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71. 发明授权

US06734174B1 Modulators of the function of receptors of the TNF/NGF receptor 失效
标题翻译： TNF / NGF受体受体功能的调节剂
公开(公告)号：US06734174B1
公开(公告)日：2004-05-11
申请号：US09646403
申请日：2001-02-21
申请人： David Wallach , Andrei Kovalenko , Marshall S. Horwitz , Yongan Li
发明人： David Wallach , Andrei Kovalenko , Marshall S. Horwitz , Yongan Li
IPC分类号： A61K3170
CPC分类号： C07K14/4703 , A61K38/00
摘要： A protein capable of modulating or mediating the intracellular activity of RIP in inflammation, cell survival and cell death pathways is provided. DNA encoding it, a method for its production and its uses are also provided.
摘要翻译：提供了能够调节或介导RIP在炎症，细胞存活和细胞死亡途径中的细胞内活性的蛋白质。还提供了编码它的DNA，其生产方法及其用途。

72. 发明授权

US06479655B1 TNF receptor promoter 失效
标题翻译： TNF受体启动子
公开(公告)号：US06479655B1
公开(公告)日：2002-11-12
申请号：US08600203
申请日：1996-02-12
申请人： David Wallach , Oliver Kemper
发明人： David Wallach , Oliver Kemper
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , C12N15/85 , C12N2310/13 , C12N2830/00 , C12N2830/85
摘要： A promoter sequence of the human p55 TNF-R gene is provided. Also provided are sequence motifs and motif regions contained within the promoter sequence. Methods for preparing these motifs or motif regions and their use in the modulation of TNF function are also provided.
摘要翻译：提供人p55 TNF-R基因的启动子序列。还提供了包含在启动子序列内的序列基序和基序区域。还提供了制备这些基序或基序区域的方法及其在调节TNF功能中的用途。

73. 发明授权

US06399327B1 Modulators of the function of FAS receptors and other proteins 失效
标题翻译： FAS受体和其他蛋白质的功能调节剂
公开(公告)号：US06399327B1
公开(公告)日：2002-06-04
申请号：US08983502
申请日：1998-04-10
申请人： David Wallach , Mark Boldin , Tanya Goncharov , Yury V. Golstev
发明人： David Wallach , Mark Boldin , Tanya Goncharov , Yury V. Golstev
IPC分类号： C12N1511
CPC分类号： C12N9/641 , A61K38/00 , C07K14/70578 , C07K14/715 , C07K14/7151 , C07K16/2866 , C07K2319/00 , C12N9/6475
摘要： The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-biding proteins having proteolytic activity are provided as well as a method of designing them.
摘要翻译：本发明提供能够通过与MORT-1蛋白结合或相互作用而与携带FAS受体或p55受体的细胞调节或介导FAS受体配体或TNF作用的蛋白，其又结合FAS受体的细胞内结构域或另一种结合p55受体的蛋白质TRADD。此外，还提供干扰具有蛋白水解活性的MORT-1结合蛋白的蛋白水解活性的肽抑制剂以及其设计方法。

74. 发明授权

US6090923A Murine monoclonal antibody binding TNF.alpha. 失效
标题翻译：鼠单克隆抗体结合TNFα
公开(公告)号：US6090923A
公开(公告)日：2000-07-18
申请号：US794365
申请日：1991-11-13
申请人： David Wallach , Talia Hahn , Zelig Eshhar
发明人： David Wallach , Talia Hahn , Zelig Eshhar
IPC分类号： G01N33/53 , A61K35/12 , A61K35/14 , A61K38/16 , A61K38/21 , A61K38/36 , A61K39/00 , A61K39/395 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/52 , C07K16/00 , C07K16/18 , C07K16/24 , C12N5/00 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/569 , G01N33/577
CPC分类号： G01N33/56972 , A61K38/21 , C07K14/47 , C07K16/24 , G01N33/56966 , G01N2333/525
摘要： A cytotoxic protein expressed by human peripheral blood mononuclear cells is isolated in essentially homogenous form. This protein may be used to elicit production of polyclonal or monoclonal anti-cytotoxin antibodies.Hybridomas secreting anti-cytotoxin antibodies are identified by a solid phase bioassay. The antibodies are useful in the immunopurification of cytotoxins. The purified cytotoxic proteins are useful for the treatment of virus-infected or tumor target cells, either alone or in combination with interferon or a metabolic blocker.
摘要翻译：由人外周血单核细胞表达的细胞毒性蛋白以基本均匀的形式被分离。该蛋白质可用于引发多克隆或单克隆抗细胞毒素抗体的产生。通过固相生物测定法鉴定分泌抗细胞毒素抗体的杂交瘤。抗体可用于细胞毒素的免疫纯化。纯化的细胞毒性蛋白质可用于单独或与干扰素或代谢阻断剂组合治疗病毒感染或肿瘤靶细胞。

75. 发明授权

US6083534A Pharmaceutical compositions for controlled release of soluble receptors 失效
标题翻译：用于可控受体释放的药物组合物
公开(公告)号：US6083534A
公开(公告)日：2000-07-04
申请号：US894913
申请日：1997-10-09
申请人： David Wallach , Josef Kost , Rom Eliaz
发明人： David Wallach , Josef Kost , Rom Eliaz
IPC分类号： A61K9/08 , A61K9/00 , A61K9/16 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/00 , A61K47/48 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C08L101/00
CPC分类号： A61K9/0024 , A61K38/1793 , A61K38/191 , A61K38/215 , A61K9/1647 , Y10S514/803 , Y10S514/825 , Y10S514/885 , Y10S514/889 , Y10S514/903 , Y10S514/921 , Y10S514/974
摘要： A controlled release pharmaceutical composition includes a biocompatible polymeric material, preferably polyethylene-vinyl acetate or poly(lactic-glucolic acid), having incorporated therein a soluble receptor capable of binding to its ligand and thus affecting the ligand's function. The soluble receptor is preferably the soluble form of TNF.alpha. receptor. Such compositions are for use in the treatment of disorders in which neutralization of the deleterious effects of TNF.alpha. is required.
摘要翻译： PCT No.PCT / US96 / 03121 Sec。 371日期1997年10月9日第 102（e）1997年10月9日PCT PCT 1996年3月1日PCT公布。 WO96 / 26738 PCT公开号日本1996年9月6日控释药物组合物包括生物相容性聚合物材料，优选聚乙烯 - 乙酸乙烯酯或聚（乳酸 - 葡萄糖酸），其中掺入了能与其配体结合并因此影响配体功能的可溶性受体。可溶性受体优选是TNFα受体的可溶形式。这样的组合物用于治疗需要中和TNFα的有害作用的疾病。

76. 发明授权

US5795975A TNF receptor promoter 失效
标题翻译： TNF受体启动子
公开(公告)号：US5795975A
公开(公告)日：1998-08-18
申请号：US532309
申请日：1995-09-22
申请人： David Wallach , Oliver Kemper , Peter Kuhnert
发明人： David Wallach , Oliver Kemper , Peter Kuhnert
IPC分类号： C12N15/113 , C12N15/85 , C07H21/04 , C12N15/00
CPC分类号： C12N15/85 , C12N15/1138 , C12N2310/13 , C12N2830/00 , C12N2830/85
摘要： A DNA molecule containing the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence is provided. Also provided is a DNA molecule which contains a gene in operative association with a promoter sequence that includes the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence.
摘要翻译：提供含有内源性第一内含子位点p55 TNF-R基因启动子/增强子序列的DNA分子。还提供了一种DNA分子，其含有与启动子序列有效结合的基因，其包括内源性第一内含子位点的p55 TNF-R基因启动子/增强子序列。

77. 发明授权

US5216128A IFN-.beta.2/IL-6 receptor its preparation and pharmaceutical compositions containing it 失效
标题翻译： IFN-（BETA）2 / IL-6受体及其制备和药物组合物
公开(公告)号：US5216128A
公开(公告)日：1993-06-01
申请号：US530580
申请日：1990-05-30
申请人： Daniela Novick , Louise Chen , Hartmut Engelmann , Michel Revel , Menachem Rubinstein , David Wallach
发明人： Daniela Novick , Louise Chen , Hartmut Engelmann , Michel Revel , Menachem Rubinstein , David Wallach
IPC分类号： G01N33/53 , A61K38/00 , A61K38/21 , A61K39/395 , A61P35/00 , C07K1/18 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/555 , C07K14/565 , C07K14/705 , C07K14/715 , C07K16/00 , C12N15/12 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K14/715 , A61K38/215 , C07K14/7155 , Y10S530/834
摘要： Human natural IFN-.beta.2/IL-6 receptor and its soluble extracellular fragment are provided in substantially purified form and are shown to stimulate and to enhance beneficial effects of IFN-.beta.2/IL-6, such as its antiproliferative activity. Polyclonal and monoclonal antibodies raised against the soluble fragment of the receptor are also provided.

78. 发明授权

US4035900A Insert installing machine 失效
标题翻译：插入安装机
公开(公告)号：US4035900A
公开(公告)日：1977-07-19
申请号：US672548
申请日：1976-03-31
申请人： Daniel Boyko , David Wallach , Mordecai Gasul
发明人： Daniel Boyko , David Wallach , Mordecai Gasul
IPC分类号： B23P19/00 , B23Q7/10
CPC分类号： B23P19/007 , Y10T29/49906 , Y10T29/53417 , Y10T29/53478
摘要： This invention pertains to machines for installing tapped nuts, studs, or the like machine parts, whether or not having their outer surface provided with thread, knurling or similar profiles, which are to be pressed into corresponding cavities provided in a work piece, usually made of a material softer than the material of the said machine parts. The machine comprises a framework for supporting a vertically reciprocable, horizontally tractable installer head with a rotatable spindle onto which inserts are threaded one at a time for the installation thereof in suitable bores provided in the work and control means for reversing the rotation of the spindle on every installing cycle, said machine comprising insert holding means transferable between a first position, wherein the insert is held in axial alignment with respect to said spindle and a second position; means for transferring the said holding means from the first position to the second position after the threading of an insert on said spindle and means for feeding inserts to said holding means when in the second position.
摘要翻译：本发明涉及用于安装螺纹螺纹，螺柱或类似机器部件的机器，无论其外表面是否具有螺纹，滚花或类似的型材，其被压入设置在工件中的相应的空腔中，通常制成的材料比所述机器部件的材料软。该机器包括用于支撑具有可旋转主轴的可垂直往复运动的水平处理的安装头的框架，在该主轴上插入件一次一个地被螺纹安装，工件和控制装置中的适当的孔中安装有插入件，用于反转主轴的旋转每个安装周期，所述机器包括可在第一位置之间传送的插入物保持装置，其中所述插入件相对于所述主轴保持轴向对准并具有第二位置; 用于在所述主轴上的插入件穿线之后将所述保持装置从所述第一位置传送到第二位置的装置，以及当处于所述第二位置时将插入件馈入所述保持装置的装置。

79. 发明授权

US08273545B2 SIVA ubiquitination and/or degradation-related activity and modulators thereof 有权
标题翻译： SIVA泛素化和/或降解相关活性及其调节剂
公开(公告)号：US08273545B2
公开(公告)日：2012-09-25
申请号：US12160627
申请日：2007-01-11
申请人： David Wallach , Parameswaran Ramakrishnan , Wang Wangxia , Andrei Kovalenko
发明人： David Wallach , Parameswaran Ramakrishnan , Wang Wangxia , Andrei Kovalenko
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： C12Q1/25 , G01N2333/9015 , G01N2500/02 , G01N2800/24
摘要： The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.
摘要翻译：本发明涉及SIVA多肽和能够调节所述活性的试剂的泛素化和/或降解相关活性。

80. 发明授权

US08236507B2 Modulators of TNF receptor associated factor (TRAF), their preparation and use 有权
标题翻译： TNF受体相关因子（TRAF）的调节剂，其制备和用途
公开(公告)号：US08236507B2
公开(公告)日：2012-08-07
申请号：US12365136
申请日：2009-02-03
申请人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
发明人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
IPC分类号： C12Q1/68 , C12P21/06 , C07K1/00
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K2319/00 , C12N2799/021
摘要： A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
摘要翻译：编码能够结合肿瘤坏死因子受体相关因子（TRAF）分子的蛋白质的DNA序列，由所述DNA序列编码的TRAF结合蛋白，其同工型，类似物，片段和衍生物，其生产DNA的方法序列和蛋白质，以及DNA序列和蛋白质的用途。

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