专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明专利

CA2635335A1 MUSCARINIC RECEPTOR ANTAGONISTS 未知
公开(公告)号：CA2635335A1
公开(公告)日：2007-07-12
申请号：CA2635335
申请日：2006-12-21
申请人： RANBAXY LAB LTD
发明人： RAY ABHIJIT , MALHOTRA SHIVANI , SHIRUMALLA RAJ KUMAR , PALLE VENKATA P , KAUR JASKIRAN , KUMAR NARESH , CHUGH ANITA , JINDAL SHELLY , BHATT BEENU , GUPTA SUMAN
IPC分类号： C07D233/14 , A61K31/4164 , A61K31/4439 , A61P1/00 , A61P11/00 , A61P13/00 , C07D233/60 , C07D233/61 , C07D401/12
摘要： Compounds of Formula (I), wherein represents a single bond when G is —OH and double bond when G is —O; R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, —NH, —NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.

72. 发明专利

BRPI0413330A 未知
公开(公告)号：BRPI0413330A
公开(公告)日：2006-10-10
申请号：BRPI0413330
申请日：2004-08-30
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , BALACHANDRAN SARALA , SALMAN MOHAMMAD , KUKREJA GAGAN , GUPTA NIDHI , RAY ABHIJIT , DASTIDAR SUNANDA G
IPC分类号： A61K31/42 , A61K31/422 , A61K31/423 , A61K31/424 , C07C45/61 , C07C269/06 , C07D261/02 , C07D261/04 , C07D261/20 , C07D413/06 , C07D413/14 , C07D487/08 , C07D491/02 , C07D498/10
摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

73. 发明专利

CY1112805T1 ΠΑΡΑΓΩΓΑ ΠΥΡΑΖΟΛΟ (3,4-B) ΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ 未知
公开(公告)号：CY1112805T1
公开(公告)日：2016-02-10
申请号：CY121100403
申请日：2012-04-26
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , RAMAIAH MANDADAPU RAGHU , PALLE VENKATA P , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： A61K31/437 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D471/04 , C07D519/00
摘要： Ηπαρούσαεφεύρεσηαναφέρεταισεαναστολείςτηςφωσφοδιεστεράσης (ΡDΕ) τύπου 4, τηςφωσφο-διεστεράσης (ΡDΕ) τύπου 7 καισεδιπλούςαναστολείςτηςΡDΕτύπου 4/ΡDΕτύπου 7. ΟιενώσειςπουαποκαλύπτονταιεδώέχουντηδομήτουΤύπουΙ: μπορούνναείναιχρήσιμεςστηθεραπευτικήαγωγή, πρόληψη, αναστολήή καταστολήνόσωντουΚΝΣ, γιαπαράδειγμα, τηςπολλαπλήςσκλήρυνσης•διάφορωνπαθολογικώνκαταστάσεωνόπωςνόσωνπουπροσβάλλουντοανοσοποιητικόσύστημα, συμπεριλαμβανομένουτουΑΙDS, τηςαπόρριψηςμοσχεύματος, αυτο-άνοσωνδιαταραχώνόπωςνόσωνπουσχετίζονταιμεΤ-λεμφοκύτταρα, γιαπαράδειγμα, ρευματοειδούςαρθρίτιδας•φλεγμονωδώννόσωνόπωςφλεγμονωδώνπαθήσεωντουαναπνευστικούσυμπεριλαμβανομένηςτηςχρόνιαςαποφρακτικήςπνευμονοπάθειας (CΟΡD), τουάσθματος, τηςβρογχίτιδας, τηςαλλεργικήςρινίτιδας, τουσυνδρόμουαναπνευστικήςδύσπνοιαςτωνενηλίκων (ΑRDS) καιάλλωνφλεγμονωδώννόσωνσυμπεριλαμβανομένηςαλλάχωρίςπεριορισμότηςψωρίασης, τουσοκ, τηςατοπικήςδερματίτιδας, τουηωσινόφιλουκοκκιώματος, τηςαλλεργικήςεπιπεφυκίτιδας, τηςοστεοαρθρίτιδας•γαστρεντερικώνφλεγμονωδώννόσωνόπωςτηςνόσουτου Crohn, κολίτιδας, παγκρεατίτιδαςκαθώςκαιδιαφορετικώντύπωνκαρκίνωνσυμπεριλαμβανομένηςτηςλευχαιμίας•ειδικότερασεανθρώπους. Παρέχονταιδιεργασίεςγιατηνπαρασκευήτωναποκαλυπτόμενωνενώσεων, φαρμακευτικώνσυνθέσεωνπουπεριέχουντιςαποκαλυπτόμενεςενώσειςκαιη χρήσητουςωςαναστολείςτηςΡDΕτύπου 4, τηςΡDΕτύπου 7 καιωςδιπλοίαναστολείςτηςΡDΕτύπου 4/ΡDΕτύπου 7.

74. 发明专利

BRPI0717058A2 未知
公开(公告)号：BRPI0717058A2
公开(公告)日：2013-10-15
申请号：BRPI0717058
申请日：2007-09-22
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA , RAY ABHIJIT
IPC分类号： C07D261/04 , A61K31/41 , A61P29/00 , C07D261/20 , C07D498/10
摘要： The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors.

75. 发明专利

EA018670B1 ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-В]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ 未知
公开(公告)号：EA018670B1
公开(公告)日：2013-09-30
申请号：EA200970852
申请日：2008-03-14
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , RAMAIAH MANDADAPU RAGHU , PALLE VENKATA P , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： A61K31/437 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D471/04 , C07D519/00
摘要： Изобретениеотноситсяк ингибиторамфосфодиэстеразы (PDE) типа 4, фосфодиэстеразы (PDE) типа 7 идвойнымингибиторам PDE типа 4/PDE типа 7. Соединения, описанныев изобретении, имеющиеструктуруформулы I, могутбытьполезныв лечении, предупреждении, ингибированииилиподавленииболезнейЦНС (центральнойнервнойсистемы), напримермножественногосклероза; различныхпатологическихсостояний, как, например, заболеваний, поражающихиммуннуюсистему, включаяСПИД (синдромприобретенногоиммунодефицита), отторжениетрансплантата, аутоиммунныерасстройства, такиекакассоциированныес Т-клеткамизаболевания, напримерревматоидныйартрит; воспалительныхзаболеваний, такихкакреспираторныевоспалительныезаболевания, включаяхроническуюобструктивнуюболезньлегких (COPD), астму, бронхит, аллергическийринит, респираторныйдистресс-синдромвзрослых (ARDS) идругиевоспалительныезаболевания, включая, ноэтимнеограничиваясь, псориаз, шок, атопическийдерматит, эозинофильнуюгранулёму, аллергическийконъюнктивит, остеоартрит; желудочно-кишечныхвоспалительныхзаболеваний, такихкакболезньКрона, колит, панкреатит, атакжеразличныхтиповрака, включаялейкоз; особенноу людей. Предложеныспособполученияописанныхсоединений, фармацевтическиекомпозиции, содержащиеописанныесоединения, иихприменениев качествеингибиторов PDE типа 4, PDE типа 7 идвойныхингибиторов PDE типа 4/PDE типа 7.

76. 发明专利

MX2013003362A INHIBIDORES DE METALOPROTEINASA DE MATRIZ. 未知
公开(公告)号：MX2013003362A
公开(公告)日：2013-06-05
申请号：MX2013003362
申请日：2011-09-26
申请人： RANBAXY LAB LTD
发明人： SATTIGERI JITENDRA , KHERA MANOJ KUMAR , RAY ABHIJIT , PALLE VENKATA P , SONI AJAY , RAUF ABDUL REHMAN ABDUL , MUSIB ARPITA , SATTIGERI VISWAJANANI , CLIFFE IAN A , BHATNAGAR PRADIP KUMAR , SRIVASTAVA PUNIT , DASTIDAR SUNANDA GHOSH , REDDY RANADHEER R , SIVAKUMAR R
IPC分类号： C07D209/48 , A61K31/27 , A61K31/4035 , A61K31/53 , A61P11/00 , A61P19/02 , A61P35/00 , C07C271/28 , C07D253/04 , C07D401/12
摘要： La presente invención se relaciona a derivados de metil sulfonamidas y N-formamidas de la fórmula I y a procesos para su síntesis. La invención también se relaciona a composiciones farmacológicas que contienen estos derivados y métodos para tratar asma, artritis reumatoide, COPD, rinitis, osteoartritis, artritis psoriática, psoriasis, fibrosis pulmonar, inflamación pulmonar, síndrome de angustia respiratoria aguda, perodontitis, esclerosis múltiple, gingivitis, aterosclerosis, ojo seco, proliferación neoíntima, que conduce a restenosis y falla cardíaca isquémica, ataque apoplético, enfermedad renal, metástasis de tumor y otros trastornos inflamatorios caracterizados por sobre-expresión y sobre-activación de una metaloproteinasa de matriz usando los compuestos.

77. 发明专利

SG188641A1 MATRIX METALLOPROTEINASE INHIBITORS 未知
公开(公告)号：SG188641A1
公开(公告)日：2013-04-30
申请号：SG2013021654
申请日：2011-09-26
申请人： RANBAXY LAB LTD
发明人： KHERA MANOJ KUMAR , PALLE VENKATA P , SATTIGERI VISWAJANANI , SATTIGERI JITENDRA , SONI AJAY , RAUF ABDUL REHMAN ABDUL , SIVAKUMAR R , REDDY RANADHEER R , MUSIB ARPITA , CLIFFE IAN A , BHATNAGAR PRADIP KUMAR , RAY ABHIJIT , SRIVASTAVA PUNIT , DASTIDAR SUNANDA GHOSH
摘要： The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds.

78. 发明专利

ES2382715T3 Derivados de pirazol[3,4-B]piridina como inhibidores de fosfodiesterasa 未知
公开(公告)号：ES2382715T3
公开(公告)日：2012-06-12
申请号：ES08737621
申请日：2008-03-14
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT , AGARWAL RITU , KHAIRNAR VINAYAK , RAMAIAH MANDADAPU , PALLE VENKATA P , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： A61K31/437 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D471/04 , C07D519/00
摘要： Compuesto que tiene la estructura de fórmula I: o sus sales farmacéuticamente aceptables, 5 en la que R1 y R2 son independientemente hidrógeno, arilo, heteroarilo, -COR4, -S(O)mR4 (en la que R4 es hidrógeno, alquilo, cicloalquilo, arilo, aralquilo, heteroarilo o heterociclilo y m es un número entero de 0-2), o en la que X es -O-, S(O)m (en la que m es un número entero de 0-2), C(=O), C=NOH, CRfRq (en la que Rf y Rq son independientemente hidrógeno, hidroxi, carboxi o ciano) o NR5 {en la que R5 es hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, arilo, heteroarilo, heterociclilo, -COR4, -S(O)mR4, -COOR4 o -CONR4R'4 (en la que R4 y R'4 son independientemente hidrógeno, alquilo, cicloalquilo, arilo, aralquilo, heteroarilo o heterociclilo y m es un número entero de 0-2)}; R3 es hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, arilo, aralquilo, aralquenilo, cicloalquilalquilo, heterociclilo, heteroarilo, heterociclilalquilo o heteroarilalquilo; M es un anillo saturado, parcialmente saturado o insaturado de 3-7 miembros que contiene átomos de carbono en el que uno o más átomos de carbono opcionalmente están sustituidos por heteroátomos seleccionados entre O, S(O)m {en la que m es un número entero de 0-2 o NR6 {en la que R6 es hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquilalquilo, arilo, heteroarilo, heterociclilo, -COR4, -S(O)mR4, -COOR4 o -CONR4R'4 (en la que R4 y R'4 son independientemente hidrógeno, alquilo, cicloalquilo, arilo, aralquilo, heteroarilo o heterociclilo y m es un número entero de 0-2)}, o uno o más átomos de carbono opcionalmente están sustituidos por oxo, halógeno, heterociclilo unido a espiro, hidroxi, ciano, alquilo, heteroarilo, heteroarilalquilo, -(CH2)mNR4R'4, -(CH2)mOR4, -(CH2)m CONR4R'4, -(CH2)mNR4COR4, o -(CH2)mCOOR4 (en la que m, R4 y R'4 son los mismos que se han definido anteriormente).

79. 发明专利

AP2413A 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other disease. 未知
公开(公告)号：AP2413A
公开(公告)日：2012-06-01
申请号：AP2007004146
申请日：2006-02-21
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , SATTIGERI VISWAJANANI JITENDRA , KHERA MANOJ KUMAR
IPC分类号： C07D209/48 , C07D213/64 , C07D239/96 , C07D249/18 , C07D265/28 , C07D471/04
摘要： The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rχ, —NHC(═O)OR4, —NHSO2R4, C(═Y)NR4R5, C(═O)OR6 [wherein Y is oxygen or sulphur], OR5, —O(C═O)NR4R5, O-acyl, S(O)mR4, —SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or —SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, —OC(═O)NR4R5, O-acyl, NH2, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rx, —NHC(═O)OR4, —NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

80. 发明专利

AT545417T 未知
公开(公告)号：AT545417T
公开(公告)日：2012-03-15
申请号：AT08737621
申请日：2008-03-14
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT , AGARWAL RITU , KHAIRNAR VINAYAK , RAMAIAH MANDADAPU , PALLE VENKATA P , II HINJEWADI , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： A61K31/437 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式