专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US4882329A Alkoxyphenylindolinone derivatives, medicaments containing them and their use 失效
标题翻译：烷氧基吲哚啉酮衍生物，含有它们的药物及其用途
公开(公告)号：US4882329A
公开(公告)日：1989-11-21
申请号：US303996
申请日：1989-01-30
申请人： Ulrich Lerch , Rainer Henning , Joachim Kaiser
发明人： Ulrich Lerch , Rainer Henning , Joachim Kaiser
IPC分类号： C07D401/14 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4427 , A61K31/445 , A61K31/495 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07D209/34 , C07D401/12
CPC分类号： C07D401/12 , C07D209/34
摘要： Calcium antagonists of the formula ##STR1## with R(1), R(2), R(3) and R(4) being, inter alia, H, alkyl, alkoxy, halogen, in some cases phenyl; m being 1-4; n being 0-3; X being CH.sub.2, O, S, CO, CHOH or CR.sub.2, and R(5) being various groups containing nitrogen atoms, are described.They are obtained by reaction of compounds II which are likewise new and which contain in place of R(5) a leaving group Y (Cl, Br, I) with the appropriate (cyclic) amino compound.Another synthesis comprises reaction of the appropriate indolinone derivative IV which has a non-etherified hydroxyl group with a side chain which contains a terminal leaving group Z (Cl, Br, I) in the presence of a base.Furthermore, indolinone derivatives VI with an ether side chain with a terminal epoxide group can be reacted with (cyclic) amines to give compounds I.
摘要翻译：具有R（1），R（2），R（3）和R（4）的式（I）的化合物拮抗剂尤其是H，烷基，烷氧基，卤素，在一些情况下为苯基; m为1-4; n为0-3; X是CH 2，O，S，CO，CHOH或CR 2，R（5）是含有氮原子的各种基团。它们通过同样新的且含有代替R（5）离去基团Y（Cl，Br，I）的化合物II与适当的（环状）氨基化合物反应而获得。另一种合成方法包括在碱存在下，具有非醚化羟基的合适的吲哚啉酮衍生物IV与含有末端离去基团Z（Cl，Br，I）的侧链的反应。此外，具有末端环氧基团的醚侧链的二氢吲哚衍生物VI可以与（环状）胺反应，得到化合物I.

72. 发明授权

US4595685A Benzothiazine derivatives 失效
标题翻译：苯并噻嗪衍生物
公开(公告)号：US4595685A
公开(公告)日：1986-06-17
申请号：US684711
申请日：1984-12-21
申请人： Rainer Henning , Ulrich Lerch , Joachim Kaiser
发明人： Rainer Henning , Ulrich Lerch , Joachim Kaiser
IPC分类号： A61K31/54 , A61K31/5415 , A61P3/00 , A61P9/00 , C07D279/16 , C07D317/00 , C07D417/04 , C07D417/12 , C07D279/10
CPC分类号： C07D417/04 , C07D279/16 , C07D417/12
摘要： Benzothiazine derivatives of the formula I ##STR1## with (R(1), R(1)', R(1)", R(4) and R(4)' equal to hydrogen, alkyl, alkoxy, halogen, nitro, hydroxyl, acetamido or amino; R(2) equal to hydrogen, alkyl, alkenyl, phenyl; R(3) equal to hydrogen, alkyl, alkenyl, phenyl; R(5) equal to hydrogen or (C.sub.1 -C.sub.3)-alkyl; R(6) equal to one of the following groups, ##STR2## with R(7) and R(8) equal to hydrogen, alkyl, cycloalkyl, phenyl; R(9) equal to hydrogen, alkyl, phenyl, pyridyl, pyrimidinyl or benzoyl; R(10) equal to hydrogen, alkyl, phenyl; R(11) equal to hydrogen, hydroxyl, alkoxy or, together with R(12), a bond; and R(12) equal to hydrogen or, together with R(11), a bond; m equal to 1, 2, 3 or 4; n equal to 0 or 1; p equal to 0, 1, 2, 3 or 4, and X equal to oxygen or two hydrogen atoms, and salts of the compounds of the formula I with physiologically tolerated acids and a process for the preparation of compounds I, likewise a method of treatment of disturbances of the calcium balance of a human body are described.
摘要翻译：式（I）与（R（1），R（1）'，R（1）“，R（4）和R（4）'等于氢，烷基，烷氧基，卤素，硝基，羟基，乙酰氨基或氨基; R（2）等于氢，烷基，烯基，苯基; R（3）等于氢，烷基，链烯基，苯基; R（5）等于氢或（C1-C3 ） - 烷基; R（6）等于以下基团之一，其中R（7）和R（8）等于氢，烷基，环烷基，苯基; R（9）等于氢，烷基，苯基，吡啶基，嘧啶基或苯甲酰基; R（10）等于氢，烷基，苯基; R（11）等于氢，羟基，烷氧基或与R（12）等于氢或与R（11）一起键; m等于1,2,3或4; n等于0或1; p等于0,1,2,3或4，X等于氧或两个氢原子，以及式I化合物与生理学上可耐受的酸的盐以及制备化合物I的方法，同样是治疗钙粘蛋白紊乱的方法描述一个人的身体。

73. 发明授权

US4148895A Basically substituted indole derivatives 失效
标题翻译：基本取代的吲哚衍生物
公开(公告)号：US4148895A
公开(公告)日：1979-04-10
申请号：US751084
申请日：1976-12-16
申请人： Rudolf Lattrell , Wilhelm Bartmann , Joachim Kaiser
发明人： Rudolf Lattrell , Wilhelm Bartmann , Joachim Kaiser
IPC分类号： C07D209/40 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/535 , A61P9/06 , A61P9/12 , C07D209/42 , C07D401/12 , C07D405/12 , C07D401/14
CPC分类号： C07D209/42 , Y10S514/821
摘要： The present invention relates to basically substituted indole derivatives and to a process for their manufacture.The novel compounds are valuable medicaments which exhibit hypotensive and antiarrhythmic activity on the cardiac circulation system.
摘要翻译：本发明涉及基本上取代的吲哚衍生物及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式