从所述组合物形成含有抗组胺剂的气溶胶的装置，用于哺乳动物的吸入。

76. 发明授权

US06716416B2 Delivery of antipsychotics through an inhalation route 有权
标题翻译：通过吸入途径递送抗精神病药
公开(公告)号：US06716416B2
公开(公告)日：2004-04-06
申请号：US10152639
申请日：2002-05-20
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antipsychotic. In a method aspect of the present invention, an antipsychotic is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antipsychotic; and, b) a device that forms an antipsychotic containing aerosol from the composition, for inhalation by the mammal.
摘要翻译：本发明涉及通过吸入途径递送抗精神病药。具体地说，它涉及用于吸入治疗的含有抗精神病药的气溶胶。在本发明的组合物方面，气溶胶包含包含至少5重量％的抗精神病药的颗粒。在本发明的方法方面，通过吸入途径将抗精神病药物递送至哺乳动物。该方法包括：a）加热组合物，其中组合物包含至少5重量％的抗精神病药物以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径将抗精神病药物递送至哺乳动物的试剂盒，其包括：a）包含至少5重量％的抗精神病药的组合物; 和b）从该组合物形成含有气溶胶的抗精神病药物的装置，用于哺乳动物的吸入。

77. 发明申请

US20130190381A1 INHIBITORS OF LONG AND VERY LONG CHAIN FATTY ACID METABOLISM AS BROAD SPECTRUM ANTI-VIRALS 有权
标题翻译：长链和非常长链脂肪酸代谢物作为广谱抗体的病毒
公开(公告)号：US20130190381A1
公开(公告)日：2013-07-25
申请号：US13579967
申请日：2011-02-18
申请人： Emre Koyuncu , Joshua D. Rabinowitz , Thomas Shenk
发明人： Emre Koyuncu , Joshua D. Rabinowitz , Thomas Shenk
IPC分类号： A61K31/713 , A61K31/439 , A61K45/06 , A61K31/4155 , A61K31/46 , A61K31/536 , A61K31/445
CPC分类号： A61K31/536 , A61K31/4155 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/713 , A61K45/06
摘要： The present invention provides methods and compounds for treating viral infections using modulators of host cell enzymes relating to long chain fatty acid and lipid droplet metabolism. It includes a method of treating viral infections using triacsin C and its relatives, analogues and derivatives as well as other inhibitors of long chain fatty acid metabolism and lipid droplet metabolism.
摘要翻译：本发明提供使用与长链脂肪酸和脂滴代谢相关的宿主细胞酶调节剂治疗病毒感染的方法和化合物。它包括使用三烯酸C及其亲属，类似物和衍生物以及长链脂肪酸代谢和脂滴代谢的其它抑制剂治疗病毒感染的方法。

78. 发明申请

US20120184600A1 Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and Associated Enzymes for Treatment of Viral Infections 有权
标题翻译：甘油-3-磷酸酰基转移酶（GPAT）和相关酶对病毒感染的抑制作用
公开(公告)号：US20120184600A1
公开(公告)日：2012-07-19
申请号：US13387452
申请日：2010-07-27
申请人： Sean Liu , Joshua D. Rabinowitz , Thomas Shenk
发明人： Sean Liu , Joshua D. Rabinowitz , Thomas Shenk
IPC分类号： A61K31/7088 , A61K31/381 , C12Q1/70 , A61K31/196 , A61P31/12 , A61P31/22 , A61K31/045 , A61K31/662
CPC分类号： A61K31/045 , A61K31/38 , A61K31/381
摘要： A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme
摘要翻译：通过施用抑制磷脂酸合成酶的化合物或其药学上可接受的衍生物来治疗或预防哺乳动物的病毒感染的方法

79. 发明授权

US08173107B2 Delivery of antipsychotics through an inhalation route 有权
标题翻译：通过吸入途径递送抗精神病药
公开(公告)号：US08173107B2
公开(公告)日：2012-05-08
申请号：US12413339
申请日：2009-03-27
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送抗精神病药。具体地说，它涉及用于吸入治疗的含有抗精神病药的气溶胶。在本发明的方法方面，通过吸入途径将抗精神病药物递送至患者。该方法包括：a）加热组合物，其中组合物包含抗精神病药，形成蒸气; 和b）允许蒸汽冷却，从而形成包含具有小于5％抗精神病药物降解产物的颗粒的凝结气溶胶。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送抗精神病药的试剂盒，其包括：a）抗精神病药组合物的薄涂层，和b）用于将所述薄涂层分配为冷凝气溶胶的装置。

80. 发明授权

US07988952B2 Delivery of drug esters through an inhalation route 有权
标题翻译：通过吸入途径递送药物酯
公开(公告)号：US07988952B2
公开(公告)日：2011-08-02
申请号：US12057330
申请日：2008-03-27
申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of drug esters through an inhalation route. Specifically, it relates to aerosols containing drug esters that are used in inhalation therapy. In a method aspect of the present invention, a drug ester is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises a drug ester, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug ester degradation product. In a kit aspect of the present invention, a kit for delivering a drug ester through an inhalation route is provided which comprises: a) a thin coating of a drug ester composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送药物酯。具体地说，它涉及用于吸入治疗的含有药物酯的气溶胶。在本发明的方法方面，通过吸入途径将药物酯递送至患者。该方法包括：a）加热组合物，其中组合物包含药物酯以形成蒸汽; 和b）允许蒸汽冷却，从而形成包含具有小于5％药物酯降解产物的颗粒的缩合气雾剂。在本发明的试剂盒方面，提供了用于通过吸入途径递送药物酯的试剂盒，其包括：a）药物酯组合物的薄涂层，以及b）用于分配所述薄涂层作为凝结气溶胶的装置。

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