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71. 发明申请

US20100174335A1 Therapy Triggered by Predication of Disordered Breathing 审中-公开
标题翻译：通过无序呼吸预测触发的治疗
公开(公告)号：US20100174335A1
公开(公告)日：2010-07-08
申请号：US12724723
申请日：2010-03-16
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3621 , A61N1/3627 , A61N1/3702
摘要： An approach to providing disordered breathing therapy includes providing therapy based on a prediction of disordered breathing. One or more patient conditions are detected and used to predict disordered breathing. Therapy is delivered to mitigate the predicted disordered breathing. The disordered breathing therapy may be adapted to enhance therapy efficacy and/or to reduce the impact of the therapy to the patient.
摘要翻译：提供无序呼吸治疗的方法包括基于无序呼吸预测提供治疗。检测一个或多个患者状况并用于预测无序呼吸。提供治疗以减轻预期的无序呼吸。无序呼吸治疗可以适应于增强治疗功效和/或减少治疗对患者的影响。

72. 发明授权

US07680537B2 Therapy triggered by prediction of disordered breathing 有权
标题翻译：通过预测无序呼吸引发的治疗
公开(公告)号：US07680537B2
公开(公告)日：2010-03-16
申请号：US10643154
申请日：2003-08-18
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61N1/18
CPC分类号： A61N1/36514 , A61N1/3621 , A61N1/3627 , A61N1/3702
摘要： An approach to providing disordered breathing therapy includes providing therapy based on a prediction of disordered breathing. One or more patient conditions are detected and used to predict disordered breathing. Therapy is delivered to mitigate the predicted disordered breathing. The disordered breathing therapy may be adapted to enhance therapy efficacy and/or to reduce the impact of the therapy to the patient.
摘要翻译：提供无序呼吸治疗的方法包括基于无序呼吸预测提供治疗。检测一个或多个患者状况并用于预测无序呼吸。提供治疗以减轻预期的无序呼吸。无序呼吸治疗可以适应于增强治疗功效和/或减少治疗对患者的影响。

73. 发明授权

US07396333B2 Prediction of disordered breathing 有权
标题翻译：预测无序呼吸
公开(公告)号：US07396333B2
公开(公告)日：2008-07-08
申请号：US10643016
申请日：2003-08-18
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61B5/00
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B2560/0242 , A61B2562/0219 , A61N1/362 , A61N1/36514
摘要： An approach for predicting disordered breathing involves detecting one or more conditions associated with disordered breathing. The detected conditions are compared to disordered breathing prediction criteria. A prediction of disordered breathing is performed based on the comparison of the detected conditions to the prediction criteria. At least one of comparing the detected conditions to the prediction criteria and predicting disordered breathing is performed at least in part implantably.
摘要翻译：预测无序呼吸的方法涉及检测与无序呼吸相关的一个或多个情况。将检测到的条件与无序呼吸预测标准进行比较。基于检测到的条件与预测标准的比较来执行无序呼吸的预测。将检测到的条件与预测标准进行比较以及预测无序呼吸的至少一个至少部分地可植入地进行。

74. 发明申请

US20100100000A1 Minute Ventilation-Based Disordered Breathing Detection 有权
标题翻译：分钟通气型无序呼吸检测
公开(公告)号：US20100100000A1
公开(公告)日：2010-04-22
申请号：US12564741
申请日：2009-09-22
申请人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
发明人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
IPC分类号： A61B5/091 , G06N5/02
CPC分类号： A61B5/0809 , A61B5/029 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/091 , A61B5/11 , A61B5/4818
摘要： A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
摘要翻译：检测多个呼吸周期的呼吸模式，分别确定每个呼吸周期的呼吸间隔（BI）和潮气量（TVOL）测量值。使用BI和TVOL测量产生不均匀采样的瞬时分钟通气（iMV）信号，并且使用不均匀采样的iMV信号产生均匀采样的iMV信号（重新采样的iMV信号）。基于基线阈值和重新采样的iMV信号之间的比较来检测无效呼吸。

75. 发明授权

US08936556B2 Minute ventilation-based disordered breathing detection 有权
标题翻译：分钟通气型无序呼吸检测
公开(公告)号：US08936556B2
公开(公告)日：2015-01-20
申请号：US12564741
申请日：2009-09-22
申请人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
发明人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
IPC分类号： A61B5/02 , G06N5/02 , A61B5/08 , A61B5/00 , A61B5/091 , A61B5/04 , A61B5/0488 , A61B5/0476 , A61B5/0402 , A61B5/029 , A61B5/11
CPC分类号： A61B5/0809 , A61B5/029 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/091 , A61B5/11 , A61B5/4818
摘要： A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
摘要翻译：检测多个呼吸周期的呼吸模式，分别确定每个呼吸周期的呼吸间隔（BI）和潮气量（TVOL）测量值。使用BI和TVOL测量产生不均匀采样的瞬时分钟通气（iMV）信号，并且使用不均匀采样的iMV信号产生均匀采样的iMV信号（重新采样的iMV信号）。基于基线阈值和重新采样的iMV信号之间的比较来检测呼吸紊乱。

76. 发明申请

US20090099621A1 RESPIRATORY STIMULATION FOR TREATING PERIODIC BREATHING 有权
标题翻译：呼吸刺激治疗周期性呼吸
公开(公告)号：US20090099621A1
公开(公告)日：2009-04-16
申请号：US12249842
申请日：2008-10-10
申请人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
发明人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/0816 , A61N1/3601
摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.
摘要翻译：描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

77. 发明申请

US20080294060A1 DEVICES AND METHODS FOR DISEASE DETECTION, MONITORING AND/OR MANAGEMENT 审中-公开
标题翻译：疾病检测，监测和/或管理的设备和方法
公开(公告)号：US20080294060A1
公开(公告)日：2008-11-27
申请号：US11751111
申请日：2007-05-21
申请人： Carlos F. Haro , Kent Lee , Kenneth C. Beck , Yi Zhang , Jeffrey E. Stahmann
发明人： Carlos F. Haro , Kent Lee , Kenneth C. Beck , Yi Zhang , Jeffrey E. Stahmann
IPC分类号： A61B5/087
CPC分类号： A61B5/087 , A61B5/03 , A61B5/0535 , A61B5/0809 , A61B5/6846
摘要： Embodiments of the invention are related to methods and devices for respiratory or cardiac disease detection, monitoring, and/or management. In an embodiment, the invention includes a method of calculating a pulmonary function parameter of a subject. The method can include obtaining a first signal indicative of lung volume change during breathing from a first sensor, obtaining a second signal indicative of distending pressure from a second sensor, and calculating the pulmonary function parameter based on the first signal and the second signal. In an embodiment, the invention includes a method of monitoring pulmonary or cardiac disease status. In an embodiment, the invention includes an implantable medical device. The implantable medical device can include a first sensor configured to produce a first signal indicative of lung volume change during breathing, a second sensor configured to produce a second signal indicative of intrapleural pressure, and a processor configured to calculate lung compliance or pulmonary resistance based on the first signal and the second signal. Other aspects and embodiments are provided herein.
摘要翻译：本发明的实施例涉及用于呼吸或心脏疾病检测，监测和/或管理的方法和装置。在一个实施例中，本发明包括计算受试者的肺功能参数的方法。该方法可以包括获得指示来自第一传感器的呼吸期间的肺体积变化的第一信号，获得表示来自第二传感器的膨胀压力的第二信号，以及基于第一信号和第二信号计算肺功能参数。在一个实施方案中，本发明包括监测肺或心脏疾病状态的方法。在一个实施例中，本发明包括可植入医疗装置。可植入医疗装置可以包括第一传感器，其被配置为产生指示呼吸期间肺体积变化的第一信号，配置成产生指示胸膜内压力的第二信号的第二传感器，以及被配置为基于以下步骤计算肺顺应性或肺阻力的处理器：第一信号和第二信号。本文提供了其它方面和实施例。

78. 发明授权

US08428711B2 Respiratory stimulation for treating periodic breathing 有权
标题翻译：呼吸刺激治疗周期性呼吸
公开(公告)号：US08428711B2
公开(公告)日：2013-04-23
申请号：US12249842
申请日：2008-10-10
申请人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
发明人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61B5/0816 , A61N1/3601
摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.
摘要翻译：描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

79. 发明授权

US08442638B2 Adaptive baroreflex stimulation therapy for disordered breathing 有权
标题翻译：适应性压力反射刺激治疗无序呼吸
公开(公告)号：US08442638B2
公开(公告)日：2013-05-14
申请号：US12781447
申请日：2010-05-17
申请人： Imad Libbus , Quan Ni , Kent Lee
发明人： Imad Libbus , Quan Ni , Kent Lee
IPC分类号： A61N1/3601 , A61N1/3611
CPC分类号： A61N1/3611 , A61N1/3601 , A61N1/36135
摘要： An approach to providing disordered breathing therapy includes delivering electrical stimulation therapy modifying a patient's baroreflex response. Disordered breathing therapy may be delivered in response to prediction or detection of disordered breathing events. Various conditions affecting the patient may be evaluated and the baroreflex therapy modified. The therapy may be modified to improve therapy efficacy, to reduce an impact to the patient and/or to mitigate therapy interactions.
摘要翻译：提供无序呼吸治疗的方法包括进行改变患者压力反射反应的电刺激疗法。无序呼吸治疗可以响应于预测或检测到无序呼吸事件而被传送。可以评估影响患者的各种状况，并修改压力反射治疗。可以修改治疗以改善治疗功效，减少对患者的影响和/或减轻治疗相互作用。

80. 发明申请

US20120283527A1 RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 失效
标题翻译：使用可移植设备进行心脏衰竭的呼吸监测
公开(公告)号：US20120283527A1
公开(公告)日：2012-11-08
申请号：US13553098
申请日：2012-07-19
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/0205 , A61B5/11 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

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