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    • 72. 发明授权
    • Method, system, and program for predicate processing by iterator functions
    • 迭代器函数进行谓词处理的方法,系统和程序
    • US07685103B2
    • 2010-03-23
    • US10675265
    • 2003-09-29
    • Kevin BrownRaghupathi Keshava Murthy
    • Kevin BrownRaghupathi Keshava Murthy
    • G06F17/30
    • G06F17/30705G06F17/30707G06F17/30896Y10S707/99933
    • Disclosed is a technique for processing predicates in an iterator function. When an iterator function included in a statement is invoked, one or more predicates included in the statement are obtained. The one or more predicates are applied to a row of data. If applying the one or more predicates results in a match, the row of data is returned. If applying the one or more predicates does not result in a match, a search is performed for another row of data for which application of the one or more predicates results in a match. Also disclosed is a technique for processing predicates in which a statement including an iterator function and one or more predicates is received. A qualification descriptor that describes the one or more predicates and one or more functions that are to be used to evaluate the one or more predicates is created. Then, the iterator function is invoked one or more times, until receiving a done indicator from the iterator function.
    • 公开了一种在迭代器函数中处理谓词的技术。 当一个语句中包含的迭代器函数被调用时,会获得语句中包含的一个或多个谓词。 一个或多个谓词被应用于一行数据。 如果应用一个或多个谓词导致匹配,则返回数据行。 如果应用一个或多个谓词不会导致匹配,则对另一行数据执行搜索,为一个或多个谓词的应用导致匹配。 还公开了一种用于处理谓词的技术,其中包括迭代器函数和一个或多个谓词的语句被接收。 创建描述一个或多个谓词和用于评估一个或多个谓词的一个或多个函数的限定描述符。 然后,迭代器函数被调用一次或多次,直到从迭代器函数接收完成的指示符。
    • 75. 发明申请
    • METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS
    • 制备4-四甲基-4-苯基哌啶化合物的方法
    • US20090240056A1
    • 2009-09-24
    • US12466797
    • 2009-05-15
    • Kevin BrownTimothy J. DoyleJohn W.F. Whitehead
    • Kevin BrownTimothy J. DoyleJohn W.F. Whitehead
    • C07D401/02C07D257/04C09K3/00
    • C07D211/64C07D257/04C07D307/22C07D401/04
    • Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Z1 and Z2 are each independently a —(C1-C4 alkyl) group; R1 is —(CH2)nC(O)N(R3)(R4) where R3 and R4 are each independently H or —(C1-C4 alkyl); R2 is halogen, —C1-C3 alkyl, —O—(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2; n is an integer ranging from 1 to 4; m is an integer ranging from 0 to 4; and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula I can be optionally substituted with one or more R2 groups.
    • 公开了可用于制备根据式I的4-四唑基-4-苯基哌啶化合物的方法,组合物和中间体,其中Ar 1是-C 3 -C 8环烷基,苯基,萘基,蒽基,菲基或 - (5-7-元) )杂芳基,各自为未取代的或被一个或多个R 2基团取代; Ar 2是苯基,萘基,蒽基,菲基或 - (5-7-元)杂芳基,各自是未取代的或被一个或多个R 2基团取代; Z 1和Z 2各自独立地为 - (C 1 -C 4烷基)基团; R1是 - (CH2)nC(O)N(R3)(R4)其中R3和R4各自独立地是H或 - (C1-C4烷基); R2是卤素,-C1-C3烷基,-O-(C1-C3烷基),-NH(C1-C3烷基)或-N(C1-C3烷基)2; n为1〜4的整数; m为0〜4的整数; 并且在某些实施方案中,连接到根据式I的化合物的哌啶环的4-位的苯基部分可以任选地被一个或多个R 2基团取代。
    • 76. 发明授权
    • Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
    • 制备4-四唑基-4-苯基哌啶化合物的方法
    • US07557219B2
    • 2009-07-07
    • US11495221
    • 2006-07-28
    • Kevin BrownTimothy J. DoyleJohn W. F. Whitehead
    • Kevin BrownTimothy J. DoyleJohn W. F. Whitehead
    • C07D257/04A61K31/445
    • C07D211/64C07D257/04C07D307/22C07D401/04
    • Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Z1 and Z2 are each independently a —(C1-C4 alkyl) group; R1 is —(CH2)nC(O)N(R3)(R4) where R3 and R4 are each independently H or —(C1-C4 alkyl); R2 is halogen, —C1-C3 alkyl, —O—(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2; n is an integer ranging from 1 to 4; m is an integer ranging from 0 to 4; and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula I can be optionally substituted with one or more R2 groups.
    • 公开了可用于制备根据式I的4-四唑基-4-苯基哌啶化合物的方法,组合物和中间体,其中Ar 1是-C 3 -C 8环烷基,苯基,萘基,蒽基,菲基或 - (5-7-元) )杂芳基,各自为未取代的或被一个或多个R 2基团取代; Ar 2是苯基,萘基,蒽基,菲基或 - (5-7-元)杂芳基,各自是未取代的或被一个或多个R 2基团取代; Z 1和Z 2各自独立地为 - (C 1 -C 4烷基)基团; R1是 - (CH2)nC(O)N(R3)(R4)其中R3和R4各自独立地是H或 - (C1-C4烷基); R2是卤素,-C1-C3烷基,-O-(C1-C3烷基),-NH(C1-C3烷基)或-N(C1-C3烷基)2; n为1〜4的整数; m为0〜4的整数; 并且在某些实施方案中,连接到根据式I的化合物的哌啶环的4-位的苯基部分可以任选地被一个或多个R 2基团取代。
    • 77. 发明申请
    • RADIOTHERAPY APPARATUS AND PARTS THEREOF
    • 放射治疗装置及其部件
    • US20090121155A1
    • 2009-05-14
    • US11937764
    • 2007-11-09
    • Kevin BrownPaul BoxallChristopher James Gibson
    • Kevin BrownPaul BoxallChristopher James Gibson
    • A61N5/00
    • A61N5/1042A61N5/1048
    • A geometry item (such as a gantry arm or an MLC leaf) of a radiotherapeutic apparatus needs to be moved in an accurate manner. The effect of inertia introduces a potential inaccuracy. A radiotherapeutic apparatus is therefore disclosed, comprising a geometry item, a radiation source capable of emitting a beam of therapeutic radiation, and a control unit, the geometry item being moveable to adjust the geometry of the beam, the radiation source having a variable dose rate, and the control unit being arranged to cause variations in the speed of movement of the geometry item and to adjust the dose rate of the radiation source for a period of time after a change in the speed of the geometry item.
    • 需要以准确的方式移动放射治疗装置的几何物体(例如龙门架或MLC叶)。 惯性的影响引起了潜在的不准确性。 因此,公开了一种放射治疗装置,其包括几何物体,能够发射治疗辐射束的辐射源和控制单元,所述几何物体可移动以调节所述束的几何形状,所述辐射源具有可变剂量率 并且所述控制单元被布置成引起所述几何物体的移动速度的变化并且在所述几何物体的速度改变之后的一段时间内调整所述辐射源的剂量率。
    • 78. 发明申请
    • RADIOTHERAPY APPARATUS AND PARTS THEREOF
    • 放射治疗装置及其部件
    • US20090110150A1
    • 2009-04-30
    • US11925339
    • 2007-10-26
    • Kevin BrownPaul Boxall
    • Kevin BrownPaul Boxall
    • H05G1/54
    • A61N5/1049
    • The detected positioning error in a geometry item of a radiotherapy apparatus is generally passed to a transfer function for the system, which outputs a signal that dictates the radiation output. If the detected error is within certain limits then the radiation is permitted whereas outside those limits it is not permitted; this corresponds to a transfer function that is a simple two step function. We propose a transfer function having a result that is (a) substantially zero outside a preset error tolerance, (b) has a maximum result at a point within that tolerance, and (c) has a result that is between zero and that maximum over a range of error values that lie between (i) the error value corresponding to the maximum output and (ii) the preset error tolerance. This means that if an error grows towards (but does not exceed) the error tolerance, the output of the radiation source will reduce and allow time for the geometry item to correct its position.
    • 放射治疗装置的几何物体中检测到的定位误差通常被传递给系统的传递函数,该系统输出指示辐射输出的信号。 如果检测到的误差在一定范围内,则允许辐射,而不允许辐射; 这对应于一个简单的两步函数的传递函数。 我们提出一种传递函数,其结果是(a)在预设误差公差之外基本上为零,(b)在该容差内的点处具有最大结果,以及(c)具有在零和最大值之间的结果 误差值范围在(i)对应于最大输出的误差值和(ii)预设误差容差之间。 这意味着如果误差朝向(但不超过)误差容限增长,则辐射源的输出将减少,并允许几何项的时间来校正其位置。
    • 79. 发明申请
    • Memory management system and method for storing and retrieving messages
    • 用于存储和检索消息的内存管理系统和方法
    • US20070113031A1
    • 2007-05-17
    • US11274154
    • 2005-11-16
    • Kevin BrownMichael Spicer
    • Kevin BrownMichael Spicer
    • G06F12/00
    • G06F12/123G06F12/023
    • Embodiments of the present invention provide an efficient manner to systematically remove data from a memory that has been transferred or copied to disk storage, thereby facilitating faster querying of data residing in the memory. In particular, memory containing data received from data sources is partitioned into a fixed quantity of buckets each associated with a respective time interval. The buckets represent contiguous intervals of time, where each interval is preferably of the same duration. When data arrives, the data is associated with a timestamp and placed in the appropriate bucket associated with a time interval corresponding to that timestamp. If a timestamp falls outside the range of time intervals associated with the buckets, the data corresponding to that timestamp is placed in an additional bucket. Data within the oldest bucket in memory is periodically removed to provide storage capacity for new incoming information.
    • 本发明的实施例提供了一种有效的方式来系统地从已经传送或复制到磁盘存储器的存储器中移除数据,从而有助于更快地查询驻留在存储器中的数据。 特别地,包含从数据源接收的数据的存储器被分割成固定数量的桶,每个桶与相应的时间间隔相关联。 桶表示连续的时间间隔,其中每个间隔优选地具有相同的持续时间。 当数据到达时,数据与时间戳相关联,并放置在与该时间戳对应的时间间隔相关联的适当桶中。 如果时间戳超出与桶相关联的时间间隔范围,则与该时间戳相对应的数据将放置在附加桶中。 定期删除内存中最旧的桶中的数据,以提供新的传入信息的存储容量。
    • 80. 发明申请
    • Itinerary planning tool, system, method, software, and hardware
    • 行程规划工具,系统,方法,软件和硬件
    • US20070078729A1
    • 2007-04-05
    • US11557397
    • 2006-11-07
    • Kevin Brown
    • Kevin Brown
    • G06Q30/00
    • G06Q30/02G06Q10/02G06Q30/0641
    • An activity-based itinerary planning tool permits a trip planner to incrementally build an itinerary, starting at a selected entry point and adding activities in a step-by-step manner, by taking into account commute times for different types of transportation and entry/exit conditions for particular activities/facilities, in order to present the user with lists of all activities/facilities that can be reached from the entry point or from already-selected activities/facilities. Also, an electronic marketplace for consumers and suppliers of activities to meet and exchange. Consumers are given search tools for narrowing all possible activities to those a consumer can actually perform and attend, based on their proximity and performance criteria. Suppliers are given tools to enter activities into a central repository, and set constraints to prevent unqualified consumers from purchasing. Detection change monitors the activities of the database for changes that will invalidate original recommendations, and provides consumer notification.
    • 基于活动的行程规划工具允许旅行计划者逐步建立行程,从选定的入口点开始,并逐步地添加活动,考虑到不同类型的交通和进出口的通勤时间 特定活动/设施的条件,以向用户提供从入境点或已选择的活动/设施可以达到的所有活动/设施的清单。 另外,电子市场为消费者和供应商的活动进行交流和交流。 消费者将根据其邻近度和性能标准,为搜索工具缩小所有可能的活动,消费者实际可以执行和参与的活动。 给供应商提供了将活动进入中央信息库的工具,并制定了约束条件,以防止不合格的消费者购买。 检测更改会监视数据库的活动,从而使原始建议无效,并提供消费者通知。