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71. 发明申请

US20140005557A1 Photoplethysmography Sensors 审中-公开
标题翻译： Photoplethysmography传感器
公开(公告)号：US20140005557A1
公开(公告)日：2014-01-02
申请号：US13650310
申请日：2012-10-12
申请人： David Rich , Richard J. Melker , Andrew Kersey , Matt Culen
发明人： David Rich , Richard J. Melker , Andrew Kersey , Matt Culen
IPC分类号： A61B5/0205 , A61B5/0295
CPC分类号： A61B5/02416 , A61B5/0261 , A61B5/0878 , A61B5/14552 , A61B5/6819
摘要： Provided according to embodiments of the invention are photoplethysmography (PPG) sensors, systems and accessories, and methods of making and using the same. In some embodiments of the invention, the PPG sensors include a clip body that includes a first end portion and a second end portion; a flex circuit attached or adjacent to the clip body, and an elastomeric sleeve that envelops (1) at least part of the first end portion and at least part of the flex circuit attached or adjacent thereto; or (2) at least part of the second end portion and at least part of the flex circuit attached or adjacent thereto.
摘要翻译：根据本发明的实施例提供的是光电体积描记术（PPG）传感器，系统和附件，以及制造和使用它们的方法。在本发明的一些实施例中，PPG传感器包括夹体，其包括第一端部和第二端部; 附接或邻近夹子主体的柔性电路以及包围（1）第一端部的至少一部分和与其相邻或相邻的柔性电路的至少一部分的弹性体套管; 或（2）第二端部的至少一部分和与其相邻或相邻的柔性电路的至少一部分。

72. 发明授权

US08211035B2 System and method for monitoring health using exhaled breath 有权
标题翻译：使用呼气监测健康的系统和方法
公开(公告)号：US08211035B2
公开(公告)日：2012-07-03
申请号：US11512856
申请日：2006-08-29
申请人： Richard J. Melker , David G. Bjoraker , Samsun Lampotang
发明人： Richard J. Melker , David G. Bjoraker , Samsun Lampotang
IPC分类号： A61B5/08 , A61M31/00
CPC分类号： A61M16/01 , A61B5/082 , A61B5/14532 , A61B5/14546 , A61B5/411 , A61B5/4821 , A61B5/7267 , A61M16/0051 , A61M16/026 , A61M16/0808 , A61M16/0841 , A61M16/1045 , A61M16/18 , A61M16/22 , A61M2016/0036 , A61M2016/1035 , A61M2202/0275 , A61M2202/0486 , A61M2205/18 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/52 , A61M2205/80 , A61M2230/43 , A61M2230/432 , A61M2230/435 , A61M2230/437 , G01N33/497
摘要： The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.
摘要翻译：本发明包括通过在患者呼出时检测诸如气味等标记物的血液中的内源性化合物浓度的系统和方法，其中所述标志物是内源性化合物本身或由内源化合物产生。在嗅觉标记的情况下，本发明优选利用诸如称为“人造”或“电子”鼻子或舌头的商业装置的电子传感器技术非侵入性地监测血液中的内源性化合物水平。本发明还包括能够跟踪血液中的内源性化合物浓度（偏远或近处）并提供关于患者的紧急或有害状况的必要警报的报告系统。

73. 发明申请

US20100255598A1 Medication Adherence Monitoring System 审中-公开
标题翻译：药物依从性监测系统
公开(公告)号：US20100255598A1
公开(公告)日：2010-10-07
申请号：US12064673
申请日：2008-02-22
申请人： Richard J. Melker , Donn Michael Dennis , Christopher D. Batich , Mark S. Gold
发明人： Richard J. Melker , Donn Michael Dennis , Christopher D. Batich , Mark S. Gold
IPC分类号： G01N33/50
CPC分类号： G01N33/58 , A61B5/083 , A61B5/411 , A61B5/4833 , A61K49/0004 , A61K51/1206 , G01N2458/15 , Y10T436/22
摘要： The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable.
摘要翻译：本发明涉及呼出呼吸中的标记物的检测，其中使用呼出呼吸中标记物的存在或不存在来检测各种临床数据，包括患者服用药物和患者酶促代谢（代谢）代谢药物的能力。本发明的一个实施方案包括用标记物标记的母体治疗剂，其中当代谢（例如通过酶促作用）治疗剂时），标记物变得挥发性或半挥发性并且存在于呼吸中。在某些相关实施方案中，标记物含有氘标记，其在治疗剂代谢时也存在于呼吸中。在本发明的另一个实施方案中，治疗剂与标记物（其可以是用氘标记或未标记）相关联，其又将在呼吸中产生容易测量的标记物。

74. 发明授权

US07785262B2 Method and apparatus for diagnosing respiratory disorders and determining the degree of exacerbations 有权
标题翻译：用于诊断呼吸系统疾病和确定恶化程度的方法和装置
公开(公告)号：US07785262B2
公开(公告)日：2010-08-31
申请号：US11122278
申请日：2005-04-25
申请人： Richard J. Melker , Neil R. Euliano
发明人： Richard J. Melker , Neil R. Euliano
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/4884 , A61B5/0205 , A61B5/02416 , A61B5/08 , A61B5/085 , A61B5/1073 , A61B5/14551 , A61B5/14552 , A61B5/411 , A61B5/4836 , A61B2560/0223 , A61M16/0069 , A61M16/1005 , A61M2205/3303 , A61M2205/3306 , A61M2205/502 , A61M2230/205
摘要： Disclosed herein are apparatuses and methods to monitor respiration and abnormal respiration events utilizing plethysmography. The apparatuses and methods provide an alternative to conventional respiration monitoring methods while enabling accurate yet minimally interruptive and invasive monitoring of respiration. The methods and apparatuses may be employed in the context of sleep studies to determine respiratory related sleep disorders.
摘要翻译：本文公开了利用体积描记法监测呼吸和异常呼吸事件的装置和方法。这些装置和方法提供了常规呼吸监测方法的替代方案，同时能够进行精确的，最小的中断和有创性的呼吸监测。可以在睡眠研究的上下文中使用方法和装置来确定呼吸相关的睡眠障碍。

75. 发明申请

US20100192952A1 Methods and Devices for Central Photoplethysmographic Monitoring Methods 有权
标题翻译：中央Photoplethysmographic监测方法和方法
公开(公告)号：US20100192952A1
公开(公告)日：2010-08-05
申请号：US12377706
申请日：2006-08-15
申请人： Richard J. Melker , Neil R. Euliano
发明人： Richard J. Melker , Neil R. Euliano
IPC分类号： A61M16/00 , A61B5/1455 , A42B1/06
CPC分类号： A61B5/0295 , A61B5/02 , A61B5/02416 , A61B5/0261 , A61B5/14552 , A61B5/6803 , A61B5/6815 , A61B5/6817 , A61B5/6819 , A61B5/6838 , A61M16/0051 , A61M16/06 , A61M16/0627 , A61M16/0683 , A61M2230/205 , A61M2230/432
摘要： Disclosed herein are methods and devices for delivering gas to a subject and obtaining plethysmograph readings from a subject. Specifically disclosed herein are masks and helmets which comprise one or more pulse oximeter probes associated therewith. The masks and helmets may be used in particular contexts, including, but not limited to, emergency responder personnel, pilots or subjects of medical attention.
摘要翻译：本文公开了用于将气体输送到对象并获得来自受试者的体积描记器读数的方法和装置。本文具体公开的是包括与其相关联的一个或多个脉搏血氧计探针的掩模和头盔。面罩和头盔可以用于特定情况，包括但不限于紧急响应者人员，飞行员或医疗关注对象。

76. 发明申请

US20080227856A1 Materials and Methods for Creating Customized Compositions Having a Temporary Visual Indicator 审中-公开
标题翻译：创建具有临时视觉指示器的定制组合的材料和方法
公开(公告)号：US20080227856A1
公开(公告)日：2008-09-18
申请号：US12111032
申请日：2008-04-28
申请人： Richard J. Melker
发明人： Richard J. Melker
IPC分类号： A01N43/08 , A01P3/00 , A01P13/00
CPC分类号： A01N25/00
摘要： The present invention relates to novel compositions, which provide an indicator for location and/or concentration of the composition during application. Following application, the indicator is no longer visible to the user. In one embodiment, the indicator is a compound that is visible at a first pH and not visible at a second pH. In another embodiment, the indicator is a photosensitive or light unstable dye, where the dye is visible for a temporary period following exposure to light.
摘要翻译：本发明涉及新的组合物，其提供了施用期间组合物的位置和/或浓度的指示剂。在应用程序之后，用户不再可以看到该指示器。在一个实施方案中，指示剂是在第一pH下可见并且在第二pH下不可见的化合物。在另一个实施方案中，指示剂是感光或光不稳定的染料，其中染料在暴露于光后的临时期间是可见的。

77. 发明申请

US20080067132A1 METHOD FOR USING PHOTOPLETHYSMOGRAPHY TO OPTIMIZE FLUID REMOVAL DURING RENAL REPLACEMENT THERAPY BY HEMODIALYSIS OR HEMOFILTRATION 有权
标题翻译：使用光化学显微镜优化通过肝细胞分析或HEMOFILION治疗的肾移植治疗期间的液体去除的方法
公开(公告)号：US20080067132A1
公开(公告)日：2008-03-20
申请号：US11532251
申请日：2006-09-15
申请人： Edward Allan Ross , Richard J. Melker
发明人： Edward Allan Ross , Richard J. Melker
IPC分类号： C02F1/00
CPC分类号： A61M1/34 , A61B5/02007 , A61B5/0261 , A61B5/0295 , A61B5/6819 , A61M1/3403 , A61M1/341 , A61M1/3609 , A61M2205/3306 , A61M2205/50
摘要： Disclosed herein are methods, systems and devices to monitor vascular volume status during renal replacement therapy utilizing at least one oximetry/photoplethysmography sensor. The methods, systems and devices provide an alternative to conventional vascular volume monitoring methods during renal replacement therapy while enabling reliable, non-invasive, and automatic monitoring of vascular volume to avert patient hypotension. The methods, systems and devices may be employed in the context of both inpatient and outpatient dialysis facilities and may also be incorporated into conventional hemodialysis and hemofiltration techniques and equipment.
摘要翻译：本文公开了使用至少一种血氧定量/光电容积描记传感器在肾脏替代治疗期间监测血管体积状态的方法，系统和装置。在肾脏替代治疗期间，方法，系统和装置提供常规血管容积监测方法的替代方案，同时实现血管容积的可靠，非侵入和自动监测以避免患者低血压。方法，系统和装置可以在住院和门诊透析设备的上下文中使用，并且还可以并入常规血液透析和血液滤过技术和设备中。

78. 发明授权

US06976487B1 Ventilatory method utilizing body length-based parameter calculations 失效
标题翻译：采用基于身体长度的参数计算的通气方法
公开(公告)号：US06976487B1
公开(公告)日：2005-12-20
申请号：US09457709
申请日：1999-12-10
申请人： Richard J. Melker , Michael J. Banner , Samsun Lampotang , Paul B. Blanch , Neil R. Euliano , Ronald G. Carovano
发明人： Richard J. Melker , Michael J. Banner , Samsun Lampotang , Paul B. Blanch , Neil R. Euliano , Ronald G. Carovano
IPC分类号： A61M16/00 , A61M16/20 , A61M15/00
CPC分类号： A61M16/206 , A61M16/0051 , A61M16/026 , A61M16/0858 , A61M16/203 , A61M16/205 , A61M16/208 , A61M16/209 , A61M2016/0021 , A61M2016/0027 , A61M2205/16
摘要： A method and apparatus for operating a ventilator in a primary electronic mode or in a back-up pneumatic mode during primary electronic mode failure. A method and apparatus for operating a ventilator in an advanced mode, having a number of ventilatory modes, or in a basic mode, having a limited number of ventilatory modes is also disclosed.
摘要翻译：一种用于在初级电子模式故障期间以主电子模式或备用气动模式操作呼吸机的方法和装置。还公开了一种用于以具有有限数量的通气模式的具有多个通气模式或以基本模式操作高级模式的呼吸机的方法和装置。

79. 发明授权

US06974706B1 Application of biosensors for diagnosis and treatment of disease 失效
标题翻译：生物传感器在疾病诊断和治疗中的应用
公开(公告)号：US06974706B1
公开(公告)日：2005-12-13
申请号：US10345532
申请日：2003-01-16
申请人： Richard J. Melker , Donn Michael Dennis
发明人： Richard J. Melker , Donn Michael Dennis
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： B82Y30/00 , G01N33/5308 , Y10S436/805 , Y10S436/811 , Y10S436/815 , Y10S436/90
摘要： A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with molecular beacons or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.
摘要翻译：一种用于检测体液中感兴趣的化合物的方法，包括呼出的呼吸和血液。本发明使用模仿天然存在的细胞机制的生物传感器，包括RNA寡核苷酸链或“适体”，与分子信标或纳米技术组合，以提供用于诊断患者内的病症和/或疾病的有效和有效的方法。本发明还提供了用于筛选可能存在于呼出气中的那些分析物/生物标志物的方法。

80. 发明授权

US06074345A Patient data acquisition and control system 失效
标题翻译：患者数据采集和控制系统
公开(公告)号：US06074345A
公开(公告)日：2000-06-13
申请号：US179768
申请日：1998-10-27
申请人： Johannes H. van Oostrom , Richard J. Melker
发明人： Johannes H. van Oostrom , Richard J. Melker
IPC分类号： A61B5/00 , G06F19/00 , H04L12/24 , H04L29/00 , H04L29/06
CPC分类号： A61B5/0002 , G06F19/327 , G06F19/3418 , H04L69/08 , H04L69/24 , A61B2562/08 , H04L41/0896 , Y10S128/904 , Y10S128/92
摘要： The present invention solves this communication problem by providing a method and apparatus for connecting to and coordinating data communications of various medical devices having different communication protocols. In a preferred embodiment, the invention provides a way to recognize common parameters and separate out only that part of the communication that is different between and specific to the various monitors and therapeutic devices. The invention efficiently utilizes defined common parameters for protocol types and selectively configures the specific settings when required, automatically.
摘要翻译：本发明通过提供一种用于连接和协调具有不同通信协议的各种医疗装置的数据通信的方法和装置来解决这种通信问题。在优选实施例中，本发明提供了一种识别常见参数并且仅分离出与各种监视器和治疗设备不同的特定通信的那部分的方法。本发明有效地利用定义的协议类型的通用参数，并在需要时自动选择配置特定设置。

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