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    • 71. 发明申请
    • PREVENTIVE/THERAPEUTIC AGENT FOR VISCERAL PAIN
    • 用于粘膜疼痛的预防/治疗剂
    • US20070249717A1
    • 2007-10-25
    • US11740541
    • 2007-04-26
    • Tetsuo YanoMasaki HashimotoSmriga MiroslavHisayuki UneyamaKunio Torii
    • Tetsuo YanoMasaki HashimotoSmriga MiroslavHisayuki UneyamaKunio Torii
    • A61K31/198
    • A61K31/198A23L33/175
    • The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.
    • 本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。 使用预防或治疗剂,可以治疗或预防伴随内脏痛,诸如肠障,肠易激综合征,功能性消化不良,胃食管疾病,功能性腹痛综合征,溃疡性结肠炎和克罗恩病等的胃肠道疾病。 此外,还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂,食物和饮料和膳食补充剂。 与现有的药剂相比,它们与胃肠道疾病相关的内脏痛具有高度的效果,显示出减少的副作用,并且是非常有效的。
    • 76. 发明授权
    • Percutaneously absorbable preparation containing cohesive strength
improving agent
    • 含有内聚强度改善剂的经皮吸收制剂
    • US5811117A
    • 1998-09-22
    • US750923
    • 1997-03-12
    • Masaki HashimotoMitsuhito ManoMutsuki AmanoTakeshi Wakiya
    • Masaki HashimotoMitsuhito ManoMutsuki AmanoTakeshi Wakiya
    • A61K9/70A61K31/565A61K47/10A61K47/12A61K47/14A61K47/18A61F13/02
    • A61K31/566A61K31/565A61K31/569A61K31/575A61K9/7053A61K9/7061A61K47/10A61K47/12A61K47/14A61K47/18
    • A percutaneously absorbable preparation which contains norethisterone, estradiol or ester thereof, each of which is highly absorbable percutaneously, can readily be stuck to the skin, and is lowly skin irritating. It is prepared by applying a pressure-sentitive adhesive layer comprising a drug and a pressure-sensitive adhesive to one side of a support. The drug comprises at least one member selected from among norethisterone, estradiol and pharmacologically acceptable esters thereof, while the adhesive comprises a copolymer composed of 20-55 mol. % of vinylpyrrolidone and 80-45 mol. % of alkyl (C.sub.4 -C.sub.18) (meth)acrylate. The adhesive layer further contains a sorbifacient comprising 0.1-10 wt. % of at least one member selected from among dicarboxylic acids, hydroxy carboxylic acids, plyoxyethylene alkyl ethers and amide compounds and 5-40 wt. %, both based on the adhesive layer, of a higher fatty acid ester prepared from a C.sub.10 -C.sub.18 fatty acid and a C.sub.1 -C.sub.20 alcohol and also contains a cohesive force improver.
    • PCT No.PCT / JP95 / 01442 Sec。 371日期1997年3月12日 102(e)1997年3月12日PCT PCT 1995年7月20日PCT公布。 公开号WO96 / 03131 日期1996年2月8日一种含有炔诺酮,雌二醇或其酯的经皮吸收制剂,其每一种均经皮可高吸收,易于粘附于皮肤,并且皮肤刺激性低。 通过将包含药物和压敏粘合剂的压力粘合剂层施加到载体的一侧来制备。 药物包含选自炔诺酮,雌二醇及其药理学上可接受的酯中的至少一种,而粘合剂包含由20-55mol组成的共聚物。 %的乙烯基吡咯烷酮和80-45mol。 %(C 4 -C 18)(甲基)丙烯酸烷基酯。 粘合剂层还包含含有0.1-10重量% %的至少一种选自二羧酸,羟基羧酸,聚氧乙烯烷基醚和酰胺化合物的成员和5-40wt。 基于粘合剂层的由C10-C18脂肪酸和C1-C20醇制备的高级脂肪酸酯的%,还含有内聚力改进剂。
    • 77. 发明授权
    • Construction for joining chainstay and seat pipes to a rear dropout in a
bicycle frame
    • 用于将链条和座管连接到自行车车架中的后部出口的结构
    • US4940356A
    • 1990-07-10
    • US215558
    • 1988-07-06
    • Masaki HashimotoNoboru Yamaguchi
    • Masaki HashimotoNoboru Yamaguchi
    • B62K25/02B62K19/22B62K19/28
    • B62K19/22B62K19/28Y10T403/471Y10T403/4924Y10T403/535Y10T403/557Y10T403/5766Y10T403/635
    • The present invention constitutes a construction joint of a bicycle frame comprising a rear dropout body having projecting portions decreasing in taper as they extend away from the body, each projecting portion defining an elongated screw hole extending along a longitudinal axis of the projecting portion, the projecting portion defining a slit extending on both sides of the screw hole; chainstay and seat stay pipes, each surrounding a projecting portion, the chainstay and seat stay pipes having gradually decreasing diameters towards the base end of the projecting portions; a screw or wedge inserted into the screw hole to enlarge the outside circumference of the projecting portion until it fixedly contacts the interior of the chainstay and seat stay pipes; and an adhesive agent spread around the projecting portion of the rear dropout body and inside the chainstay and seat stay pipes.
    • 本发明构成了一种自行车车架的结构接头,其包括一个具有突出部分的后退出体,该突出部分沿着远离本体延伸的锥形减小,每个突出部分限定沿着突出部分的纵向轴线延伸的细长螺钉孔, 限定在所述螺钉孔的两侧延伸的狭缝的部分; 链条和座椅支撑管,每个围绕突出部分,链条和座椅支撑管具有朝向突出部分的基端的直径逐渐减小; 插入螺丝孔中的螺钉或楔块,以扩大突出部分的外周,直到其固定地接触链条和座椅支撑管的内部; 以及粘合剂,其分布在后退出体的突出部分周围以及链条状和座椅支撑管内。
    • 78. 发明授权
    • Pipe joining construction of a bicycle frame
    • 管道连接自行车架的结构
    • US4856800A
    • 1989-08-15
    • US186146
    • 1988-04-26
    • Masaki HashimotoNoboru Yamaguchi
    • Masaki HashimotoNoboru Yamaguchi
    • B23K20/00B29C65/70B29K105/06B62K19/16B62K19/18B62K19/28
    • B62K19/28Y10T403/472Y10T403/475
    • A bicycle frame of the present invention is formed as follows.First, the worker puts and bonds a pipe made by fibre reinforced plastics around a cylindrical projecting part of a lug made by thin wall thickness light alloy.Next, the worker covers a joining part of the said projecting part of a lug and pipe made by fibrer reinforced plastics by sheet molding compound, (hereinafter it is called "SMC").Last, the joining part of the projecting part of a lug and the pipe covered by said SMC is put in a molds for compression molding.As the SMC consists of required quantity of plastics and chopped fibre same as filament comprised in the pipe made by fibre reinforced plastics, bonding of the pipe made by fibre reinforced plastics and said SMC is very good. Consequently, the joining strength of the pipe and lug is very strong in the present invention.
    • 本发明的自行车车架如下形成。 首先,工人将由纤维增强塑料制成的管子放在由薄壁厚度轻合金制成的凸耳的圆柱形突出部分上。 接下来,工人通过片状模塑料覆盖由纤维增强塑料制成的凸耳和管的所述突出部分的接合部分(以下称为“SMC”)。 最后,将凸耳的突出部分和由所述SMC覆盖的管的接合部分放入用于压缩成型的模具中。 由于SMC由纤维增强塑料制成的管中包含的所需量的塑料和短切纤维组成,所以由纤维增强塑料制成的管和所述SMC的接合是非常好的。 因此,在本发明中,管和凸耳的接合强度非常强。