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    • 74. 发明申请
    • Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    • 使用组织荧光测定糖化终产物或疾病状态的测量
    • US20070088205A1
    • 2007-04-19
    • US11561380
    • 2006-11-17
    • Edward HullMarwood EdigerChristopher BrownJohn MaynardRobert Johnson
    • Edward HullMarwood EdigerChristopher BrownJohn MaynardRobert Johnson
    • A61B5/00
    • A61B5/1455A61B5/0059A61B5/0064A61B5/0066A61B5/0068A61B5/0071A61B5/0075A61B5/14532A61B5/412A61B5/441
    • A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.
    • 确定个体中组织状态(例如,糖基化终产物或疾病状态)的量度的方法。 用激发光照射个体组织的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光,激发光的扫描(以多个波长照射组织),单个波长的检测,检测波长的扫描(检测多个波长的发射光)及其组合。 本发明还可以包括校正技术,其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如,如果不采用适当的校正,组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型,包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用,有助于测定组织状态。 本发明还包括适于执行该方法的装置,包括用于检测荧光和组织状态测量的适当的光源,检测器和模型(例如,在计算机上实现)。
    • 77. 发明申请
    • Adaptive compensation for measurement distortions in spectroscopy
    • 光谱测量失真的自适应补偿
    • US20050143943A1
    • 2005-06-30
    • US10733195
    • 2003-12-11
    • Christopher Brown
    • Christopher Brown
    • G01D18/00G01J3/28G01N21/27
    • G01J3/28G01N21/274
    • Methods of reducing the effects of measurement device artifacts on a measurement of a sample are presented. A number of reference measurements performed with the measurement device are observed to identify reference independent components of the reference measurements. The variations of the reference independent components are used as surrogates for possible artifacts of the measurement device. A number of measurements of subjects similar to the sample are observed, and similarity components of the subject measurements that vary in a manner similar to the reference independent components may be identified. The sample measurement is then adjusted to remove at least part of the similarity components that correspond to the variations in the reference independent components. The adjustment of the sample measurement is thereby improved by reducing the effects of artifacts of the measurement device.
    • 提出了减少测量装置伪影对样品测量的影响的方法。 观察使用测量装置进行的许多参考测量来识别参考测量的参考独立分量。 参考独立分量的变化被用作测量装置的可能伪影的代理。 观察到类似于样品的受试者的多个测量,并且可以以类似于参考独立成分的方式来识别受试者测量的相似性分量。 然后调整样品测量以去除与参考独立组分的变化相对应的至少部分相似性成分。 从而通过减少测量装置的伪影的影响来提高样本测量的调整。
    • 79. 发明授权
    • Three-dimensional model acquisition using planar mirrors
    • 使用平面镜的三维模型采集
    • US09230325B2
    • 2016-01-05
    • US13589023
    • 2012-08-17
    • Bo HuJacek Antoni WojtczakChristopher Brown
    • Bo HuJacek Antoni WojtczakChristopher Brown
    • H04N13/02G06T7/00G06K9/00
    • G06T7/80G06T7/55G06T2207/30196G06T2207/30204
    • 3-D model acquisition of an object is performed using two planar mirrors and a camera. According to some embodiments, 3-D reconstruction is achieved by recovering the scene geometry, including the equations of the mirrors, the camera parameters and the position of the markers, which give the location and orientation of the subjects. After establishing the geometry, a volume intersection algorithm is applied to build a 3-D model of the subject. Camera parameters and spatial constraints of the mirrors may be initially unknown. Camera parameters may be solved with reference to the object and references in the object. Further, distance from the camera to at least one point on the object may be determined once camera parameters are solved. Markers having fixed relative positions may be provided on the object for reference.
    • 使用两个平面镜和相机执行对象的3-D模型采集。 根据一些实施例,通过恢复包括反射镜的方程,摄像机参数和标记的位置的场景几何来实现3维重建,其给出了被摄体的位置和取向。 建立几何体后,应用体积交集算法来构建主体的三维模型。 镜子的相机参数和空间约束可能最初是未知的。 可以参考对象中的对象和引用来解决相机参数。 此外,一旦照相机参数被解决,可以确定从相机到物体上的至少一个点的距离。 可以在物体上提供具有固定相对位置的标记以供参考。
    • 80. 发明授权
    • Sensor circuit and display apparatus
    • 传感器电路和显示装置
    • US08658957B2
    • 2014-02-25
    • US13381291
    • 2010-06-23
    • Christopher BrownHiromi KatohKohei Tanaka
    • Christopher BrownHiromi KatohKohei Tanaka
    • H01L27/00
    • H01L31/101G02F1/13318G02F1/13338G06F3/0412G06F3/044G09G2360/142G09G2360/144H01L27/1446
    • A sensor circuit or a display apparatus from which a highly accurate sensor output can be obtained includes a photodiode, a capacitor that is connected to the photodiode via an accumulation node and accumulates charges according to an electric current in the photodiode; a sensor switching element transistor that causes the accumulation node and an output line to be conductive with respect to each other in response to a readout signal and outputs an output signal according to the potential of the accumulation node to the output line; a variable capacitor that is provided between the accumulation node and an input electrode, and whose capacitance varies when a pressure is applied by a touching operation; and a control switching element transistor to which a control signal for switching conduction and non-conduction between the variable capacitor and the accumulation node is input.
    • 可以从其获得高精度传感器输出的传感器电路或显示装置包括光电二极管,经由累积节点连接到光电二极管的电容器,并根据光电二极管中的电流累积电荷; 传感器开关元件晶体管,其响应于读出信号使所述累积节点和输出线相对于彼此导电,并且根据所述累积节点的电位将输出信号输出到所述输出线; 设置在所述蓄积节点和输入电极之间的可变电容器,并且当通过触摸操作施加压力时,其电容变化; 以及输入用于切换可变电容器和累积节点之间的导通和非导通的控制信号的控制开关元件晶体管。