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71. 发明授权

US6014581A Interface for performing a diagnostic or therapeutic procedure on heart tissue with an electrode structure 失效
标题翻译：用于在具有电极结构的心脏组织上执行诊断或治疗程序的界面
公开(公告)号：US6014581A
公开(公告)日：2000-01-11
申请号：US48636
申请日：1998-03-26
申请人： James G. Whayne , Dorin Panescu , David McGee , Daniel A. Dupree , David K. Swanson , Tuan Nguyen
发明人： James G. Whayne , Dorin Panescu , David McGee , Daniel A. Dupree , David K. Swanson , Tuan Nguyen
IPC分类号： A61B5/042 , A61B5/044
CPC分类号： A61B5/6858 , A61B5/0422 , A61B5/7435 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , A61B2562/0209 , A61B2562/043
摘要： An interface for performing a diagnostic or therapeutic procedure on heart tissue with an electrode structure includes a controller which operates to establish an operating condition for the electrode structure, a processing unit coupled to the controller, a memory storage device including process software adapted to be executed by the processing unit and a graphical user interface including a display screen coupled to the processing unit. The process software performs a first control application and a second control application, each control application prescribing procedures for carrying out a given task using the electrode structure, at least one of the control applications prescribing a clinical procedure affecting heart tissue. The process software further performs a first function to create on the display screen separate first and second display regions, a second function to show in the first display region a selection menu display comprising a first field for selecting the first control application for execution and a second field for selecting the second control application for execution, and a third function to show in the second display region a first graphical display during execution of the first control application and a second graphical display during execution of the second control application.
摘要翻译：用于利用电极结构对心脏组织执行诊断或治疗过程的界面包括操作以建立电极结构的操作条件的控制器，耦合到控制器的处理单元，包括适于执行的处理软件的存储器存储设备由处理单元和包括耦合到处理单元的显示屏幕的图形用户界面。处理软件执行第一控制应用和第二控制应用，每个控制应用程序规定使用电极结构执行给定任务的过程，至少一个控制应用程序规定影响心脏组织的临床过程。处理软件还执行第一功能，以在显示屏幕上创建分开的第一和第二显示区域，第二功能在第一显示区域中显示包括用于选择要执行的第一控制应用程序的第一字段的选择菜单显示，以及第二功能用于选择用于执行的第二控制应用程序的第一控制应用程序的第一图形显示，以及在执行第二控制应用期间在第二显示区域中显示第一图形显示的第三功能和执行第二控制应用期间的第二图形显示。

72. 发明授权

US5904651A Systems and methods for visualizing tissue during diagnostic or therapeutic procedures 失效
标题翻译：在诊断或治疗过程中可视化组织的系统和方法
公开(公告)号：US5904651A
公开(公告)日：1999-05-18
申请号：US739504
申请日：1996-10-28
申请人： David K. Swanson , David McGee , Dorin Panescu , James G. Whayne , Harm TenHoff
发明人： David K. Swanson , David McGee , Dorin Panescu , James G. Whayne , Harm TenHoff
IPC分类号： A61B1/313 , A61B5/00 , A61B5/05 , A61B8/12 , A61B8/14 , A61N1/05
CPC分类号： A61B8/12 , A61B5/0084 , A61B5/6852 , A61B8/445 , A61B8/54 , A61B8/543 , A61B5/0066 , A61B5/7285 , A61B6/541
摘要： A catheter tube carries an imaging element for visualizing tissue. The catheter tube also carries a support structure, which extends beyond the imaging element for contacting surrounding tissue away from the imaging element. The support element stabilizes the imaging element, while the imaging element visualizes tissue in the interior body region. The support structure also carries a diagnostic or therapeutic component to contact surrounding tissue.
摘要翻译：导管管携带用于使组织可视化的成像元件。导管还具有延伸超过成像元件的支撑结构，用于使周围组织远离成像元件。支撑元件稳定成像元件，而成像元件可视化内部身体区域中的组织。支撑结构还携带用于接触周围组织的诊断或治疗部件。

73. 发明授权

US5879348A Electrode structures formed from flexible, porous, or woven materials 失效
标题翻译：由柔性，多孔或编织材料形成的电极结构
公开(公告)号：US5879348A
公开(公告)日：1999-03-09
申请号：US631577
申请日：1996-04-12
申请人： Patrick M. Owens , James G. Whayne , David K. Swanson , Dorin Panescu
发明人： Patrick M. Owens , James G. Whayne , David K. Swanson , Dorin Panescu
IPC分类号： A61B18/14 , A61N1/06 , A61B17/39
CPC分类号： A61N1/06 , A61B18/1492 , A61B2018/00065 , A61B2018/00113 , A61B2018/00214 , A61B2018/00267 , A61B2018/00839 , A61B2018/1253 , A61B2018/1472 , A61B2218/002
摘要： Electrode structures are formed from flexible, porous, or woven materials. One such structure is made by forming first and second body sections, each including a peripheral edge. The first and second body sections are joined together about their peripheral edges with a seam, thereby forming a composite structure. Another one of such structures is made by forming a body having a three dimensional shape and opposite open ends, and at least partially closing at least one of the opposite ends by forming a seam. Another one of such structures is formed from a sheet of material having peripheral edges. The sheet is placed on the distal end of a fixture, while the peripheral edges of the sheet are gathered about the proximal end of a fixture, thereby imparting to the sheet a desired shape. At least one pleat is formed to secure the gathered peripheral edges together. The seams or pleats are formed by thermal bonding, or ultrasonic welding, or laser welding, or adhesive bonding, or sewing.
摘要翻译：电极结构由柔性，多孔或编织材料形成。一个这样的结构通过形成第一和第二主体部分而形成，每个主体部分包括周边边缘。第一和第二主体部分通过接缝围绕其周边边缘连接在一起，从而形成复合结构。通过形成具有三维形状和相对的开口端的主体，并且通过形成接缝至少部分地闭合相对端中的至少一个来制造另一个这样的结构。这种结构中的另一个由具有外围边缘的材料片形成。片材被放置在固定装置的远端，而片材的周边边缘围绕固定装置的近端聚集，从而赋予片材所需的形状。形成至少一个褶皱以将聚集的周边边缘固定在一起。接缝或褶皱是通过热粘合或超声波焊接，或激光焊接，粘合或粘合形成的。

74. 发明授权

US5871483A Folding electrode structures 失效
标题翻译：折叠电极结构
公开(公告)号：US5871483A
公开(公告)日：1999-02-16
申请号：US629171
申请日：1996-04-08
申请人： Jerome Jackson , Dorin Panescu , David K. Swanson , Russell B. Thompson , James G. Whayne
发明人： Jerome Jackson , Dorin Panescu , David K. Swanson , Russell B. Thompson , James G. Whayne
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61N1/05 , A61B17/39
CPC分类号： A61B18/1492 , A61N1/056 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00839
摘要： Improved folding electrode assemblies and associated methods employ a structure comprising a wall peripherally enclosing an interior. The structure is adapted to selectively assume a geometry that changes between an expanded geometry having a first maximum diameter and a collapsed geometry having a second maximum diameter less than the first maximum diameter. At least one folding region in the wall is adapted to fold upon itself along a predefined fold line as the structure geometry changes. The folding region is formed when a portion of the wall is coated with an electrically conductive material for the purpose of transmitting electrical ablating energy, while another portion of the wall is left free of the electrically conductive material. Alternatively, the folding region is formed by forming an array of apertures in the wall.
摘要翻译：改进的折叠电极组件和相关联的方法采用包括外围围绕内部的壁的结构。该结构适于选择性地假设在具有第一最大直径的膨胀几何形状和具有小于第一最大直径的第二最大直径的折叠几何形状之间变化的几何形状。当结构几何形状改变时，壁中的至少一个折叠区域适于沿着预定折叠线自身折叠。当壁的一部分涂覆有用于传递电消融能量的导电材料时，同时壁的另一部分没有导电材料形成折叠区域。或者，通过在壁中形成孔阵列来形成折叠区域。

75. 发明授权

US5846239A Tissue heating and ablation systems and methods using segmented porous electrode structures 失效
标题翻译：组织加热和消融系统和使用分段多孔电极结构的方法
公开(公告)号：US5846239A
公开(公告)日：1998-12-08
申请号：US634338
申请日：1996-04-12
申请人： David K. Swanson , Dorin Panescu , James G. Whayne , Patrick M. Owens , Russell B. Thompson
发明人： David K. Swanson , Dorin Panescu , James G. Whayne , Patrick M. Owens , Russell B. Thompson
IPC分类号： A61N1/05 , A61B17/39
CPC分类号： A61N1/05 , A61B18/1492 , A61B2018/00238 , A61B2018/00357 , A61B2018/00791 , A61B2018/00839
摘要： A porous electrode assembly for tissue heating and ablation systems and methods includes a wall having an exterior peripherally surrounding an interior area. The assembly includes a lumen to convey a medium containing ions into the interior area. An element couples the medium within the interior area to a source of electrical energy. According to the invention, the wall includes at least two spaced apart zones. Each zone comprises a porous material sized to pass ions contained in the medium, to thereby enable ionic transport of electrical energy from the source through the medium and porous material to the exterior of the wall. In a preferred embodiment, the at least two zones are spaced apart by a third zone comprising a material that blocks passage of ions contained in the medium.
摘要翻译：用于组织加热和消融系统和方法的多孔电极组件包括具有周围围绕内部区域的外部的壁。组件包括用于将含有离子的介质输送到内部区域中的内腔。元件将内部区域内的介质耦合到电能源。根据本发明，壁包括至少两个间隔开的区域。每个区域包括多孔材料，其尺寸适于通过包含在介质中的离子，从而使得电能从源通过介质和多孔材料离子输送到壁的外部。在一个优选实施例中，所述至少两个区域间隔开第三区域，所述第三区域包括阻挡介质中包含的离子通过的材料。

76. 发明授权

US5722416A Systems and methods for analyzing biopotential morphologies in heart tissue to locate potential ablation sites 失效
标题翻译：用于分析心脏组织中的生物电位形态以定位潜在消融部位的系统和方法
公开(公告)号：US5722416A
公开(公告)日：1998-03-03
申请号：US393126
申请日：1995-02-17
申请人： David K. Swanson , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Dorin Panescu , James G. Whayne
IPC分类号： A61B1/005 , A61B5/042 , A61B5/0452 , A61N1/05 , A61N1/40 , G06F17/00 , A61B5/0402
CPC分类号： A61N1/403 , A61B5/0422 , A61B5/04525 , A61B5/6855 , A61B5/6858 , A61N1/056 , A61B1/0051
摘要： Systems and methods analyze biopotential morphologies in body tissue. The systems and methods use a template of a biopotential event of known cause in body tissue. The template comprises a plot of variations in biopotentials over time and not a spacial distribution of endocardial surface activation. The systems and methods compare this template to a sample of a biopotential event externally triggered in body tissue. The sample comprises a plot of variations in biopotentials over time and not a spacial distribution of endocardial surface activation. The systems and methods generate an output based upon the comparison. The systems and methods can be used to compare an event-specific template of a cardiac event of known diagnosis to a sample of a paced cardiac event. The comparison yields a matching factor indicating how alike the input sample is to the input template. The systems and methods compare the matching factor to a predetermined value to determine the location of sites that are potentially appropriate for ablation. A matching factor that indicates close similarity between the sample and the template suggests that the pacing site lies close to a region potentially appropriate for ablation to treat the arrhythmia.
摘要翻译：系统和方法分析身体组织中的生物电位形态。系统和方法使用身体组织中已知原因的生物潜在事件的模板。该模板包括随时间的生物电势的变化图，而不是心内膜表面活化的空间分布。系统和方法将该模板与身体组织中外部触发的生物潜在事件的样本进行比较。样品包括生物电势随时间变化的图，而不是心内膜表面活化的空间分布。系统和方法基于比较产生输出。系统和方法可用于将已知诊断的心脏事件的事件特定模板与起搏心脏事件的样本进行比较。比较产生一个匹配因子，表明输入样本与输入模板的相似度。系统和方法将匹配因子与预定值进行比较，以确定潜在适合于消融的部位的位置。表明样品和模板之间密切相似的匹配因子表明，起搏部位靠近可能适合消融治疗心律失常的区域。

77. 发明授权

US5595183A Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes 失效
标题翻译：使用多个电极结构和粗纱电极检查心脏组织的系统和方法
公开(公告)号：US5595183A
公开(公告)日：1997-01-21
申请号：US390383
申请日：1995-02-17
申请人： David K. Swanson , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Dorin Panescu , James G. Whayne
IPC分类号： A61B5/0408 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B18/14 , A61N1/05 , A61N1/362
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/6858 , A61N1/056 , A61B18/1492 , A61B2090/065 , A61B2562/0209 , A61B2562/043
摘要： Systems and methods use an array of multiple electrodes supported for operative association with a region of heart tissue, in tandem with a roving second electrode supported for movement relative to the multiple electrode means for operative association with selected, different regions of endocardial tissue within the heart. An analog or digital processing element conditions one of the multiple electrodes and the roving electrode to emit a pacing signal while the other one of the multiple electrodes and the roving electrode records paced electrograms occurring as a result of the pacing signal. A processing element and method input a template of a cardiac event of known diagnosis sensed using the array of multiple electrodes. The processing element and method inputs a sample of a cardiac event acquired by pacing from at least one roving electrode and sensed with the array of multiple electrodes. The processing element and method electronically compare the input sample to the input template and generates an output based upon the comparison. The output can aid the physician in locating potentially appropriate sites for ablation.
摘要翻译：系统和方法使用多个电极的阵列，其被支撑用于与心脏组织的区域操作性关联，与被支撑用于相对于多个电极装置移动的粗纱第二电极串联，以与心脏内心脏组织的选定的不同区域有效结合。模拟或数字处理元件调节多个电极和粗纱电极之一以发出起搏信号，而多个电极和粗纱电极中的另一个记录起搏电迹作为起搏信号的结果。处理元件和方法输入使用多个电极阵列感测的已知诊断的心脏事件的模板。处理元件和方法输入通过起搏从至少一个粗纱电极获取的心脏事件的样本，并用多个电极的阵列感测。处理元件和方法将输入样本与输入模板进行电子比较，并根据比较生成输出。输出可以帮助医生定位潜在的适当的消融部位。

78. 发明授权

US07194294B2 Multi-functional medical catheter and methods of use 有权
标题翻译：多功能医用导管及使用方法
公开(公告)号：US07194294B2
公开(公告)日：2007-03-20
申请号：US10428308
申请日：2003-05-02
申请人： Dorin Panescu , David K. Swanson
发明人： Dorin Panescu , David K. Swanson
IPC分类号： A61B5/04 , A61B18/14
CPC分类号： A61B5/0422 , A61B5/0538 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4472 , A61B18/1492 , A61B2017/00106 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/124 , A61B2018/1467 , A61B2090/065 , A61B2090/3782 , A61B2090/3784 , A61B2090/3929 , A61B2090/3958 , A61B2090/3975 , A61M25/0133 , A61M2025/0161 , A61N1/056 , A61N1/08 , A61N7/02 , A61N2007/0078
摘要： The present invention provides multi-functional medical catheters, systems and methods for their use. In one particular embodiment, a medical catheter (100) includes a flexible elongate body (105) having a proximal end (110) and a distal end (120). A plurality of spaced apart electrodes (130–136) are operably attached to the flexible body near the distal end. At least some of the electrodes are adapted for mapping a tissue and, in some embodiments, at least one of the electrodes is adapted for ablating a desired portion of the tissue. The catheter includes a plurality of tissue orientation detectors (140–146) disposed between at least some of the electrodes. In this manner, the medical catheter is capable of tissue mapping, tissue imaging, tissue orientation, and/or tissue treatment functions.
摘要翻译：本发明提供了多功能医用导管，其使用的系统和方法。在一个具体实施例中，医疗导管（100）包括具有近端（110）和远端（120）的柔性细长主体（105）。多个间隔开的电极（130-136）在远端附近可操作地附接到柔性体。至少一些电极适于映射组织，并且在一些实施例中，电极中的至少一个适于消融组织的期望部分。导管包括设置在至少一些电极之间的多个组织取向检测器（140-146）。以这种方式，医用导管能够进行组织测绘，组织成像，组织取向和/或组织处理功能。

79. 发明授权

US6022346A Tissue heating and ablation systems and methods using self-heated electrodes 失效
标题翻译：组织加热和消融系统和使用自热电极的方法
公开(公告)号：US6022346A
公开(公告)日：2000-02-08
申请号：US480138
申请日：1995-06-07
申请人： Dorin Panescu , Sidney D. Fleischman , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , David K. Swanson
IPC分类号： A61B18/12 , A61B18/14 , A61N1/40 , A61B17/39
CPC分类号： A61B18/1206 , A61B18/1492 , A61N1/403 , A61B18/1402 , A61B2018/00083 , A61B2018/00095 , A61B2018/00791 , A61B2018/00803
摘要： Systems and methods using an electrode able to transmit heating or ablation energy into tissue include first and second sensing elements associated with the electrode for measuring first and second temperatures. The electrode also includes a heating element in thermal conductive contact with the electrode for heating the electrode. The systems and methods sequentially activate the heating element and sense temperatures without transmitting tissue heating or ablation energy, and then transmit heating or ablation energy and sense temperatures without activating the heating element, to derive from the sensed temperatures a prediction of maximum tissue temperature.
摘要翻译：使用能够将加热或消融能量传递到组织中的电极的系统和方法包括与用于测量第一和第二温度的电极相关联的第一和第二感测元件。电极还包括与用于加热电极的电极导热接触的加热元件。系统和方法顺序地激活加热元件并且感测温度而不传递组织加热或消融能量，然后传递加热或消融能量并感测温度而不激活加热元件，从感测的温度导出最大组织温度的预测。

80. 发明授权

US5833621A Systems and methods for matching electrical characteristics and propagation velocities in cardiac tissue 失效
标题翻译：用于匹配心脏组织中电特性和传播速度的系统和方法
公开(公告)号：US5833621A
公开(公告)日：1998-11-10
申请号：US589799
申请日：1996-01-22
申请人： Dorin Panescu , David K. Swanson
发明人： Dorin Panescu , David K. Swanson
IPC分类号： A61B5/05 , A61B5/053 , A61N1/05 , A61B5/04
CPC分类号： A61B5/053 , A61B5/0538 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods also sense the timing of local depolarization events in the tissue in which impedance is sensed and derive therefrom the propagation velocities of the sensed depolarization events. The systems and methods match the derived tissue electrical characteristics with the derived propagation velocities in spatial relation to the electrodes to characterize the morphology of the contacted heart tissue. This matching provides precise differentiation between regions of infarcted heart tissue and healthy heart tissue.
摘要翻译：系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。系统和方法还感测组织中的局部去极化事件的定时，其中阻抗被感测并从其导出感测去极化事件的传播速度。系统和方法将衍生的组织电特征与与电极空间关系的导出传播速度相匹配，以表征所接触的心脏组织的形态。这种匹配提供梗塞心脏组织和健康心脏组织的区域之间的精确分化。

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