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71. 发明授权

US08046065B2 Fusion pacing enhancements 有权
标题翻译：融合起搏增强功能
公开(公告)号：US08046065B2
公开(公告)日：2011-10-25
申请号：US11671304
申请日：2007-02-05
申请人： John E. Burnes , Karen J. Kleckner , Thomas J. Mullen
发明人： John E. Burnes , Karen J. Kleckner , Thomas J. Mullen
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： The disclosure provides methods and apparatus of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. It includes—upon expiration or reset of a programmable AV Evaluation Interval (AVEI)—performing the following: temporarily increasing a paced AV interval and a sensed AV interval and testing for adequate AV conduction and measuring an intrinsic atrio-ventricular (PR) interval for a right ventricular (RV) chamber. Thus, in the event that the AV conduction test reveals a physiologically acceptable intrinsic PR interval then storing the physiologically acceptable PR interval in a memory structure (e.g., a median P-R from one or more cardiac cycles). In the event that the AV conduction test reveals an AV conduction block condition or if unacceptably long PR intervals are revealed then a pacing mode-switch to a bi-ventricular (Bi-V) pacing mode occurs and the magnitude of the AVEI is increased.
摘要翻译：本公开提供了左心室起搏的方法和装置，包括自动调节心房（AV）起搏延迟间隔和内部AV节点传导测试。它包括 - 可编程AV评估间隔（AVEI）的到期或复位 - 执行以下操作：临时增加节奏的AV间隔和感测到的AV间隔，并测试足够的AV传导并测量内在的心房（PR）间隔右心室（RV）室。因此，在AV传导测试揭示生理上可接受的固有PR间隔的情况下，然后将生理上可接受的PR间期存储在存储器结构中（例如，来自一个或多个心动周期的中值P-R）。在AV传导测试显示AV传导阻滞状态或者如果不能接受的长PR间隔被揭示的情况下，则起搏模式切换到双心室（Bi-V）起搏模式并且增加AVEI的幅度。

72. 发明授权

US08005539B2 Implantable medical device crosstalk evaluation and mitigation 有权
标题翻译：植入式医疗器械串扰评估和缓解
公开(公告)号：US08005539B2
公开(公告)日：2011-08-23
申请号：US12362773
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/00
CPC分类号： A61N1/3605 , A61N1/36114 , A61N1/36521 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

73. 发明授权

US07970466B2 Method and apparatus for optimization and assessment of response to extra-systolic stimulation (ESS) therapy 失效
标题翻译：用于优化和评估对收缩期刺激（ESS）治疗的反应的方法和装置
公开(公告)号：US07970466B2
公开(公告)日：2011-06-28
申请号：US10680494
申请日：2003-10-07
申请人： Lawrence J. Mulligan , D. Curtis Deno , John E. Burnes , Nirav V. Sheth
发明人： Lawrence J. Mulligan , D. Curtis Deno , John E. Burnes , Nirav V. Sheth
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36578
摘要： A method and apparatus for optimizing and assessing the response to extra-systolic stimulation (ESS) are provided. An optimization/monitoring parameter is calculated as a function of potentiation ratio, PR, and recirculation fraction, RF, derived from measurements of myocardial contractile function during and after ESS. PR may be computed as the ratio of the contractile function on post-extra-systolic beats during ESS to baseline contractile function. RF may be computed as the slope of a linear regression performed on a plot of the contractile function for a post-extra-systolic beat versus the contractile function for the previous post-extra-systolic beat after ESS is ceased. The ESI resulting in a maximum optimization/monitoring parameter, preferably computed as the product of PR and RF, is determined as the optimal ESI. The operating ESI may be automatically adjusted, and/or PR and RF data may be stored for monitoring purposes.
摘要翻译：提供了一种用于优化和评估对收缩期刺激（ESS）的反应的方法和装置。根据ESS期间和之后的心肌收缩功能测量得出，优化/监测参数作为增强比PR和再循环分数RF的函数计算。 PR可以计算为ESS期间收缩功能对收缩后收缩期与基线收缩功能的比值。 RF可以被计算为在ESS停止之后针对收缩后收缩压的收缩功能图与先前的收缩后节拍后的收缩功能的曲线进行的线性回归的斜率。产生最大优化/监测参数的ESI，优选地计算为PR和RF的乘积，被确定为最佳ESI。可以自动调整操作ESI，并且可以存储和/或PR和RF数据用于监视目的。

74. 发明申请

US20100152804A1 SECURE AND EFFICACIOUS THERAPY DELIVERY FOR A PACING ENGINE 有权
标题翻译：安全和有效的治疗发动机
公开(公告)号：US20100152804A1
公开(公告)日：2010-06-17
申请号：US12633893
申请日：2009-12-09
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译：据信上述方法和装置对于患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益被指示。应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。

75. 发明申请

US20100114241A1 INTERFERENCE MITIGATION FOR IMPLANTABLE DEVICE RECHARGING 有权
标题翻译：用于可移植设备充电的干扰减轻
公开(公告)号：US20100114241A1
公开(公告)日：2010-05-06
申请号：US12610025
申请日：2009-10-30
申请人： William T. Donofrio , Paul Gordon Krause , Gerald P. Arne , James D. Reinke , David Jerome Peichel , Timothy Davis , John E. Burnes
发明人： William T. Donofrio , Paul Gordon Krause , Gerald P. Arne , James D. Reinke , David Jerome Peichel , Timothy Davis , John E. Burnes
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61N1/3718 , A61N1/3787 , H02M1/44
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.
摘要翻译：治疗或监测系统可以实施一种或多种技术，以减轻对植入患者中的第一可植入医疗装置（IMD）充电的充电装置的操作与植入患者体内的第二IMD之间的干扰。在一些示例中，技术可以包括响应于接收到将第二IMD植入患者中的指示来修改充电装置的操作参数。这些技术还可以包括响应于检测到充电装置的存在或操作来修改第二IMD的操作参数。

76. 发明申请

US20100114211A1 SHUNT-CURRENT REDUCTION TECHNIQUES FOR AN IMPLANTABLE THERAPY SYSTEM 有权
标题翻译：用于可植入治疗系统的分流电流减少技术
公开(公告)号：US20100114211A1
公开(公告)日：2010-05-06
申请号：US12551331
申请日：2009-08-31
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
IPC分类号： A61N1/08 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3718 , A61N1/08 , A61N1/086 , A61N1/36114 , A61N1/37288
摘要： Techniques for minimizing interference between the first and second medical devices or between the different therapy modules of a common medical device are described herein. In some examples, a medical device may include shunt-current mitigation circuitry and/or at least one clamping structure that helps minimize or even eliminate shunt-current that feeds into a first therapy module of the medical device via one or more electrodes electrically connected to the first therapy module. The shunt-current may be generated by the delivery of electrical stimulation by a second therapy module. The second therapy module may be enclosed in a common housing with the first therapy module or may be separate, e.g., a part of a separate medical device.
摘要翻译：本文描述了用于最小化第一和第二医疗装置之间或在普通医疗装置的不同治疗模块之间的干扰的技术。在一些示例中，医疗装置可以包括分流电流缓解电路和/或至少一个夹持结构，其有助于最小化或甚至消除通过电连接到医疗装置的一个或多个电极馈入医疗装置的第一治疗模块的分流电流第一疗法模块。分流电流可以通过第二治疗模块的电刺激递送来产生。第二治疗模块可以用第一治疗模块封闭在共同的壳体中，或者可以是分离的，例如单独的医疗装置的一部分。

77. 发明申请

US20100114201A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
标题翻译：可伸缩医疗器械CROSSTALK评估和缓解
公开(公告)号：US20100114201A1
公开(公告)日：2010-05-06
申请号：US12362838
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/37 , A61B5/0205
CPC分类号： A61N1/3621 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3706 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

78. 发明申请

US20100016914A1 APPARATUS AND METHODS FOR AUTOMATIC ADJUSTMENT OF AV INTERVAL TO ENSURE DELIVERY OF CARDIAC RESYNCHRONIZATION THERAPY 有权
标题翻译：用于自动调整AV间隔以确保进行心脏再生治疗的装置和方法
公开(公告)号：US20100016914A1
公开(公告)日：2010-01-21
申请号：US12505925
申请日：2009-07-20
申请人： Thomas J. Mullen , John E. Burnes , Aleksandre T. Sambelashvili
发明人： Thomas J. Mullen , John E. Burnes , Aleksandre T. Sambelashvili
IPC分类号： A61N1/365 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： The disclosure provides methods and apparatus of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. It includes—upon expiration or reset of a programmable AV Evaluation Interval (AVEI)—performing the following: temporarily increasing a paced AV interval and a sensed AV interval and testing for adequate AV conduction and measuring an intrinsic atrio-ventricular (PR) interval for a right ventricular (RV) chamber. Thus, in the event that the AV conduction test reveals a physiologically acceptable intrinsic PR interval then storing the physiologically acceptable PR interval in a memory structure (e.g., a median P-R from one or more cardiac cycles). In the event that the AV conduction test reveals an AV conduction block condition or if unacceptably long PR intervals are revealed then a pacing mode-switch to a bi-ventricular (Bi-V) pacing mode occurs and the magnitude of the AVEI is increased.
摘要翻译：本公开提供了左心室起搏的方法和装置，包括自动调节心房（AV）起搏延迟间隔和内部AV节点传导测试。它包括 - 可编程AV评估间隔（AVEI）的到期或复位 - 执行以下操作：临时增加节奏的AV间隔和感测到的AV间隔，并测试足够的AV传导并测量内在的心房（PR）间隔右心室（RV）室。因此，在AV传导测试揭示生理上可接受的固有PR间隔的情况下，然后将生理上可接受的PR间期存储在存储器结构中（例如，来自一个或多个心动周期的中值P-R）。在AV传导测试显示AV传导阻滞状态或者如果不能接受的长PR间隔被揭示的情况下，则起搏模式切换到双心室（Bi-V）起搏模式并且增加AVEI的幅度。

79. 发明授权

US07623917B2 Method of optimizing data collection and therapy delivery based on respiration 有权
标题翻译：基于呼吸优化数据收集和治疗传递的方法
公开(公告)号：US07623917B2
公开(公告)日：2009-11-24
申请号：US11322761
申请日：2005-12-30
申请人： Yong K. Cho , John E. Burnes
发明人： Yong K. Cho , John E. Burnes
IPC分类号： A61N1/36
CPC分类号： A61N1/36521 , A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0816 , A61N1/3627 , A61N1/368
摘要： A method and system for improving or optimizing the collection of data from and the delivery of therapy to a patient by an implantable medical device (IMD) is disclosed which uses information about the patient's respiratory cycle.
摘要翻译：公开了一种用于通过可植入医疗装置（IMD）来改善或优化从患者和患者的治疗获取数据的方法和系统，其使用关于患者的呼吸周期的信息。

80. 发明申请

US20090276025A1 TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 有权
公开(公告)号：US20090276025A1
公开(公告)日：2009-11-05
申请号：US12433768
申请日：2009-04-30
申请人： John E. Burnes , Mary M. Morris , Michael R.S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
发明人： John E. Burnes , Mary M. Morris , Michael R.S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.

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