专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明专利

BRPI0414544A 未知
公开(公告)号：BRPI0414544A
公开(公告)日：2006-11-07
申请号：BRPI0414544
申请日：2004-09-17
申请人： NOVARTIS AG
发明人： IMBACH PATRICIA , ROESEL JOHANNES
IPC分类号： A61K31/506 , A61K35/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12
摘要： A method of preventing or treating proliferative disorders such as a tumor disease, by inhibiting ALK activity with compounds of formula (1):

72. 发明专利

DE60209227T2 未知
公开(公告)号：DE60209227T2
公开(公告)日：2006-08-17
申请号：DE60209227
申请日：2002-05-29
申请人： NOVARTIS AG
发明人： FURET PASCAL , GUAGNANO VITO , IMBACH PATRICIA , LANG MARC
IPC分类号： A61K38/00 , C07K5/06 , A61K31/69 , A61P35/00 , A61P43/00
摘要： Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and the use of such derivatives in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans

73. 发明专利

PE20060622A1 DERIVADOS DE PIRIMIDINA COMO INHIBIDORES DE FAK 未知
公开(公告)号：PE20060622A1
公开(公告)日：2006-08-14
申请号：PE2005000982
申请日：2005-08-25
申请人： NOVARTIS AG
发明人： UMEMURA ICHIRO , TENO NAOKI , KAWAHARA EIJI , MATSUURA NAOKO , KONISHI KAZUHIDE , MIYAKE TAKAHIRO , OHMORI OSAMU , IMBACH PATRICIA , ROESEL JOHANNES
IPC分类号： A61K31/505 , A61K31/506 , A61P35/00 , C07D239/00 , C07D239/48 , C07D401/00 , C07D401/12 , C07D401/14 , C07D403/00 , C07D403/12 , C07D403/14 , C07D409/00 , C07D409/12 , C07D409/14 , C07D413/00 , C07D413/12 , C07D498/00 , C07D498/04
摘要： REFERIDA A UN COMPUESTO DERIVADO DE PIRIMIDINA DE FORMULA I, DONDE R0 ES H; R1 ES H, HETEROCICLO DE 5 O 6 ELEMENTOS, ENTRE OTROS; R2 ES H; R3 ES SULFAMOILO SUSTITUIDO POR ALQUILO C1-C7, HETEROCICLO DE 5 O 6 ELEMENTOS QUE COMPRENDE 1,2,3 O 4 ATOMOS DE N, ENTRE OTROS; R4 ES H; R5 ES HALOGENO; R6 ES H; R7 ES H, ALCOXI C1-C7, ENTRE OTROS; R8 ES H, HALOGENO, ALCOXI C1-C7, ENTRE OTROS; R9 ES H, HETEROCICLO DE 5 O 6 ELEMENTOS QUE COMPRENDE 1,2 O 3 ATOMOS DE N U O, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{5-BROMO-2-[5-(3-DIMETILAMINO-PIRROLIDI-1-NIL)-2-METOXI-FENILAMINO]-PIRIMIDI-4-NILAMINO}-N-METIL-BENCENOSULFONAMIDA, 2-{5-BROMO-2-[2-METOXI-5-(2-MORFOLI-4-NIL-ETOXI)-FENILAMINO]-PIRIMIDI-4-NILAMINO}-N-ISOPROPIL-BENCENOSULFONAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA FAK Y SON UTILES PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA INMUNOLOGICO, DESORDENES INDUCIDOS POR LINFOCITOS T, LINFOCITOS B, MASTOCITOS Y/O EOSINOFILOS, ARTEROSCLEROSIS, ENTRE OTROS

74. 发明专利

DE60209227D1 未知
公开(公告)号：DE60209227D1
公开(公告)日：2006-04-20
申请号：DE60209227
申请日：2002-05-29
申请人： NOVARTIS AG
发明人： FURET PASCAL , GUAGNANO VITO , IMBACH PATRICIA , LANG MARC
IPC分类号： A61K38/00 , C07K5/06 , A61K31/69 , A61P35/00 , A61P43/00
摘要： Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and the use of such derivatives in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans

75. 发明专利

PE20051089A1 DERIVADOS DE PIRAZOLO [1,5-A] PIRIMIDIN-7-IL-AMINA COMO INHIBIDORES DE QUINASA DE PROTEINA 未知
公开(公告)号：PE20051089A1
公开(公告)日：2006-01-25
申请号：PE2005000080
申请日：2005-01-20
申请人： NOVARTIS AG
发明人： BOLD GUIDO , FLOERSHEIMER ANDREAS , FURET PASCAL , IMBACH PATRICIA , MASUYA KEIICHI , SCHOEPFER JOSEPH , MARTINY-BARON GEORG
IPC分类号： A61K31/505 , C07D487/04
摘要： SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOLO [1,5-a] PIRIMIDIN-7-IL-AMINA DE FORMULA (I), EN DONDE R1 ES H, HALOGENO O ALQUILO INFERIOR; R2 ES H, ARILO, HETEROARILO, ALQUILO INFERIOR, CICLOALQUILO, BENCILO, BENZOTIENILO, INDOLILO ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO INFERIOR, OPCIONALMENTE SUSTITUIDOS; A ES H, HALOGENO, BENZOTIENILO, PIRIDILO, FENILO, PIPERAZINILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: 3-{7-AMINO-3-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO-[1,5-A]-PIPRIMIDIN-6-IL}-FENOL, 6-(3-BENCILOXI-FENIL)-3-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO[1,5-A]PIRIMIDIN-7-IL)-FENOL, 6-(3-METOXI-FENIL)-4-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO[1,5-A]PIRIMIDIN-7-IL-AMINA, ENTRE OTROS. SE REFIERE A UNA COMPOSICION Y UN PROCESO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA DE DIFERENTES GRADOS DE ESPECIFICIDAD, POR LO QUE SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS TALES COMO TUMOR BENIGNO O MALIGNO

76. 发明专利

AU2005205915A1 Pyrazolo[1,5-a]pyrimidin-7-yl-amine derivatives for use in the treatment of protein kinase dependent diseases 未知
公开(公告)号：AU2005205915A1
公开(公告)日：2005-08-04
申请号：AU2005205915
申请日：2005-01-21
申请人： NOVARTIS AG
发明人： FURET PASCAL , BOLD GUIDO , MASUYA KEIICHI , IMBACH PATRICIA , FLOERSHEIMER ANDREAS , SCHOEPFER JOSEPH , MARTINY-BARON GEORG
IPC分类号： A61K31/505 , C07D487/04
摘要： The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

77. 发明专利

DE60011889T2 未知
公开(公告)号：DE60011889T2
公开(公告)日：2005-07-14
申请号：DE60011889
申请日：2000-04-25
申请人： NOVARTIS AG
发明人： FRANCE DENNIS , FUERST PETER , ZIMMERMANN JOHANN , GARCIA-ECHEVERRIA CARLOS , SCHOLZ DIETER , FURET PASCAL , IMBACH PATRICIA
IPC分类号： A61K38/00 , A61P17/06 , A61P35/00 , A61P43/00 , C07C237/12 , C07C271/22 , C07K5/00 , A61K31/325
摘要： The present invention relates to the new use of 2,4-diamino-3-hydroxycarboxylic acids of formula (I), in which A and B independently represent a bond or an unsubstituted or substituted amino acyl moiety; R1 represents hydrogen; an amino protecting group; or a group of formula R5Y- wherein R5 represents hydrogen or an unsubstituted or substituted alkyl, alkenyl, alkinyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl group; and Y represents -CO-; -NH-CO-; -NH-CS-; -SO2-; -O-CO-; or -O-CS-; R2 represents the side chain of a natural amino acid; an alkyl, arylalkyl, heteroarylalkyl or cycloalkylalkyl group; or trimethylsilylmethyl, 2-thienylmethyl or styrylmethyl; R3 represents halogen, alkyl, alkoxy or hydroxyalkoxy; and R4 represents 2(R)-hydroxyindan-1(S)-yl; (S)-2-hydroxy-1-phenylethyl; or 2-hydroxy-benzyl unsubstituted or substituted in 4-position by methoxy; in the manufacture of a pharmaceutical composition for the treatment of a proliferative disease, e.g., of a solid tumor; to a method of treatment of warm-blooded animals; and to 2,4-diamino-3-hydroxycarboxylic acids of formula (I*), wherein A and B independently represent an unsubstituted or substituted amino acyl moiety; R2 represents arylalkyl; R3 represents halogen, alkyl, alkoxy or hydroxyalkoxy; R4 represents 2-hydroxy-benzyl unsubstituted or substituted in 4 position by methoxy; and R5 represents arylalkyl and Y represents -CO-; or R5 represents alkyl substituted by cycloalkyl, naphthyl, pyridyl or phenyl in which phenyl is substituted by alkyl or amino; and Y represents -O-CO; pharmaceutically acceptable salts thereof; and the use of such compounds of formula (I*) for the therapeutic treatment of the human or animal body, especially the treatment of proliferative diseases.

78. 发明专利

AU2004295061A1 1H-imidazoquinoline derivatives as protein kinase inhibitors 未知
公开(公告)号：AU2004295061A1
公开(公告)日：2005-06-16
申请号：AU2004295061
申请日：2004-11-19
申请人： NOVARTIS AG
发明人： CARAVATTI GIORGIO , GARCIA-ECHEVERRIA CARLOS , IMBACH PATRICIA , CAPRARO HANS-GEORG , FURET PASCAL , STAUFFER FREDERIC
IPC分类号： A61K31/435 , C07D471/04
摘要： The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinolines.

79. 发明专利

CA2546673A1 DIARYL UREA DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 未知
公开(公告)号：CA2546673A1
公开(公告)日：2005-06-09
申请号：CA2546673
申请日：2004-11-26
申请人： NOVARTIS AG
发明人： FLOERSHEIMER ANDREAS , GUAGNANO VITO , GARCIA-ECHEVERRIA CARLOS , VAUPEL ANDREA , IMBACH PATRICIA , ROESEL JOHANNES , BOLD GUIDO , CARAVATTI GIORGIO , MASUYA KEIICHI
IPC分类号： A61K31/00 , C07D239/34 , C07D239/46 , C07D401/12 , C07D403/12
摘要： The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumour diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N'-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N'-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N'-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.

80. 发明专利

DE60010234D1 未知
公开(公告)号：DE60010234D1
公开(公告)日：2004-06-03
申请号：DE60010234
申请日：2000-02-16
申请人： NOVARTIS AG
发明人： IMBACH PATRICIA , CAPRARO HANS-GEORG , ZIMMERMANN JUERG , CARAVATTI GIORGIO , FURET PASCAL , BRILL KARL-DIETHER
IPC分类号： A61K31/52 , A61P19/00 , A61P19/10 , A61P35/00 , C07D473/16 , C07D473/40
摘要： 2-Amino-6-anilino-purine derivatives of the formula I in which the symbols are as defined in claim 1, are described. These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and protein tyrosine kinase pp60c-src and can be used for treatment of hyperproliferative diseases, for example tumor diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60c-src, in particular osteoporosis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式