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71. 发明授权

US07947690B2 Pyrimidine derivative condensed with a non-aromatic ring 失效
标题翻译：与非芳香环稠合的嘧啶衍生物
公开(公告)号：US07947690B2
公开(公告)日：2011-05-24
申请号：US11577648
申请日：2005-10-17
申请人： Yasuhiro Yonetoku , Kenji Negoro , Kenichi Onda , Masahiko Hayakawa , Daisuke Sasuga , Takahiro Nigawara , Kazuhiko Iikubo , Hiroyuki Moritomo , Shigeru Yoshida , Takahide Ohishi
发明人： Yasuhiro Yonetoku , Kenji Negoro , Kenichi Onda , Masahiko Hayakawa , Daisuke Sasuga , Takahiro Nigawara , Kazuhiko Iikubo , Hiroyuki Moritomo , Shigeru Yoshida , Takahide Ohishi
IPC分类号： A61K31/519 , A61K31/497 , C07D495/04 , A61P3/10 , C07D487/04 , C07D471/04 , C07D239/72 , A61K31/517
CPC分类号： C07D239/70 , C07D239/94 , C07D495/04
摘要： The present invention provides a condensed pyrimidine compound represented by formula (I) or pharmaceutically acceptable salt thereof: where A represents a ring where at least one carbon atom within said ring is optionally substituted with one or more groups selected from the group consisting of lower alkyl, —O-(lower alkyl), halogen atom, carboxyl, —CO2-(lower alkyl), and carbamoyl, R1 represents: (1) phenyl substituted with at least three halogen atoms, which may have at least one additional substituent, or (2) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl, each of which is optionally substituted; and R2 represents a group represented by formula (II) or an optionally substituted cyclic amino: wherein R21 and R22 may be identical or different and each represents —H, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, phenyl, heteroaryl, non-aromatic heterocyclyl, or —O-(lower alkyl), each of which is optionally substituted.
摘要翻译：本发明提供由式（I）表示的稠合嘧啶化合物或其药学上可接受的盐：其中A表示环，其中所述环中至少一个碳原子任选被一个或多个选自以下的基团取代：低级烷基，-O-（低级烷基），卤素原子，羧基，-CO 2 - （低级烷基）和氨基甲酰基，R 1表示：（1）被至少三个卤素原子取代的苯基，其可以具有至少一个另外的取代基，或（2）环丙基，环丁基，环戊基，环己基或环庚基，其各自任选被取代; 并且R 2表示由式（II）表示的基团或任选取代的环状氨基：其中R 21和R 22可以相同或不同，并且各自表示-H，低级烷基，低级烯基，低级炔基，环烷基，苯基，杂芳基，芳族杂环基或-O-（低级烷基），其各自任选被取代。

72. 发明授权

US07871238B2 Fuel pump 有权
标题翻译：燃油泵
公开(公告)号：US07871238B2
公开(公告)日：2011-01-18
申请号：US11737959
申请日：2007-04-20
申请人： Shigeru Yoshida , Satoshi Miura
发明人： Shigeru Yoshida , Satoshi Miura
IPC分类号： F04D29/44
CPC分类号： F02M37/048 , F04D5/005 , F04D5/006 , F04D29/445
摘要： A vapor lock in a fuel pump can be prevented by reducing the formation of vapor within the fuel. A first group of concavities may be formed in an inner circumferential region of an intake side face of an impeller, and a second group of concavities may be formed concentrically in a region outside of the first group of concavities. A third group of concavities that communicates with the second group of concavities may be formed in a discharge side face of the impeller. The impeller is housed within a casing. A first groove that faces the first group of concavities and a second groove that faces the second group of concavities may be formed in the face of the casing that faces the intake side face of the impeller. A third groove that faces the third group of concavities may be formed in the face of the casing that faces the discharge side face of the impeller.
摘要翻译：可以通过减少燃料内的蒸汽的形成来防止燃料泵中的蒸气锁。第一组凹部可以形成在叶轮的进气侧面的内周区域中，并且第二组凹部可以同心地形成在第一组凹部之外的区域中。可以在叶轮的排出侧面形成与第二组凹部连通的第三组凹部。叶轮容纳在外壳内。面对第一组凹部的第一凹槽和面向第二组凹部的第二凹槽可以形成在面向叶轮的进气侧面的壳体的表面中。面向第三组凹部的第三凹槽可以形成在面向叶轮的排出侧面的壳体的表面中。

73. 发明授权

US07761046B2 Hybrid paper supply module and image forming apparatus equipped with such hybrid paper supply module, and also paper supply mechanism and image forming apparatus equipped with such paper supply mechanism 有权
标题翻译：混合纸供应模块和配备有这种混合纸供应模块的成像设备，以及配备有这种供纸机构的供纸机构和成像设备
公开(公告)号：US07761046B2
公开(公告)日：2010-07-20
申请号：US10949303
申请日：2004-09-27
申请人： Yoshiaki Hiramoto , Susumu Hashimoto , Shigeru Yoshida , Takashi Kubo , Yasuaki Fukada , Yasushi Matsutomo
发明人： Yoshiaki Hiramoto , Susumu Hashimoto , Shigeru Yoshida , Takashi Kubo , Yasuaki Fukada , Yasushi Matsutomo
IPC分类号： G03G15/00 , B65H3/44 , B65H1/04
CPC分类号： G03G15/6502 , B65H1/266 , B65H3/44 , B65H2402/10 , B65H2405/11164 , B65H2405/3311 , B65H2405/332 , B65H2407/21 , G03G2215/00383 , G03G2215/00392
摘要： Mechanism unit(s) functioning as automatic-feed cassette(s) and mechanism unit(s) functioning as manual-feed tray(s) together form a single integral module, constituting a hybrid paper supply module. A plurality of hybrid paper supply modules are stacked together to constitute a paper supply mechanism. Manual-feed tray(s) with which manual-feed mechanism unit(s) of respective hybrid paper supply module(s) is or are provided is or are maintained in stored state(s) as a result of electromagnetic attraction produced by electromagnet(s). In correspondence to image forming condition(s), electromagnetic attraction at one electromagnet is terminated, causing manual-feed tray(s) to assume deployed state(s). Furthermore, primary path(s) passing vertically through module interior(s) is or are formed so as to permit transport of recording paper toward printing unit(s) of hybrid device(s) regardless of from which hybrid paper supply module(s) it is that recording paper is taken up.
摘要翻译：用作自动进给盒的机构单元和用作手动进纸托盘的机构单元一起形成单个整体模块，构成混合纸供应模块。多个混合供纸模块堆叠在一起以构成供纸机构。作为由电磁铁产生的电磁吸引的结果，或设置有各自的混合供纸模块的手动进给机构单元的手动进给托盘被保持在存储状态（ s）。对应于图像形成条件，一个电磁体的电磁吸引终止，导致手动进给托盘呈现部署状态。此外，垂直穿过模块内部的主要路径被形成为允许将记录纸传送到混合装置的打印单元，而不管混合纸张供应模块是哪一个，记录纸被拿走了。

74. 发明申请

US20100152165A1 CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：羧酸衍生物
公开(公告)号：US20100152165A1
公开(公告)日：2010-06-17
申请号：US12517033
申请日：2007-11-29
申请人： Kenji Negoro , Kei Ohnuki , Toshio Kurosaki , Fumiyoshi Iwasaki , Yasuhiro Yonetoku , Kazuyuki Tsuchiya , Norio Asai , Shigeru Yoshida , Takatoshi Soga , Daisuke Suzuki
发明人： Kenji Negoro , Kei Ohnuki , Toshio Kurosaki , Fumiyoshi Iwasaki , Yasuhiro Yonetoku , Kazuyuki Tsuchiya , Norio Asai , Shigeru Yoshida , Takatoshi Soga , Daisuke Suzuki
IPC分类号： A61K31/55 , C07D215/20 , A61K31/47 , C07D223/16 , C07D279/16 , A61K31/5415 , A61K31/4375 , C07D471/02
CPC分类号： C07D471/04 , C07D209/08 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/227 , C07D215/26 , C07D215/38 , C07D215/40 , C07D215/58 , C07D265/36 , C07D279/16 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
摘要： [Problem] To provide a pharmaceutical, particularly a compound which can be used as an insulin secretion promoter or a preventive or therapeutic agent for diabetes mellitus and the like diseases in which GPR40 is concerned.[Means for resolution] It was found that novel carboxylic acid derivatives or salts thereof, characterized in that carboxylic acid is linked to a 6-membered monocyclic aromatic ring via two atoms and said aromatic ring is linked to a nitrogen-containing bicyclic ring via a linker, have excellent GPR40 receptor agonist action. In addition, since the carboxylic acid derivatives of the invention showed excellent insulin secretion promoting action and blood glucose reducing action, they are useful as an insulin secretion promoter and a preventive or therapeutic agent for diabetes mellitus.
摘要翻译： [问题]提供可以用作胰岛素分泌促进剂的药物，特别是涉及GPR40的糖尿病等的预防或治疗剂的化合物。 [解决方法]发现新的羧酸衍生物或其盐，其特征在于羧酸通过两个原子与6元单环芳香环连接，所述芳环经由含氮双环通过接头，具有优异的GPR40受体激动作用。此外，由于本发明的羧酸衍生物显示出优异的胰岛素分泌促进作用和降血糖作用，因此它们可用作糖尿病的胰岛素分泌促进剂和预防或治疗剂。

75. 发明申请

US20100075305A1 Detection of bacterium by utilizing dnaj gene and use thereof 审中-公开
标题翻译：利用dnaj基因检测细菌及其用途
公开(公告)号：US20100075305A1
公开(公告)日：2010-03-25
申请号：US12311217
申请日：2007-09-26
申请人： Takayuki Ezaki , Kiyofumi Ohkusu , Shigeru Yoshida
发明人： Takayuki Ezaki , Kiyofumi Ohkusu , Shigeru Yoshida
IPC分类号： C12Q1/68 , C12Q1/04 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q2600/16 , G01N33/56911 , Y02A50/451 , Y02A50/52
摘要： Disclosed is a method for detecting the species of a bacterium in a simple manner. Specifically disclosed is a method for detecting the species of a bacterium, which can detect at least one bacterial species selected from Staphylococcus species, Streptococcus species, Klebsiella species, Escherichia species, Mycobacterium species, Legionella species, Vibrio species, Bacillus species, Neisseria species, Campylobacter species, Chlamydia species, Chlamydophila species, Mycoplasma species, Listeria species, Salmonella species and Yersinia species, and which comprises the steps of: a) contacting a sample suspected to contain a nucleic acid derived from the bacterial species; and b) detecting the presence or absence of the hybridization between the nucleic acid molecule and the nucleic acid contained in the sample.
摘要翻译：公开了以简单的方式检测细菌的种类的方法。具体公开了一种检测细菌种的方法，该细菌可以检测至少一种选自葡萄球菌属，链球菌属，克雷伯菌属，埃希氏杆菌属，分枝杆菌属，军团菌属，弧菌属，芽孢杆菌属，奈瑟氏球菌属，弯曲杆菌属，衣原体属，衣原体属，支原体属，利斯特氏菌属，沙门氏菌属和耶尔森氏菌属，包括以下步骤：a）使疑似含有源自细菌种的核酸的样品接触; 和b）检测核酸分子与样品中所含的核酸之间是否存在杂交。

76. 发明申请

US20090186909A1 Oxadiazolidinedione Compound 有权
标题翻译：恶二唑烷二酮化合物
公开(公告)号：US20090186909A1
公开(公告)日：2009-07-23
申请号：US12298522
申请日：2007-04-23
申请人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
发明人： Kenji Negoro , Fumiyoshi Iwasaki , Kei Ohnuki , Toshio Kurosaki , Yasuhiro Yonetoku , Norio Asai , Shigeru Yoshida , Takatoshi Soga
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4245 , C07D413/12 , C07D271/07
CPC分类号： C07D271/06 , C07D271/07 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： [Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.[Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.
摘要翻译：可以提供可用作药物的化合物，特别是胰岛素分泌促进剂或用于预防/治疗其中涉及GPR40的疾病如糖尿病等的化合物。 [解决方法]已经发现，恶二唑烷二酮化合物或其药学上可接受的盐，其特征在于具有通过在恶二唑烷二酮环的2位上的连接基与环状基团结合的苄基等取代基，具有优异的GPR40激动作用。此外，由于本发明的恶二唑烷二酮化合物显示出优异的胰岛素分泌促进作用和血糖降低作用，因此可用作胰岛素分泌促进剂或糖尿病的预防/治疗剂。

77. 发明申请

US20080091699A1 Method of converting structured data 审中-公开
标题翻译：转换结构化数据的方法
公开(公告)号：US20080091699A1
公开(公告)日：2008-04-17
申请号：US11905304
申请日：2007-09-28
申请人： Satoshi Nakashima , Junichi Odagiri , Shigeru Yoshida , Takuroh Yamaguchi
发明人： Satoshi Nakashima , Junichi Odagiri , Shigeru Yoshida , Takuroh Yamaguchi
IPC分类号： G06F17/30
CPC分类号： G06F17/227 , G06F17/2247
摘要： A structured data conversion device is designed to convert a set of first structured data into a set of second structured data that is described in a language different from that of the first structured data, and comprises: an inverse conversion information creation unit extracting data as inverse conversion information from the first structured data, the data that is extracted being deleted when the first structured data is converted into the second structured data and being necessary when the second structured data is inversely converted into the first structured data; and an inverse conversion information storing unit embedding in the second structured data the inverse conversion information when the first structured data is converted into the second structured data.
摘要翻译：结构化数据转换装置被设计成将一组第一结构化数据转换成以与第一结构化数据不同的语言描述的一组第二结构化数据，并且包括：反转换信息创建单元，将数据提取为反向来自第一结构化数据的转换信息，当第一结构化数据被转换成第二结构化数据时被提取的数据被删除，并且当第二结构化数据被反向转换成第一结构化数据时是需要的; 以及逆变换信息存储单元，当所述第一结构化数据被转换为所述第二结构化数据时，将所述第二结构化数据嵌入所述逆变换信息。

78. 发明授权

US07347637B2 Hybrid paper supply module and image forming apparatus equipped with such hybrid paper supply module 有权
标题翻译：混合纸供应模块和配有这种混合纸供应模块的成像设备
公开(公告)号：US07347637B2
公开(公告)日：2008-03-25
申请号：US10932062
申请日：2004-09-02
申请人： Takashi Kubo , Susumu Hashimoto , Shigeru Yoshida , Yoshiaki Hiramoto , Yasuaki Fukada , Yasushi Matsutomo , Hideo Yoshikawa
发明人： Takashi Kubo , Susumu Hashimoto , Shigeru Yoshida , Yoshiaki Hiramoto , Yasuaki Fukada , Yasushi Matsutomo , Hideo Yoshikawa
IPC分类号： B41J13/10 , G03G15/00
CPC分类号： B65H3/44 , B65H2402/10 , B65H2405/32 , B65H2407/21
摘要： Mechanism unit(s) 6 functioning as automatic-feed cassette(s) and mechanism unit(s) 7 functioning as manual-feed tray(s) together form a single integral module, constituting hybrid paper supply module 5. Manual-feed mechanism unit(s) 7 is or are arranged below transport paths 36, 37, which extend toward printing unit(s) 3. Furthermore, path(s) along which recording paper P taken up from automatic-feed cassette mechanism unit(s) 6 is transported and path(s) along which recording paper P taken up from manual-feed mechanism unit(s) 7 is transported are made to intersect within the module, decreasing length(s) of respective path(s).
摘要翻译：用作自动进给盒的机构单元6和用作手动进给托盘的机构单元7一起构成单个整体模块，构成混合供纸模块5。手动进给机构单元7设置在传送路径36,37的下方，传送路径36,37朝向打印单元3延伸。此外，传送从自动供给盒机构单元6取出的记录纸P的路径，并且传送从手动进给机构单元7取出的记录纸P的路径使得在模块内相交，减小相应路径的长度（s）。

79. 发明申请

US20080070896A1 Pyrimidine Derivative Condensed with a Non-Aromatic Ring 失效
标题翻译：用非芳香环稠合的嘧啶衍生物
公开(公告)号：US20080070896A1
公开(公告)日：2008-03-20
申请号：US11577648
申请日：2005-10-17
申请人： Yasuhiro Yonetoku , Kenji Negoro , Kenichi Onda , Masahiko Hayakawa , Daisuke Sasuga , Takahiro Nigawara , Kazuhiko Iikubo , Hiroyuki Moritomo , Shigeru Yoshida , Takahide Ohishi
发明人： Yasuhiro Yonetoku , Kenji Negoro , Kenichi Onda , Masahiko Hayakawa , Daisuke Sasuga , Takahiro Nigawara , Kazuhiko Iikubo , Hiroyuki Moritomo , Shigeru Yoshida , Takahide Ohishi
IPC分类号： A61K31/519 , A61K31/497 , A61K31/5377 , A61K31/551 , A61P3/00 , C07D285/36 , C07D413/14 , C07D495/04 , C07D487/04 , C07D403/04 , C07D239/70 , A61K31/554 , A61K31/55 , A61K31/517
CPC分类号： C07D239/70 , C07D239/94 , C07D495/04
摘要： There are provided new pyrimidine derivatives condensed with a non-aromatic ring selected from dihydrothiophene, dihydrofuran, cycloalkane moiety, and the like or pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising said compound as an active ingredient. These compounds exhibit excellent promoting activity on insulin secretion and activity against hyperglycemia. Hence, the pharmaceutical compositions comprising such compounds as active ingredients, based on these actions, are useful for treating and/or preventing insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes), insulin-resistant diseases, obesity, and the like.
摘要翻译：提供了与选自二氢噻吩，二氢呋喃，环烷烃部分等的非芳香环稠合的新的嘧啶衍生物或其药学上可接受的盐; 以及包含所述化合物作为活性成分的药物组合物。这些化合物对胰岛素分泌表现出优异的促进活性和抗高血糖的活性。因此，基于这些作用，包含这些化合物作为活性成分的药物组合物可用于治疗和/或预防胰岛素依赖性糖尿病（1型糖尿病），非胰岛素依赖性糖尿病（2型糖尿病），胰岛素抵抗疾病，肥胖等。

80. 发明申请

US20060266693A1 Filter 审中-公开
标题翻译：过滤
公开(公告)号：US20060266693A1
公开(公告)日：2006-11-30
申请号：US11440139
申请日：2006-05-25
申请人： Shigeru Yoshida , Nobuo Suzuki
发明人： Shigeru Yoshida , Nobuo Suzuki
IPC分类号： B01D29/00
CPC分类号： F02M37/22 , B01D29/56 , B01D29/86 , B01D35/027
摘要： Filter (30) may comprise a first filter cloth (36) and a second filter cloth (32) disposed downstream from the first filter cloth (36). A particle diameter allowed passage by the second filter cloth (32) may be smaller than a particle diameter allowed passage by the first filter cloth (36). A space (34) may be provided between the first filter cloth (36) and the second filter cloth (32), the space (34) allowing the passage of foreign matter having a particle diameter greater than the particle diameter allowed passage by the first filter cloth (36).
摘要翻译：过滤器（30）可以包括布置在第一滤布（36）下游的第一滤布（36）和第二滤布（32）。允许通过第二滤布（32）的粒径可以小于允许通过第一滤布（36）的粒径。可以在第一滤布（36）和第二滤布（32）之间设置空间（34），空间（34）允许粒径大于粒径的异物通过第一滤布（36）。

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