专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

US20050164275A1 Phosphodiesterases 审中-公开
公开(公告)号：US20050164275A1
公开(公告)日：2005-07-28
申请号：US11048744
申请日：2005-02-03
申请人： Michael Thornton , Li Ding , Chandra Arvizu , Monique Yao , Catherine Tribouley , Preeti Lal , April Hafalia , Mariah Baughn , Jayalaxmi Ramkumar , Yan Lu , Narinder Chawla
发明人： Michael Thornton , Li Ding , Chandra Arvizu , Monique Yao , Catherine Tribouley , Preeti Lal , April Hafalia , Mariah Baughn , Jayalaxmi Ramkumar , Yan Lu , Narinder Chawla
IPC分类号： A01K67/00 , C07H21/04 , C12N9/16 , C12Q1/68
CPC分类号： C12N9/16 , A01K2217/05
摘要： The invention provides human phosphodiesterases (HPDE) and polynucleotides which identify and encode HPDE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of HPDE.

72. 发明申请

US20050064543A1 Secreted proteins 审中-公开
标题翻译：分泌蛋白
公开(公告)号：US20050064543A1
公开(公告)日：2005-03-24
申请号：US10487078
申请日：2002-08-15
申请人： Y. Tang , Bridget Warren , Kimberly Gietzen , Preeti Lal , Henry Yue , Cynthia Honchell , Patricia Lehr-Mason , Neil Burford , Yuming Xu , Mariah Baughn , Brendan Duggan , Uyen Tran , Ernestine Lee , Ian Forsythe , Thomas Richardson , Sally Lee , Kavitha Thangavelu , Huibin Yue , Brooke Emerling , Narinder Chawla , Yalda Azimzai , Bharati Sanjanwala , April Hafalia , Mark Borowsky , Danniel Nguyen , Craig Ison , Anna Astromoff , Li Ding , Soo Yeun Lee , Shanya Becha , Jayalaxmi Ramkumar , Ameena Gandhi , Pei Jin , Glenn Fu , Anita Swarnakar
发明人： Y. Tang , Bridget Warren , Kimberly Gietzen , Preeti Lal , Henry Yue , Cynthia Honchell , Patricia Lehr-Mason , Neil Burford , Yuming Xu , Mariah Baughn , Brendan Duggan , Uyen Tran , Ernestine Lee , Ian Forsythe , Thomas Richardson , Sally Lee , Kavitha Thangavelu , Huibin Yue , Brooke Emerling , Narinder Chawla , Yalda Azimzai , Bharati Sanjanwala , April Hafalia , Mark Borowsky , Danniel Nguyen , Craig Ison , Anna Astromoff , Li Ding , Soo Yeun Lee , Shanya Becha , Jayalaxmi Ramkumar , Ameena Gandhi , Pei Jin , Glenn Fu , Anita Swarnakar
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P37/06 , A61P43/00 , C07K1/22 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N9/16 , C12N9/64 , C12N15/02 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C07H21/04 , C12N9/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C12N9/1205 , C12N9/16 , C12N9/6421
摘要： Various embodiments of the invention provide human secreted proteins(SECP) and polynucleotides which identify and encode SECP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译：本发明的各种实施方案提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其它实施方案提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。

73. 发明授权

US06759060B2 Synthetic particulate vectors and preparation process 失效
标题翻译：合成颗粒载体及其制备方法
公开(公告)号：US06759060B2
公开(公告)日：2004-07-06
申请号：US09112367
申请日：1998-07-09
申请人： Daniel Samain , Igancio De Miguel , Frédérique N'guyen , Pascal Delrieu , Li Ding , Nadine Candelotto , Corinne Segreto , Didier Betbeder , Roger Kravtzoff , Michel Major
发明人： Daniel Samain , Igancio De Miguel , Frédérique N'guyen , Pascal Delrieu , Li Ding , Nadine Candelotto , Corinne Segreto , Didier Betbeder , Roger Kravtzoff , Michel Major
IPC分类号： A61K916
CPC分类号： A61K9/5123 , A23L27/70 , A23L27/72 , A61K8/11 , A61K8/14 , A61K8/66 , A61K8/97 , A61K9/1652 , A61K9/5015 , A61K9/5161 , A61K2800/412 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S514/951 , Y10S514/952 , Y10T428/2991
摘要： A synthetic particulate vector comprising a non-liquid hydrophilic nucleus which does not have an external lipid layer grafted thereon. A method for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtainable through said method, and pharmaceutical, cosmetological or food compositions containing such vectors are also disclosed.
摘要翻译：包含不具有接枝在其上的外部脂质层的非液体亲水核的合成颗粒载体。还公开了通过包封可电离活性成分制备颗粒载体的方法，通过所述方法可获得的载体和含有这些载体的药物，美容组合物或食物组合物的方法。

74. 发明授权

US5736371A Biodegradable particulate vector for transporting molecules having biological activity 失效
标题翻译：用于输送具有生物活性的分子的可生物降解的颗粒载体
公开(公告)号：US5736371A
公开(公告)日：1998-04-07
申请号：US243079
申请日：1994-05-16
申请人： Daniel Samain , Ignacio De Miguel , Jaouad Meniali , Karim Ioualalen , Li Ding , Monique Cervilla , Valerie Rieumajou , Pascal Delrieu , Laurent Imbertie
发明人： Daniel Samain , Ignacio De Miguel , Jaouad Meniali , Karim Ioualalen , Li Ding , Monique Cervilla , Valerie Rieumajou , Pascal Delrieu , Laurent Imbertie
IPC分类号： A61K9/127 , A61K9/16 , A61K9/51 , C12N11/12 , A61K38/43 , C07K17/12 , C12N11/10
CPC分类号： A61K9/5161 , A61K9/127 , A61K9/167 , A61K9/5192 , Y10S530/813 , Y10S530/814
摘要： A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus for containing a biologically active molecule, a first layer of fatty acid compounds covalently bonded to the nucleus and a second layer of phospholipids hydrophobically bonded to the first layer. The nucleus is between 10 nm and 10 .mu.m in size and is formed of a cross-linked polysaccharide or oligosaccharide matrix onto which ionic ligands are uniformly grafted. The cross-linked polysaccharide may be dextran, cellulose or starch cross-linked with epichlorohydrin. The ligand may be an acidic compound selected from succinic acid, phosphoric acid, citric acid, glycine, alanine, glutamic acid and aspartic acid, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino)ethylamine fastened onto the matrix via the acidic compound. The polysaccharide or oligosaccharide may be co-cross-linked with a protein such as keratin/collagen or elastase. The vector may be prepared by reacting succinic acid monochloride in aqueous solution with a cross-linked polysaccharide or oligosaccharide matrix to graft succinic acid onto the matrix to form the nucleus, grinding the nucleus to a size between 10 nm and 10 .mu.m, drying the ground nucleus, coupling fatty acid compounds to the nucleus to form a first layer and hydrophobically bonding phospholipids to the first layer to form a second layer. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.
摘要翻译：制备用于输送生物活性分子的可生物降解的颗粒载体，其包含含有生物活性分子的核，与核共价键合的第一层脂肪酸化合物和与第一层疏水结合的第二层磷脂。核的尺寸在10nm和10μm之间，并且由交联的多糖或寡糖基质形成，其上离子配体被均匀地接枝到其上。交联多糖可以是与表氯醇交联的葡聚糖，纤维素或淀粉。配体可以是选自琥珀酸，磷酸，柠檬酸，甘氨酸，丙氨酸，谷氨酸和天冬氨酸的酸性化合物，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基）乙胺通过酸性化合物固定在基质上。多糖或寡糖可以与蛋白质如角蛋白/胶原或弹性蛋白酶共交联。载体可以通过使琥珀酸一氯化物在水溶液中与交联的多糖或寡糖基质反应来将琥珀酸接枝到基质上以形成核，将细胞核研磨至10nm至10μm的大小，干燥研磨核，将脂肪酸化合物偶联到细胞核上形成第一层，并将磷脂与第一层疏水结合形成第二层。琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

75. 发明授权

US09159544B2 Mass analyser and method of mass analysis 有权
标题翻译：质量分析仪和质量分析方法
公开(公告)号：US09159544B2
公开(公告)日：2015-10-13
申请号：US14001747
申请日：2011-09-28
申请人： Li Ding , Mikhail Sudakov , Sumio Kumashiro
发明人： Li Ding , Mikhail Sudakov , Sumio Kumashiro
IPC分类号： H01J49/42 , H01J49/02 , H01J49/00 , H01J49/06 , H01J49/40
CPC分类号： H01J49/027 , H01J49/0031 , H01J49/061 , H01J49/406 , H01J49/408 , H01J49/4245
摘要： An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.
摘要翻译：用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动基本上位于阵列之间。放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

76. 发明授权

US08890058B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08890058B2
公开(公告)日：2014-11-18
申请号：US12093862
申请日：2005-11-16
申请人： Sadao Takeuchi , Hiroaki Waki , Li Ding , Roger Giles
发明人： Sadao Takeuchi , Hiroaki Waki , Li Ding , Roger Giles
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/067 , H01J49/066
摘要： The present invention provides a mass spectrometer having an ion lens capable of transporting an ion having a large mass to charge ratio with a high level of ion-passing efficiency even under a low-vacuum atmosphere. In conventional atmospheric pressure ionization mass spectrometers or similar mass spectrometers, applying an excessively high voltage to the ion lens undesirably causes an electric discharge. Therefore, the passing efficiency for an ion having a large mass to charge ratio cannot be adequately improved, which leads to a poor detection sensitivity. To solve this problem, the mass spectrometer according to the present invention includes a voltage controller 21 that controls a variable radiofrequency (RF) voltage generator 24 so that both the amplitude and the frequency of the RF voltage applied to the lens electrodes of an ion lens 5 are changed according to the mass to charge ratio of an ion to be analyzed. This control enables the ion lens 5 to focus an ion and transport it to the subsequent stage with a high level of passing efficiency even in the case of analyzing an ion having a large mass to charge ratio. Thus, the detection sensitivity is improved. The aforementioned control is conducted on the basis of the control data stored in a voltage control data storage 22. These data are obtained in advance by a measurement of a sample containing a substance having a known mass to charge ratio, in which the intensity of the signal of an ion detector is maintained while the analysis conditions are changed.
摘要翻译：本发明提供一种质谱仪，其具有能够即使在低真空气氛下也能以高水平的离子通过效率将具有大质荷比的离子输送的离子透镜。在传统的大气压电离质谱仪或类似的质谱仪中，对离子透镜施加过高的电压会导致放电。因此，不能充分提高质荷比大的离子的通过效率，导致检测灵敏度差。为了解决这个问题，根据本发明的质谱仪包括控制可变射频（RF）电压发生器24的电压控制器21，使得施加到离子透镜的透镜电极的RF电压的幅度和频率 5根据待分析的离子的质荷比而改变。这种控制使得离子透镜5能够聚焦离子并且即使在分析具有大的质荷比的离子的情况下，也可以将其输送到具有高水平的通过效率的后续阶段。因此，提高了检测灵敏度。上述控制是根据存储在电压控制数据存储器22中的控制数据进行的。这些数据是通过测量包含具有已知质荷比的物质的样品预先获得的，其中，在分析条件改变的同时保持离子检测器的信号。

77. 发明申请

US20140217275A1 Mass Analyser and Method of Mass Analysis 有权
标题翻译：质量分析仪和质量分析方法
公开(公告)号：US20140217275A1
公开(公告)日：2014-08-07
申请号：US14001747
申请日：2011-09-28
申请人： Li Ding , Mikhail Sudakov , Sumio Kumashiro
发明人： Li Ding , Mikhail Sudakov , Sumio Kumashiro
IPC分类号： H01J49/42 , H01J49/00 , H01J49/06
CPC分类号： H01J49/027 , H01J49/0031 , H01J49/061 , H01J49/406 , H01J49/408 , H01J49/4245
摘要： An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.
摘要翻译：用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动基本上位于阵列之间。放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

78. 发明授权

US08486055B2 Method for modifying the refractive index of ocular tissues 有权
$Method for modifying the refractive index of ocular tissues$
标题翻译：改变眼组织折射率的方法
公开(公告)号：US08486055B2
公开(公告)日：2013-07-16
申请号：US12146976
申请日：2008-06-26
申请人： Wayne H. Knox , Li Ding , Krystel R. Huxlin , Jay F. Kunzler
发明人： Wayne H. Knox , Li Ding , Krystel R. Huxlin , Jay F. Kunzler
IPC分类号： A61B18/18
CPC分类号： A61F9/00804 , A61F9/008 , A61F9/00829 , A61F2009/00842 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088
摘要： A method for modifying the refractive index of ocular tissues. The method comprises irradiating select regions of ocular tissue with a visible or near-IR laser. The irradiation results in the formation of structures in the ocular tissue, characterized by a change in refractive index, and which exhibit little or no scattering loss.
摘要翻译：一种改变眼组织折射率的方法。该方法包括用可见光或近红外激光照射眼组织的选择区域。照射导致眼组织中的结构的形成，其特征在于折射率的变化，并且表现出很少或没有散射损失。

79. 发明申请

US20120248307A1 Linear Ion Trap Analyzer 有权
标题翻译：线性离子阱分析仪
公开(公告)号：US20120248307A1
公开(公告)日：2012-10-04
申请号：US13079740
申请日：2011-04-04
申请人： Li Ding , Tao Lin , Gongyu Jiang , Hui Mu
发明人： Li Ding , Tao Lin , Gongyu Jiang , Hui Mu
IPC分类号： H01J49/34
CPC分类号： H01J49/423
摘要： The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.
摘要翻译：本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

80. 发明申请

US20110270038A1 VIDEO LARYNGOSCOPE 有权
标题翻译：视频曲目
公开(公告)号：US20110270038A1
公开(公告)日：2011-11-03
申请号：US13138112
申请日：2009-12-31
申请人： Wenqiang Jiang , Li Ding
发明人： Wenqiang Jiang , Li Ding
IPC分类号： A61B1/267
CPC分类号： A61B1/267 , A61B1/00052 , A61B1/00073 , A61B1/06
摘要： A video laryngoscope has a handle and a groove on one side of the handle. The groove is used for guiding a guide wire when the larynogoscope is placed in a patient's mouth. A video camera located near the end of the handle is used to view the area around the glottis. When the guide wire is properly positioned near the glottis, the upper part of the guide wire is disengaged from the groove so as to allow an endotracheal tube to be slipped over the guide wire and to be inserted into part of the trachea through the glottis. When the tube is properly inserted for intubation, the guide wire is removed from the tube. An illuminating light source such as an LED lamp can be installed at the end of the handle to provide illumination for the video camera.
摘要翻译：视频喉镜在手柄的一侧具有手柄和凹槽。当喉镜放置在患者口中时，该凹槽用于引导导丝。位于手柄末端附近的摄像机用于查看声门周围的区域。当引导线适当地定位在声门附近时，导丝的上部与凹槽脱离，以允许气管内导管滑过导丝并通过声门插入到气管的一部分中。当管正确插入插管时，导丝从管中取出。诸如LED灯的照明光源可以安装在手柄的端部以为摄像机提供照明。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式