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71. 发明申请

US20070185144A1 Beta-secretase modulators and methods of use 有权
标题翻译： β-分泌酶调节剂和使用方法
公开(公告)号：US20070185144A1
公开(公告)日：2007-08-09
申请号：US11595187
申请日：2006-11-10
申请人： Wenge Zhong , Stephen Hitchcock , Brian Albrecht , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Dean Hickman , Daniel Horne , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang
发明人： Wenge Zhong , Stephen Hitchcock , Brian Albrecht , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Dean Hickman , Daniel Horne , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang
IPC分类号： A61K31/4747 , A61K31/4743 , A61K31/4741 , A61K31/4025 , A61K31/353 , A61K31/277 , A61K31/165 , C07D491/02
CPC分类号： C07D405/12 , C07D311/68 , C07D413/12 , C07D491/052
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中A，B，W，R 3，R 4，R 5，i和 j在本文中定义。本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

72. 发明申请

US20070185103A1 Beta-secretase modulators and methods of use 有权
标题翻译： β-分泌酶调节剂和使用方法
公开(公告)号：US20070185103A1
公开(公告)日：2007-08-09
申请号：US11600264
申请日：2006-11-14
申请人： Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Quifen Xue , Bryant Yang , Wenge Zhong
发明人： Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Quifen Xue , Bryant Yang , Wenge Zhong
IPC分类号： A61K31/538 , A61K31/503 , A61K31/4704 , A61K31/4745 , A61K31/4188 , A61K31/4162 , C07D487/02 , C07D471/02
CPC分类号： C07D405/12 , C07D413/12
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j分别为本文定义。本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

73. 发明授权

US07227924B2 Computed tomography scanning system and method using a field emission x-ray source 有权
标题翻译：计算机断层扫描系统和使用场发射X射线源的方法
公开(公告)号：US07227924B2
公开(公告)日：2007-06-05
申请号：US11051332
申请日：2005-02-07
申请人： Otto Z. Zhou , Yuan Cheng , Jian Zhang , Yueh Lee , Jianping Lu , Weili Lin
发明人： Otto Z. Zhou , Yuan Cheng , Jian Zhang , Yueh Lee , Jianping Lu , Weili Lin
IPC分类号： G01N23/00
CPC分类号： A61B6/032 , A61B6/4028 , A61B6/4488 , A61B6/508 , A61B6/541 , B82Y10/00 , G01N23/046 , G01N2223/419 , G01N2223/612 , H01J35/065 , H01J35/14
摘要： Computed tomography scanning systems and methods using a field emission x-ray source are disclosed. An exemplary micro-computed tomography scanner comprises a micro-focus field emission x-ray source, an x-ray detector, an object stage placed between the x-ray source and the detector, an electronic control system and a computer that control the x-ray radiation and detector data collection, and computer software that reconstructs the three dimension image of the object using a series of projection images collected from different projection angles. Exemplary methods obtain a computed tomography image of an object in oscillatory motion using the micro computed tomography scanner.
摘要翻译：公开了使用场致发射X射线源的计算机断层摄影扫描系统和方法。示例性的微型计算机断层扫描仪包括微焦点场发射x射线源，x射线检测器，放置在x射线源和检测器之间的物体台，控制x射线源的电子控制系统和计算机射线辐射和检测器数据采集，以及使用从不同投影角度收集的一系列投影图像重建对象的三维图像的计算机软件。示例性方法使用微型计算机断层摄影扫描仪获得振荡运动中物体的计算机断层摄影图像。

74. 发明申请

US20060241115A1 Compounds and methods of use 有权
公开(公告)号：US20060241115A1
公开(公告)日：2006-10-26
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
IPC分类号： A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , C07D43/02
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

75. 发明申请

US20060083106A1 Fluid mixing device 失效
标题翻译：流体混合装置
公开(公告)号：US20060083106A1
公开(公告)日：2006-04-20
申请号：US11294095
申请日：2005-12-05
申请人： Donald Gringer , Yuan Cheng , Howard Soled
发明人： Donald Gringer , Yuan Cheng , Howard Soled
IPC分类号： B01F5/12 , B01F7/32
CPC分类号： B01F7/00583 , B01F7/00241 , B01F7/1625 , B01F2215/005
摘要： A mixing device includes vanes arranged so that the outer edges of the vanes define a frusto-conical surface in order to facilitate improved circulation of the liquid being mixed. In one embodiment, the outer edges of the vanes are tapered outward to form the frusto-conical surface. In an alternative embodiment, the inner and outer edges of the vanes are aligned with each other, and the vanes are tilted relative to a central axis to form the frusto-conical surface. Turbines extend between the vanes and shaft for rotating the mixing device. The turbines are arranged to avoid inhibiting entry of liquids through the top and bottom of the mixing device. Feet extend downward from the bottom edge of the mixing device to facilitate mixing of liquids on the bottom of the container.
摘要翻译：混合装置包括布置成使得叶片的外边缘限定截头圆锥形表面的叶片，以便于改进被混合的液体的循环。在一个实施例中，叶片的外边缘向外锥形以形成截头圆锥形表面。在替代实施例中，叶片的内边缘和外边缘彼此对准，并且叶片相对于中心轴线倾斜以形成截头圆锥形表面。涡轮机在叶片和轴之间延伸以旋转混合装置。涡轮机布置成避免阻止液体通过混合装置的顶部和底部进入。脚从混合装置的底部边缘向下延伸，以便于容器底部的液体混合。

76. 发明申请

US20060080843A1 Push-pull stripper-scraper 有权
标题翻译：推拉式剥皮机
公开(公告)号：US20060080843A1
公开(公告)日：2006-04-20
申请号：US10970222
申请日：2004-10-20
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B26B3/00
CPC分类号： B44D3/164
摘要： In a preferred embodiment, the push-pull stripper-scraper comprises a single stripping blade and a quadruple-edged scraping blade. The stripping blade accommodates a sliding carrier plate which incorporates guide channels for sliding along the stripping blade. The carrier plate is adapted to retain the scraping blade, thus, the scraping blade moves in unison with the carrier plate as the it shifts in position along the stripping blade. The carrier plate, stripping blade and scraping blade also include apertures through which a fastening means secures these respective components but which nevertheless selectively permits movement of the carrier plate along the stripping blade. Significantly, the device allows a user to switch between using the stripping blade and scraping blade, respectively, without changing tools. This is particularly advantageous when using the device in conjunction with an extension pole.
摘要翻译：在优选实施例中，推拉式剥离刮刀包括单个剥离刮刀和四刃刮刀。剥皮刀片容纳滑动承载板，其包括用于沿着剥离刀片滑动的引导通道。承载板适于保持刮刀，因此当刮板沿着剥离刀片位移时，刮刀与承载板一致地移动。承载板，剥离刀片和刮刀还包括孔，紧固装置通过孔固定这些相应的部件，但仍选择性地允许承载板沿着剥离刀片移动。重要的是，该装置允许用户分别在使用剥离刀片和刮刀之间切换，而不改变工具。当将该装置与延伸杆结合使用时，这是特别有利的。

77. 发明授权

US06969690B2 Methods and apparatus for patterned deposition of nanostructure-containing materials by self-assembly and related articles 有权
标题翻译：通过自组装和相关制品图案化沉积纳米结构材料的方法和装置
公开(公告)号：US06969690B2
公开(公告)日：2005-11-29
申请号：US10803639
申请日：2004-03-18
申请人： Otto Z. Zhou , Soojin Oh , Jian Zhang , Yuan Cheng , Hideo Shimoda
发明人： Otto Z. Zhou , Soojin Oh , Jian Zhang , Yuan Cheng , Hideo Shimoda
IPC分类号： B05D1/00 , B05D1/02 , B05D1/18 , B05D3/06 , B05D5/08 , C25D20060101 , G03F7/40 , H01J9/02 , H01L21/26 , H01L21/469 , H01L21/76
CPC分类号： H01J9/025 , B05D1/002 , B05D1/02 , B05D1/18 , B05D1/185 , B05D3/065 , B05D3/068 , B05D5/08 , B05D2203/35 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/40 , G03F7/405 , H01J2201/30469 , Y10S977/883
摘要： Methods and apparatus are described for patterned deposition of nanostructure-containing materials by self-assembly and related articles. According to an exemplary embodiment self-assembly method for depositing nanostructure-containing materials includes forming a nanostructure-containing material. The nanostructure-containing material is chemically functionalized and dispersed in a liquid medium to form a suspension. At least a portion of a substrate having a surface that can attract the functionalized nanostructure-containing material is brought into contact with the suspension. The substrate is separated from the suspension. The nanostructure-containing material adheres to the portion of the substrate when separated from the suspension. According to another exemplary embodiment, hydrophilic and hydrophobic regions are formed on the surface of the substrate before bringing the substrate into contact with the suspension. The functionalized nanostructure-containing material is hydrophilic and adheres to the hydrophilic region of the substrate when separated from the suspension.
摘要翻译：描述了通过自组装和相关制品图案化沉积纳米结构材料的方法和装置。根据示例性实施例，用于沉积含纳米结构的材料的自组装方法包括形成含纳米结构的材料。将含纳米结构的材料化学功能化并分散在液体介质中以形成悬浮液。具有能够吸引官能化的纳米结构材料的表面的基材的至少一部分与悬浮液接触。将底物与悬浮液分离。当与悬浮液分离时，含纳米结构的材料粘附到基底的一部分。根据另一示例性实施方案，在使基材与悬浮液接触之前，在基材的表面上形成亲水和疏水区域。当与悬浮液分离时，含官能化纳米结构的材料是亲水性的并且粘附到基底的亲水区域。

78. 发明授权

US06384244B2 Process for preparing cis- aminochromanols 失效
标题翻译：顺式氨基色甘醇的制备方法
公开(公告)号：US06384244B2
公开(公告)日：2002-05-07
申请号：US09853796
申请日：2001-05-11
申请人： Ian Davies , Karl Hansen , Paul N. Devine , Louis Matty, Jr. , Yuan Cheng , Philippe M. Rabbat
发明人： Ian Davies , Karl Hansen , Paul N. Devine , Louis Matty, Jr. , Yuan Cheng , Philippe M. Rabbat
IPC分类号： C07D31104
CPC分类号： C07D311/68
摘要： cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.
摘要翻译：通过在催化剂和选自HBr，HCl和有机磺酸的酸的存在下氢化相应的肟，以高产率和高反应性获得顺式 - 氨基色甘醇。顺式 - 氨基苯并二氢吡喃醇可用作生产可用于治疗HIV感染和艾滋病的HIV蛋白酶抑制剂的中间体。

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