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    • 71. 发明申请
    • LEVER TYPE CONNECTOR
    • 杠杆式连接器
    • US20130102172A1
    • 2013-04-25
    • US13808136
    • 2011-07-07
    • Tohru KobayashiTohru Suzuki
    • Tohru KobayashiTohru Suzuki
    • H01R13/629
    • H01R13/62955H01R13/62933H01R13/62938
    • A lever type connector in which workability in inserting terminals is enhanced is provided. A lever type connector 1 includes a connector housing 22 for containing terminals 61 at terminal ends of wires, and a lever 30 which is rotatably mounted on the connector housing 22, and rotated at a wire extending side of the connector housing 22 thereby to move a mating connector to be engaged with the connector housing 22 up to a normally engaged position. The lever 30 includes a pair of arm parts 31 (31a, 31b), and a connecting part 38 for interconnecting respective base end parts 51 (51a, 51b) of the arm parts 31. A recess part 53 for enlarging a distance between the base end parts 51 is provided on at least one of inner walls 50 (50a, 50b) of the base end parts 51 of the arm parts 31 which are opposed to each other.
    • 提供了一种提高了插入端子的可加工性的杠杆式连接器。 杠杆式连接器1包括用于在电线的末端容纳端子61的连接器壳体22和可旋转地安装在连接器壳体22上并在连接器壳体22的线延伸侧旋转的杆30,从而移动 配合连接器将与连接器壳体22接合直到正常接合位置。 杆30包括一对臂部31(31a,31b)和用于互连臂部31的各个基端部51(51a,51b)的连接部38.用于扩大基部之间的距离的凹部53 端部51设置在彼此相对的臂部31的基端部51的至少一个内壁50(50a,50b)上。
    • 73. 发明授权
    • Lever-type connector with a housing with plurality of projections for engaging a retaining portion of a lever
    • 杠杆式连接器,其具有多个用于接合杆的保持部分的突起的壳体
    • US08025513B2
    • 2011-09-27
    • US12877463
    • 2010-09-08
    • Tohru KobayashiShoji Yamamoto
    • Tohru KobayashiShoji Yamamoto
    • H01R13/62
    • H01R13/62938H01R13/62966
    • A lever type connector includes a lever which includes a pair of parallel plates and a grip portion connecting parallel plates each other and is attached to a connector housing. Each of the parallel plates is formed with a reception hole into which one of shafts is inserted and a cam groove. First and second retaining projections which retain the lever by engaging with a retaining portion provided on the lever are provided at opposite ends of the opposite sides of the connector housing. The lever is retained by the first retaining projection so as to be located at a position where a rear face is exposed so that a terminal connected with a wire can be inserted through the rear face, and is retained by the second retaining projection so as to dispose the cam groove at a position where the cam groove can receive a cam pin of a mating connector.
    • 杠杆式连接器包括一个杠杆,该杠杆包括一对平行板和一个把平行板相互连接并连接在连接器壳体上的把手部分。 每个平行板形成有一个轴插入其中的接收孔和一个凸轮槽。 通过与设置在杠杆上的保持部分接合而保持杠杆的第一和第二保持突起设置在连接器壳体的相对侧的相对端。 杠杆由第一保持突起保持,以便位于暴露后表面的位置,使得与线连接的端子可以通过后表面插入,并被第二保持突起保持,以便 将凸轮槽配置在凸轮槽可以容纳配合连接器的凸轮销的位置。
    • 76. 发明申请
    • ALKALINE PROTEASE
    • 碱性蛋白酶
    • US20080177040A1
    • 2008-07-24
    • US12049022
    • 2008-03-14
    • Mitsuyoshi OkudaTsuyoshi SatoKazuhiro SaitoNobuyuki SumitomoYoshifumi IzawaKatsuhisa SaekiTohru KobayashiMasafumi Nomura
    • Mitsuyoshi OkudaTsuyoshi SatoKazuhiro SaitoNobuyuki SumitomoYoshifumi IzawaKatsuhisa SaekiTohru KobayashiMasafumi Nomura
    • C07K2/00
    • C11D3/386C12N9/54C12Y304/21062
    • Provided in the present invention is an alkaline protease wherein an amino acid residue at (a) position 65, (b) position 101, (c) position 163, (d) position 170, (e) position 171, (f) position 273, (g) position 320, (h) position 359 or (i) position 387 of SEQ. ID NO:1 or at a position corresponding thereto has been selected from the following amino acid residues: position (a): proline, position (b): asparagine, position (c): histidine, aspartic acid, phenylalanine, lysine, asparagine, serine, isoleucine, leucine, glutamine, threonine and valine, position (d): valine and leucine, position (e): alanine, glutamic acid, glycine and threonine, position (f): isoleucine, glycine and threonine, position (g): phenylalanine, valine, threonine, leucine, isoleucine and glycine, position (h): serine, leucine, valine, isoleucine and glutamine, position (i): alanine, lysine, glutamine, glutamic acid, arginine and histidine.The present invention makes it possible to efficiently produce and provide alkaline proteases having activity even in the presence of a highly concentrated fatty acid, and exhibiting excellent detergency for the removal of a complex stain containing protein, sebum and the like, and therefore being useful as an enzyme to be incorporated in a detergent.
    • 在本发明中提供的是碱性蛋白酶,其中(a)位置65,(b)位置101,(c)位置163,(d)位置170,(e)位置171,(f) ,(g)位置320,(h)位置359或(i)SEQ ID NO: 位置(a):脯氨酸,位置(b):天冬酰胺,位置(c):组氨酸,天冬氨酸,苯丙氨酸,赖氨酸,天冬酰胺, 位置(d):缬氨酸和亮氨酸,位置(e):丙氨酸,谷氨酸,甘氨酸和苏氨酸,位置(f):异亮氨酸,甘氨酸和苏氨酸,位置(g) 位置(h):丝氨酸,亮氨酸,缬氨酸,异亮氨酸和谷氨酰胺,位置(i):丙氨酸,赖氨酸,谷氨酰胺,谷氨酸,精氨酸和组氨酸,位置(h):缬氨酸,缬氨酸,苏氨酸,亮氨酸,异亮氨酸和甘氨酸。 本发明使得可以有效地生产和提供具有活性的碱性蛋白酶,即使在高度浓缩的脂肪酸的存在下也具有优异的去污力来去除含有蛋白质,皮脂等的复合污渍,因此可用作 要掺入洗涤剂中的酶。
    • 77. 发明授权
    • Alkaline protease
    • 碱性蛋白酶
    • US07101698B2
    • 2006-09-05
    • US10456479
    • 2003-06-09
    • Tsuyoshi SatoMitsuyoshi OkudaYasushi TakimuraNobuyuki SumitomoMasafumi NomuraTohru Kobayashi
    • Tsuyoshi SatoMitsuyoshi OkudaYasushi TakimuraNobuyuki SumitomoMasafumi NomuraTohru Kobayashi
    • C12N9/54C12N15/74C12P21/00C07K14/32
    • C07H21/04C12N9/54
    • The present invention relates to an alkaline protease having a prepro sequence, wherein the prepro sequence is a mutant sequence of the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having 80% or higher homology to the amino acid sequence of SEQ ID NO: 1, in which amino acid residues at (a) position 52, (b) position 75, and (c) position 142 of SEQ ID NO: 1, or amino acid residues at positions corresponding to these positions are substituted by the following amino acid residues: at position (a): aspartic acid or arginine, at position (b): alanine or arginine, and at position (c): lysine; and the alkaline protease, when in a mature form, has the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having a homology of 80% or higher to this amino acid sequence. The present invention also relates to, for example, a gene encoding the alkaline protease. According to the present invention, an alkaline protease increased in production can be produced. In particular, there can be efficiently produced an alkaline protease having an activity even in the presence of a fatty acid of high concentration and exhibiting excellent detergency against complex soils containing proteins and sebum.
    • 本发明涉及具有前序列的碱性蛋白酶,其中前序列是SEQ ID NO:1的氨基酸序列的突变序列或与SEQ ID NO:1的氨基酸序列具有80%以上同源性的氨基酸序列 SEQ ID NO:1的(a)位置52,(b)位置75和(c)位置142处的氨基酸残基或对应于这些位置的位置处的氨基酸残基被替换为SEQ ID NO: 以下氨基酸残基:位置(a):天冬氨酸或精氨酸,位置(b):丙氨酸或精氨酸,和位置(c):赖氨酸; 碱性蛋白酶以成熟形式具有SEQ ID NO:2的氨基酸序列或与该氨基酸序列同源性为80%以上的氨基酸序列。 本发明还涉及例如编码碱性蛋白酶的基因。 根据本发明,可以生产生产中增加的碱性蛋白酶。 特别是,即使在高浓度的脂肪酸的存在下也能够有效地生成具有活性的碱性蛋白酶,并且对于含有蛋白质和皮脂的复杂土壤表现出优异的去污力。
    • 79. 发明申请
    • Dithia-s-indacene derivative
    • 二硫杂萘衍生物
    • US20050258398A1
    • 2005-11-24
    • US11115375
    • 2005-04-27
    • Tohru KobayashiYoshiki Hasegawa
    • Tohru KobayashiYoshiki Hasegawa
    • G02F1/13C07D495/02C07D495/04C09K19/02C09K19/34H01L51/50H05B33/14H05B33/22
    • C07D495/04C09K19/3491
    • A 1,5-dithia-s-indacene or 1,7-dithia-s-indacene derivative represented by general formula (1): wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group or an alkoxy group; R3-R12 each independently represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom or a cyano group; either of X1 and X2 represents a sulfur atom while the other represents a carbon atom; either of X3 and X4 represents a sulfur atom while the other represents a carbon atom; R13, R14, R15 or R16 is present only in the case where X1, X2, X3 or X4, respectively, is a carbon atom, and R13, R14, R15 or R16 each independently represents a hydrogen atom, an alkyl group or a halogen atom; and a broken line independently indicates a double bond in the case where X1, X2, X3 or X4 to which the broken line is connected represents a carbon atom or a broken line independently indicates a single bond in case X1, X2, X3 or X4 to which the broken line is connected represents a sulfur atom. A liquid crystal composition comprising the 1,5-dithia-s-indacene or 1,7-dithia-s-indacene derivative represented by the general formula (1). An electronic device comprising the liquid crystal composition.
    • 由通式(1)表示的1,5-二硫代顺 - 或1,5-二硫代 - 顺 - 并吲哚衍生物:其中R 1和R 2各自 独立地表示氢原子,烷基或烷氧基; R 3〜R 12各自独立地表示氢原子,烷基,烷氧基,卤素原子或氰基; X 1和X 2中的任一个表示硫原子,而另一个表示碳原子; X 3和X 4中的任一个表示硫原子,而另一个表示碳原子; R 13,R 14,R 15或R 16只存在于X < 1,X 2,X 3或X 4分别是碳原子,R 13, R 14,R 15或R 16各自独立地表示氢原子,烷基或卤素原子; 在X 1,X 2,X 3或X 4的情况下,虚线独立地表示双键, SUP>连接的虚线表示碳原子或虚线独立地表示在X 1,X 2,X 3, / SUP>或X 4连接的X 4代表硫原子。 一种液晶组合物,其包含由通式(1)表示的1,5-二硫代 - 顺 - 原油或1,7-二硫代 - 顺/并吲哚衍生物。 一种包含液晶组合物的电子器件。