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71. 发明申请

US20110125206A1 SINGLE CHAMBER IMPLANTABLE MEDICAL DEVICE FOR CONFIRMING ARRHYTHMIA THROUGH RETROSPECTIVE CARDIAC SIGNALS 审中-公开
标题翻译：通过回顾性心脏病信号确认ARRHYTHMIA的单室可植入医疗器械
公开(公告)号：US20110125206A1
公开(公告)日：2011-05-26
申请号：US12625416
申请日：2009-11-24
申请人： Gene A. Bornzin , Jong Gill , Jeffery D. Snell
发明人： Gene A. Bornzin , Jong Gill , Jeffery D. Snell
IPC分类号： A61N1/39 , A61B5/0452 , A61B5/046
CPC分类号： A61N1/36507 , A61B5/0031 , A61B5/0422 , A61B5/0452 , A61N1/3956
摘要： An implantable medical device is provided that comprises a housing, sensors configured to be located to proximate a heart, and a sensing module to sense cardiac signals originating from the heart over a channel defined by the sensors. The cardiac signals include intrinsic R-wave events and associated intrinsic confirmation events when the heart exhibits normal sinus rhythm. The device further includes memory to store the cardiac signals sensed over a channel, and a detection module. The detection module identifies an R-wave event within the cardiac signals. The detection module captures, in the memory, a segment of the cardiac signals that precedes the R-wave event as a retrospective segment. The detection module determines whether the retrospective segment includes an intrinsic confirmation event that is associated with and occurs before the R-wave event. The detection module declares an arrhythmia based at least in part on the determination of whether the retrospective segment includes the intrinsic confirmation event is absent from the retrospective segment.
摘要翻译：提供了一种植入式医疗装置，其包括壳体，被配置为邻近心脏定位的传感器，以及感测模块，用于感测通过由传感器限定的通道的来自心脏的心脏信号。当心脏呈现正常窦性心律时，心脏信号包括固有的R波事件和相关的固有确认事件。该装置还包括用于存储通过信道感测的心脏信号的存储器和检测模块。检测模块识别心脏信号内的R波事件。检测模块在存储器中捕获在作为回顾段的R波事件之前的心脏信号的一部分。检测模块确定回溯段是否包括与R波事件相关联并发生的固有确认事件。检测模块至少部分地基于回顾段中是否包含内在确认事件的确定来声明心律失常。

72. 发明授权

US07908004B1 Considering cardiac ischemia in electrode selection 有权
标题翻译：考虑到电极选择中的心脏缺血
公开(公告)号：US07908004B1
公开(公告)日：2011-03-15
申请号：US11847878
申请日：2007-08-30
申请人： Jong Gill , Kyungmoo Ryu
发明人： Jong Gill , Kyungmoo Ryu
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61B5/04525 , A61N1/3686
摘要： Exemplary systems, devices, and methods for considering cardiac ischemia in electrode selection are described. One method determines whether an electrode of a multiple-electrode lead is proximate a region of cardiac ischemia or infarct. The method also paces through a different electrode of the multiple-electrode lead in an instance where the electrode is determined to be proximate the region.
摘要翻译：描述了用于考虑电极选择中心脏缺血的示例性系统，装置和方法。一种方法确定多电极引线的电极是否接近心脏缺血或梗死的区域。在确定电极靠近该区域的情况下，该方法还穿过多电极引线的不同电极。

73. 发明授权

US07783352B1 Optimizing anti-tachycardia pacing for terminating atrial fibrillation 有权
标题翻译：优化抗心动过速起搏用于终止房颤
公开(公告)号：US07783352B1
公开(公告)日：2010-08-24
申请号：US11473403
申请日：2006-06-23
申请人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/08
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395
摘要： An implantable system terminates atrial fibrillation by applying optimized anti-tachycardia pacing (ATP). In one implementation, the system senses and paces at multiple sites on the left atrium. At each site, the system senses reentrant circuits causing the atrial fibrillation. In one implementation, the system applies ATP tuned to the frequency of the reentrant circuit at the electrode that senses the most regular reentrant circuit. In another implementation, the system applies ATP at multiple electrodes, delivering each pulse at each site when the excitable gap is near the site. In other variations, the ATP is optimized for different patterns of sequential, simultaneous, or syncopated delivery to terminate the atrial fibrillation. The system can also monitor multiple heart chambers for cardiac events that favor terminating atrial fibrillation via ATP. The system then times delivery of the ATP according to these cardiac events.
摘要翻译：可植入系统通过应用优化的抗心动过速起搏（ATP）来终止房颤。在一个实施中，系统在左心房的多个位置感觉和步调。在每个部位，系统检测引起房颤的折返回路。在一个实现中，该系统将ATP调谐到感测最常规的可重入电路的电极处的可重入电路的频率。在另一个实施方案中，该系统在多个电极上施加ATP，当可兴奋的间隙在该位置附近时，在每个位置递送每个脉冲。在其他变体中，ATP针对不同的顺序，同时或间歇递送模式进行优化，以终止心房颤动。该系统还可以监测多个心室，用于通过ATP终止心房颤动的心脏事件。然后系统根据这些心脏事件递送ATP。

74. 发明申请

US20100121396A1 ENHANCED HEMODYNAMICS THROUGH ENERGY-EFFICIENT ANODAL PACING 审中-公开
标题翻译：通过高能量阳极加强增强血液动力学
公开(公告)号：US20100121396A1
公开(公告)日：2010-05-13
申请号：US12267941
申请日：2008-11-10
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61N1/3627 , A61N1/36535 , A61N1/36557 , A61N1/36564 , A61N1/37252 , A61N2001/083
摘要： An implantable device may employ anodal-based cardiac stimulation to improve hemodynamics. Anodal pacing may be provided on a conditional basis (e.g., upon detection of a defined condition). An implantable device may provide anodal pacing or cathodal pacing according to a defined ratio. An implantable device may use automatic capture detection to determine a pacing energy level that provides effective anodal pacing while attempting to minimize the power consumption associated with the anodal pacing.
摘要翻译：可植入装置可采用基于阳极的心脏刺激来改善血液动力学。可以在有条件的基础上（例如，在检测到定义的条件时）提供定型起搏。可植入装置可以根据规定的比例提供阳极起搏或阴极起搏。可植入装置可以使用自动捕获检测来确定提供有效的阳极起搏的起搏能量水平，同时尝试最小化与阳极起搏相关联的功率消耗。

75. 发明申请

US20100121394A1 System and Method for Setting Atrioventricular Pacing Delays Based on Far-Field Atrial Signals 审中-公开
公开(公告)号：US20100121394A1
公开(公告)日：2010-05-13
申请号：US12267476
申请日：2008-11-07
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0452
摘要： An intrinsic inter-atrial conduction delay is determined by a pacemaker or implantable cardioverter-defibrillator based, at least in part, on far-field atrial events sensed using ventricular pacing/sensing leads. An atrioventricular pacing delay is then set based on the inter-atrial conduction delay. By detecting atrial events using ventricular leads, rather than using atrial leads, a more useful measurement of the intrinsic inter-atrial conduction delay can be obtained. In this regard, since atrial electrodes detect atrial activity locally around the electrodes, a near-field atrial event sensed using an atrial electrode might not properly represent the actual timing of the atrial event across both the right and left atria. Far-field atrial events sensed using ventricular leads thus allow for a more useful measurement of inter-atrial conduction delays for use in setting atrioventricular pacing delays. The delivery of individual V-pulses to the heart of the patient may be timed relative to the ends of individual far-field atrial events.

76. 发明授权

US07505813B1 System and method for determining preferred atrioventricular pacing delay values based on intracardiac electrogram signals 有权
标题翻译：基于心内电图信号确定优选房室起搏延迟值的系统和方法
公开(公告)号：US07505813B1
公开(公告)日：2009-03-17
申请号：US11199619
申请日：2005-08-08
申请人： Jong Gill , Alexander Huemmer , Gene A. Bornzin , Euljoon Park
发明人： Jong Gill , Alexander Huemmer , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3682
摘要： Techniques are provided for use by an implantable medical device for determining optimal or preferred atrioventricular (AV) pacing delay values for use in pacing the heart. Briefly, the atria and ventricles are paced using an initial AV pacing delay set to a value less than an intrinsic AV conduction delay so that intrinsic ventricular depolarizations are avoided. An internal electrical cardiac signal is sensed and atrial evoked responses and subsequent ventricular evoked responses are identified therein. Time delays between the atrial and ventricular evoked responses are measured and then a preferred or optimal AV pacing delay value is determined based on: the initial AV pacing delay; the measured time delays between the atrial and ventricular evoked responses; and on a predetermined preferred time delay to be achieved between atrial and ventricular evoked responses. Similar procedures are employed in connection with atrial sensed events. A calibration procedure is also described.
摘要翻译：技术被提供用于由可植入医疗装置用于确定用于起搏心脏的最佳或优选房室（AV）起搏延迟值。简而言之，心房和心室使用初始AV起搏延迟设定为小于固有AV传导延迟的值来进行起搏，从而避免内在的心室去极化。感测到内部电气心脏信号，并在其中识别心房诱发反应和随后的心室诱发反应。测量心房和心室诱发反应之间的时间延迟，然后基于：初始AV起搏延迟确定优选的或最佳的AV起搏延迟值; 测量心房和心室诱发反应之间的时间延迟; 并且在心房和心室诱发反应之间达到预定的优选时间延迟。与心房感觉事件有关的类似手术。还描述了校准过程。

77. 发明授权

US07289847B1 Implantable cardiac device and method of treating atrial fibrillation 有权
标题翻译：植入式心脏装置及治疗心房颤动的方法
公开(公告)号：US07289847B1
公开(公告)日：2007-10-30
申请号：US11038553
申请日：2005-01-18
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： An apparatus and method of treating atrial fibrillation (AF) are provided. The apparatus includes means for detecting AF in a heart of a patient, means for classifying the AF as one of a plurality of AF types, means for selecting a therapy for delivery to the heart, from a plurality of therapies, based on AF type, and means for delivering the selected therapy to the heart. The plurality of therapies includes ATP therapy, a hybrid therapy including a combination of ATP therapy and drug therapy, and shock therapy. The method includes sensing an electrogram signal from the heart, analyzing the electrogram signal to detect AF in the heart, classifying the AF as one of a plurality of AF types, selecting a therapy for delivery to the heart, from a plurality of therapies, based on the AF type, and delivering the selected therapy to the heart.
摘要翻译：提供了一种治疗心房颤动（AF）的装置和方法。该装置包括用于检测患者心脏中的AF的装置，用于将AF分类为多个AF类型之一的装置，用于基于AF类型从多种治疗中选择用于递送至心脏的治疗的装置，以及用于将所选择的治疗递送至心脏的装置。多种疗法包括ATP疗法，包括ATP疗法和药物治疗组合的混合疗法以及休克疗法。该方法包括感测来自心脏的电描记图信号，分析电描记图信号以检测心脏中的AF，将AF分类为多个AF类型之一，从多个疗法中选择用于递送至心脏的治疗，基于在AF类型上，并将所选择的治疗递送到心脏。

78. 发明授权

US09002450B2 Systems and methods for assessing the sphericity and dimensional extent of heart chambers for use with an implantable medical device 有权
标题翻译：用于评估与可植入医疗装置一起使用的心室的球形度和尺寸范围的系统和方法
公开(公告)号：US09002450B2
公开(公告)日：2015-04-07
申请号：US12975085
申请日：2010-12-21
申请人： Stuart Rosenberg , Yelena Nabutovsky , Cecilia Qin Xi , Jong Gill , Kyungmoo Ryu , Brian Jeffrey Wenzel , William Hsu
发明人： Stuart Rosenberg , Yelena Nabutovsky , Cecilia Qin Xi , Jong Gill , Kyungmoo Ryu , Brian Jeffrey Wenzel , William Hsu
IPC分类号： A61N1/00 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： Techniques are provided for use with an implantable medical device for assessing left ventricular (LV) sphericity and atrial dimensional extent based on impedance measurements for the purposes of detecting and tracking heart failure and related conditions such as volume overload or mitral regurgitation. In some examples described herein, various short-axis and long-axis impedance vectors are exploited that pass through portions of the LV for the purposes of assessing LV sphericity. In other examples, impedance measurements taken along a vector between a right atrial (RA) ring electrode and an LV electrode implanted near the atrioventricular (AV) groove are exploited to assess LA extent, biatrial extent or mitral annular diameter. The assessment techniques can be employed alone or in conjunction with other heart failure detection techniques, such as those based on left atrial pressure (LAP.)
摘要翻译：提供技术用于可植入医疗装置，用于基于阻抗测量来评估左心室（LV）球形度和心房尺寸范围，以便检测和跟踪心力衰竭和相关状况（例如体积过载或二尖瓣反流）。在本文描述的一些示例中，为了评估LV球形度的目的，利用穿过LV的部分的各种短轴和长轴阻抗矢量。在其他示例中，利用沿右心房（RA）环电极和植入在房室（AV）槽附近的LV电极之间的载体进行的阻抗测量来评估LA范围，生物学程度或二尖瓣环直径。评估技术可以单独使用或与其他心力衰竭检测技术结合使用，例如基于左心房压力（LAP）的那些。

79. 发明授权

US08478405B2 Optimizing anti-tachycardia pacing for terminating atrial fibrillation 有权
标题翻译：优化抗心动过速起搏用于终止房颤
公开(公告)号：US08478405B2
公开(公告)日：2013-07-02
申请号：US12841012
申请日：2010-07-21
申请人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/08
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/395
摘要： An implantable system terminates atrial fibrillation by applying optimized anti-tachycardia pacing (ATP). In one implementation, the system senses and paces at multiple sites on the left atrium. At each site, the system senses reentrant circuits causing the atrial fibrillation. In one implementation, the system applies ATP tuned to the frequency of the reentrant circuit at the electrode that senses the most regular reentrant circuit. In another implementation, the system applies ATP at multiple electrodes, delivering each pulse at each site when the excitable gap is near the site. In other variations, the ATP is optimized for different patterns of sequential, simultaneous, or syncopated delivery to terminate the atrial fibrillation. The system can also monitor multiple heart chambers for cardiac events that favor terminating atrial fibrillation via ATP. The system then times delivery of the ATP according to these cardiac events.
摘要翻译：可植入系统通过应用优化的抗心动过速起搏（ATP）来终止房颤。在一个实施中，系统在左心房的多个位置感觉和步调。在每个部位，系统检测引起房颤的折返回路。在一个实现中，该系统将ATP调谐到感测最常规的可重入电路的电极处的可重入电路的频率。在另一个实施方案中，该系统在多个电极上施加ATP，当可兴奋的间隙在该位置附近时，在每个位置递送每个脉冲。在其他变体中，ATP针对不同的顺序，同时或间歇递送模式进行优化，以终止心房颤动。该系统还可以监测多个心室，用于通过ATP终止心房颤动的心脏事件。然后系统根据这些心脏事件递送ATP。

80. 发明申请

US20130158619A1 MULTI-VENTRICULAR SITE TIMING OPTIMIZATION USING CARDIOGENIC IMPEDANCE 审中-公开
标题翻译：多中心站点时序优化使用心脏阻力
公开(公告)号：US20130158619A1
公开(公告)日：2013-06-20
申请号：US13329091
申请日：2011-12-16
申请人： Kwangdeok Lee , Jong Gill , Kyungmoo Ryu
发明人： Kwangdeok Lee , Jong Gill , Kyungmoo Ryu
IPC分类号： A61N1/365
CPC分类号： A61N1/3684 , A61B5/0538 , A61B5/686 , A61B5/6869 , A61N1/36521 , A61N1/3682
摘要： A method of calculating a timing delay for an implantable medical device based on cardiogenic impedance estimates cardiogenic impedance from a signal between a first electrode and a second electrode positioned in at least one chamber of a heart. The method also determines the timing delay based on the estimated cardiogenic impedance.
摘要翻译：基于心源阻抗计算可植入医疗装置的定时延迟的方法根据位于心脏的至少一个腔室中的第一电极和第二电极之间的信号估计心源阻抗。该方法还基于估计的心源阻抗确定定时延迟。

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