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71. 发明申请

US20120122099A1 COMPOSITIONS FOR USE IN IDENTIFICATION OF BACTERIA 审中-公开
公开(公告)号：US20120122099A1
公开(公告)日：2012-05-17
申请号：US11683302
申请日：2007-03-07
申请人： Rangarajan Sampath , Thomas A. Hall , David J. Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas A. Hall , David J. Ecker , Lawrence Blyn
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.

72. 发明授权

US08013142B2 Compositions for use in identification of bacteria 失效
标题翻译：用于鉴定细菌的组合物
公开(公告)号：US08013142B2
公开(公告)日：2011-09-06
申请号：US11685610
申请日：2007-03-13
申请人： Rangarajan Sampath , Thomas A. Hall , David J. Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas A. Hall , David J. Ecker , Lawrence Blyn
IPC分类号： C07H21/04 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
摘要翻译：本发明提供通过分子量和碱组成分析快速鉴定和定量细菌的组合物，试剂盒和方法。

73. 发明授权

US07956175B2 Compositions for use in identification of bacteria 失效
公开(公告)号：US07956175B2
公开(公告)日：2011-06-07
申请号：US11683280
申请日：2007-03-07
申请人： Rangarajan Sampath , Thomas A. Hall , David J. Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas A. Hall , David J. Ecker , Lawrence Blyn
IPC分类号： C07H21/04 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.

74. 发明授权

US06969763B1 Molecular interaction sites of interleukin-2 RNA and methods of modulating the same 失效
标题翻译：白细胞介素-2 RNA的分子相互作用位点及其调控方法
公开(公告)号：US06969763B1
公开(公告)日：2005-11-29
申请号：US09310844
申请日：1999-05-12
申请人： David J. Ecker , Richard Griffey , Stanley T. Crooke , Ranga Sampath , Eric Swayze , Venkatraman Mohan , Steven Hofstadler , John McNeil
发明人： David J. Ecker , Richard Griffey , Stanley T. Crooke , Ranga Sampath , Eric Swayze , Venkatraman Mohan , Steven Hofstadler , John McNeil
IPC分类号： C07H21/04 , C07K14/54 , C07K14/55 , C40B30/02 , C40B50/02 , G06F19/00
CPC分类号： C40B50/02 , C07H21/04 , C07K14/5406 , C07K14/55 , C40B30/02 , G06F19/14 , G06F19/16 , G06F19/28
摘要： Methods for the identification of compounds which modulate, either inhibit or stimulate, biomolecules are provided. Nucleic acids, especially RNAs are preferred substrates for such modulation. The present methods are particularly powerful in that they provide novel combinations of techniques which give rise to compounds, usually “small” organic compounds, which are highly potent modulators of RNA and other biomolecular activity. In accordance with preferred aspects of the invention, very large numbers of compounds may be tested essentially simultaneously to determine whether they are likely to interact with a molecular interaction site and modulate the activity of the biomolecule. Pharmaceuticals, veterinary drugs, agricultural chemicals, industrial chemicals, research chemicals and many other beneficial compounds may be identified in accordance with embodiments of this invention.
摘要翻译：提供了用于鉴定调节，抑制或刺激生物分子的化合物的方法。核酸，特别是RNA是用于这种调节的优选底物。本发明的方法特别强大，因为它们提供了引起化合物（通常是“小”）有机化合物的技术的新组合，其是RNA和其它生物分子活性的高效调节剂。根据本发明的优选方面，可以基本上同时测试非常大量的化合物以确定它们是否可能与分子相互作用位点相互作用并且调节生物分子的活性。根据本发明的实施方案，可以鉴定药物，兽药，农药，工业化学品，研究化学品和许多其它有益化合物。

75. 发明授权

US07108974B2 Method for rapid detection and identification of bioagents 有权
公开(公告)号：US07108974B2
公开(公告)日：2006-09-19
申请号：US10156608
申请日：2002-05-24
申请人： David J. Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil
发明人： David J. Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.

76. 发明申请

US20080160512A1 Method for rapid detection and identification of bioagents 有权
标题翻译：快速检测和鉴定生物标签的方法
公开(公告)号：US20080160512A1
公开(公告)日：2008-07-03
申请号：US11233630
申请日：2005-09-21
申请人： David J. Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil
发明人： David J. Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译：通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及独特的括号可变序列区域识别生物制剂。结果是“基本组成签名”（BCS），然后与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。

77. 发明授权

US5681944A Antisense oligonucleotides directed to papillomavirus 失效
标题翻译：针对乳头瘤病毒的反义寡核苷酸
公开(公告)号：US5681944A
公开(公告)日：1997-10-28
申请号：US334215
申请日：1994-11-04
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： C12N15/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K14/025 , C12N15/09 , C12N15/113 , C12Q1/68 , C12Q1/70
CPC分类号： C12N15/1131 , C07K14/005 , C12Q1/70 , C12Q1/708 , A61K38/00 , C12N2310/315 , C12N2710/20022 , C12Q1/6883
摘要： Oligonucleotides are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotides are provided which are hybridizable with selected messenger RNA from a human papillomavirus. The oligonucleotide is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E6 and E7 messenger RNAs.
摘要翻译：提供能够与乳头瘤病毒的信使RNA反义相互作用的寡核苷酸。这样的寡核苷酸或寡核苷酸类似物可用于诊断和治疗以及用于研究目的。根据本发明的优选实施方案，提供可与来自人乳头瘤病毒的选定信使RNA杂交的寡核苷酸。寡核苷酸能够抑制RNA的功能，因此可用于由这种乳头瘤病毒感染的治疗。根据优选实施方案，乳头瘤病毒的一部分被靶向用于反义攻击。因此优选提供与E2，E6和E7信使RNA杂交的寡核苷酸。

78. 发明授权

US5658891A Oligonucleotide therapies for modulating the effects of herpesviruses 失效
标题翻译：用于调节疱疹病毒的作用的寡核苷酸疗法
公开(公告)号：US5658891A
公开(公告)日：1997-08-19
申请号：US329212
申请日：1994-10-26
申请人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
发明人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07K14/03 , C12N7/04 , C12N15/09 , C12N15/113 , C12Q1/68 , C12N5/10
CPC分类号： C12N15/1133 , C07K14/005 , A61K38/00 , C12N2310/3125 , C12N2310/315 , C12N2710/16622
摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a gene corresponding to one of the open reading frames UL5, UL8, UL9, UL13, UL29, UL30, UL39, UL40, UL42 AND UL52 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site; it is also preferred that they comprise the sequence CAT. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide specifically hybridizable with RNA or DNA deriving from one of the foregoing genes of the herpesvirus; are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断疱疹病毒感染。根据优选实施方案，提供寡核苷酸，其与衍生自相应于疱疹的开放阅读框UL5，UL8，UL9，UL13，UL29，UL30，UL39，UL29，UL30，UL39，UL40，UL42和UL52中的一个的基因的RNA或DNA特异性杂交单克隆病毒类型1.寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与翻译起始位点特异性杂交; 还优选它们包含序列CAT。治疗疑似感染疱疹病毒的动物的方法，包括使动物与可衍生自疱疹病毒的前述基因之一的RNA或DNA特异性杂交的寡核苷酸接触; 被披露。公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。

79. 发明授权

US5514577A Oligonucleotide therapies for modulating the effects of herpes viruses 失效
标题翻译：用于调节疱疹病毒效应的寡核苷酸疗法
公开(公告)号：US5514577A
公开(公告)日：1996-05-07
申请号：US31147
申请日：1993-03-12
申请人： Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
发明人： Kenneth G. Draper , Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Ronnie C. Hanecak , Kevin P. Anderson , Vickie L. Brown-Driver , Jacqueline R. Wyatt
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K38/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07H21/04 , C07K14/03 , C12N15/113 , C12N15/117 , C12Q1/70 , C12N7/06
CPC分类号： C12N15/1133 , A61K31/70 , C07H21/00 , C07K14/005 , C12N15/1137 , C12N15/117 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/346 , C12N2310/3517 , C12N2310/3521 , C12N2710/16622
摘要： Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a herpesvirus gene corresponding to one of the open reading frames UL5, UL8, UL9, UL20, UL27, UL29, UL30, UL42, UL52 and IE175 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site, a coding region or a 5'-untranslated region. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide of the invention are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断疱疹病毒感染。根据优选实施方案，提供寡核苷酸，其与衍生自对应于开放阅读框UL5，UL8，UL9，UL20，UL27，UL29，UL20，UL27，UL29，UL30，UL42，UL52和IE175之一的疱疹病毒基因的RNA或DNA特异性杂交单纯疱疹病毒1型。寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与翻译起始位点，编码区或5'-非翻译区具体杂交。公开了治疗疑似被疱疹病毒感染的动物的方法，包括使动物与本发明的寡核苷酸接触。公开了用于治疗由单纯疱疹病毒1型，2型单纯疱疹病毒，巨细胞病毒，人疱疹病毒6，爱泼斯坦巴尔病毒或水痘带状疱疹病毒引起的感染的方法。

80. 发明授权

US5248670A Antisense oligonucleotides for inhibiting herpesviruses 失效
标题翻译：用于抑制HERPESVIRUSES的抗体寡核苷酸
公开(公告)号：US5248670A
公开(公告)日：1993-09-28
申请号：US485297
申请日：1990-02-26
申请人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
发明人： Kenneth G. Draper , David J. Ecker , Christopher K. Mirabelli , Stanley T. Crooke
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/22 , C07H21/00 , C07K14/03 , C12N7/04 , C12N15/09 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1133 , C07K14/005 , A61K38/00 , C12N2310/3125 , C12N2310/315 , C12N2710/16622
摘要： Antisense oligonucleotides are disclosed having a length of 15-30 nucleotides containing the CAT sequence and hybridizable to herpes simplex virus type I gene UL13, UL39, or UL40. These antisense oligomers inhibit the replication of the virus at least three-fold. Pharmaceutical compositions containing these oligonucleotides as the active ingredients are also disclosed.
摘要翻译：公开了具有长度为15-30个核苷酸的反义寡核苷酸，其含有CAT序列并可与单纯疱疹病毒I型基因UL13，UL39或UL40杂交。这些反义寡聚体抑制病毒复制至少三倍。还公开了含有这些寡核苷酸作为活性成分的药物组合物。

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