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71. 发明申请

US20210138203A1 HELICAL GUIDEWIRES AND RELATED SYSTEMS 有权
公开(公告)号：US20210138203A1
公开(公告)日：2021-05-13
申请号：US17038095
申请日：2020-09-30
申请人： Robert Lederman , Adam Greenbaum , Nasser Rafiee , Stuart MacDonald , Mai Le Diep , Rogers Toby , Jaffar Khan , John Horrigan
发明人： Robert Lederman , Adam Greenbaum , Nasser Rafiee , Stuart MacDonald , Mai Le Diep , Rogers Toby , Jaffar Khan , John Horrigan
IPC分类号： A61M25/09 , A61M25/01 , A61F2/24
摘要： In accordance with some implementations, various embodiments of a guidewire or catheter having an elongate core with a helical section are provided. In accordance with one implementation, a guidewire is provided. The guidewire includes a core wire having a proximal end, a distal end and is defined by an outer surface between the proximal end and the distal end of the core wire. The core wire has a centerline that traverses the length of the core wire from the proximal end to the distal end of the core wire. The centerline is located approximately at the center of mass along the core wire within the outer surface of the core wire. Preferably, the core wire has a substantially straight proximal portion and a helically curved segment located distally with respect to the proximal portion. The centerline of the core wire is substantially straight along the straight proximal portion, and, the centerline is helically curved along the helically curved segment. The disclosure similarly provides a catheter having the aforementioned attributes.

72. 发明申请

US20180098850A1 ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS 审中-公开
公开(公告)号：US20180098850A1
公开(公告)日：2018-04-12
申请号：US15796344
申请日：2017-10-27
申请人： Nasser Rafiee , Stuart MacDonald , Koosha Rafiee , Rany Busold , Robert J. Lederman , Rogers Toby
发明人： Nasser Rafiee , Stuart MacDonald , Koosha Rafiee , Rany Busold , Robert J. Lederman , Rogers Toby
IPC分类号： A61F2/24 , A61M25/01
CPC分类号： A61F2/2451 , A61B17/0467 , A61B17/0487 , A61B17/221 , A61B17/320016 , A61B17/3201 , A61B2017/00358 , A61B2017/0496 , A61F2/2466 , A61F2230/0045 , A61F2250/0065 , A61M25/01 , A61M2025/0175
摘要： Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

73. 发明申请

US20180008248A1 DEVICES AND METHODS FOR CLOSURE OF TRANSVASCULAR OR TRANSCAMERAL ACCESS PORTS 审中-公开
公开(公告)号：US20180008248A1
公开(公告)日：2018-01-11
申请号：US15664642
申请日：2017-07-31
申请人： Nasser Rafiee , Stuart MacDonald , Robert J. Lederman , Toby Rogers , Rany Busold , Koosha Rafiee
发明人： Nasser Rafiee , Stuart MacDonald , Robert J. Lederman , Toby Rogers , Rany Busold , Koosha Rafiee
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61F2/88 , A61F2/90 , A61F2/966 , A61B17/34
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12145 , A61B17/1215 , A61B2017/00247 , A61B2017/00557 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00641 , A61B2017/00964 , A61B2017/00991 , A61B2017/3425 , A61B2090/376 , A61B2090/3966 , A61F2/0077 , A61F2/88 , A61F2/90 , A61F2/966 , A61F2230/0078 , A61F2230/0091 , A61F2250/0098
摘要： The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

74. 发明授权

US08795352B2 Devices and methods for treating valvular regurgitation 有权
标题翻译：治疗瓣膜反流的装置和方法
公开(公告)号：US08795352B2
公开(公告)日：2014-08-05
申请号：US12326525
申请日：2008-12-02
申请人： Patricia O'Beirne , Nasser Rafiee
发明人： Patricia O'Beirne , Nasser Rafiee
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/0487 , A61B2017/00243 , A61B2017/00783 , A61B2017/0409 , A61B2017/0441 , A61B2017/0496 , A61F2/2427 , A61F2/2442 , A61F2/2466
摘要： A system for treating mitral valve regurgitation includes a tensioning device having a plurality of helical anchors and a tensioning filament. One embodiment of the invention includes a method for attaching a tensioning device to the annulus of a mitral valve in a trans-leaflet configuration, and applying a tension force to the tension filament in order to exert force vectors on the annulus, thereby reshaping the mitral valve annulus so that the coaption of the anterior and posterior leaflets of the mitral is improved during ventricular contraction.
摘要翻译：用于治疗二尖瓣反流的系统包括具有多个螺旋锚和张紧丝的张紧装置。本发明的一个实施例包括一种用于将张紧装置附接到跨瓣构造的二尖瓣环上的方法，并且向张力丝施加张力以在环上施加力矢量，从而重新形成二尖瓣瓣膜环，使得在心室收缩期间二尖瓣的前叶和后叶的结构得到改善。

75. 发明授权

US07695510B2 Annuloplasty device having shape-adjusting tension filaments 有权
标题翻译：具有形状调节拉力丝的瓣膜成形术装置
公开(公告)号：US07695510B2
公开(公告)日：2010-04-13
申请号：US11247724
申请日：2005-10-11
申请人： Eliot Bloom , Nasser Rafiee
发明人： Eliot Bloom , Nasser Rafiee
IPC分类号： A61F2/24
CPC分类号： A61F2/2454 , A61F2/2445
摘要： A system for treating mitral valve regurgitation includes a tensioning device having a flexible annuloplasty ring, a plurality of anchoring members and a tensioning filament attached to the flexible ring. One embodiment of the invention includes a method for attaching a flexible annuloplasty ring to the annulus of a mitral valve, and adjusting the lengths of segments of the tension filament attached to the flexible ring in order to exert force vectors on the annulus, thereby reshaping the mitral valve annulus so that the anterior and posterior leaflets of the mitral valve close completely during ventricular contraction.
摘要翻译：用于治疗二尖瓣关闭不全的系统包括具有柔性瓣环成形术环的张紧装置，多个锚固构件和连接到柔性环的张紧细丝。本发明的一个实施例包括一种用于将柔性瓣环成形术环连接到二尖瓣环上的方法，以及调节连接到柔性环的拉力丝的段的长度，以便在环上施加力矢量，从而重新形成二尖瓣环，使得二尖瓣的前叶和后叶在心室收缩期间完全闭合。

76. 发明申请

US20090248133A1 Double-Walled Stent System 有权
标题翻译：双壁支架系统
公开(公告)号：US20090248133A1
公开(公告)日：2009-10-01
申请号：US12060340
申请日：2008-04-01
申请人： Eliot Bloom , Nasser Rafiee , Morgan House
发明人： Eliot Bloom , Nasser Rafiee , Morgan House
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/823 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91591 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61F2230/0071 , A61F2230/0076 , A61F2250/0037 , A61F2250/0063 , A61F2250/0082
摘要： A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component is secured to the interior stent component in a non-fixed, sliding relationship. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.
摘要翻译：公开了一种特别适用于治疗右心室流出道异常的双壁支架系统，其具有外部支架部件和内部支架部件。外部支架部件以非固定的滑动关系固定到内部支架部件。外部支架部件包括多个纵向延伸的连接器，例如直线或正弦带。内部支架部件具有大致管状的圆柱形主体并且在外部支架部件内居中。支架系统具有收缩输送构型和用于接触血管壁的径向扩张构型。当部署时，外部支架部件的纵向延伸的连接器与血管壁接触并将支架系统固定到治疗部位。内部支架部件也径向扩张，但保持在外部部件的中心，并且几乎不与血管壁接触。

77. 发明申请

US20090163987A1 Compliant Venous Graft 有权
标题翻译：合并静脉移植
公开(公告)号：US20090163987A1
公开(公告)日：2009-06-25
申请号：US12388702
申请日：2009-02-19
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Narenk Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Narenk Douk , Michael F. Wolf
IPC分类号： A61F2/06 , A61B17/00
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

78. 发明申请

US20070203391A1 System for Treating Mitral Valve Regurgitation 审中-公开
标题翻译：二尖瓣反流治疗系统
公开(公告)号：US20070203391A1
公开(公告)日：2007-08-30
申请号：US11678466
申请日：2007-02-23
申请人： Eliot Bloom , Morgan House , Nasser Rafiee , Michael Finney
发明人： Eliot Bloom , Morgan House , Nasser Rafiee , Michael Finney
IPC分类号： A61F2/02 , A61B17/34
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0482 , A61B2017/00247 , A61B2017/00867 , A61B2017/06052 , A61B2018/00392
摘要： A system for treating mitral valve regurgitation comprising at least delivery catheters, puncture catheters, and tensioning devices. The devices include tension members linking a proximal anchor and distal anchor that can be constructed from a tubular braded material and have internal reinforcing members. In some embodiments, the anchors and tension members may flex in response to a heart beat. The system can also include temporary anchors so a clinician can review and adjust the vector of the tension member. Delivery catheters can also include temporary anchors to secure the catheter in position. When positioned across the left ventricle of a heart, the device can reduce the lateral distance between the walls of the ventricle and thus allow better coaption of the mitral valve leaflets thereby reducing heart valve regurgitation.
摘要翻译：一种用于治疗二尖瓣反流的系统，至少包括输送导管，穿刺导管和张紧装置。这些装置包括连接近端锚固件和远端锚固件的张紧构件，其可以由管状胎体材料构造并具有内部加强构件。在一些实施例中，锚和张紧构件可以响应于心跳而弯曲。该系统还可以包括临时锚，所以临床医生可以检查和调整张力构件的矢量。输送导管还可以包括用于将导管固定就位的临时锚。当位于心脏的左心室时，该装置可以减小心室壁之间的横向距离，从而允许二尖瓣小叶更好地分离，从而减少心脏瓣膜反流。

79. 发明授权

US6106510A Extruded guide catheter shaft with bump extrusion soft distal segment 失效
标题翻译：挤出引导导管轴与凸出挤压软远端段
公开(公告)号：US6106510A
公开(公告)日：2000-08-22
申请号：US86074
申请日：1998-05-28
申请人： Peter A. Lunn , Nasser Rafiee , David J. Lentz , Peter G. Strickler
发明人： Peter A. Lunn , Nasser Rafiee , David J. Lentz , Peter G. Strickler
IPC分类号： A61M25/00 , A61M25/09 , A61B6/00
CPC分类号： A61M25/0012 , A61M25/005 , A61M25/0054 , A61M2025/0081
摘要： A medical catheter including a continuous liner defining a guidewire lumen. The liner has a constant inner diameter and a constant outer diameter. A continuous layer is braided over the liner and encapsulated between the liner and a bump layer. The bump layer has a proximal segment, and a bump section. The bump section has a transition zone at the proximal end of the bump section. The proximal segment has a distal end affixed to the proximal end of the bump section. The proximal segment of the bump layer has an outer diameter which is less than the outer diameter of the bump section of the bump layer. The transition zone has an outer diameter which smoothly transitions from the outer diameter of the distal end of the proximal segment of the bump layer to the larger outer diameter at the distal end of the transition zone. The bump layer is encapsulated between the outer jacket layer and the braided layer. The outer jacket layer has a constant outer diameter and an inner diameter conforming to the variable outer diameter of the bump layer. The bump layer is made of a material with a greater flexural modulus than that of the outer jacket layer, such that the flexibility of the catheter is greater at the distal end of the catheter than at the proximal end of the catheter.
摘要翻译：一种医疗导管，其包括限定导丝管腔的连续衬里。内衬具有恒定的内径和恒定的外径。连续层被编织在衬垫上并且封装在衬垫和凸起层之间。凸起层具有近端段和凸起部分。突起部分在凸起部分的近端处具有过渡区域。近端段具有固定到凸起部分的近端的远端。凸块层的近端段的外径小于凸块层的凸块部分的外径。过渡区具有从突起层的近端段的远端的外径平滑地过渡到过渡区的远端处的较大外径的外径。凸起层被封装在外护套层和编织层之间。外护套层具有恒定的外径和与凸起层的可变外径一致的内径。凸起层由具有比外护套层的挠曲模量更大的挠曲模量的材料制成，使得导管的柔性在导管的远端比在导管的近端处更大。

80. 发明申请

US20210145430A1 TISSUE CROSSING SYSTEM AND ANCHORS FOR USE THEREWITH 有权
公开(公告)号：US20210145430A1
公开(公告)日：2021-05-20
申请号：US17086354
申请日：2020-10-31
申请人： Nasser Rafiee , Morgan House
发明人： Nasser Rafiee , Morgan House
IPC分类号： A61B17/04 , A61B17/00
摘要： The present disclosure provides for novel ways of delivering tensioning elements, such as tethers, and deployable anchors, to a desired location within the anatomy of a patient. More specifically, the present disclosure provides a system and method for delivering deployable anchors to a desire location within the anatomy and tethering the anchors together through tissue. The deployable anchors may include anchors that have a pre-deployment elongate configuration and a post-deployment planar configuration.

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