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71. 发明授权

US08211439B2 Albumin fusion proteins comprising insulin polypeptides 有权
标题翻译：包含胰岛素多肽的白蛋白融合蛋白
公开(公告)号：US08211439B2
公开(公告)日：2012-07-03
申请号：US11929939
申请日：2007-10-30
申请人： Craig A. Rosen , Steven M. Ruben , Olivier Blondel
发明人： Craig A. Rosen , Steven M. Ruben , Olivier Blondel
IPC分类号： A61K39/00 , A61K38/28 , C07H21/04 , C12P21/02 , C07K14/76 , C12N15/17
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

72. 发明申请

US20110081360A1 Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US20110081360A1
公开(公告)日：2011-04-07
申请号：US12943722
申请日：2010-11-10
申请人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , C07H21/04 , C07K16/00 , A61P37/04 , A61P9/00 , A61P17/06 , A61P17/00 , A61P11/00
CPC分类号： C07K14/7158 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

73. 发明授权

US07906634B2 HEMCM42 nucleic acids 有权
标题翻译： HEMCM42核酸
公开(公告)号：US07906634B2
公开(公告)日：2011-03-15
申请号：US12324825
申请日：2008-11-26
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

74. 发明授权

US07879328B2 Antibodies that immunospecifically bind to B lymphocyte stimulator 有权
标题翻译：免疫特异性结合B淋巴细胞刺激物的抗体
公开(公告)号：US07879328B2
公开(公告)日：2011-02-01
申请号：US11054515
申请日：2005-02-10
申请人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395
CPC分类号： C07K16/2875 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K2317/21 , C07K2317/622 , G01N33/5008 , G01N33/5011 , G01N33/5052 , G01N33/5091 , G01N33/564 , G01N33/574 , G01N33/68
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

75. 发明授权

US07838636B1 Antibodies to HWHGU54 polypeptides 有权
标题翻译： HWHGU54多肽的抗体
公开(公告)号：US07838636B1
公开(公告)日：2010-11-23
申请号：US11760578
申请日：2007-06-08
申请人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
发明人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
IPC分类号： C07K16/40 , C12P21/08 , C12P21/06 , C12N15/09
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

76. 发明申请

US20100143246A1 Interleukin 17 Receptor-Like Protein 失效
标题翻译：白介素17受体样蛋白
公开(公告)号：US20100143246A1
公开(公告)日：2010-06-10
申请号：US12618178
申请日：2009-11-13
申请人： Yanggu Shi , Steven M. Ruben
发明人： Yanggu Shi , Steven M. Ruben
IPC分类号： A61K51/10 , A61K39/395 , A61P35/00 , A61P25/00 , A61P37/00 , A61P19/02 , A61P19/08 , G01N33/53
CPC分类号： C07K16/2866 , C07K2317/76 , G01N33/6869 , G01N2333/7155 , G01N2800/24 , Y10S435/81 , Y10S436/808
摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
摘要翻译：本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。特别地，提供编码人IL17RLP蛋白的分离的核酸分子。还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

77. 发明申请

US20100093627A1 ALBUMIN FUSION PROTEINS 有权
公开(公告)号：US20100093627A1
公开(公告)日：2010-04-15
申请号：US12534585
申请日：2009-08-03
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
IPC分类号： A61K38/38 , C12N15/63 , C12N5/00 , C12N1/19 , C12N5/07 , C12P21/00 , C07K14/76 , A61P3/00 , A61P37/06
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

78. 发明申请

US20090247482A1 50 Human Secreted Proteins 审中-公开
标题翻译： 50人类分泌蛋白
公开(公告)号：US20090247482A1
公开(公告)日：2009-10-01
申请号：US12275899
申请日：2008-11-21
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K31/7088 , C12N15/11 , C12N15/00 , C12N5/06 , C12N15/87 , C12P21/04
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

79. 发明授权

US07595038B2 Methods of treatment using antibodies to follistatin-3 有权
标题翻译：使用抗卵泡抑素-3治疗的方法
公开(公告)号：US07595038B2
公开(公告)日：2009-09-29
申请号：US11738846
申请日：2007-04-23
申请人： D. Roxanne Duan , Steven M. Ruben
发明人： D. Roxanne Duan , Steven M. Ruben
IPC分类号： A61K38/18
CPC分类号： C07K14/4703 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
摘要翻译：本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。

80. 发明申请

US20090104619A1 Human G-Protein Coupled Receptors 审中-公开
标题翻译：人类G蛋白偶联受体
公开(公告)号：US20090104619A1
公开(公告)日：2009-04-23
申请号：US12332174
申请日：2008-12-10
申请人： Yi Li , Steven M. Ruben
发明人： Yi Li , Steven M. Ruben
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/21 , C12P21/06 , C07K14/435 , C07K16/00
CPC分类号： C07K14/705
摘要： Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.
摘要翻译：公开了两种人G-蛋白偶联受体多肽和编码每种这样的多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽鉴定这种多肽的拮抗剂和激动剂的方法。还公开了用于检测每个G蛋白偶联受体的核酸序列中的突变的诊断方法。

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