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71. 发明授权

US07366567B2 Method for treating myocardial infarction 有权
公开(公告)号：US07366567B2
公开(公告)日：2008-04-29
申请号：US11088231
申请日：2005-03-23
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

72. 发明授权

US07356366B2 Device for monitoring fluid status 有权
标题翻译：用于监测流体状态的装置
公开(公告)号：US07356366B2
公开(公告)日：2008-04-08
申请号：US10909926
申请日：2004-08-02
申请人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
发明人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61B5/00
CPC分类号： A61B5/0538 , A61B5/053 , A61B5/14535 , A61N1/36521
摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.
摘要翻译：描述了通过电阻抗测量来确定患者的血细胞比容的技术。可植入装置可被配置为利用该技术来评估心脏病人的流体状态。为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

73. 发明授权

US06973349B2 Method and apparatus for minimizing post-infarct ventricular remodeling 有权
公开(公告)号：US06973349B2
公开(公告)日：2005-12-06
申请号：US10005184
申请日：2001-12-05
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/05 , A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.

74. 发明授权

US5540727A Method and apparatus to automatically optimize the pacing mode and pacing cycle parameters of a dual chamber pacemaker 失效
标题翻译：自动优化双室心脏起搏器的起搏模式和起搏循环参数的方法和装置
公开(公告)号：US5540727A
公开(公告)日：1996-07-30
申请号：US339813
申请日：1994-11-15
申请人： Bruce A. Tockman , Julio C. Spinelli , Rodney W. Salo
发明人： Bruce A. Tockman , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3688
摘要： A cardiac stimulating system incorporating a microprocessor-based controller is designed to automatically optimize both the pacing mode and one or more pacing cycle parameters in a way that results in optimization of a cardiac performance parameter, such as cardiac output. For each of a plurality of modes in which a DDD cardiac pacer can operate, a pacing parameter such as the AV interval of the pacer is incrementally adjusted and following that, an observation is made as to the effect of the adjustment on cardiac output. After the process has been repeated for all possible pacing modes, a determination is made to find the pacing mode and the AV interval or other pacing parameter that results in the maximum cardiac output or other optimal cardiac performance parameter. It is these pacing parameters that are then programmed into the microcontroller for causing the pacemaker to function in the desired mode and at the desired parameter values.
摘要翻译：设计包含基于微处理器的控制器的心脏刺激系统被设计为以导致心脏性能参数（例如心输出量）的优化的方式自动优化起搏模式和一个或多个起搏周期参数。对于DDD心脏起搏器可以操作的多种模式中的每种，逐步调整起搏参数，例如起搏器的AV间隔，并且随后观察调节对心输出量的影响。在针对所有可能的起搏模式重复该过程之后，确定找到导致最大心输出量或其他最佳心脏性能参数的起搏模式和AV间隔或其他起搏参数。正是这些起搏参数然后被编程到微控制器中，以使起搏器在期望的模式和期望的参数值下起作用。

75. 发明授权

US5487752A Automated programmable stimulating device to optimize pacing parameters and method 失效
标题翻译：自动可编程刺激装置优化起搏参数和方法
公开(公告)号：US5487752A
公开(公告)日：1996-01-30
申请号：US339567
申请日：1994-11-15
申请人： Rodney W. Salo , Julio C. Spinelli , Bruce A. Tockman
发明人： Rodney W. Salo , Julio C. Spinelli , Bruce A. Tockman
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/36514 , A61N1/3682
摘要： A method and apparatus for automatically optimizing a cardiac performance parameter of the heart, such as its cardiac output mean arterial pressure pO.sub.2 or pCO.sub.2. The performance parameter is optimized by periodically pacing the heart for a short period of time with stimulating pulses having a modified pacing parameter value. The intrinsic operation of the heart is monitored a majority of the time and establishes a baseline value for the cardiac performance parameter. The heart is then paced with the modified pacing parameter value during an interval that is approximately a 1:4 ratio with respect to the baseline monitoring interval. The method of the present invention can be achieved using a totally implanted pacemaker, an implanted pulse generator in combination with external equipment communicating with the pacemaker via telemetry, or by using equipment located external the patient.
摘要翻译：用于自动优化心脏的心脏性能参数的方法和装置，例如其心输出量平均动脉压pO2或pCO2。性能参数通过在具有改变的起搏参数值的刺激脉冲中周期性地对心脏起搏一段时间进行优化。在大多数时间内监测心脏的固有操作，并建立心脏性能参数的基线值。然后在相对于基线监测间隔约为1：4的间隔的间隔内，使用修改的起搏参数值对心脏进行起搏。本发明的方法可以使用完全植入的起搏器，植入式脉冲发生器与通过遥测与起搏器通信的外部设备，或通过使用位于病人外部的设备来实现。

76. 发明授权

US5334222A Cardiac stimulating apparatus and method for heart failure therapy 失效
标题翻译：心脏刺激装置及心力衰竭治疗方法
公开(公告)号：US5334222A
公开(公告)日：1994-08-02
申请号：US970893
申请日：1992-11-03
申请人： Rodney W. Salo , Julio C. Spinelli , Bruce A. Tockman
发明人： Rodney W. Salo , Julio C. Spinelli , Bruce A. Tockman
IPC分类号： A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3627 , A61N1/3682
摘要： A cardiac rhythm management device includes a dual-chamber pacemaker especially designed for treating congestive heart failure and a defibrillator as a back-up measure. The device incorporates a programmed microcontroller which is operative to adjust the AV delay of the pacemaker to a minimum or maximum length consistent with optimal cardiac function. The cardiac stimulator includes apparatus for sensing cardiac function from cycle-to-cycle and determining whether incremental changes made to the AV delay interval enhances or worsens the measured cardiac function. On each iterative cycle, the AV delay interval is changed, either incremented or decremented, until a cross-over point is reached in which it is noted that the cardiac function ceases to improve and this is followed with a further incremental adjustment in an opposite direction to compensate for any overshoot. By providing a cardiac defibrillator in combination with the pacing device with closed-loop control of the AV interval, incidences of sudden death due to lethal arrhythmias is reduced.
摘要翻译：心律管理装置包括专门设计用于治疗充血性心力衰竭的双腔心脏起搏器和除颤器作为后备措施。该装置包括编程的微控制器，其可操作以将起搏器的AV延迟调整到与最佳心脏功能一致的最小或最大长度。心脏刺激器包括用于从周期到周期感测心脏功能的装置，以及确定对AV延迟间隔做出的增量变化是否增强或恶化测量的心脏功能。在每个迭代循环中，AV延迟间隔被改变，递增或递减，直到达到交叉点，其中注意到心脏功能不再改善，并且随后在相反方向上进一步增量调整以补偿任何过冲。通过与AV间隔的闭环控制提供与起搏装置组合的心脏除颤器，减少了因致命性心律失常引起的猝死的发生。

77. 发明授权

US4911174A Method for matching the sense length of an impedance measuring catheter to a ventricular chamber 失效
标题翻译：将阻抗测量导管的感测长度与心室的匹配的方法
公开(公告)号：US4911174A
公开(公告)日：1990-03-27
申请号：US309221
申请日：1989-02-13
申请人： Brian D. Pederson , Rodney W. Salo
发明人： Brian D. Pederson , Rodney W. Salo
IPC分类号： A61B10/00 , A61B5/042 , A61B5/05 , A61B5/053 , A61B5/107
CPC分类号： A61B5/0538 , A61B5/042 , A61B5/0422 , A61B5/0535 , A61B2562/0209 , A61B2562/043
摘要： A method for matching the distance spanned by a plurality of surface electrodes on an impedance measuring catheter to the size of a ventricular chamber to be measured is disclosed. The catheter includes a plurality of longitudinally spaced electrodes extending from its distal end and spanning a distance known to be greater than the maximum length of a ventricular chamber. With the distal end of the catheter located at the apex of the ventricle, an AC drive signal is applied between the distal electrode and a proximal electrode known to be outside of the ventricle. By then sensing the resulting voltage between successive adjacent electrode pairs and comparing same, the pair where a different characteristic is exhibited is known to be at the transition between the ventricle and the atrium.

78. 发明授权

US4674518A Method and apparatus for measuring ventricular volume 失效
标题翻译：测量心室容量的方法和装置
公开(公告)号：US4674518A
公开(公告)日：1987-06-23
申请号：US773048
申请日：1985-09-06
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61B5/05 , A61B5/029 , A61B5/103 , A61B5/107 , G01F17/00 , A61B5/04
CPC分类号： A61B5/1073 , A61B5/029 , A61B5/0295 , G01F17/00
摘要： A method and apparatus for the instantaneous measurement of venticular volume using an intracavity electrical impedance catheter having plural pairs of spaced surface electrodes driven by a corresponding plurality of electrical signals, each of the signals exhibiting a different discrete frequency, and having plural pairs of spaced surface electrodes for sensing the potentials at predetermined locations within the ventricle. Switching means are provided for selectively coupling the drive signals to predetermined pairs of surface electrodes and for selecting the sensing electrode pairs to be utilized at any given time for read-back of the sensed potentials. The read-back signals are demodulated and converted from an analog signal to a digital quantity. Then, a digital computer is used to determine from the sensed digital quantities the extrapolated value of impedance corresponding to sources spaced an infinite distance apart. Knowing the extrapolated impedance value, the volume of blood in the ventricle can be computed using the formula V=.rho.L.sup.2 /R.sub.0 wherein R.sub.0 is the extrapolated impedance value, L is the distance between the spaced sensing electrodes spanning the ventricle and .rho. is the resistivity of the blood.
摘要翻译：一种用于使用腔内电阻抗导管瞬时测量通气量的方法和装置，其具有由相应的多个电信号驱动的多对间隔表面电极，每个信号呈现不同的离散频率，并且具有多对间隔表面用于感测心室内预定位置处的电位的电极。提供开关装置，用于选择性地将驱动信号耦合到预定的一对表面电极，并用于选择在任何给定时间用于读出感测电位的感测电极对。回读信号被解调并从模拟信号转换成数字量。然后，使用数字计算机从感测的数字量中确定对应于间隔无限距离的源的阻抗的外推值。知道外插阻抗值，可以使用公式V = rho L2 / R0计算心室内血液的体积，其中R0是外推阻抗值，L是跨越心室的间隔感应电极之间的距离，rho是电阻率的血液

79. 发明授权

US08798747B2 Method and apparatus for control of cardiac therapy using non-invasive hemodynamic sensor 有权
标题翻译：使用非侵入性血液动力学传感器控制心脏治疗的方法和装置
公开(公告)号：US08798747B2
公开(公告)日：2014-08-05
申请号：US13273108
申请日：2011-10-13
申请人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
发明人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译：心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。

80. 发明授权

US08612001B2 Method and apparatus for minimizing post-infarct ventricular remodeling 失效
标题翻译：用于最小化梗死后心室重塑的方法和装置
公开(公告)号：US08612001B2
公开(公告)日：2013-12-17
申请号：US13034560
申请日：2011-02-24
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译：心脏节律管理装置，其中预激励起搏应用于心室心肌梗死区域附近的一个或多个部位。这种起搏服务器可以预防或最小化梗死后重塑。

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