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71. 发明授权

US07674777B2 Immunostimulatory nucleic acid molecules 失效
标题翻译：免疫刺激核酸分子
公开(公告)号：US07674777B2
公开(公告)日：2010-03-09
申请号：US10769282
申请日：2004-01-30
申请人： Arthur M. Krieg , Dennis Klinman , Alfred D. Steinberg
发明人： Arthur M. Krieg , Dennis Klinman , Alfred D. Steinberg
IPC分类号： A01N61/00 , A01N37/18 , A01N43/04 , C07H21/04 , C07H21/02 , A61K39/38 , A61K39/00 , A61K45/00 , A61K47/00 , A61K31/00 , A61K38/00 , A61K9/127
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
摘要翻译：公开了含有未甲基化CpG二核苷酸的核酸和基于其刺激免疫应答的能力并将Th2应答重定向到受试者中Th1应答的治疗效用。公开了治疗特应性疾病，包括特应性皮炎的方法。

72. 发明申请

US20070066553A1 Immunostimulatory nucleic acid molecules 有权
公开(公告)号：US20070066553A1
公开(公告)日：2007-03-22
申请号：US11503483
申请日：2006-08-11
申请人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
IPC分类号： A61K48/00
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

73. 发明申请

US20060094683A1 Immunomodulatory oligonucleotides 审中-公开
标题翻译：免疫调节寡核苷酸
公开(公告)号：US20060094683A1
公开(公告)日：2006-05-04
申请号：US11296644
申请日：2005-12-07
申请人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： A61K31/4706 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12Q1/68
摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
摘要翻译：公开了含有非乙酸化CpG二核苷酸的寡核苷酸和基于其在受试者中刺激免疫应答的能力的治疗效用。还公开了用于治疗由受试者中由未乙酸化的CpG二核苷酸引发的与免疫系统活化相关的疾病的治疗方法，其包括对所述受试者施用不含非甲基化CpG序列（即甲基化CpG序列或不含CpG序列）的寡核苷酸以超过未甲基化的CpG核酸用于结合的酸。进一步公开了含有二核苷酸的甲基化CpG用于反义治疗或体内杂交探针，以及用作抗病毒治疗剂的免疫抑制性寡核苷酸。

74. 发明申请

US20050239736A1 Immunomodulatory oligonucleotides 审中-公开
公开(公告)号：US20050239736A1
公开(公告)日：2005-10-27
申请号：US11067516
申请日：2005-02-25
申请人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
IPC分类号： A61K31/4706 , A61K39/39 , C07H21/00 , C12Q1/68 , A61K48/00 , C07H21/02
CPC分类号： A61K31/4706 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12Q1/68
摘要： Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.

75. 发明申请

US20050215500A1 Immunostimulatory nucleic acid molecules 审中-公开
公开(公告)号：US20050215500A1
公开(公告)日：2005-09-29
申请号：US10972301
申请日：2004-10-22
申请人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
IPC分类号： C12N15/09 , A61K9/127 , A61K31/00 , A61K31/175 , A61K31/335 , A61K31/47 , A61K31/4706 , A61K31/70 , A61K31/7088 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/52 , C12N15/117 , C12Q1/68
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

76. 发明申请

US20050171047A1 Immunostimulatory nucleic acid molecules 有权
公开(公告)号：US20050171047A1
公开(公告)日：2005-08-04
申请号：US11036527
申请日：2005-01-14
申请人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
IPC分类号： C12N15/09 , A61K9/127 , A61K31/00 , A61K31/175 , A61K31/335 , A61K31/47 , A61K31/4706 , A61K31/70 , A61K31/7088 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/52 , C12N15/117 , C12Q1/68 , A61K39/35
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

77. 发明申请

US20050148537A1 Immunostimulatory nucleic acid molecules 审中-公开
公开(公告)号：US20050148537A1
公开(公告)日：2005-07-07
申请号：US10987146
申请日：2004-11-12
申请人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Dennis Klinman , Alfred Steinberg
IPC分类号： C12N15/09 , A61K9/127 , A61K31/00 , A61K31/175 , A61K31/335 , A61K31/47 , A61K31/4706 , A61K31/70 , A61K31/7088 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/52 , C12N15/117 , C12Q1/68
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

78. 发明申请

US20050049215A1 Immunostimulatory nucleic acid molecules 审中-公开
公开(公告)号：US20050049215A1
公开(公告)日：2005-03-03
申请号：US10888449
申请日：2004-07-09
申请人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
发明人： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
IPC分类号： C12N15/09 , A61K9/127 , A61K31/00 , A61K31/175 , A61K31/335 , A61K31/47 , A61K31/4706 , A61K31/70 , A61K31/7088 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/52 , C12N15/117 , C12Q1/68
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

79. 发明授权

US06207646B1 Immunostimulatory nucleic acid molecules 失效
标题翻译：免疫刺激核酸分子
公开(公告)号：US06207646B1
公开(公告)日：2001-03-27
申请号：US08738652
申请日：1996-10-30
申请人： Arthur M. Krieg , Joel Kline , Dennis Klinman , Alfred D. Steinberg
发明人： Arthur M. Krieg , Joel Kline , Dennis Klinman , Alfred D. Steinberg
IPC分类号： A61P3706
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed.
摘要翻译：公开了含有未甲基化CpG二核苷酸的核酸和基于其刺激免疫应答的能力并将Th2应答重定向到受试者中Th1应答的治疗效用。

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