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71. 发明申请

US20140048702A1 Ion Guide With Orthogonal Sampling 有权
标题翻译：离子指南与正交采样
公开(公告)号：US20140048702A1
公开(公告)日：2014-02-20
申请号：US14004529
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/02
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The Ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.
摘要翻译：公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不是轴向的被捕获或以其它方式轴向限制在RF离子导向器内。离子导向器在使用中以选自以下的压力保持：（i）0.0001-0.001毫巴; （ii）0.001-0.01毫巴; （iii）0.01-0.1毫巴; （iv）0.1-1毫巴; （v）1-10毫巴; （vi）10-100毫巴; 和（vii）> 100mbar。

72. 发明授权

US08106350B2 Correction of deadtime effects in mass spectrometry 有权
标题翻译：修正质谱中的死时效应
公开(公告)号：US08106350B2
公开(公告)日：2012-01-31
申请号：US11816643
申请日：2006-02-22
申请人： Martin Green , Jason Lee Wildgoose , Marc V. Gorenstein
发明人： Martin Green , Jason Lee Wildgoose , Marc V. Gorenstein
IPC分类号： H01J49/26
CPC分类号： H01J49/025 , H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.
摘要翻译：公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Qi来校正质谱中的失真，其中：式（I），其中qi是离子到达的实际总数记录在第i个时间段中的事件和x是对应于与估计的死时间周期相对应的时间段数的整数。

73. 发明授权

US08076637B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08076637B2
公开(公告)日：2011-12-13
申请号：US12524378
申请日：2008-01-25
申请人： Steven Derek Pringle , Jason Lee Wildgoose
发明人： Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译：公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。所得到的离子信号被去卷积以提供质谱。

74. 发明申请

US20100327157A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100327157A1
公开(公告)日：2010-12-30
申请号：US12518173
申请日：2007-12-10
申请人： Martin Green , Jason Lee Wildgoose
发明人： Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/065 , H01J49/40 , H01J49/4225 , H01J49/426
摘要： A mass spectrometer is disclosed comprising a time of flight mass analyser (7). The time of flight mass analyser (7) comprises an ion guide comprising a plurality of electrodes (1) which are interconnected by a series of resistors (2) forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes (1). A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.
摘要翻译：公开了一种包括飞行时间质量分析器（7）的质谱仪。飞行时间质量分析器（7）包括离子导向器，其包括由形成分压器的一系列电阻器（2）互连的多个电极（1）。通过向电极（1）施加两相RF电压，离子在径向上被限制在离子导向器内。在分压器上施加单相附加RF电压，使得沿着离子导向器的长度保持不均匀的伪势力。

75. 发明申请

US20100096543A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20100096543A1
公开(公告)日：2010-04-22
申请号：US12522769
申请日：2008-01-15
申请人： Daniel James Kenny , Jason Lee Wildgoose
发明人： Daniel James Kenny , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/401
摘要： A Time of Flight mass analyser is disclosed wherein the time period between successive orthogonal acceleration pulses is less than the time of flight of ions having the maximum mass to charge ratio of interest. As a result, some ions are subject to wrap-around and will appear in a subsequent mass spectrum. Mass spectra obtained at two different sampling rates may be compared and mass peaks relating to ions which have and have not been subject to wrap-around may be identified.
摘要翻译：公开了一种飞行时间质量分析器，其中连续正交加速脉冲之间的时间段小于具有最大质荷比的离子的飞行时间。结果，一些离子被卷绕并将出现在随后的质谱中。可以比较以两种不同采样速率获得的质谱，并且可以鉴定与具有和未被卷绕的离子相关的质谱峰。

76. 发明授权

US09190251B2 Pre-scan for mass to charge ratio range 有权
标题翻译：预扫描质量与充电比例范围
公开(公告)号：US09190251B2
公开(公告)日：2015-11-17
申请号：US14004520
申请日：2012-03-13
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , H01J49/0031
摘要： A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters.
摘要翻译：公开了一种质谱法，其包括在第一次分析期间根据一个或多个参数对离子样品进行第一次分析，其中扫描一个或多个参数和/或离子。然后自动确定来自第一次分析的一个或多个参数的一个或多个感兴趣范围。然后自动执行离子样品的第二次后续分析，其中第二分析限于一个或多个参数的一个或多个感兴趣的范围。

77. 发明申请

US20140326867A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20140326867A1
公开(公告)日：2014-11-06
申请号：US14270433
申请日：2014-05-06
申请人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译：公开了一种质谱仪，其中离子信号被分成第一和第二信号。第一和第二信号乘以不同的增益并被数字化。对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。然后将光谱与其他对应的光谱组合以形成相加光谱。

78. 发明授权

US08779354B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08779354B2
公开(公告)日：2014-07-15
申请号：US13453657
申请日：2012-04-23
申请人： Martin Green , Jason Lee Wildgoose , Jeffrey Mark Brown
发明人： Martin Green , Jason Lee Wildgoose , Jeffrey Mark Brown
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了一种质谱仪，其包括电子转移解离单元。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。电池包括形成球形捕获体积的多个环形电极。在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。从而提供具有增强的灵敏度的电子转移解离电池。在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

79. 发明授权

US08735808B2 Method of mass spectrometry and mass spectrometer using peak deconvolution 有权
标题翻译：使用峰值去卷积的质谱法和质谱仪的方法
公开(公告)号：US08735808B2
公开(公告)日：2014-05-27
申请号：US13576344
申请日：2011-02-14
申请人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
发明人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
IPC分类号： H01J49/40 , G01R23/16
CPC分类号： H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitized by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.
摘要翻译：公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。然后将多个离子到达时间组合以产生复合离子到达时间强度谱。

80. 发明申请

US20140048701A1 Pre-Scan For Mass to Charge Ratio Range 有权
标题翻译：预扫描质量与充电比率范围
公开(公告)号：US20140048701A1
公开(公告)日：2014-02-20
申请号：US14004520
申请日：2012-03-13
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , H01J49/0031
摘要： A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters.
摘要翻译：公开了一种质谱法，其包括在第一次分析期间根据一个或多个参数对离子样品进行第一次分析，其中扫描一个或多个参数和/或离子。然后自动确定来自第一次分析的一个或多个参数的一个或多个感兴趣范围。然后自动执行离子样品的第二次后续分析，其中第二分析限于一个或多个参数的一个或多个感兴趣的范围。

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