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71. 发明申请

US20120064582A1 Nucleotide Sequences Encoding Alanine Racemase from Coryneform 有权
标题翻译：从棒状杆菌编码丙氨酸消旋酶的核苷酸序列
公开(公告)号：US20120064582A1
公开(公告)日：2012-03-15
申请号：US13240147
申请日：2011-09-22
申请人： Andreas Tauch , Michael Binder , Walter Pfefferle , Georg Thierbach , Jörn Kalinowski , Alfred Pühler
发明人： Andreas Tauch , Michael Binder , Walter Pfefferle , Georg Thierbach , Jörn Kalinowski , Alfred Pühler
IPC分类号： C12N1/21 , C12P13/04 , C12P1/04
CPC分类号： C12N9/90 , C12P13/06 , C12P13/08 , C12Y501/01001
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码alr基因的多核苷酸序列的分离的多核苷酸，以及具有其中alr基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带alr基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

72. 发明授权

US08048665B2 Nucleotide sequences encoding alanine racemase from coryneform 有权
标题翻译：从棒状杆菌编码丙氨酸消旋酶的核苷酸序列
公开(公告)号：US08048665B2
公开(公告)日：2011-11-01
申请号：US10304743
申请日：2002-11-27
申请人： Andreas Tauch , Michael Binder , Walter Pfefferle , Georg Thierbach , Jörn Kalinowski , Alfred Pühler
发明人： Andreas Tauch , Michael Binder , Walter Pfefferle , Georg Thierbach , Jörn Kalinowski , Alfred Pühler
IPC分类号： C12N9/00 , C12N9/90 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/90 , C12P13/06 , C12P13/08 , C12Y501/01001
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码alr基因的多核苷酸序列的分离的多核苷酸，以及具有其中alr基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带alr基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

73. 发明授权

US07205131B2 Process for the preparation of L-amino acids via overexpression of the PTSH gene 有权
标题翻译：通过PTSH基因的过表达制备L-氨基酸的方法
公开(公告)号：US07205131B2
公开(公告)日：2007-04-17
申请号：US10916437
申请日：2004-08-12
申请人： Mike Farwick , Bettina Möckel , Walter Pfefferle
发明人： Mike Farwick , Bettina Möckel , Walter Pfefferle
IPC分类号： C12P13/04 , C12N1/20 , C12N15/00 , C07K1/00 , C07H21/04
CPC分类号： C12N9/1205 , C12P13/04 , C12P13/08
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID no. 2, b) polynucleotide which codes for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no.2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative production of L-amino acids with enhancement of the ptsH gene coding for component H of the phosphotransferase system, and the use of the above polynucleotides as primer or hybridisation probe.
摘要翻译：本发明涉及含有选自组合的多核苷酸序列的分离的多核苷酸

74. 发明授权

US06972190B2 Nucleotide sequences which code for the cstA gene 失效
标题翻译：编码cstA基因的核苷酸序列
公开(公告)号：US06972190B2
公开(公告)日：2005-12-06
申请号：US09935799
申请日：2001-08-24
申请人： Bettina Möckel , Achim Marx , Walter Pfefferle , Mike Farwick , Thomas Hermann
发明人： Bettina Möckel , Achim Marx , Walter Pfefferle , Mike Farwick , Thomas Hermann
IPC分类号： C07K14/34 , C12N1/21 , C12N15/12 , C12N15/31 , C12P13/08 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the carbon starvation protein A (cstA) gene, and a host-vector system having a coryneform host bacterium in which the cstA gene is present in enhanced form and a vector which carries at least the cstA gene according to SEQ ID NO: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码碳饥饿蛋白A（cstA）基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中cstA基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和携带至少根据SEQ ID NO：1的cstA基因的载体，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

75. 发明授权

US06825030B2 Nucleotide sequences encoding a sensor kinase, citA, from corynebacterium glutamicum 失效
标题翻译：编码来自谷氨酸棒杆菌的传感器激酶citA的核苷酸序列
公开(公告)号：US06825030B2
公开(公告)日：2004-11-30
申请号：US09804060
申请日：2001-03-13
申请人： Bettina Möckel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Bettina Möckel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12N120
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/10 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： The present invention is related to nucleotide sequences encoding a sensor kinse, citA, from Corynebacterium glutamicum.
摘要翻译：本发明涉及编码来自谷氨酸棒杆菌的传感器kinse（citA）的核苷酸序列。

76. 发明授权

US06623946B1 Nucleotide sequences encoding the sucC and sucD genes 失效
标题翻译：编码sucC和sucD基因的核苷酸序列
公开(公告)号：US06623946B1
公开(公告)日：2003-09-23
申请号：US09728498
申请日：2000-11-27
申请人： Bettina Möckel , Walter Pfefferle , Achim Marx
发明人： Bettina Möckel , Walter Pfefferle , Achim Marx
IPC分类号： C12N916
CPC分类号： C12N9/93 , C12P13/04 , C12P13/14
摘要： Polynucleotides that contain polynucleotide sequences encoding the sucC and sucD genes, selected from the group a) a polynucleotide that is at least 70% identical to a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID NO:2, b) a polynucleotide that is at least 70% identical to a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID NO:3, c) a polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:2, d) a polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:3, e) a polynucleotide that is complementary to one of the polynucleotides of a), b), c) or d), and f) a polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b), c), d) or e), a process for the fermentative production of L-amino acids using coryneform bacteria in which the genes are present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
摘要翻译：含有编码sucC和sucD基因的多核苷酸序列的多核苷酸，选自组a）与编码含有SEQ ID NO：2的氨基酸序列的多肽的多核苷酸至少70％同一性的多核苷酸，b）多核苷酸与编码含有SEQ ID NO：3的氨基酸序列的多肽的多核苷酸至少70％相同，c）编码包含与氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸 SEQ ID NO：2的d氨基酸序列，d）编码含有与SEQ ID NO：3的氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸，e）与 a），b），c）或d）的多核苷酸，和f）包含a），b），c），d）或e）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，发酵生产的方法的L-氨基酸其中基因以减毒形式存在的干细胞，以及多核苷酸序列用作杂交探针。

77. 发明授权

US06319528B1 Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof 有权
标题翻译：含有D-泛酸和/或其盐的饲料添加剂及其制备方法
公开(公告)号：US06319528B1
公开(公告)日：2001-11-20
申请号：US09686172
申请日：2000-10-12
申请人： Michael Binder , Klaus-Erich Uffmann , Iiona Walger , Ulrich Becker , Walter Pfefferle , Heinz Friedrich
发明人： Michael Binder , Klaus-Erich Uffmann , Iiona Walger , Ulrich Becker , Walter Pfefferle , Heinz Friedrich
IPC分类号： A23L1302
CPC分类号： C12P13/02 , A23K20/174 , Y10S426/807
摘要： The invention provides a feedstuff additive based on a fermentation broth obtained by the fermentation of D-pantothenic acid producing microorganisms. The broth contains D-pantothenic acid, one or more salts of D-pantothenic acid, or mixtures thereof. Conversion of the broth to a solid, free-flowing form is achieved by drying or granulation
摘要翻译：本发明提供了通过发酵D-泛酸产生微生物获得的发酵液的饲料添加剂。肉汤含有D-泛酸，一种或多种D-泛酸盐，或其混合物。通过干燥或造粒将肉汤转化成固体，自由流动的形式

78. 发明授权

US6133000A Fermentative preparation of amino acids 失效
标题翻译：氨基酸的发酵制备
公开(公告)号：US6133000A
公开(公告)日：2000-10-17
申请号：US087969
申请日：1998-06-01
申请人： Walter Pfefferle , Hermann Lotter , Heinz Friedrich , Wolfgang Degener
发明人： Walter Pfefferle , Hermann Lotter , Heinz Friedrich , Wolfgang Degener
IPC分类号： C12P13/08
CPC分类号： C12P13/08
摘要： A process is disclosed for the fermentative preparation of amino acids, in which an L-lysine producing bacterial strain of the species Corynebacterium glutamicum is cultivated in a nutrient medium and the amino acids can be isolated from the culture medium at the end of fermentation. After the vigorous growth phase, the bacterial culture has at its disposal a smaller quantity of assimilable carbon source than it could metabolize on the basis of the structure of the strain and the quanitity of other necessary supplements provided in the nutrient medium.
摘要翻译：公开了用于发酵制备氨基酸的方法，其中在营养培养基中培养棒状杆菌谷氨酸棒杆菌种的L-赖氨酸生产菌株，并且可以在发酵结束时从培养基中分离出氨基酸。在生长旺盛阶段之后，细菌培养物可以根据菌株的结构和营养培养基中提供的其他必需的补充剂的量来代替较少数量的可同化碳源。

79. 发明授权

US5795732A Stirred-tank reactors and method of use 失效
标题翻译：搅拌釜反应器及使用方法
公开(公告)号：US5795732A
公开(公告)日：1998-08-18
申请号：US657381
申请日：1996-06-03
申请人： Bernhard Schilling , Walter Pfefferle , Bernd Bachmann , Wolfgang Leuchtenberger , Wolf-Dieter Deckwer
发明人： Bernhard Schilling , Walter Pfefferle , Bernd Bachmann , Wolfgang Leuchtenberger , Wolf-Dieter Deckwer
IPC分类号： C12M1/04 , C12M1/06 , C12M1/02 , C12P1/00
CPC分类号： C12M27/02 , C12M27/22
摘要： The invention is relates to improved stirred-tank reactors which are suitable, due to special fittings, for converting the results of e.g. microbial or enzymatic processes obtained when they are used on a laboratory scale into an industrial scale. A shaft-driven disk agitator is provided, with at least one perforated disk being attached in the reactor above and/or below the disk agitator.
摘要翻译：本发明涉及改进的搅拌釜反应器，其由于特殊的配件而适用于将例如硫酸氢铵当它们在实验室规模上用于工业规模时获得的微生物或酶法。提供了一种轴驱动盘式搅拌器，其中在盘式搅拌器上方和/或下方的反应器中附着至少一个穿孔盘。

80. 发明授权

US07202061B2 Process for the preparation of L-amino acids by attenuating the mikE17 gene 有权
标题翻译：通过减弱mikE17基因制备L-氨基酸的方法
公开(公告)号：US07202061B2
公开(公告)日：2007-04-10
申请号：US10923726
申请日：2004-08-24
申请人： Mike Farwick , Klaus Hutchmacher , Walter Pfefferle
发明人： Mike Farwick , Klaus Hutchmacher , Walter Pfefferle
IPC分类号： C12P13/04 , C12N1/20 , C12N15/00 , C07K1/00 , C07J21/04
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the mikE17 gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含选自组内的多核苷酸序列

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