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71. 发明授权

US08911406B2 Guide wire exchange catheter system 有权
标题翻译：导丝交换导管系统
公开(公告)号：US08911406B2
公开(公告)日：2014-12-16
申请号：US11457147
申请日：2006-07-12
申请人： Douglas G. Evans , John E. Nash , Steven J. Link
发明人： Douglas G. Evans , John E. Nash , Steven J. Link
IPC分类号： A61M5/178 , A61M25/09 , A61M25/01
CPC分类号： A61M25/09041 , A61M25/0172 , A61M2025/018 , A61M2025/0183
摘要： A guide wire exchange system including an elongate, flexible, guide wire exchange catheter capable exchanging one guide wire for another in a safe, efficient, and secured manner, where a primary guide wire, after having been advanced through the body, is to be replaced with a secondary guide wire that is to be securely advanced through the body to the target site by the advancement of the exchange catheter over the path of the primary wire. The exchange catheter may include a securement element in order to releasably secure at least one guide wire to the exchange catheter at or near the distal end of the exchange catheter. Once secured, both the exchange catheter and the secured guide wire(s) may be advanced or retracted in a synchronous manner, without the possibility of divergence at the distal ends of the secured components as they are being manipulated by an operator.
摘要翻译：引导线交换系统，其包括细长的，柔性的导丝线交换导管，其能够以安全，有效和固定的方式交换一根导丝，其中主导丝在被推进穿过身体之后被更换其中次级导丝将通过在主线路的路径上的交换导管的前进而牢固地推进到身体到达目标位置。交换导管可以包括固定元件，以便在交换导管的远端处或附近将至少一根导丝可释放地固定到交换导管。一旦固定，交换导管和固定的导丝线可以以同步方式前进或缩回，而不会在被操作者操纵的情况下在固定部件的远端发散。

72. 发明授权

US08523801B2 Catheter with associated extension lumen 有权
标题翻译：导管与相关的延伸腔
公开(公告)号：US08523801B2
公开(公告)日：2013-09-03
申请号：US13597037
申请日：2012-08-28
申请人： John E. Nash , Gregory Walters
发明人： John E. Nash , Gregory Walters
IPC分类号： A61M25/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22039 , A61B2017/22082 , A61B2017/22084 , A61B2217/005 , A61M1/0084 , A61M25/0032
摘要： An intra-luminal device for the extraction of occlusive or partially occlusive material is disclosed. Said device comprises a novel catheter extension which minimizes cavitation of extracted fluids and also allows the better navigation of tortuous lumens or vasculature.
摘要翻译：公开了用于提取闭塞或部分封闭材料的腔内装置。所述装置包括一个新的导管延伸部，其最小化提取的流体的空化，并且还允许更好地导航曲折的内腔或脉管系统。

73. 发明申请

US20120323168A1 CATHETER WITH ASSOCIATED EXTENSION LUMEN 有权
标题翻译：带有相关延伸灯的导管
公开(公告)号：US20120323168A1
公开(公告)日：2012-12-20
申请号：US13597037
申请日：2012-08-28
申请人： John E. Nash , Gregory Walters
发明人： John E. Nash , Gregory Walters
IPC分类号： A61M1/00 , A61M5/168
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22039 , A61B2017/22082 , A61B2017/22084 , A61B2217/005 , A61M1/0084 , A61M25/0032
摘要： An intra-luminal device for the extraction of occlusive or partially occlusive material is disclosed. Said device comprises a novel catheter extension which minimizes cavitation of extracted fluids and also allows the better navigation of tortuous lumens or vasculature.
摘要翻译：公开了用于提取闭塞或部分封闭材料的腔内装置。所述装置包括一个新的导管延伸部，其最小化提取的流体的空化，并且还允许更好地导航曲折的内腔或脉管系统。

74. 发明授权

US07998107B2 Interventional procedure drive and control system 有权
标题翻译：介入程序驱动和控制系统
公开(公告)号：US07998107B2
公开(公告)日：2011-08-16
申请号：US10253034
申请日：2002-09-24
申请人： John E. Nash , Gregory Walters , Stephen Heiman , Jim Barnitz , Pete Fatone
发明人： John E. Nash , Gregory Walters , Stephen Heiman , Jim Barnitz , Pete Fatone
IPC分类号： A61M1/00
CPC分类号： A61M1/0058 , A61M1/0035
摘要： A pumping system for use in medical applications where liquids must be infused and aspirated from a mammalian patient, and whose economics are such that it is cost effective to simply dispose of it after a single use. The system features positive displacement pump(s) such as reciprocating pump(s) containing a damping mechanism to dampen out the peaks and valleys in the fluid pressure that is pumped, which is important for preventing cavitation. The system furthermore features a shut-off valve on the extraction side so that certain injected fluids such as contrast medium, are not immediately pumped out of the patient. In a preferred embodiment, the system also features means for independently controlling the fluid pressure/volume on the infusion and extraction sides, self-priming capability, a continuous fluid path, and visual air bubble detection, with viewports located at important points in the fluid path, such as at pumps and valves.
摘要翻译：一种用于医疗应用的泵送系统，其中液体必须从哺乳动物患者输注和吸入，并且其经济性使得在一次使用后简单处置它具有成本效益。该系统具有容积式泵，例如包含阻尼机构的往复泵，以阻止所泵送的流体压力中的峰和谷，这对于防止空化是重要的。该系统还具有在提取侧的截止阀，使得某些注射的流体（例如造影剂）不会立即泵出患者体内。在优选实施例中，系统还具有用于独立地控制输液和抽出侧的流体压力/体积，自吸能力，连续流体路径和视觉气泡检测的装置，其中视口位于流体中的重要点路径，如泵和阀门。

75. 发明申请

US20100094196A1 Systems and methods for delivering agents into targeted tissue of a living being 审中-公开
标题翻译：将药剂递送到生活目标组织中的系统和方法
公开(公告)号：US20100094196A1
公开(公告)日：2010-04-15
申请号：US12567592
申请日：2009-09-25
申请人： John E. Nash , Douglas G. Evans , David M. Hoganson
发明人： John E. Nash , Douglas G. Evans , David M. Hoganson
IPC分类号： A61M25/00 , A61M5/307 , A61F2/84 , A61B17/32 , A61N1/00
CPC分类号： A61B17/32037 , A61B17/320758 , A61B17/3478 , A61B18/14 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22038 , A61B2018/00208 , A61B2018/00291 , A61B2018/00392 , A61B2018/00839 , A61B2018/1861 , A61B2018/2005
摘要： The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
摘要翻译：该系统基本上包括用于进入生命体内的目标组织的递送系统，以及在心肌和其它选择组织中的选定位置处引入至少一种药剂。输送系统被布置成进入心脏的组织。可以在经腔，经胸和直接手术进入程序中使用一个或多个系统。在适当的情况下，例如在心室内进入的情况下，系统的部分可操纵以适当地定向装置。仪器可以刺穿心脏组织并产生从心内膜，心外膜或心脏血管延伸的通道。当使用组织穿透时，该装置可以包括控制穿透深度的特征。为了最大程度地减少通道通道的流出，设备可以扩大小的初始穿刺，后来在设备移除后收缩。当需要形成通道时，可以通过例如旋转尖端装置，加压流体喷射装置，振动器械和刺穿针状尖端装置来实现。该系统可以在该过程中利用某种形式的机械作用或能量的应用（例如电，声，热，光，加压流体，射频（RF），核）。机械作用或能量施加可能会影响距离设备一定距离的周围组织。递送到组织的药剂可以包括一种或多种药物，生物活性剂，不透射线材料等。

76. 发明申请

US20080082049A1 GUIDE WIRE EXCHANGE CATHETER SYSTEM 有权
标题翻译：指导式交流电源系统
公开(公告)号：US20080082049A1
公开(公告)日：2008-04-03
申请号：US11457147
申请日：2006-07-12
申请人： Douglas G. Evans , John E. Nash , Steven J. Link
发明人： Douglas G. Evans , John E. Nash , Steven J. Link
IPC分类号： A61M5/178
CPC分类号： A61M25/09041 , A61M25/0172 , A61M2025/018 , A61M2025/0183
摘要： A guide wire exchange system including an elongate, flexible, guide wire exchange catheter capable exchanging one guide wire for another in a safe, efficient, and secured manner, where a primary guide wire, after having been advanced through the body, is to be replaced with a secondary guide wire that is to be securely advanced through the body to the target site by the advancement of the exchange catheter over the path, of the primary wire. The exchange catheter may include a securement element in order to releasably secure at least one guide wire to the exchange catheter at or near the distal end of the exchange catheter. Once secured, both the exchange catheter and the secured guide wire(s) may be advanced or retracted in a synchronous manner, without the possibility of divergence at the distal ends of the secured components as they are being manipulated by an operator.
摘要翻译：引导线交换系统，其包括细长的，柔性的导丝线交换导管，其能够以安全，有效和固定的方式交换一根导丝，其中主导丝在被推进穿过身体之后被更换其中次级导丝将通过主导线的路径上的交换导管的前进而被牢固地推进到身体到达目标位置。交换导管可以包括固定元件，以便在交换导管的远端处或附近将至少一根导丝可释放地固定到交换导管。一旦固定，交换导管和固定的导丝线可以以同步方式前进或缩回，而不会在被操作者操纵的情况下在固定部件的远端发散。

77. 发明授权

US06261244B1 Viscosity measuring apparatus and method of use 失效
标题翻译：粘度测量装置及其使用方法
公开(公告)号：US06261244B1
公开(公告)日：2001-07-17
申请号：US09383177
申请日：1999-08-25
申请人： Kenneth Kensey , John E. Nash , Harold E. Clupper
发明人： Kenneth Kensey , John E. Nash , Harold E. Clupper
IPC分类号： A61B500
CPC分类号： A61B5/150786 , A61B5/02035 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6866 , G01N11/04 , G01N11/08 , G06F19/00
摘要： A blood viscosity measuring system and method that monitors the rising head of a column of fluid representing a living being's blood in-vivo to determine the blood viscosity over a range of shears. The system includes a capillary tube, at least a portion of which is located within the vascular system of the being, and a riser tube, having a liquid therein coupled to the capillary tube. A sensor and associated microprocessor are provided to determine the change in the height of the liquid in the riser tube at plural points along the length of the tube from which the viscosity is calculated.
摘要翻译：一种血液粘度测量系统和方法，其在体内监测表示活体血液的一列流体的上升头，以确定剪切范围内的血液粘度。该系统包括毛细管，其毛细管的至少一部分位于血管系统的内部，以及提升管，其中具有联接到毛细管的液体。提供传感器和相关的微处理器以确定沿着管的长度的多个点处的提升管中液体的高度的变化，其中计算粘度。

78. 发明授权

US6056762A Anastomosis system and method of use 失效
标题翻译：吻合系统及使用方法
公开(公告)号：US6056762A
公开(公告)日：2000-05-02
申请号：US861584
申请日：1997-05-22
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/11 , A61F2/06
CPC分类号： A61B17/11 , A61F2/064 , A61B2017/00004 , A61B2017/1107 , A61B2017/1135 , A61F2002/065
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes an anastomosis connector device and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The deployment device may include a dilator to facilitate the placement of the anastomosis device within the interior of the vessel, duct, lumen or other tubular organ. The anastomosis device is preferably formed of a resorbable material and is configured to minimize blood or other fluid turbulence therethrough. The device may include snap-connectors or other components for securing it to the tissue of the vessel, duct, lumen or tubular organ and hemostasis-inducing sealing rings to prevent blood leakage. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.
摘要翻译：用于实现生物体内的天然血管，管道，管腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括吻合连接器装置和用于将装置运送到血管，管道，管腔或管状器官内所需位置的展开装置。展开装置可以包括扩张器，以便于将吻合装置放置在血管，管道，管腔或其它管状器官的内部。吻合装置优选地由可再吸收的材料形成并且被构造成使通过其中的血液或其它流体湍流最小化。该装置可以包括卡扣连接器或其它部件，用于将其固定到血管，管道，管腔或管状器官的组织，以及止血诱导密封环以防止血液渗漏。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。

79. 发明授权

US6036705A Anastomosis connection system and method of use 有权
公开(公告)号：US6036705A
公开(公告)日：2000-03-14
申请号：US323193
申请日：1999-06-01
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/11 , A61F2/06
CPC分类号： A61B17/11 , A61F2/064 , A61B2017/00004 , A61B2017/1107 , A61B2017/1135 , A61F2002/065
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes an anastomosis connector device and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The deployment device may include a dilator to facilitate the placement of the anastomosis device within the interior of the vessel, duct, lumen or other tubular organ. The anastomosis device is preferably formed of a resorbable material and is configured to minimize blood or other fluid turbulence therethrough. The device may include snap-connectors or other components for securing it to the tissue of the vessel, duct, lumen or tubular organ and hemostasis-inducing sealing rings to prevent blood leakage. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.

80. 发明授权

US6019735A Viscosity measuring apparatus and method of use 失效
公开(公告)号：US6019735A
公开(公告)日：2000-02-01
申请号：US919906
申请日：1997-08-28
申请人： Kenneth Kensey , John E. Nash , Harold E. Clupper
发明人： Kenneth Kensey , John E. Nash , Harold E. Clupper
IPC分类号： G01N33/49 , A61B5/145 , A61B5/15 , A61B5/157 , A61B8/12 , A61B10/00 , A61B18/00 , A61B19/00 , G01N11/00 , G01N11/04 , G01N33/15 , G01N33/487 , A61B5/00
CPC分类号： A61B5/150786 , A61B5/02035 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6866 , G01N11/04 , G01N11/08
摘要： A blood viscosity measuring system and method that monitors the rising head of a column of fluid representing a living being's blood in-vivo to determine the blood viscosity over a range of shears. The system includes a capillary tube, at least a portion of which is located within the vascular system of the being, and a riser tube, having a liquid therein coupled to the capillary tube. A sensor and associated microprocessor are provided to determine the change in the height of the liquid in the riser tube at plural points along the length of the tube from which the viscosity is calculated.

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