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    • 73. 发明授权
    • Birefringent filter using reflective polarizers and dichroic elements
    • 使用反射偏振器和二向色元件的双折射滤光片
    • US07982955B2
    • 2011-07-19
    • US11986257
    • 2007-11-20
    • Peter Miller
    • Peter Miller
    • G02B27/28
    • G02B27/288G02B27/283
    • An optical filter uses two or more reflective polarizers together with retarders to form birefringent filters with controlled transmission. The energy reflected by these polarizers is absorbed by one or more dichroic elements, which can be adjacent to a reflective polarizer; or spaced apart from it by one or more retarder elements. These dichroic elements act as dampers, so the energy of rays undergoing multiple reflections is markedly reduced or virtually eliminated, and high image quality is maintained. This provides a filter arrangement with enhanced spectral range, image quality, or greater extinction, or lower cost, compared to filters using dichroic or prism-type polarizers.
    • 光学滤波器使用两个或更多个反射偏振器与延迟器一起形成具有受控传输的双折射滤光器。 由这些偏振器反射的能量被一个或多个可与反射型偏振器相邻的二色性元件吸收; 或与一个或多个延迟元件间隔开。 这些二色性元素作为阻尼器,因此经历多重反射的光线的能量被显着地减少或实质上消除,并且维持高图像质量。 与使用二向色或棱镜式偏振器的滤光片相比,这提供了具有增强的光谱范围,图像质量或更大消光或更低成本的滤光器装置。
    • 76. 发明申请
    • Visualizing Birefringent Structures in Samples
    • 可视化样品中的双折射结构
    • US20090135422A1
    • 2009-05-28
    • US12273299
    • 2008-11-18
    • Peter MillerDavid Fletcher-HolmesCathy M. BoutinClifford Hoyt
    • Peter MillerDavid Fletcher-HolmesCathy M. BoutinClifford Hoyt
    • G01J4/00
    • G01J4/04G01N21/23
    • Apparatus and methods are disclosed for viewing low-birefringence structures within samples directly, with the eye, in real-time. The sample is placed between an entrance polarizer and analyzer polarizer, the transmission state of one of which is changed dynamically to create a modulated view of the scene; against this background, birefringent structures are visible because of their different appearance when modulated. Modulation rates of 4 or more states per second; use of 4 or more states, or even a continuum of states, which lie substantially on a latitude line on the Poincare sphere; and orientation of the polarization components to produce a uniform background; produce a clear view that does not produce operator fatigue. Broad-band wavelength operation spanning 50 nm or more, or the whole visible range, is achieved, and it is compatible with integration into other microscopy modes such as Hoffman relief contrast.
    • 公开了用于在眼睛内实时观察样品内的低双折射结构的装置和方法。 将样品放置在入射偏振器和分析器偏振器之间,其中一个的传输状态被动态地改变以产生场景的调制视图; 在这种背景下,双折射结构是可见的,因为它们在调制时的外观不同。 每秒4个或更多个状态的调制率; 使用4个或更多的状态,甚至是连续的状态,它们基本上位于庞加莱球体上的纬度线上; 和偏振分量的取向产生均匀的背景; 产生不会产生操作员疲劳的清晰视图。 实现跨越50nm或更大,或整个可见光范围的宽带波长操作,并且与其他显微镜模式(例如Hoffman浮雕对比度)的集成兼容。
    • 77. 发明申请
    • Surface measurement of in-vivo subjects using spot projector
    • 使用投影仪进行体内受试者的表面测量
    • US20080198355A1
    • 2008-08-21
    • US12005510
    • 2007-12-27
    • Peter DomenicaliClifford HoytPeter Miller
    • Peter DomenicaliClifford HoytPeter Miller
    • G01C11/12
    • G01B11/24G01N21/763G01N2021/6417
    • The invention provides for surface mapping of in-vivo imaging subjects using a single camera and an illuminator that projects a plurality of targets such as spots on the subject. By limiting the depth-of-field of the camera lens, or of the illuminator optics, or both, a spatial plane is defined in which the spots are most sharply in focus. Controlled displacement of this plane relative to the subject is achieved through movement of the mechanical stage on which a subject is placed; or through movement of the best-focus plane by adjustment of the camera, lens, or illuminator optics. Images are taken at several relative positions of the best-focus plane and the subject, and the height of individual points on the subject is determined through analysis of focus, given the known displacements. A mesh or other surface can be constructed from individual point locations, to provide a surface map of the subject. Accuracy of 0.5 mm can be readily attained for mice and similarly sized subjects.
    • 本发明提供使用单个照相机和照射器的体内成像对象的表面映射,所述照相机将多个目标(例如斑点)投射在对象上。 通过限制照相机镜头或照明器光学器件或两者的景深,定义了一个空间平面,其中斑点最为突出。 该平面相对于被摄体的受控位移通过放置被摄体的机械台的移动来实现; 或者通过相机,透镜或照明器光学元件的调整来移动最佳对焦平面。 在最佳聚焦平面和被摄体的几个相对位置摄取图像,并且在给定已知位移的情况下,通过分析焦点来确定被摄体上各个点的高度。 可以从各个点位置构建网格或其他表面,以提供对象的表面图。 对于小鼠和类似大小的受试者,可以容易地获得0.5mm的精度。
    • 78. 发明申请
    • Optical filter assembly with selectable bandwidth and rejection
    • 光滤波器组件,具有可选择的带宽和抑制
    • US20080144177A1
    • 2008-06-19
    • US11899293
    • 2007-09-05
    • Peter Miller
    • Peter Miller
    • G02B5/30G01J3/50H01J40/14G02B27/28H01J5/16
    • H01J5/16G01J3/02G01J3/0224G01J3/2823G01J3/32G01J2003/1213G02B5/3083G02B27/288
    • An optical filter assembly having selectable bandwidth is presented. The optical filter assembly includes a first optical filter, a first optical retarder with optical retardance R1, a second optical retarder with optical retardance R2, a polarization switch positioned between the first and second retarders which causes their retardances to substantially add in a first switch setting and to substantially subtract in a second switch setting, and an exit polarizer. A multispectral imaging system using tunable optical filters having selectable bandwidth is presented. A method of filtering light is also presented. The method includes providing a first optical filter, providing a dynamic bandwidth stage including a polarization switch, selecting a first setting of the polarization switch, and producing a first filter action for light passing through the first filter and the dynamic bandwidth stage.
    • 提出了具有可选带宽的光学滤波器组件。 光学滤光器组件包括第一滤光器,具有光学延迟R1的第一光学延迟器,具有光学延迟R2的第二光学延迟器,位于第一和第二延迟器之间的偏振开关,其使得其延迟基本上增加第一开关设置 并且在第二开关设置中基本上减去,以及出射偏振器。 提出了一种使用具有可选带宽的可调谐滤光片的多光谱成像系统。 还提出了一种过滤光的方法。 该方法包括提供第一滤光器,提供包括偏振开关的动态带宽级,选择偏振开关的第一设置,以及产生通过第一滤波器和动态带宽级的光的第一滤波器动作。