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71. 发明授权

US08415304B2 Sparc and methods of use thereof 有权
标题翻译： Sparc及其使用方法
公开(公告)号：US08415304B2
公开(公告)日：2013-04-09
申请号：US12295068
申请日：2007-03-29
申请人： Vuong Trieu , Neil P. Desai , Patrick Soon-Shiong
发明人： Vuong Trieu , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A01N61/00 , A61K31/00 , A61K38/00 , A61K49/00 , G01N1/00 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574 , C12Q1/00
CPC分类号： G01N33/57488 , A61K31/337 , G01N33/574 , G01N33/57407 , G01N33/57484 , G01N33/57492 , G01N2333/4727 , G01N2333/71 , G01N2333/91205 , G01N2800/52 , Y10T436/25
摘要： The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.
摘要翻译：本发明提供用于预测或确定哺乳动物肿瘤对化学治疗剂的反应和用于治疗哺乳动物肿瘤的方法，包括检测和定量分离自哺乳动物的样品中的SPARC蛋白或RNA。本发明还提供了用于预测哺乳动物肿瘤对化学治疗剂的反应的试剂盒，其包括用于从肿瘤分离蛋白质或RNA的手段，SPARC蛋白或RNA检测和定量方法，控制RNA和用于预测基于肿瘤中SPARC蛋白或RNA水平的肿瘤反应。

72. 发明授权

US08314156B2 Compositions and methods of delivery of pharmacological agents 有权
标题翻译：组合物和药理学递送方法
公开(公告)号：US08314156B2
公开(公告)日：2012-11-20
申请号：US13038287
申请日：2011-03-01
申请人： Neil P. Desai , Patrick Soon-Shiong , Vuong Trieu
发明人： Neil P. Desai , Patrick Soon-Shiong , Vuong Trieu
IPC分类号： A61K47/42 , A61K9/14 , A61K9/51 , C07K14/76
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/0078 , A61K9/107 , A61K9/1075 , A61K9/146 , A61K9/19 , A61K31/00 , A61K31/05 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/198 , A61K31/24 , A61K31/337 , A61K31/343 , A61K31/355 , A61K31/427 , A61K31/436 , A61K31/4745 , A61K31/7048 , A61K38/13 , A61K47/18 , B82Y5/00 , Y10S977/705 , Y10S977/773 , Y10S977/779 , Y10S977/906 , Y10S977/911 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. He human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The inventor also provides methods for reducing on or more side effects of administration of the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.
摘要翻译：本发明涉及包含药剂和药学上可接受的载体的药物组合物，该载体包含蛋白质，例如人血清白蛋白和/或去铁胺。他人血清白蛋白以有效降低与药物组合物的给药相关的一种或多种副作用的量存在。本发明人还提供减少药物组合物施用的副作用的方法以及用于增强药剂与细胞的转运和结合的方法。

73. 发明授权

US08257733B2 Methods and compositions for treating proliferative diseases 有权
标题翻译：治疗增殖性疾病的方法和组合物
公开(公告)号：US08257733B2
公开(公告)日：2012-09-04
申请号：US11544242
申请日：2006-10-06
申请人： Neil P. Desai , Patrick Soon-Shiong , Tapas De
发明人： Neil P. Desai , Patrick Soon-Shiong , Tapas De
IPC分类号： A61K9/127 , A61K31/397
CPC分类号： A61K9/146 , A61K9/0019 , A61K9/5169 , A61K31/165 , A61K31/17 , A61K31/282 , A61K31/337 , A61K31/395 , A61K31/436 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/555 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K33/24 , A61K38/16 , A61K38/38 , A61K39/39558 , A61K45/06 , A61K47/42 , A61K47/643 , A61K47/6931 , A61N5/10 , A61K2300/00
摘要： The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
摘要翻译：本发明提供了治疗增殖性疾病（例如癌症）的组合治疗方法，其包括第一疗法，其包括向个体施用有效量的纳米颗粒组合物中的紫杉烷，以及第二疗法，其可包括例如放射，外科手术，施用化学治疗剂或其组合。还提供了基于节律剂给药方案向个体施用纳米颗粒组合物中的药物紫杉烷的方法。

74. 发明授权

US08137684B2 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 有权
标题翻译：药理剂的制剂，其制备方法及其使用方法
公开(公告)号：US08137684B2
公开(公告)日：2012-03-20
申请号：US11520523
申请日：2006-09-12
申请人： Neil P. Desai , Chunlin Tao , Andrew Yang , Leslie Louie , Patrick Soon-Shiong
发明人： Neil P. Desai , Chunlin Tao , Andrew Yang , Leslie Louie , Patrick Soon-Shiong
IPC分类号： A61K31/337
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K9/1075 , A61K9/5052 , A61K9/5169 , A61K47/42
摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.
摘要翻译：根据本发明，提供了用于体内递送基本上不溶于水的药理学活性剂（例如抗癌药物紫杉醇）的组合物和方法，其中药理活性剂以包被的蛋白质（其作为稳定剂）。特别地，生物相容性分散介质中的蛋白质和药理学活性剂在没有任何常规表面活性剂的情况下进行高剪切，并且在没有用于颗粒的任何聚合物芯材料的情况下进行。该方法产生直径小于约1微米的颗粒。使用特定的组成和制备条件（例如，向有机相中加入极性溶剂）以及仔细选择合适的有机相和相分数使得能够可重复地生产直径小于200nm的异常小的纳米颗粒，其中可以无菌过滤。根据本发明制备的颗粒系统可以转化成可再分散的干粉，其包含用蛋白质包被的水不溶性药物的纳米颗粒，以及结合有药理学分子的游离蛋白质。这导致独特的递送系统，其中药理活性剂的一部分容易生物利用（以与蛋白质结合的分子的形式），并且部分药剂存在于颗粒内，而其中没有任何聚合物基质。

75. 发明申请

US20110151012A1 COMPOSITIONS COMPRISING POORLY WATER SOLUBLE PHARMACEUTICAL AGENTS AND ANTIMICROBIAL AGENTS 审中-公开
标题翻译：包含不良水溶性药物和抗微生物剂的组合物
公开(公告)号：US20110151012A1
公开(公告)日：2011-06-23
申请号：US12824014
申请日：2010-06-25
申请人： Neil P. Desai , Raj Selvaraj , Andrew Yang , Patrick Soon-Shiong
发明人： Neil P. Desai , Raj Selvaraj , Andrew Yang , Patrick Soon-Shiong
IPC分类号： A61K9/14 , A61K31/337 , A61K31/395 , A01N37/44 , A01N59/02 , A01N37/06 , A01N37/10 , A01N43/08 , A01N31/04 , A01N37/04 , A01P1/00 , A61P35/00 , B82Y5/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/19 , A61K9/5169 , A61K38/13 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42 , Y02A50/473 , Y10S977/702 , Y10S977/705 , Y10S977/773 , Y10S977/788 , Y10T428/2982 , A61K2300/00
摘要： The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
摘要翻译：本发明提供了包含水溶性差的药剂，载体蛋白和抗微生物剂的组合物，其中组合物中显着的微生物生长被抑制。组合物中抗微生物剂的量可以低于诱导毒性作用的水平或者可以控制或耐受潜在副作用的水平。还提供了包含难溶于水的药剂，载体蛋白，糖和任选的抗微生物剂的组合物。还提供了使用组合物的方法。

76. 发明申请

US20100305148A1 DI-ESTER PRODRUGS OF CAMPTOTHECIN, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开
标题翻译：角蛋白制剂的制剂及其制备方法及其治疗应用
公开(公告)号：US20100305148A1
公开(公告)日：2010-12-02
申请号：US12759144
申请日：2010-04-13
申请人： Patrick Soon-Shiong , Neil P. Desai , Chunlin Tao , Cheng Zhi Yu
发明人： Patrick Soon-Shiong , Neil P. Desai , Chunlin Tao , Cheng Zhi Yu
IPC分类号： A61K31/4375 , C07D491/22 , A61P35/02 , A61P35/00
CPC分类号： C07D491/22 , C07D498/14
摘要： The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.
摘要翻译：本发明涉及喜树碱的10,20-二-O-酯衍生物及其药物制剂。本发明的化合物和药物制剂在保持抗癌活性的同时具有增加的生物寿命和生物利用度和降低的毒性。

77. 发明申请

US20100297243A1 PRION FREE NANOPARTICLE COMPOSITIONS AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：无铅纳米材料组合物及其制备方法
公开(公告)号：US20100297243A1
公开(公告)日：2010-11-25
申请号：US12761292
申请日：2010-04-15
申请人： Neil P. Desai , Viktor Peykov , Patrick Soon-Shiong
发明人： Neil P. Desai , Viktor Peykov , Patrick Soon-Shiong
IPC分类号： A61K9/14 , A61K31/337 , A61P31/12
CPC分类号： A61K9/5169 , A61K9/1658 , A61K31/337 , A61K47/42 , B82Y5/00 , G01N33/6896 , G01N2800/2828 , Y10S210/905 , Y10S977/773 , Y10S977/906
摘要： The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
摘要翻译：本发明提供了包含白蛋白和基本上水不溶性药物的纳米颗粒的无朊病毒组合物。还提供了制备无朊病毒组合物和从纳米颗粒组合物中除去朊病毒蛋白的方法。还提供了使用组合物的方法以及用于实施方法的试剂盒。

78. 发明申请

US20100215751A1 METHODS AND COMPOSITIONS FOR TREATING RECURRENT CANCER 有权
标题翻译：治疗癌症的方法和组合
公开(公告)号：US20100215751A1
公开(公告)日：2010-08-26
申请号：US12600991
申请日：2008-06-02
申请人： Neil P. Desai , Patrick Soon-Shiong
发明人： Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K9/14 , A61K31/335 , A61P35/04
CPC分类号： A61K47/42 , A61K9/5169 , A61K31/282 , A61K31/337 , A61K31/555 , A61K38/38 , A61K47/643 , A61K47/6929 , Y10S977/773 , Y10S977/906 , A61K2300/00
摘要： The present invention provides methods of treating recurrent cancer (such as recurrent ovarian, peritoneal, or fallopian tube cancer) in an individual, comprising administering to the individual an effective amount of a composition (such as Nab-paclitaxel or Abraxane®) comprising nanoparticles comprising a taxane and a carrier protein.
摘要翻译：本发明提供了治疗个体中复发性癌症（例如复发性卵巢，腹膜或输卵管癌）的方法，包括向个体施用有效量的包含纳米颗粒的组合物（例如Nab-紫杉醇或Abraxane），其包含紫杉烷和载体蛋白。

79. 发明申请

US20100112077A1 NANOPARTICLES OF PACLITAXEL AND ALBUMIN IN COMBINATION WITH BEVACIZUMAB AGAINST CANCER 审中-公开
标题翻译： PACLITAXEL和ALBUMIN与BEVACIZUMAB抗癌联合使用的纳米颗粒
公开(公告)号：US20100112077A1
公开(公告)日：2010-05-06
申请号：US12513843
申请日：2007-11-06
申请人： Neil P. Desai , Patrick Soon-Shiong
发明人： Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K9/14 , A61K39/395 , A61P35/00
CPC分类号： A61K9/5169 , A61K9/0019 , A61K31/282 , A61K31/337 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-VEGF antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
摘要翻译：本发明提供了治疗增殖性疾病（例如癌症）的组合治疗方法，其包括第一疗法，其包括向个体施用有效量的纳米颗粒组合物中的紫杉烷，以及第二疗法，其可包括例如放射，外科手术，化疗剂（如抗VEGF抗体）的施用，或其组合。还提供了基于节律剂给药方案向个体施用纳米颗粒组合物中的药物紫杉烷的方法。

80. 发明申请

US20090291139A1 SPARC AND METHODS OF USE THEREOF 有权
标题翻译： SPARC及其使用方法
公开(公告)号：US20090291139A1
公开(公告)日：2009-11-26
申请号：US12295068
申请日：2007-03-29
申请人： Vuong Trieu , Neil P. Desai , Patrick Soon-Shiong
发明人： Vuong Trieu , Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K9/14 , C12Q1/68 , C12Q1/02 , A61K31/337 , A61K38/02 , A61K39/395
CPC分类号： G01N33/57488 , A61K31/337 , G01N33/574 , G01N33/57407 , G01N33/57484 , G01N33/57492 , G01N2333/4727 , G01N2333/71 , G01N2333/91205 , G01N2800/52 , Y10T436/25
摘要： The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.
摘要翻译：本发明提供用于预测或确定哺乳动物肿瘤对化学治疗剂的反应和用于治疗哺乳动物肿瘤的方法，包括检测和定量分离自哺乳动物的样品中的SPARC蛋白或RNA。本发明还提供了用于预测哺乳动物肿瘤对化学治疗剂的反应的试剂盒，其包括用于从肿瘤分离蛋白质或RNA的手段，SPARC蛋白或RNA检测和定量方法，控制RNA和用于预测基于肿瘤中SPARC蛋白或RNA水平的肿瘤反应。

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