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71. 发明授权

US09089651B2 Dose setting mechanism 有权
标题翻译：剂量设定机制
公开(公告)号：US09089651B2
公开(公告)日：2015-07-28
申请号：US13878464
申请日：2011-10-11
申请人： Joseph Butler , David Plumptre
发明人： Joseph Butler , David Plumptre
IPC分类号： A61M5/315
CPC分类号： A61M5/31536 , A61M5/31525 , A61M5/31535 , A61M5/31541 , A61M5/31551 , A61M5/31571 , A61M5/3158 , A61M5/31593
摘要： A system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a clutch ring rotationally fixed relative to the housing when a dose less than the minimum allowable dose is selected. The dose setting mechanism also includes a drug delivery device housing and a dose dial component positioned in the housing and rotatable during a dose setting step. A drive sleeve is positioned within the dose dial component, a spindle is positioned within the drive sleeve, and a clutch is positioned between the dose dial component and the drive sleeve. When the dose dial component is rotated to select a dose less than a minimum dose, a clutch ring prevents the drive sleeve from rotating to thereby prevent the selected dose from being administered.
摘要翻译：一种用于当选择小于最小允许剂量的剂量时，通过提供具有相对于壳体旋转固定的离合器环的剂量调节机构来防止递送小于预定最小剂量的药物的系统。剂量设定机构还包括药剂输送装置壳体和位于壳体中并可在剂量设定步骤期间旋转的剂量拨号部件。驱动套筒定位在剂量拨盘部件内，主轴定位在驱动套筒内，并且离合器定位在剂量拨号部件和驱动套筒之间。当剂量拨号组件旋转以选择小于最小剂量的剂量时，离合器环防止驱动套筒旋转，从而防止施用所选择的剂量。

72. 发明申请

US20120165750A1 Drug Delivery Device Inner Housing Having Helical Spline 审中-公开
标题翻译：药物输送装置内壳具有螺旋花键
公开(公告)号：US20120165750A1
公开(公告)日：2012-06-28
申请号：US13322829
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/31
CPC分类号： A61M5/31525 , A61M5/31541 , A61M5/31543 , A61M5/31551 , A61M5/31585
摘要： A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.
摘要翻译：公开了用于药物输送装置的剂量设定机构。该机构包括外壳和具有外槽和螺旋花键的内壳。内壳螺旋花键引导驾驶员分配一定剂量。拨号套筒设置在外壳体和内壳体之间并且可旋转地与内壳体接合。当剂量被设定时，拨盘套筒旋转并且从外壳体和内壳体两者平移。

73. 发明申请

US20120165742A1 DRUG DELIVERY DOSE SETTING MECHANISM WITH VARIABLE MAXIMUM DOSE 有权
标题翻译：具有可变最大剂量的药物递送剂量设定机构
公开(公告)号：US20120165742A1
公开(公告)日：2012-06-28
申请号：US13320634
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/31
CPC分类号： A61M5/31536 , A61M2005/3154
摘要： A method and system for proving a drug delivery device having a variable maximum dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first tubular member and the second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device.
摘要翻译：用于证明具有可变最大剂量的药物递送装置的方法和系统。药物递送装置包括第一管状构件和可旋转地联接到第一管状构件的第二管状构件。最大限制部件可操作地联接到第一管状部件和第二管状部件，使得最大止挡部件可从第一位置移动到第二位置。第一位置定义可由所述药物递送装置的使用者设定的第一最大剂量，而第二位置限定可由所述药物递送装置的使用者设定的第二最大剂量。

74. 发明申请

US20120165740A1 Medicament Identification System for Multi-Dose Injection Devices 审中-公开
标题翻译：多剂量注射装置药物识别系统
公开(公告)号：US20120165740A1
公开(公告)日：2012-06-28
申请号：US13322840
申请日：2010-05-28
申请人： David Plumptre , Chris Smith
发明人： David Plumptre , Chris Smith
IPC分类号： A61M5/31 , B23P17/04
CPC分类号： A61M5/31551 , A61M2005/3125 , A61M2205/583 , A61M2205/584 , Y10T29/49826
摘要： A dynamic identification system for a multi-dose injection device includes a dose dial sleeve (40) containing indicia (41; 42) of the medicament contained within the device becomes visible or available to the olfactory or gustation senses only during dose setting as the dial sleeve (40) is translated proximally out of the outer housing of the device. A user can readily identify the medicament contained within the device (1) as the dose is being set. A static identifier (50) located on the device that matches the dynamic identifier on the dial sleeve (40) can also be used as a medicament identifier.
摘要翻译：用于多剂量注射装置的动态识别系统包括仅在剂量设定期间容纳在装置中的包含在药物中的药物的标记（41; 42）变得可见或可用于嗅觉或阵风感觉的剂量拨号套筒（40）套筒（40）向近侧平移，离开设备的外壳体。当剂量被设定时，用户可以容易地识别包含在装置（1）内的药物。位于设备上的与拨盘套筒（40）上的动态标识符匹配的静态标识符（50）也可以用作药物标识符。

75. 发明申请

US20120046613A1 Drug Delivery Device with Piston Rod Carrying Dose Markings 有权
标题翻译：带活塞杆的药物输送装置携带剂量标记
公开(公告)号：US20120046613A1
公开(公告)日：2012-02-23
申请号：US13141080
申请日：2009-12-21
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/31
CPC分类号： A61M5/31511 , A61M5/24 , A61M5/31525 , A61M2005/2407 , A61M2005/3125 , A61M2005/3126 , A61M2005/3142
摘要： The present invention relates to a drug delivery (5) comprising a housing (10) with a proximal end (30) and a distal end (22), a cartridge holder (14) adapted to retain a cartridge (16), the cartridge holder (14) comprising an at least partially transparent side wall (36), a piston rod (26), the piston rod (26) being adapted to drive a piston so as to engage the piston (28) into the cartridge (16), anda plurality of symbols (32) on the piston rod (26), the symbols (32) representing dosage information during operation of the drug delivery device (5) and being visible through a window aperture (40) in the housing (10) or in the cartridge holder (14). Furthermore, using a plurality of symbols (32) on a piston rod (26) to represent dosage information during operation of the drug delivery device (5) is disclosed.
摘要翻译：本发明涉及药物输送（5），其包括具有近端（30）和远端（22）的壳体（10），适于保持药筒（16）的药筒保持器（14）（14），包括至少部分透明的侧壁（36），活塞杆（26），所述活塞杆（26）适于驱动活塞以将所述活塞（28）接合到所述盒（16）中，和活塞杆（26）上的多个符号（32），符号（32）表示药物输送装置（5）的操作期间的剂量信息，并且通过壳体（10）中的窗孔（40）可见，或在盒保持器（14）中。此外，公开了在药物输送装置（5）的操作期间使用活塞杆（26）上的多个符号（32）来表示剂量信息。

76. 发明授权

US09149583B2 Drug delivery dose setting mechanism with variable maximum dose 有权
标题翻译：具有可变最大剂量的药物递送剂量设定机制
公开(公告)号：US09149583B2
公开(公告)日：2015-10-06
申请号：US13320634
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/31536 , A61M2005/3154
摘要： A method and system for proving a drug delivery device having a variable maximum dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first tubular member and the second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device.
摘要翻译：用于证明具有可变最大剂量的药物递送装置的方法和系统。药物递送装置包括第一管状构件和可旋转地联接到第一管状构件的第二管状构件。最大限制部件可操作地联接到第一管状部件和第二管状部件，使得最大止挡部件可从第一位置移动到第二位置。第一位置定义可由所述药物递送装置的使用者设定的第一最大剂量，而第二位置限定可由所述药物递送装置的使用者设定的第二最大剂量。

77. 发明授权

US09089656B2 Spindle and bearing combination and drug delivery device 有权
标题翻译：主轴和轴承组合和药物输送装置
公开(公告)号：US09089656B2
公开(公告)日：2015-07-28
申请号：US13322813
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/50 , A61M5/315
CPC分类号： A61M5/5066 , A61M5/31511 , A61M5/31515 , A61M5/3158 , A61M5/5086 , Y10T29/49826
摘要： An improved spindle and bearing combination for a drug delivery device is provided that has a first connection between the spindle (1) and bearing (4) comprising a web (5) and a second connection that replaces the first connection when the web (5) is severed that allows the spindle (1) to rotate relative to the bearing (4).
摘要翻译：提供了用于药物输送装置的改进的主轴和轴承组合，其具有在所述心轴（1）和包括腹板（5）的轴承（4）之间的第一连接和当所述腹板（5））替代所述第一连接时的第二连接，被切断，允许主轴（1）相对于轴承（4）旋转。

78. 发明授权

US08790315B2 Dose setting mechanism for a drug delivery device 有权
标题翻译：用于药物输送装置的剂量设定机构
公开(公告)号：US08790315B2
公开(公告)日：2014-07-29
申请号：US13375185
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/00 , A61M5/315
CPC分类号： A61M5/31551 , A61M5/31511 , A61M5/31541
摘要： The invention relates to a dose setting mechanism, which is operable to be coupled to a medication cartridge and which comprises means that prevent the user from setting a dose greater than the remaining medication in the cartridge. The dose setting mechanism comprises a shaft. A helical groove having a first pitch is provided along a first portion of the shaft. The dose setting mechanism further comprises a nut member disposed on the helical groove of said shaft. During dose setting, the shaft is rotated relative to the nut member while the nut member traverses along the groove from a distal end of the shaft towards a proximal end of the shaft. The mechanism further comprises means preventing a user of said dose setting mechanism from setting a dose of said medication that is greater than said remaining medication in said cartridge, said means comprising a second pitch provided along a second portion of said shaft, wherein said first pitch is different from said second pitch, wherein said second pitch is preferably greater than said first pitch.
摘要翻译：本发明涉及一种剂量设定机构，其可操作以联接到药物盒，并且其包括防止使用者设定大于药筒中剩余药物的剂量的装置。剂量设定机构包括轴。具有第一间距的螺旋槽沿轴的第一部分设置。剂量设定机构还包括设置在所述轴的螺旋槽上的螺母构件。在剂量设定期间，轴相对于螺母构件旋转，同时螺母构件沿着凹槽从轴的远端朝向轴的近端横向移动。该机构还包括防止所述剂量设定机构的使用者在所述药筒中设定大于所述剩余药物的剂量的装置，所述装置包括沿所述轴的第二部分设置的第二间距，其中所述第一间距与所述第二间距不同，其中所述第二间距优选大于所述第一间距。

79. 发明申请

US20130289518A1 Dose Setting Mechanism and Method of Using the Same 有权
标题翻译：剂量设定机构及其使用方法
公开(公告)号：US20130289518A1
公开(公告)日：2013-10-31
申请号：US13878113
申请日：2011-10-11
申请人： Joseph Butler , David Plumptre
发明人： Joseph Butler , David Plumptre
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/31551 , A61M5/31561 , A61M5/31585 , A61M2205/581 , A61M2205/582 , A61M2205/584 , A61M2205/585
摘要： The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial component positioned in the housing and rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery having, preferably located at a distal end, clutch teeth, and a clutch ring engaged with the housing in a first rotatable configuration and in a second non-rotatable configuration.
摘要翻译：本发明涉及药物输送装置的剂量设定机构及其使用方法。该机构包括药物输送装置壳体，位于壳体中并可在剂量设定和剂量递送期间旋转的剂量拨号部件，在剂量设定期间可旋转的离合器以及在剂量递送期间不可旋转的离合器，优选位于远端，离合器齿以及离合器环，其以第一可旋转构造和第二不可旋转构造与壳体接合。

80. 发明申请

US20130197479A1 Dose Setting Mechanism and Method of Setting a Dose 有权
标题翻译：剂量设定机制及设定方法
公开(公告)号：US20130197479A1
公开(公告)日：2013-08-01
申请号：US13878555
申请日：2011-10-11
申请人： Joseph Butler , David Plumptre
发明人： Joseph Butler , David Plumptre
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M5/31585 , A61M2005/3126
摘要： A method and system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a spindle nut and a sprung lock nut. The mechanism includes a housing and a dose dial component positioned in the housing. The dose dial component is rotatable during a dose setting step. The mechanism further includes a drive sleeve positioned within the dose dial component. The drive sleeve is configured to drive a rotatable spindle during a dose administration step. The spindle nut is coupled to the spindle and the sprung lock nut is removably coupled to the drive sleeve and rotationally fixed to the housing. In one arrangement, when the dose dial component is rotated to select a dose less than a preselected minimum dose, the sprung lock nut allows the spindle nut to rotate thereby preventing the dose from being administered.
摘要翻译：一种用于通过提供具有心轴螺母和弹簧锁定螺母的剂量设定机构来防止小于预定最小剂量的药物的递送的方法和系统。该机构包括定位在壳体中的壳体和剂量拨号部件。在剂量设定步骤期间，剂量拨号组件可旋转。该机构还包括位于剂量拨号部件内的驱动套筒。驱动套筒构造成在剂量给药步骤期间驱动可旋转的主轴。主轴螺母联接到主轴，弹簧锁定螺母可拆卸地联接到驱动套筒并旋转地固定到壳体。在一种布置中，当剂量拨号组件旋转以选择小于预选的最小剂量的剂量时，弹簧锁定螺母允许主轴螺母旋转，从而防止施用该剂量。

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