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71. 发明授权

US06519488B2 Method and system for reducing arterial restenosis in the presence of an intravascular stent 失效
公开(公告)号：US06519488B2
公开(公告)日：2003-02-11
申请号：US09940336
申请日：2001-08-27
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.

72. 发明授权

US06285909B1 Preserving patient specific data in implantable pulse generator systems 有权
标题翻译：在植入式脉冲发生器系统中保存患者特定数据
公开(公告)号：US06285909B1
公开(公告)日：2001-09-04
申请号：US09321254
申请日：1999-05-27
申请人： Robert J. Sweeney , Brian Brandell , Bruce H. KenKnight
发明人： Robert J. Sweeney , Brian Brandell , Bruce H. KenKnight
IPC分类号： A61N1362
CPC分类号： A61N1/37252 , A61N1/37288
摘要： A method and a system for preserving patient specific data in implantable pulse generator systems. A communication link is established with a first implantable pulse generator. Electronic cardiac data contained within the first implantable pulse generator is retrieved through the communication link. The electronic cardiac data is then electronically downloaded to a second implantable pulse generator. Prior to downloading, the electronic cardiac data can be formatted into a format compatible with the second implantable pulse generator.
摘要翻译：一种用于在植入式脉冲发生器系统中保存患者特定数据的方法和系统。建立与第一可植入脉冲发生器的通信链路。通过通信链路检索包含在第一可植入脉冲发生器内的电子心脏数据。然后将电子心脏数据电子下载到第二可植入脉冲发生器。在下载之前，电子心脏数据可以被格式化成与第二可植入脉冲发生器兼容的格式。

73. 发明授权

US06272377B1 Cardiac rhythm management system with arrhythmia prediction and prevention 有权
标题翻译：心律失常预防与心律失常管理系统
公开(公告)号：US06272377B1
公开(公告)日：2001-08-07
申请号：US09411345
申请日：1999-10-01
申请人： Robert J. Sweeney , Bruce H. KenKnight
发明人： Robert J. Sweeney , Bruce H. KenKnight
IPC分类号： A61B50468
CPC分类号： A61N1/3622 , G06F19/00 , G16H50/30
摘要： A cardiac rhythm management system predicts when an arrhythmia will occur and in one embodiment invokes a therapy to prevent or reduce the consequences of the arrhythmia. A cardiac arrhythmia trigger/marker is detected from a patient, and based on the trigger/marker, the system estimates a probability of a cardiac arrhythmia occurring during a predetermined future time interval. The system provides a list of triggers/markers, for which detection values are recurrently obtained at various predetermined time intervals. Based on detection values and conditional probabilities associated with the triggers/markers, a probability estimate of a future arrhythmia is computed. An arrhythmia prevention therapy is selected and activated based on the probability estimate of the future arrhythmia.
摘要翻译：心律管理系统预测何时发生心律失常，并且在一个实施例中调用治疗以预防或减少心律失常的后果。从患者检测到心律失常触发/标记，并且基于触发/标记，系统估计在预定的未来时间间隔期间发生心律失常的概率。该系统提供了一个触发/标记列表，为各种预定时间间隔循环获得检测值。基于与触发/标记相关联的检测值和条件概率，计算未来心律失常的概率估计。基于对未来心律失常的概率估计，选择并激活心律失常预防疗法。

74. 发明授权

US06251125B1 Method and apparatus for treating ventricular fibrillation using electrogram features 失效
标题翻译：使用电描记图特征治疗心室颤动的方法和装置
公开(公告)号：US06251125B1
公开(公告)日：2001-06-26
申请号：US09053115
申请日：1998-04-01
申请人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
发明人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
IPC分类号： A61N139
CPC分类号： A61N1/3962
摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.
摘要翻译：通过以提高除颤休克成功概率的方式协调将感染的心室颤动复合物递送除颤电击的心室除颤的方法和系统。在心室纤维性颤动期间，在两个心室位置监测心室电活动，以检测心室心脏组织的粗略心室颤动复合物和收缩。伴随发生粗心室颤动复合物和心室心脏组织的收缩，特别是在其上坡部分发生除颤休克，以获得最佳的成功概率。

75. 发明授权

US06168801A Controlled release drug delivery 有权
标题翻译：控制释放药物递送
公开(公告)号：US06168801A
公开(公告)日：2001-01-02
申请号：US09272428
申请日：1999-03-19
申请人： Ronald W. Heil, Jr. , Bruce H. KenKnight
发明人： Ronald W. Heil, Jr. , Bruce H. KenKnight
IPC分类号： A61F202
CPC分类号： A61K9/0024
摘要： Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. The combination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.
摘要翻译：生物活性材料提供在圆柱形载体介质中，通过提供具有溶解或分散在其中的至少两种具有共同的生物活性核，但具有不同溶解度参数的化合物的载体，可以更好地控制输送速率和输送时间。具有不同溶解度参数的相同药物的两种不同变体的组合提供了材料对化合物释放速率的控制（通过改变变体的比例），最重要的是通过使得能够延长器件的使用寿命在更长的时间内释放有效含量的化合物。由硅树脂构成的圆柱形载体介质还包括尾部，裙部或限速膜。

76. 发明授权

US6152955A Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation 失效
标题翻译：可植入的保形线圈贴片电极，具有多个用于心脏复律和除颤的导电元件
公开(公告)号：US6152955A
公开(公告)日：2000-11-28
申请号：US240396
申请日：1999-01-29
申请人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
发明人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0587
摘要： Body-implantable leads with open, unbacked (uninsulated) electrode structures having electrical discharge surfaces formed by conductive elements, such as mesh and braid, and preferably coils. The electrode structures can be classified by pattern: (1) loops, (2) linear arrays and (3) radial arrays. The electrodes are located on or near the epicardial surface of the right and left heart.
摘要翻译：具有开放，未背衬（未绝缘）电极结构的体内可植入引线，其具有由诸如网和编织物的导电元件形成的放电表面，并且优选线圈。电极结构可以通过图案分类：（1）环，（2）线性阵列和（3）径向阵列。电极位于右心左心外表面上或附近。

77. 发明授权

US6032079A Implantable conformal coil electrode with multiple conductive elements for cardioversion and defibrillation 失效
标题翻译：可植入的保形线圈电极，具有多个用于心脏复律和除颤的导电元件
公开(公告)号：US6032079A
公开(公告)日：2000-02-29
申请号：US240447
申请日：1999-01-29
申请人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
发明人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0587
摘要： Body-implantable leads with open, unbacked (uninsulated) electrode structures having electrical discharge surfaces formed by conductive elements, such as mesh and braid, and preferably coils. The electrode structures can be classified by pattern: (1) loops, (2) linear arrays and (3) radial arrays. The electrodes are located on or near the epicardial surface of the right and left heart.
摘要翻译：具有开放，未背衬（未绝缘）电极结构的体内可植入引线，其具有由诸如网和编织物的导电元件形成的放电表面，并且优选线圈。电极结构可以通过图案分类：（1）环，（2）线性阵列和（3）径向阵列。电极位于右心左心外表面上或附近。

78. 发明授权

US5916243A Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation 失效
公开(公告)号：US5916243A
公开(公告)日：1999-06-29
申请号：US609215
申请日：1996-03-01
申请人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
发明人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0587
摘要： Body-implantable leads with open, unbacked (uninsulated) electrode structures having electrical discharge surfaces formed by conductive elements, such as mesh and braid, and preferably coils. The electrode structures can be classified by pattern: (1) loops, (2) linear arrays and (3) radial arrays. The electrodes are located on or near the epicardial surface of the right and left heart.

79. 发明授权

US5916238A Implantable intravenous cardiac stimulation system with pulse generator housing serving as optional additional electrode 失效
公开(公告)号：US5916238A
公开(公告)日：1999-06-29
申请号：US964120
申请日：1997-11-04
申请人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
发明人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
IPC分类号： A61N1/05 , A61N1/368 , A61N1/375 , A61N1/39
CPC分类号： A61N1/056 , A61N1/05 , A61N1/368 , A61N1/375 , A61N1/3756
摘要： A pulse generator housing for enclosing and containing pulse generator defibrillation circuitry. The housing is formed entirely of electrically conductive metal defining an electrically conductive outer surface which is connected to the pulse generator circuitry for delivering defibrillating energy to the heart. The pulse generator housing is implanted in the pectoral region proximate the heart with the conductive surface facing the heart. Regions of the conductive outer surface may be electrically isolated and dedicated for separately sensing and shocking. The outer surface may be coated with platinum. Additional coiled segment electrodes may extend from the housing and be electrically connected to the conductive outer surface so as to increase the effective conductive surface area. A sensor is provided to determine whether the housing is inside or outside a body of a patient to disconnect the pulse generator housing conductive surface from the pulse generator circuitry when the unit is outside the body of a patient.

80. 发明授权

US08571654B2 Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US08571654B2
公开(公告)日：2013-10-29
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

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