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71. 发明授权

US07449616B2 Anti-NGF antibodies and methods using same 有权
标题翻译：抗NGF抗体及其使用方法
公开(公告)号：US07449616B2
公开(公告)日：2008-11-11
申请号：US10745775
申请日：2003-12-24
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译：本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。

72. 发明申请

US20070275374A1 Methods For Idendifying Drug Targets And Modulators Of Neurons and Compositions Comprising The Same 审中-公开
标题翻译：用于描述包含其的神经元和组合物的药物靶标和调节剂的方法
公开(公告)号：US20070275374A1
公开(公告)日：2007-11-29
申请号：US10547955
申请日：2004-03-17
申请人： Jan Grimm , Arnon Rosenthal
发明人： Jan Grimm , Arnon Rosenthal
IPC分类号： C12Q1/68 , C12M3/00 , G01N33/53
CPC分类号： G01N33/5058
摘要： The invention provides methods of identifying drug targets in dopaminergic and/or noradrenergic neurons and to the drug targets identified by such methods. This invention also provides a method of screening for agents that modulate dopaminergic neurons and/or noradrenergic neuron activity, function and/or drug target expression, and agents that bind drug targets and to kits for use in the methods described herein.
摘要翻译：本发明提供了鉴定多巴胺能和/或去甲肾上腺素能神经元中的药物靶标以及通过这些方法鉴定的药物靶标的方法。本发明还提供了筛选调节多巴胺能神经元和/或去甲肾上腺素能神经元活性，功能和/或药物靶标表达的试剂以及结合药物靶标的试剂和用于本文所述方法的试剂盒的方法。

73. 发明申请

US20070031418A1 Methods for treating lower motor neuron diseases and compositions containing the same 审中-公开
标题翻译：用于治疗较低运动神经元疾病的方法和含有它们的组合物
公开(公告)号：US20070031418A1
公开(公告)日：2007-02-08
申请号：US11412685
申请日：2006-04-26
申请人： Lucia Tabares , Arnon Rosenthal , John Lin
发明人： Lucia Tabares , Arnon Rosenthal , John Lin
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/56 , C07K2317/75 , C07K2317/92
摘要： This invention provides methods for the treatment, prevention, and/or amelioration of symptoms relating to lower motor neuron diseases (such as spinal muscular atrophy). The methods comprise administration of an agonist anti-trkC antibody. Compositions and kits are also provided.
摘要翻译：本发明提供了治疗，预防和/或改善与较低运动神经元疾病（如脊髓性肌萎缩症）有关的症状的方法。所述方法包括施用激动剂抗-trkC抗体。还提供了组合和成套工具。

74. 发明申请

US20060292114A1 Neurturin receptor 有权
公开(公告)号：US20060292114A1
公开(公告)日：2006-12-28
申请号：US11508791
申请日：2006-08-22
申请人： Robert Klein , Arnon Rosenthal , Mary Hynes
发明人： Robert Klein , Arnon Rosenthal , Mary Hynes
IPC分类号： A61K38/20 , A61K38/19 , A61K38/18 , A61K38/22 , A61K39/395
CPC分类号： C07K14/705 , A01K67/0275 , A61K2039/505 , C07K16/22 , G01N33/6863 , G01N33/6872 , Y10S930/12
摘要： NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNRα-ligands, for example NTN, by providing NTNRα to the cell.

75. 发明授权

US07026138B1 Polynucleotides encoding GFRα3 有权
标题翻译：编码GFRalpha3的多核苷酸
公开(公告)号：US07026138B1
公开(公告)日：2006-04-11
申请号：US09272835
申请日：1999-03-19
申请人： Frederic J. de Sauvage , Robert D. Klein , Heidi S. Phillips , Arnon Rosenthal
发明人： Frederic J. de Sauvage , Robert D. Klein , Heidi S. Phillips , Arnon Rosenthal
IPC分类号： C12N15/12 , C12N15/79 , C12N15/85
CPC分类号： C07K14/71
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，其表达和免疫粘附和抗体对哺乳动物GFRalpha3，GDNF（即GFR）受体家族的新型α-亚单位受体。它进一步涉及通过检测酪氨酸激酶受体激活（即自身磷酸化）或与配体诱导的α-亚基受体均二聚化或同型寡聚化相关的其他活性来测量α-亚单位受体活化的测定法。

76. 发明授权

US06566091B1 Neurotrophic factor 失效
标题翻译：神经营养因子
公开(公告)号：US06566091B1
公开(公告)日：2003-05-20
申请号：US08451390
申请日：1995-05-26
申请人： Arnon Rosenthal
发明人： Arnon Rosenthal
IPC分类号： C12N1512
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475
摘要： A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally occurring amino acid sequence variants of NT-4, designated NT-4&bgr;, NT-4&ggr;, and NT-4&Dgr;. The neurotropic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.
摘要翻译：已经通过人类基因组DNA的PCR扩增鉴定了一种称为神经营养因子-4（NT-4）的新型多肽。本文提供了可用于诊断和NT-4重组制备中的NT-4的核酸。本文还提供了编码NT-4，称为NT-4beta，NT-4gamma和NT-4DELTA的天然存在的氨基酸序列变体的核酸。本发明的神经营养因子可用于神经细胞的治疗和诊断测定。

77. 发明授权

US06372453B1 Neurturin receptor 失效
标题翻译： Neurturin受体
公开(公告)号：US06372453B1
公开(公告)日：2002-04-16
申请号：US08802805
申请日：1997-02-18
申请人： Robert D. Klein , Arnon Rosenthal
发明人： Robert D. Klein , Arnon Rosenthal
IPC分类号： C12P2106
CPC分类号： C07K14/71 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , Y10S530/827
摘要： NTNR&agr;, NTNR&agr; extracellular domain (ECD), NTNR&agr; variants, chimeric NTNR&agr; (e.g., NTNR&agr; immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&agr;-ligands, for example NTN. by providing NTNR&agr; to the cell.
摘要翻译：公开了NTNRα，NTNRα胞外结构域（ECD），NTNRα变体，嵌合NTNRα（例如NTNRαpha免疫粘附素）和与其结合的抗体（包括激动剂和中和抗体）。描述了这些分子的各种用途，包括通过对NTNRα-配体（例如NTN）的应答来调节细胞活性和存活的方法。通过向单元格提供NTNRalpha。

78. 发明授权

US06342348B1 Neurturin receptor 有权
标题翻译： Neurturin受体
公开(公告)号：US06342348B1
公开(公告)日：2002-01-29
申请号：US09487685
申请日：2000-01-19
申请人： Robert D. Klein , Arnon Rosenthal , Mary A. Hynes
发明人： Robert D. Klein , Arnon Rosenthal , Mary A. Hynes
IPC分类号： C12Q100
CPC分类号： G01N33/6872 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/71 , C07K2319/00 , G01N33/6863
摘要： NTNR&agr;, NTNR&agr; extracellular domain (ECD), NTNR&agr; variants, chimeric NTNR&agr; (e.g., NTNR&agr; immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&agr;-ligands, for example NTN, by providing NTNR&agr; to the cell.
摘要翻译：公开了NTNRα，NTNRα胞外结构域（ECD），NTNRα变体，嵌合NTNRα（例如NTNRαpha免疫粘附素）和与其结合的抗体（包括激动剂和中和抗体）。描述了这些分子的各种用途，包括通过向细胞提供NTNRα来调节细胞活性和通过对NTNRα-配体（例如NTN）的响应来调节细胞活性和存活的方法。

79. 发明授权

US06277820B1 Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells 失效
标题翻译：神经祖细胞多巴胺能和血清素能神经元形成的方法
公开(公告)号：US06277820B1
公开(公告)日：2001-08-21
申请号：US09057860
申请日：1998-04-09
申请人： Arnon Rosenthal , Mary A. Hynes , Weilan Ye
发明人： Arnon Rosenthal , Mary A. Hynes , Weilan Ye
IPC分类号： A61K3818
CPC分类号： C12N5/0619 , A61K35/12 , A61K38/1709 , A61K38/1825 , C12N2501/119 , C12N2501/41 , A61K2300/00
摘要： The present invention relates to neuronal formation and methods of treating diseases characterized by abnormalities in the activity of dopaminergic (DA) and serotonergic (5HT) neurons. In particular, the invention relates to a method of forming serotonergic neurons in vitro by contacting neuroprogenitor cells to an effective amount of native sequence, variants and functional fragments of FGF-4, FGF-8 and Shh. Additionally, disclosed is a method for forming dopaminergic neurons by contacting neuroprogenitor cells to an effective amount of FGF-8 and Shh. Further described are compositions, cell culture compositions and medical devices which contain sufficient amount of FGF-8, Shh or FGF-8, Shh and FGF-4 to stimulate differentiation into dopaminergic or serotonergic neurons, respectively. Further described are methods of using serotoneurgic neurons to treat disorders relating to food intake, hormone secretion, stress response, pain and immune function, sexual activity, cardiovascular function and temperature regulation, in particular, depression, proclivity to suicide, violent aggressive behavior, obsessive-compulsive behavior and anorexia/bulimia and schizophrenia. Further described are methods of using dopaminergic neurons to treat disorders relating postural reflexes, movement and reward-associated behaviors, specifically, Parkinson's disease, schizophrenia and drug addiction. Further described is the coadministration of a neuronal survival factor, for example, NGF, CNTF, BDNF, NT-3, NT-4, aFGF, IL-1&bgr;, TNF&agr;, IGF-1, IGF-2, TGF-&bgr;, TGF-&bgr;1 or skeletal muscle extract.
摘要翻译：本发明涉及神经元形成和治疗特征为多巴胺能（DA）和5-羟色胺能（5HT）神经元活性异常的疾病的方法。特别地，本发明涉及通过将神经祖细胞与FGF-4，FGF-8和Shh的有效量的天然序列，变体和功能片段接触而在体外形成血清素能神经元的方法。此外，公开了通过使神经祖细胞与有效量的FGF-8和Shh接触来形成多巴胺能神经元的方法。进一步描述的是组合物，细胞培养组合物和含有足量的FGF-8，Shh或FGF-8，Shh和FGF-4分别刺激分化为多巴胺能或5-羟色胺能神经元的医疗装置。进一步描述的是使用血清素治疗神经元治疗与食物摄入，激素分泌，应激反应，疼痛和免疫功能，性活动，心血管功能和温度调节有关的疾病，特别是抑郁症，倾向于自杀，暴力侵略行为，强迫症 - 疲劳行为和厌食/贪食和精神分裂症。进一步描述的是使用多巴胺能神经元来治疗与姿势反射，运动和回报相关行为相关的疾病，特别是帕金森病，精神分裂症和药物成瘾的方法。进一步描述的是神经元存活因子例如NGF，CNTF，BDNF，NT-3，NT-4，aFGF，IL-1β，TNFα，IGF-1，IGF-2，TGF-β，TGF- β1或骨骼肌提取物。

80. 发明授权

US6136958A Antibodies to vertebrate smoothened proteins 失效
标题翻译：脊椎动物平滑蛋白的抗体
公开(公告)号：US6136958A
公开(公告)日：2000-10-24
申请号：US953823
申请日：1997-09-30
申请人： Frederic J. de Sauvage , Arnon Rosenthal , Donna M. Stone
发明人： Frederic J. de Sauvage , Arnon Rosenthal , Donna M. Stone
IPC分类号： C07K14/705 , C12N15/12 , C07K16/28
CPC分类号： C07K14/705 , C07K2319/00 , C07K2319/30
摘要： Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.
摘要翻译：提供了平滑化的新型脊椎动物同系物，包括人和大鼠的平滑化。还提供了包括脊椎动物平滑嵌合体，编码脊椎动物的核酸平滑化合物和平滑的脊椎动物抗体的组合物。

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