专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US5863780A Human Protein Kinases 失效
标题翻译：人类蛋白激酶
公开(公告)号：US5863780A
公开(公告)日：1999-01-26
申请号：US712709
申请日：1996-09-12
申请人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
发明人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
IPC分类号： C12N15/00 , A61K38/00 , A61K38/45 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/48 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.
摘要翻译：本发明提供了鉴定和编码HPK的新型人蛋白激酶（HPK）和多核苷酸。本发明提供了包含编码HPK的核酸序列的基因工程表达载体和宿主细胞。本发明还提供包含HPK或HPK拮抗剂的药物组合物，以及特异性结合HPK的抗体。此外，本发明提供了用于治疗或预防与HPK异常表达相关的疾病的HPK的反义分子。

72. 发明授权

US5648239A Human camp-dependent protein kinase inhibitor homolog 失效
标题翻译：人阵营依赖蛋白激酶抑制剂同源物
公开(公告)号：US5648239A
公开(公告)日：1997-07-15
申请号：US667679
申请日：1996-06-21
申请人： Phillip R. Hawkins , Jennifer L. Hillman , Janice Au-Young
发明人： Phillip R. Hawkins , Jennifer L. Hillman , Janice Au-Young
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K38/55 , A61K39/395 , A61K48/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C12N15/11 , C12N15/63 , C12N15/85
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention provides a polynucleotide (ipka) which identifies and encodes a novel human cAMP-dependent protein kinase A inhibitor homolog (IPKA). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKA.
摘要翻译：本发明提供鉴定和编码新的人cAMP依赖性蛋白激酶A抑制剂同源物（IPKA）的多核苷酸（ipka）。本发明提供了包含编码IPKA的核酸序列的基因工程表达载体和宿主细胞。

73. 发明授权

US06913891B1 Human myeloid terminal differentiation response gene 失效
标题翻译：人骨髓末端分化反应基因
公开(公告)号：US06913891B1
公开(公告)日：2005-07-05
申请号：US09208206
申请日：1998-12-09
申请人： Benjamin Graeme Cocks , Janice Au-Young , Jeffrey J. Seilhamer
发明人： Benjamin Graeme Cocks , Janice Au-Young , Jeffrey J. Seilhamer
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/12 , C12N15/19 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for myd118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 and MYD118 polypeptide. The invention specifically provides for use of the myd118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for myd118. The invention further provides antibodies which specifically bind to MYD118.
摘要翻译：本发明提供编码和鉴定指定为MYD118的新型人骨髓末端分化应答基因的多核苷酸和氨基酸序列。本发明还提供了myd118反义分子。本发明进一步提供用于产生纯化的MYD118多肽的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和MYD118多肽的抑制剂; 以及基于编码MYD118和MYD118多肽的多核苷酸序列的药物组合物和治疗方法。本发明特别提供了myd118多核苷酸序列用作检测骨髓增生性疾病和白血病的诊断组合物。本发明还涉及基于myd118的核苷酸序列的治疗方法和组合物。本发明进一步提供特异性结合MYD118的抗体。

74. 发明授权

US06190663B1 Human MAP kinase homolog 失效
标题翻译：人MAP激酶同源物
公开(公告)号：US06190663B1
公开(公告)日：2001-02-20
申请号：US09124163
申请日：1998-07-28
申请人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
发明人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
IPC分类号： A61K3900
CPC分类号： C12N9/1205 , A61K38/00 , C12N9/12 , Y10S530/827
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
摘要翻译：本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

75. 发明授权

US06172199B2 Human ubiquitin-conjugating enzyme 失效
标题翻译：人泛素结合酶
公开(公告)号：US06172199B2
公开(公告)日：2001-01-09
申请号：US09318317
申请日：1999-05-25
申请人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K39395
CPC分类号： C12N9/93 , C07K16/40
摘要： The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nuclei acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.
摘要翻译：本发明提供鉴定和编码新型泛素缀合酶（UBCP）的多核苷酸（ubcp）。本发明提供了包含编码UBCP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与UBCP表达有关的疾病的药物组合物中使用基本上纯化的UBCP及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与UBCP表达相关的疾病的药物组合物中的ubcp的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与特异性结合UBCP的ubcp或抗UBCP抗体的基因组序列或转录物杂交。

76. 发明授权

US6080848A Human brain associated protein 失效
标题翻译：人脑相关蛋白
公开(公告)号：US6080848A
公开(公告)日：2000-06-27
申请号：US71434
申请日：1998-05-01
申请人： Sven Henrichwark , Janice Au-Young , Karl J. Guegler , Neil C. Corley , Mariah R. Baughn
发明人： Sven Henrichwark , Janice Au-Young , Karl J. Guegler , Neil C. Corley , Mariah R. Baughn
IPC分类号： A61K38/00 , C07K14/47 , C07H21/04 , C07H21/02
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a human human brain-associated protein (HBAP-1) and polynucleotides which identify and encode HBAP-1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HBAP-1.
摘要翻译：本发明提供了人类人脑相关蛋白（HBAP-1）和鉴定和编码HBAP-1的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HBAP-1表达相关的疾病的方法。

77. 发明授权

US6045792A Human proteins kinases 失效
标题翻译：人类蛋白激酶
公开(公告)号：US6045792A
公开(公告)日：2000-04-04
申请号：US111444
申请日：1998-07-07
申请人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
发明人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
IPC分类号： C12N15/00 , A61K38/00 , A61K38/45 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/48
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.
摘要翻译：本发明提供了鉴定和编码HPK的新型人蛋白激酶（HPK）和多核苷酸。本发明提供了包含编码HPK的核酸序列的基因工程表达载体和宿主细胞。本发明还提供包含HPK或HPK拮抗剂的药物组合物，以及特异性结合HPK的抗体。此外，本发明提供了用于治疗或预防与HPK异常表达相关的疾病的HPK的反义分子。

78. 发明授权

US6034219A Human macrophage antigen 失效
标题翻译：人巨噬细胞抗原
公开(公告)号：US6034219A
公开(公告)日：2000-03-07
申请号：US113789
申请日：1998-07-10
申请人： Jennifer L. Hillman , Janice Au-Young , Surya K. Goli
发明人： Jennifer L. Hillman , Janice Au-Young , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C07K14/47 , C07K16/18
CPC分类号： C07K14/7056 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human macrophage antigen (TMAH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding TMAH. The invention also provides for the use of substantially purified TMAH and its agonists, antibodies, antagonists or inhibitors in pharmaceutical compositions for treatment of diseases associated with expression of TMAH. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the genomic sequence or transcripts encoding TMAH and anti-TMAH antibodies which specifically bind to TMAH.
摘要翻译：本发明提供鉴定和编码新型人巨噬细胞抗原（TMAH）的多核苷酸。本发明提供了包含编码TMAH的核酸序列的基因工程表达载体和宿主细胞。本发明还提供了用于治疗与TMAH表达相关的疾病的药物组合物中基本上纯化的TMAH及其激动剂，抗体，拮抗剂或抑制剂的用途。本发明还描述了利用多核苷酸与编码TMAH的基因组序列或转录物和特异性结合TMAH的抗TMAH抗体杂交的诊断测定法。

79. 发明授权

US5989883A Human ubiquitin-conjugating enzyme 有权
标题翻译：人泛素结合酶
公开(公告)号：US5989883A
公开(公告)日：1999-11-23
申请号：US196525
申请日：1998-11-20
申请人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/00 , C12Q1/68 , C12R1/19 , C12N9/10
CPC分类号： C12N9/93 , C07K16/40
摘要： The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.
摘要翻译：本发明提供鉴定和编码新型泛素缀合酶（UBCP）的多核苷酸（ubcp）。本发明提供了包含编码UBCP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与UBCP表达有关的疾病的药物组合物中使用基本上纯化的UBCP及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与UBCP表达相关的疾病的药物组合物中的ubcp的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与特异性结合UBCP的ubcp或抗UBCP抗体的基因组序列或转录物杂交。

80. 发明授权

US5912144A Edg-1-receptor homolog 失效
标题翻译： Edg-1受体同源物
公开(公告)号：US5912144A
公开(公告)日：1999-06-15
申请号：US845566
申请日：1997-04-24
申请人： Janice Au-Young , Karl J. Guegler
发明人： Janice Au-Young , Karl J. Guegler
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P29/00 , A61P35/00 , A61P35/02 , C07H21/04 , C07K14/705 , C07K16/28 , C12N1/21 , C12N15/12 , C12Q1/68 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a new edg-1 like receptor (NEDG) and polynucleotides which identify and encode NEDG. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of NEDG.
摘要翻译：本发明提供新的edg-1样受体（NEDG）和鉴定和编码NEDG的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与NEDG表达相关的疾病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式