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71. 发明授权

US07245969B2 Cardiac rhythm management system selecting A-V delay based on interval between atrial depolarization and mitral valve closure 失效
标题翻译：心脏节律管理系统根据心房去极化与二尖瓣关闭间隔选择A-V延迟
公开(公告)号：US07245969B2
公开(公告)日：2007-07-17
申请号：US10633392
申请日：2003-08-01
申请人： William C. Lincoln , Gerrard M. Carlson
发明人： William C. Lincoln , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/368
摘要： A cardiac rhythm management system selects an atrioventricular (A-V) delay based on a time-interval between an atrial depolarization and mitral valve closure (MVC). For several different A-V delays, the system measures time intervals between atrial depolarizations (i.e., sensed or paced P-waves) and accelerometer-detected MVCs. Based on this information, the system selects a particular A-V delay for improving cardiac output during subsequent delivery of cardiac rhythm management therapy.
摘要翻译：心律管理系统基于心房去极化和二尖瓣关闭（MVC）之间的时间间隔选择房室（A-V）延迟。对于几个不同的A-V延迟，系统测量心房去极化（即，感测或起搏的P波）和加速度计检测的MVC之间的时间间隔。基于该信息，系统在随后的心律管理治疗递送期间选择用于改善心输出量的特定A-V延迟。

72. 发明授权

US07062314B2 Cardiac rhythm management device with triggered diagnostic mode 失效
公开(公告)号：US07062314B2
公开(公告)日：2006-06-13
申请号：US10035009
申请日：2001-12-28
申请人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Gerrard M. Carlson
发明人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Gerrard M. Carlson
IPC分类号： A61B5/0468
CPC分类号： A61N1/36592 , A61B5/4035 , A61N1/3622
摘要： A device and method in which spectral analysis of heart rate variability is performed in order to assess autonomic balance. When a threshold level is reached, a diagnostic mode is triggered in which the device performs computationally intensive data analysis to assess the probability of a pathological event such as an arrhythmia occurring.

73. 发明授权

US06718197B1 LV ectopic density trending 失效
标题翻译： LV异位密度趋势
公开(公告)号：US06718197B1
公开(公告)日：2004-04-06
申请号：US09704844
申请日：2000-11-02
申请人： Gerrard M. Carlson , Julio C. Spinelli
发明人： Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61B504
CPC分类号： A61B5/0468
摘要： Ectopic beat activity detection of the human heart is monitored by time interval measurements of depolarizations in the heart. The intervals between beats are categorized as being long beats, short beats or normal beats. Then the sequence of categories of beats is analyzed to determine the types of ectopic beats occurring and to count such occurrences and display such information to a health care provider to help monitor, diagnose and treat patients. For patients with pacemakers installed the information can be used to adjust pacemaker settings. The information may also be used to alert the health care providers to dangerous patterns indicating serious conditions which need immediate treatment.
摘要翻译：通过心脏去极化的时间间隔测量来监测人心脏的异位搏动活动检测。节拍之间的间隔被分为长节拍，短节拍或正常节拍。然后分析节拍类别的顺序，以确定发生的异位搏动的类型并计数这种事件，并将此类信息显示给医疗保健提供者，以帮助监测，诊断和治疗患者。对于安装起搏器的患者，可以使用这些信息来调整起搏器设置。这些信息还可用于警示医疗保健提供者需要立即治疗的严重情况的危险模式。

74. 发明授权

US6119043A Atrial and ventricular cardiac lead having a mechanical bias 失效
标题翻译：心房和心室心脏铅具有机械偏置
公开(公告)号：US6119043A
公开(公告)日：2000-09-12
申请号：US129348
申请日：1998-08-05
申请人： William Hsu , Jay A. Warren , Gerrard M. Carlson
发明人： William Hsu , Jay A. Warren , Gerrard M. Carlson
IPC分类号： A61N1/362 , A61N1/00
CPC分类号： A61N1/3622
摘要： A method and system for discriminating atrial and ventricular signal components from a single heart lead, and for using this information for identifying an arrhythmia condition as being atrial or ventricular in origin. The invention is effective in identifying P waves occurring in complex signal which includes relatively stronger R waves or other ventricular artifacts which mask the P waves. The contribution of the R wave signal to the complex signal is obtained by filtering, time windowing and transfer function estimation, then the R wave estimate is subtracted from the combined signal to leave the P wave. The ratio of P waves to R waves, P--P and R--R intervals, and their ratios to one another and to fixed values can be estimated, and used in a comparison to discriminate between atrial and ventricular arrhythmia, to thereby enable appropriate treatment.
摘要翻译：用于区分来自单个心脏引线的心房和心室信号分量的方法和系统，以及用于将该信息用于将心律失常状态识别为心房或心室起源的方法和系统。本发明有效地识别出复杂信号中出现的P波，其中包含相对较强的R波或掩蔽P波的其他心室伪像。通过滤波，时间窗口和传递函数估计得到R波信号对复信号的贡献，然后将R波估计从组合信号中减去离开P波。可以估计P波与R波，P-P和R-R间隔的比率以及它们彼此之间的比值和固定值，并用于比较以区分心房和心室心律不齐，从而使得能够进行适当的治疗。

75. 发明授权

US5776072A Discrimination of atrial and ventricular signals from a single cardiac lead 失效
公开(公告)号：US5776072A
公开(公告)日：1998-07-07
申请号：US579872
申请日：1995-12-28
申请人： William Hsu , Jay A. Warren , Gerrard M. Carlson
发明人： William Hsu , Jay A. Warren , Gerrard M. Carlson
IPC分类号： A61N1/362 , A61B5/046
CPC分类号： A61N1/3622
摘要： A method and system for discriminating atrial and ventricular signal components from a single heart lead, and for using this information for identifying an arrhythmia condition as being atrial or ventricular in origin. The invention is effective in identifying P waves occurring in complex signal which includes relatively stronger R waves or other ventricular artifacts which mask the P waves. The contribution of the R wave signal to the complex signal is obtained by filtering, time windowing and transfer function estimation, then the R wave estimate is subtracted from the combined signal to leave the P wave. The ratio of P waves to R waves, P--P and R--R intervals, and their ratios to one another and to fixed values can be estimated, and used in a comparison to discriminate between atrial and ventricular arrhythmia, to thereby enable appropriate treatment.

76. 发明授权

US08888710B2 System and method for assessing cardiac performance through cardiac vibration monitoring 有权
标题翻译：通过心脏振动监测评估心脏性能的系统和方法
公开(公告)号：US08888710B2
公开(公告)日：2014-11-18
申请号：US13208722
申请日：2011-08-12
申请人： Ramesh Wariar , Gerrard M. Carlson
发明人： Ramesh Wariar , Gerrard M. Carlson
IPC分类号： A61B5/02 , A61B7/04
CPC分类号： A61B7/04 , A61B5/021 , A61B7/00
摘要： A system and method for assessing cardiac performance through cardiac vibration monitoring is described. Cardiac vibration measures are directly collected through an implantable medical device. Cardiac events including at least one first heart sound reflected by the cardiac vibration measures are identified. The first heart sound is correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.
摘要翻译：描述了通过心脏振动监测来评估心脏性能的系统和方法。通过植入式医疗设备直接收集心脏振动。识别心脏事件，包括由心脏振动测量反射的至少一个第一心音。第一个心音与胸腔内压力作用的心脏尺寸相关。心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。

77. 发明授权

US08831724B2 Method and apparatus for using heart rate variability as a safety check in electrical therapies 有权
标题翻译：使用心率变异性作为电疗法安全检查的方法和装置
公开(公告)号：US08831724B2
公开(公告)日：2014-09-09
申请号：US12694124
申请日：2010-01-26
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/36592
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

78. 发明授权

US08768718B2 Between-patient comparisons for risk stratification of future heart failure decompensation 有权
标题翻译：患者对未来心力衰竭代偿失调风险分层的比较
公开(公告)号：US08768718B2
公开(公告)日：2014-07-01
申请号：US11616430
申请日：2006-12-27
申请人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： G06Q50/00 , A61B5/00
CPC分类号： G06Q50/22 , A61B5/0031 , A61N1/37282 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
摘要： This document discusses, among other things, systems and methods for using between-patient comparisons for risk stratification of future heart failure decompensation. A method comprises receiving patient data of a current patient, the patient data collected by a patient monitoring device; determining a reference group related to the patient; determining a reference group dataset selected from the reference group, wherein the dataset includes patient data that is of a similar type received from the patient monitoring device; generating a model of the reference group dataset; and automatically comparing the received physiological data to a model to derive an index for the patient.
摘要翻译：本文件除了其他内容之外还讨论了使用患者间比较以预测未来心力衰竭代偿失调的风险分层的系统和方法。一种方法包括接收当前患者的患者数据，由患者监测装置收集的患者数据; 确定与患者相关的参考组; 确定从所述参考组中选择的参考组数据集，其中所述数据集包括从所述患者监视装置接收到的类似类型的患者数据; 生成参考组数据集的模型; 并且将接收到的生理数据自动地与模型进行比较以导出患者的指标。

79. 发明授权

US08579828B2 Managing preload reserve by tracking the ventricular operating point with heart sounds 有权
公开(公告)号：US08579828B2
公开(公告)日：2013-11-12
申请号：US13447506
申请日：2012-04-16
申请人： Gerrard M. Carlson , Ramesh Wariar , Krzysztof Z. Siejko
发明人： Gerrard M. Carlson , Ramesh Wariar , Krzysztof Z. Siejko
IPC分类号： A61B5/021 , A61B5/0225
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.

80. 发明授权

US08532771B2 Maximum pacing rate limiter system 失效
标题翻译：最大起搏速率限制系统
公开(公告)号：US08532771B2
公开(公告)日：2013-09-10
申请号：US13115825
申请日：2011-05-25
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

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