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71. 发明申请

US20090221614A1 SELECTIVE SERINE/THREONINE KINASE INHIBITORS 有权
标题翻译：选择性丝氨酸/螺旋激酶抑制剂
公开(公告)号：US20090221614A1
公开(公告)日：2009-09-03
申请号：US12088059
申请日：2006-09-26
申请人： Jack Taunton , Michael Cohen , Kevin Shokat , Chao Zhang
发明人： Jack Taunton , Michael Cohen , Kevin Shokat , Chao Zhang
IPC分类号： A61K31/519 , C07D487/02 , C07D209/56 , C07D239/72 , C07D223/14 , C07D209/36 , C12N9/99 , C12N9/12 , C12N5/00 , C40B40/04 , A61P35/00
CPC分类号： C07D487/04 , C07D239/42 , C07D403/06 , C07D487/14 , C07D519/00
摘要： Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
摘要翻译：在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使本身或细胞或受试者中的激酶与抑制有效量的具有由两个或更多个的杂环核心结构组成的化合物接触来实现含有至少一个氮环原子的稠环，以及能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电取代基。优选的化合物包括具有这样的亲电子取代基的某些吡咯并嘧啶和羟吲哚，以及任选的能够与位于激酶的关守位置的苏氨酸或更小残基相互作用的芳族或杂芳族取代基。缺乏这种半胱氨酸残基的激酶可以被改造或修饰，使得它们能够被这种化合物抑制，通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其它氨基酸残基。

72. 发明申请

US20090145289A1 COMPOSITE ARMOR PLATE AND METHOD FOR USING THE SAME 审中-公开
标题翻译：复合铠装板及其使用方法
公开(公告)号：US20090145289A1
公开(公告)日：2009-06-11
申请号：US12333183
申请日：2008-12-11
申请人： Michael Cohen
发明人： Michael Cohen
IPC分类号： F41H5/04 , F41H5/02
CPC分类号： F41H5/0492 , F41H5/0414
摘要： The invention provides an armor plate for absorbing and dissipating kinetic energy from armor piercing 7.62 mm projectiles having a projectile length of from 32.8 mm to 37 mm, the armor plate comprising a plurality of ceramic pellets and a solidified material, each ceramic pellet having a body portion and a convexly curved end portion, each body portion having two opposite ends, an axis passing through each end and a substantially constant cross-section along the axis, and each convexly curved end portion extending from an end of the corresponding body portion, each body portion having a body portion length along the axis between the two ends, the ceramic pellets being embedded in the solidified material so that the solidified material retains the ceramic pellets in a ceramic pellet layer which is one pellet thick with the convexly curved end portions lying at or adjacent an impact receiving side of the armor plate, wherein the ceramic pellet layer is the only layer of ceramic pellets in the armor plate, wherein the ceramic pellet layer has an edge extending therearound formed by a subset of the ceramic pellets, wherein the ceramic pellets are arranged so that the body portion of substantially each pellet, other than of the pellets of the subset, lies in contact with or closely adjacent to the respective body portions of six neighboring ones of the ceramic pellets so that there are a plurality of valleys extending through the ceramic pellet layer with each valley being bordered by three adjacent ceramic pellets, wherein substantially each valley has a shape and size such that the diameter of the largest imaginary circle that will fit into the each valley between the neighboring body portions and substantially perpendicularly to the neighboring axes is from 1.96 mm to 3.7 mm, and wherein each body portion length is from 5.57 mm to 10.73 mm.
摘要翻译：本发明提供了一种装甲板，用于吸收和消散具有射弹长度为32.8mm至37mm的装甲穿戴7.62mm弹丸的动能，该装甲板包括多个陶瓷颗粒和固化材料，每个陶瓷颗粒具有主体每个主体部分具有两个相对的端部，穿过每个端部的轴线和沿轴线的基本上恒定的横截面，并且每个凸出的弯曲端部部分从相应的主体部分的端部延伸，每个主体部分具有沿着两端之间的轴线的主体部分长度，陶瓷颗粒被嵌入固化材料中，使得固化材料将陶瓷颗粒保持在陶瓷颗粒层中，陶瓷颗粒层是一个颗粒厚，凸起弯曲的端部位于处于或邻近装甲板的冲击接收侧，其中陶瓷颗粒层是唯一的陶瓷颗粒层在所述装甲板中，其中所述陶瓷颗粒层具有由所述陶瓷颗粒的一部分形成的沿其周边延伸的边缘，其中所述陶瓷颗粒被布置成使得除了所述子集的颗粒之外的基本上每个颗粒的主体部分位于与六个相邻陶瓷颗粒的相应主体部分接触或紧密相邻，使得存在延伸穿过陶瓷颗粒层的多个谷，每个谷由三个相邻的陶瓷颗粒界定，其中基本上每个谷具有形状和尺寸使得将配合到相邻主体部分之间并且基本上垂直于相邻轴线的每个谷中的最大假想圆的直径为1.96mm至3.7mm，并且其中每个主体部分长度为5.57mm至 10.73毫米。

73. 发明申请

US20090016999A1 Embryonic cell compositions for wound treatment 审中-公开
标题翻译：用于伤口治疗的胚胎细胞组合物
公开(公告)号：US20090016999A1
公开(公告)日：2009-01-15
申请号：US12216971
申请日：2008-07-14
申请人： Michael Cohen , Jacob Cohen
发明人： Michael Cohen , Jacob Cohen
IPC分类号： A61K35/12 , A61P17/02
CPC分类号： A61K35/51 , A61K35/545
摘要： Compositions including formulations comprising stem cells, such as umbilical cord blood stem cells, or embryonic germ cell derivatives, or embryonic stem cells, are provided for enhancement of wound healing. Methods for using the compositions and formulations for enhancing would healing are also provided. Wounds to both soft and bony tissues are encompassed, and include wounds created by surgical procedures.
摘要翻译：包括包含干细胞的制剂如脐带血干细胞或胚胎生殖细胞衍生物或胚胎干细胞的组合物用于增强伤口愈合。还提供了使用组合物和制剂来增强愈合的方法。包括软组织和骨组织的伤口，包括由外科手术创建的伤口。

74. 发明授权

US07402541B2 Silicon nitride compositions 有权
标题翻译：氮化硅组合物
公开(公告)号：US07402541B2
公开(公告)日：2008-07-22
申请号：US11378886
申请日：2006-03-16
申请人： Michael Cohen
发明人： Michael Cohen
IPC分类号： C04B35/584 , F41H5/02
CPC分类号： C04B35/119 , C04B35/584 , C04B2235/3217 , C04B2235/3225 , C04B2235/3847 , C04B2235/3878 , C04B2235/3895 , C04B2235/72 , C04B2235/728 , F41H5/0414 , F41H5/0492
摘要： The present invention provides silicon nitride with tungsten carbide additives in a sinterable material comprising silicon nitride and tungsten carbide, in which the silicon nitride content is a minimum of about 80% and wherein the total nitride component is about 28-40 w/w % N2, and further comprising about 1.5-3.5 w/w % Al, about 2-6 w/w % Y, about 1.5-7 w/w % W, and about 3-9 w/w % O2. which after sintering will produce ceramic bodies with a high degree of toughness suitable for armor applications.
摘要翻译：本发明在包含氮化硅和碳化钨的可烧结材料中提供氮化硅与碳化钨添加剂，其中氮化硅含量最小为约80％，其中总氮化物组分为约28-40w / w％N 并且还包含约1.5-3.5w / w％Al，约2-6w / w％Y，约1.5-7w / w％W和约3-9w / w ％O 2 2。其烧结后将产生适合于护甲应用的高韧性的陶瓷体。

75. 发明申请

US20080166804A1 Compostions and methods for growing human embryonic stem cells 审中-公开
标题翻译：用于培养人胚胎干细胞的组合物和方法
公开(公告)号：US20080166804A1
公开(公告)日：2008-07-10
申请号：US11826539
申请日：2007-07-16
申请人： Michael J. Shamblott , Michael Cohen
发明人： Michael J. Shamblott , Michael Cohen
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N2502/04 , C12N2533/54
摘要： Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic germ (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived.
摘要翻译：通过利用从人类胚胎（EG）细胞衍生物（例如胚状体衍生细胞）的培养基获得的分泌产物，提供用于诱导和培养人胚胎干（ES）细胞并保持其培养多能性的方法。底物包括诸如胶原I，纤连蛋白或超纤连蛋白的化合物，或通常人衍生的细胞外基质。

76. 发明申请

US20080120560A1 REGION SELECTION FOR IMAGE COMPOSITING 有权
标题翻译：区域选择图像组成
公开(公告)号：US20080120560A1
公开(公告)日：2008-05-22
申请号：US11561407
申请日：2006-11-19
申请人： Michael Cohen , Matthew T. Uyttendaele , R. Alex Colburn
发明人： Michael Cohen , Matthew T. Uyttendaele , R. Alex Colburn
IPC分类号： G06F3/048
CPC分类号： G06T11/60
摘要： A technique for image compositing which allows a user to select the best image of an object, such as for example a person, from a set of images interactively and see how it will be assembled into a final photomontage. A user can select a source image from the set of images as an initial composite image. A region, representing a set of pixels to be replaced, is chosen by the user in the composite image. A corresponding same region is reflected in one or more source images, one of which will be selected by the user for painting into the composite image. The technique optimizes the selection of pixels around the user-chosen region or regions for cut points that will be least likely to show seams where the source images are merged in the composite image.
摘要翻译：一种用于图像合成的技术，其允许用户以交互方式从一组图像中选择对象（例如，人）的最佳图像，并且看到它将如何组装成最终的照片蒙版。用户可以从图像集中选择源图像作为初始合成图像。表示要替换的像素集合的区域由用户在合成图像中选择。相应的相同区域被反映在一个或多个源图像中，其中一个源图像将由用户选择以绘制到合成图像中。该技术优化了围绕用户选择的区域或区域的像素的选择，用于切割点，其将最不可能显示在合成图像中合并源图像的接缝。

77. 发明授权

US07327899B2 System and method for head size equalization in 360 degree panoramic images 有权
标题翻译：用于360度全景图像的头部尺寸均衡的系统和方法
公开(公告)号：US07327899B2
公开(公告)日：2008-02-05
申请号：US11465703
申请日：2006-08-18
申请人： Zicheng Liu , Ross Cutler , Michael Cohen , Zhengyou Zhang
发明人： Zicheng Liu , Ross Cutler , Michael Cohen , Zhengyou Zhang
IPC分类号： G06K9/36 , G09G5/00 , H04N7/00
CPC分类号： G06T3/0062 , G06K9/00228 , G06T3/4038 , G06T5/006 , G06T7/30
摘要： A real-time approximately 360 degree image correction system and a method for alleviating distortion and perception problems in images captured by omni-directional cameras. In general, the real-time panoramic image correction method generates a warp table from pixel coordinates of a panoramic image and applies the warp table to the panoramic image to create a corrected panoramic image. The corrections are performed using a parametric class of warping functions that include Spatially Varying Uniform (SVU) scaling functions. The SVU scaling functions and scaling factors are used to perform vertical scaling and horizontal scaling on the panoramic image pixel coordinates. A horizontal distortion correction is performed using the SVU scaling functions at at least two different scaling factors. This processing generates a warp table that can be applied to the panoramic image to yield the corrected panoramic image. In one embodiment the warp table is concatenated with a stitching table used to create the panoramic image.
摘要翻译：一种实时大约360度的图像校正系统和一种减轻全方位摄像机拍摄图像失真和感知问题的方法。通常，实时全景图像校正方法从全景图像的像素坐标生成扭曲表，并将经线表应用于全景图像，以创建校正的全景图像。校正使用包括空间变化均匀（SVU）缩放函数的参数化的翘曲函数类来执行。 SVU缩放函数和缩放因子用于对全景图像像素坐标执行垂直缩放和水平缩放。使用SVU缩放函数以至少两个不同的缩放因子执行水平失真校正。该处理产生可应用于全景图像以产生经校正的全景图像的经向表。在一个实施例中，经线台与用于创建全景图像的缝合台连接。

78. 发明申请

US20070268307A1 Device, Method, Software and Data Carrier Comprising Software for Displaying Information on a Screen 审中-公开
标题翻译：设备，方法，软件和数据载体包含在屏幕上显示信息的软件
公开(公告)号：US20070268307A1
公开(公告)日：2007-11-22
申请号：US10582645
申请日：2004-12-22
申请人： Michael Cohen
发明人： Michael Cohen
IPC分类号： G09G5/00
CPC分类号： G06F3/0481 , G09G5/14
摘要： The present invention relates to a device comprising a memory and a processing unit for displaying information on at least one screen, comprising: first display means for displaying at least two display areas, such as a frame or a window, on the screen, second display means for displaying inside one of the display areas selectable information objects about which further information is available, selection means for selecting one of the selectable information objects, choosing means for choosing a displayed display area and/or screen in which the further information relating to the selected information object will be displayed.
摘要翻译：本发明涉及一种包括存储器和用于在至少一个屏幕上显示信息的处理单元的设备，包括：第一显示装置，用于在屏幕上显示诸如帧或窗口之类的至少两个显示区域，第二显示器用于在一个显示区域内显示可进一步的信息的可选择的信息对象的装置，用于选择可选择的信息对象中的一个的选择装置，用于选择所显示的显示区域和/或屏幕的选择装置，其中与将显示选定的信息对象。

79. 发明授权

US07184609B2 System and method for head size equalization in 360 degree panoramic images 有权
标题翻译：用于360度全景图像的头部尺寸均衡的系统和方法
公开(公告)号：US07184609B2
公开(公告)日：2007-02-27
申请号：US11106311
申请日：2005-04-14
申请人： Zicheng Liu , Ross Cutler , Michael Cohen , Zhengyou Zhang
发明人： Zicheng Liu , Ross Cutler , Michael Cohen , Zhengyou Zhang
IPC分类号： G06K9/36 , G09G5/00 , H04N7/00
CPC分类号： G06T3/0062 , G06K9/00228 , G06T3/4038 , G06T5/006 , G06T7/30
摘要： A real-time approximately 360 degree image correction system and a method for alleviating distortion and perception problems in images captured by omni-directional cameras. In general, the real-time panoramic image correction method generates a warp table from pixel coordinates of a panoramic image and applies the warp table to the panoramic image to create a corrected panoramic image. The corrections are performed using a parametric class of warping functions that include Spatially Varying Uniform (SVU) scaling functions. The SVU scaling functions and scaling factors are used to perform vertical scaling and horizontal scaling on the panoramic image pixel coordinates. A horizontal distortion correction is performed using the SVU scaling functions at at least two different scaling factors. This processing generates a warp table that can be applied to the panoramic image to yield the corrected panoramic image. In one embodiment the warp table is concatenated with a stitching table used to create the panoramic image.
摘要翻译：一种实时大约360度的图像校正系统和一种减轻全方位摄像机拍摄图像失真和感知问题的方法。通常，实时全景图像校正方法从全景图像的像素坐标生成扭曲表，并将经线表应用于全景图像，以创建校正的全景图像。校正使用包括空间变化均匀（SVU）缩放函数的参数化的翘曲函数类来执行。 SVU缩放函数和缩放因子用于对全景图像像素坐标执行垂直缩放和水平缩放。使用SVU缩放函数以至少两个不同的缩放因子执行水平失真校正。该处理产生可应用于全景图像以产生经校正的全景图像的经向表。在一个实施例中，经线台与用于创建全景图像的缝合台连接。

80. 发明申请

US20060184872A1 Presentation viewing tool designed for the viewer 有权
标题翻译：为观众设计的演示文稿查看工具
公开(公告)号：US20060184872A1
公开(公告)日：2006-08-17
申请号：US11057997
申请日：2005-02-15
申请人： Lubomira Dontcheva , Steven Drucker , Michael Cohen
发明人： Lubomira Dontcheva , Steven Drucker , Michael Cohen
IPC分类号： G06F17/00 , G06F17/21
CPC分类号： G06F17/242 , G06F17/241
摘要： The subject invention provides a unique system and method that facilitates a viewer's viewing experience of a presentation as shown on the viewer's own machine. The system and method provide the viewer with navigation and annotation control of the viewer's view of the presentation without affecting the presenter's presentation and/or the presenter's display of the presentation. When viewing a presentation, the viewer can annotate at least a portion of the presentation with text, audio, ink markings, as well as insert URL or other web-based information. Searches can be conducted during the viewing of the presentation to further supplement content in the presentation. The search results including the pertinent URLs can be added in whole or in part to the relevant portions of the presentation. Furthermore, the viewer can view the presentation in a variety of perspectives and zoom levels to gain context over the presentation or parts thereof.
摘要翻译：本发明提供了一种独特的系统和方法，其便于观看者自己的机器上显示的观看者的呈现观看体验。该系统和方法向观众提供观众对演示视图的导航和注释控制，而不影响演示者的呈现和/或演示者对演示的显示。当观看演示时，观众可以用文本，音频，墨水标记以及插入URL或其他基于网络的信息来注释演示文稿的至少一部分。可以在观看演示文稿期间进行搜索，以进一步补充演示文稿中的内容。包括相关URL的搜索结果可以全部或部分添加到演示文稿的相关部分。此外，观看者可以以各种视角和缩放级别来观看呈现，以获得呈现或其部分的上下文。

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