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71. 发明申请

US20050009846A1 2,6,9-Substituted purine derivatives and their use in the treatment of proliferative disorders 失效
标题翻译： 2,6,9-取代的嘌呤衍生物及其在治疗增殖性疾病中的应用
公开(公告)号：US20050009846A1
公开(公告)日：2005-01-13
申请号：US10742237
申请日：2003-12-18
申请人： Peter Fischer , Mike Jarman , Ted McDonald , Bernard Nutley , Florence Raynaud , Stuart Wilson , Paul Workman
发明人： Peter Fischer , Mike Jarman , Ted McDonald , Bernard Nutley , Florence Raynaud , Stuart Wilson , Paul Workman
IPC分类号： A61K31/52 , A61P17/06 , A61P25/28 , A61P31/12 , A61P35/00 , A61P35/02 , A61P43/00 , C07D473/16 , C07D473/14
CPC分类号： C07D473/16
摘要： The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R2是2-羟甲基吡咯烷-1-基或NHCH（R4）CH（R3）OH，其中R3是氢或甲基，R4是甲基，乙基或异丙基 R6是3-硝基苯基氨基，3,4-二甲氧基苄基氨基，3-碘苄基 - 氨基，吡啶-2-基 - 甲基氨基，吡啶-4-基 - 甲基氨基或茚满-5-氨基; R9是异丙基或环戊基。在另一方面，本发明涉及包含所述化合物的药物组合物及其在治疗抗增生性疾病和/或病毒性疾病中的用途。

72. 发明授权

US06740781B2 Process for separating reaction mixtures and recycling quaternary salts and bases 失效
标题翻译：分离反应混合物和回收季盐和碱的方法
公开(公告)号：US06740781B2
公开(公告)日：2004-05-25
申请号：US10320061
申请日：2002-12-16
申请人： Peter Fischer , Sven Michael Hansen , Claus-Peter Reisinger
发明人： Peter Fischer , Sven Michael Hansen , Claus-Peter Reisinger
IPC分类号： C07F902
CPC分类号： B01J31/0268 , B01J31/0214 , B01J31/0215 , B01J31/0235 , B01J31/0239 , B01J31/26 , B01J31/28 , B01J31/4015 , B01J31/4053 , B01J38/48 , B01J2231/34 , C07C37/72 , C07C37/74 , C07C68/08 , Y02P20/127 , Y02P20/52 , Y02P20/584 , C07C69/96 , C07C39/04
摘要： A process for the removal and recovery of quaternary salt (A) and base (D) from a reaction mixture is disclosed. The reaction mixture resulting from oxidative direct carbonylation contains in addition to (A) and (D), at least one hydroxyaromatic compound (B) and at least one reaction product (C) and optionally a solvent, and the process entails a) adding acid to the reaction mixture to cause conversion of (D) into a hydroxyaromatic compound (B2) b) separating the reaction mixture into b1.) that contains (C) and optionally (B) and/or (B2) and b2.) that contains (A) and optionally (B) and/or (B2), and c) reacting b1.) with a base (E) to re-form (D).
摘要翻译：公开了从反应混合物中除去和回收季盐（A）和碱（D）的方法。由氧化性直接羰基化产生的反应混合物除（A）和（D）外还含有至少一种羟基芳族化合物（B）和至少一种反应产物（C）和任选的溶剂，该方法包括：向使（D）转化为羟基芳族化合物（B2）的反应混合物b）将含有（C）和任选（B）和/或（B2）和b2。）的反应混合物分离成b1。 A）和任选地（B）和/或（B2），和c）使b1。）与碱（E）反应以重新形成（D）。

73. 发明授权

US06734278B2 Production of polyester carbonates 失效
标题翻译：生产聚酯碳酸酯
公开(公告)号：US06734278B2
公开(公告)日：2004-05-11
申请号：US10263221
申请日：2002-10-02
申请人： Silke Kratschmer , Wolfgang Alewelt , Friedrich-Karl Bruder , Wilfried Haese , Rolf Wehrmann , Peter Fischer , Marco Roelofs , Lothar Bunzel
发明人： Silke Kratschmer , Wolfgang Alewelt , Friedrich-Karl Bruder , Wilfried Haese , Rolf Wehrmann , Peter Fischer , Marco Roelofs , Lothar Bunzel
IPC分类号： C08G6400
CPC分类号： C08G63/64
摘要： The present invention provides a two-stage process for the production of polyester carbonates with aliphatic dicarboxylic acids, the polyester carbonates obtained thereby, a process for the production of extrudates and molded articles from the polyester carbonates, and the extrudates and molded articles obtained thereby.
摘要翻译：本发明提供了用于生产聚酯碳酸酯与脂族二羧酸的二阶段方法，由此得到的聚酯碳酸酯，由聚酯碳酸酯生产挤出物和模制品的方法，以及由此得到的挤出物和模塑制品。

74. 发明授权

US06706797B1 Polycarbonate molding compounds with good demolding properties and molded bodied and semifinished products produced from the same 失效
标题翻译：具有良好脱模性能的聚碳酸酯模塑料和由其制成的成型体和半成品
公开(公告)号：US06706797B1
公开(公告)日：2004-03-16
申请号：US10030843
申请日：2002-01-09
申请人： Wolfgang Ebert , Ralf Kaufmann , Christoph Schwemler , Wilfried Haese , Peter Fischer , Martin Döbler , Joachim Genz
发明人： Wolfgang Ebert , Ralf Kaufmann , Christoph Schwemler , Wilfried Haese , Peter Fischer , Martin Döbler , Joachim Genz
IPC分类号： C08L6900
CPC分类号： C08K5/01 , C08L69/00
摘要： A thermoplastic molding composition comprising polycarbonate resin having improved mold release properties is disclosed the composition contain polycarbonate resin and 0.005 to 5.0% relative to the weight of the composition of at least one hydrocarbon in the form of C15-600-methyl-branched alkane. The hydrocarbon is characterized in that the weight proportion of its branches is 5 to 30 percent relative to the weight of carbons in the alkane chain.
摘要翻译：公开了包含聚碳酸酯树脂的组合物和相对于至少一种C 15-600-甲基支链烷烃形式的烃的重量为0.005-5.0％的包含聚碳酸酯树脂的热塑性模塑组合物。烃的特征在于其分支的重量比例相对于烷烃链中的碳的重量为5至30％。

75. 发明授权

US5964573A Housing for a side channel compressor 失效
标题翻译：侧通道压缩机外壳
公开(公告)号：US5964573A
公开(公告)日：1999-10-12
申请号：US43282
申请日：1998-09-14
申请人： Peter Fischer
发明人： Peter Fischer
IPC分类号： F04D23/00 , F04D29/42 , F01D1/12 , F01D25/24
CPC分类号： F04D23/008 , F04D29/023 , F04D29/403 , F05D2300/43
摘要： The invention relates to a housing consisting of two housing halves for a side channel compressor. The strength of such a housing can be appreciably increased in that the front wall (3) of each housing half (1) and (2) has formed on it at least two rings (4) and (5), spaced radially from one another and projecting axially relative to the front wall (3), and rib walls (7) extending in a spoke-like manner between these rings (4) and (5).
摘要翻译： PCT No.PCT / DE96 / 01625 Sec。 371日期：1998年9月14日 102（e）1998年9月14日PCT PCT 1996年9月2日PCT公布。公开号WO97 / 10438 日期1997年3月20日本发明涉及一种由侧通道压缩机的两个半壳体组成的壳体。这种壳体的强度可以明显增加，因为每个壳体半部（1）和（2）的前壁（3）在其上形成有至少两个彼此径向间隔开的环（4）和（5）并且相对于前壁（3）轴向地突出，以及在这些环（4）和（5）之间以轮辐状的方式延伸的肋壁（7）。

76. 发明授权

US5962408A Disulphide-cyclo-�H-Cys-Glu-Gln-Tyr-Cys-OH!, and its use in blood-clotting disorders 失效
标题翻译：二硫 - 环 - [H-Cys-Glu-Gln-Tyr-Cys-OH]及其在血液凝固疾病中的应用
公开(公告)号：US5962408A
公开(公告)日：1999-10-05
申请号：US849249
申请日：1997-09-10
申请人： Lars Orning , Kjell Steinar Sakariassen , Kjell Eric Agner , Peter Fischer , May Engebretsen
发明人： Lars Orning , Kjell Steinar Sakariassen , Kjell Eric Agner , Peter Fischer , May Engebretsen
IPC分类号： A61K38/00 , A61P7/04 , C07K7/64 , C12N9/64 , A61K38/12 , C07K5/00 , C07K7/00
CPC分类号： C12N9/6437 , C12Y304/21021
摘要： The present invention relates to disulphide-cyclo-�H-Cys-Glu-Gln-Tyr-Cys-OH! and salts thereof which are useful in the treatment of blood clotting disorders.
摘要翻译： PCT No.PCT / GB95 / 02945 Sec。 371日期：1997年9月10日 102（e）1997年9月10日PCT 1995年12月15日PCT PCT。 WO96 / 18653 PCT出版物日期：1996年6月20日本发明涉及可用于治疗凝血障碍的二硫化环 - 环 - [H-Cys-Glu-Gln-Tyr-Cys-OH]及其盐。

77. 发明授权

US5591000A Compressor unit 失效
标题翻译：压缩机单元
公开(公告)号：US5591000A
公开(公告)日：1997-01-07
申请号：US561576
申请日：1995-11-21
申请人： Peter Fischer
发明人： Peter Fischer
IPC分类号： F04D23/00 , F04D29/62 , F04D5/00
CPC分类号： F04D29/624 , F04D23/008
摘要： A compressor unit is provided, which has at least two side-channel compressors arranged axially next to one another, and in which housing halves within each compressor each have, on a housing wall extending between an axially extending hub extension and a housing protrusion caused by a side channel, an axial extension 11. Side-channel compressors of different sizes can be assembled into a unit by the fact that the axial extension extends in each case into the parting plane of the housing halves, and is in each case equipped with a centering rim, projecting beyond the parting plane that mates with a centering step provided on the axial extension of the adjacent housing half and standing back from the parting plane. The inner housing halves are attached to one another at the axial extensions. The outer housing halves are attached to the inner housing halves by the attachment elements introduced into the passthrough openings.
摘要翻译：提供了一种压缩机单元，其具有至少两个侧向通道压缩机，其彼此轴向地布置，并且每个压缩机内的壳体半部分在每个压缩机中具有在由轴向延伸的毂延伸部和壳体突出部之间延伸的壳体壁上，侧通道，轴向延伸部11.不同尺寸的侧通道压缩机可以通过以下事实组装成单元：轴向延伸部在每种情况下都延伸到壳体半部的分型平面内，并且在每种情况下都配备有定心边缘突出超过分离平面，与设置在相邻壳体半部的轴向延伸部上并从分型平面垂直的定心台阶配合。内壳半部在轴向延伸部处彼此附接。通过引入穿通开口的附接元件将外壳半部附接到内壳半部。

78. 发明授权

US4428533A Windshield wiper shaft bushing assembly with washer jet 失效
标题翻译：带刮水器喷射的挡风玻璃雨刷轴衬套件
公开(公告)号：US4428533A
公开(公告)日：1984-01-31
申请号：US333191
申请日：1981-12-21
申请人： Erwin Pietryk , Peter Fischer , Axel Rauthmann
发明人： Erwin Pietryk , Peter Fischer , Axel Rauthmann
IPC分类号： B60S1/34 , B60S1/52 , B60S1/58 , B05B15/06
CPC分类号： B60S1/3415 , B60S1/52 , B60S1/583
摘要： In a wiper shaft bushing assembly with a washer jet for motor vehicle screens, in which the wiper shaft is guided in a wiper bushing and is surrounded by an elastic plastic sleeve in which a washer jet is located. The one-piece plastic sleeve surrounds the wiper bushing and the elongated wiper shaft preferably eccentrically. The sleeve has shaped in its wall located farthest from the wiper shaft a closed off liquid channel which is connected on the inner end to a lateral tube connection for connection to the washer pump and on its outer end to a ball socket for receiving a spherical directable nozzle body of the washer jet.
摘要翻译：在具有用于机动车辆屏幕的洗衣机喷射器的擦拭器轴衬套组件中，其中擦拭器轴在擦拭器衬套中被引导并被其中定位有洗衣机喷射器的弹性塑料套筒包围。一体式塑料套筒围绕雨刷衬套和细长的擦拭器轴优选偏心。套筒在其最靠近擦拭器轴的壁上成形为封闭的液体通道，其封闭的液体通道连接到内部端部，用于连接到洗衣机泵的侧管连接件，其外端连接到球窝，用于接收球形可指定洗衣机喷嘴的喷嘴体。

79. 发明授权

US4397688A Continuous process of smelting metallic lead directly from lead- and sulfur-containing materials 失效
标题翻译：直接从含铅和含硫材料冶炼金属铅的连续工艺
公开(公告)号：US4397688A
公开(公告)日：1983-08-09
申请号：US271078
申请日：1981-06-08
申请人： Werner Schwartz , Peter Fischer
发明人： Werner Schwartz , Peter Fischer
IPC分类号： C22B5/02 , C22B13/02 , C22B13/06 , C22B15/00
CPC分类号： C22B13/02
摘要： A slag phase and lead phase are conducted in a counter-current to each other in an elongated horizontal reactor, in which a gas atmosphere is conducted in a counter-current to the slag phase. To maintain the molten bath at a constant temperature and to permit an operation at the lowest possible temperatures whereby an undercooling of the melt is prevented, the temperature of the molten bath in the reducing zone is maintained constant by a controlled supply of additional heat, the temperature of the molten bath in the oxidizing zone is maintained constant by a control of the ratio of oxidizable sulfur to oxygen in such a manner that in case of a temperature rise the ratio of sulfur to oxygen is increased in order to decrease the lead oxide content of the slag and in case of a temperature drop of the ratio of sulfur to oxygen is decreased in order to increase the lead oxide content of the slag and the increase and decrease of the ratio of sulfur to oxygen are controlled allowing for the fact that the heat content of the gases entering the oxidizing zone from the reducing zone is changed with the lead oxide content of the slag.
摘要翻译：炉渣相和铅相在细长的水平反应器中以相反的方式进行，其中气体气氛以与炉渣相逆流的方式进行。为了将熔浴保持在恒定温度并允许在最低可能的温度下进行操作，由此可以防止熔体的过冷，通过受控的额外的热量使还原区中的熔池的温度保持恒定，通过控制可氧化硫与氧的比例，氧化区中的熔融液的温度保持恒定，使得在升高硫与氧的比率的情况下，为了降低氧化铅含量，的炉渣，并且在硫与氧的比例的温度降低的情况下，为了增加炉渣的氧化铅含量而降低硫的比例，并且控制硫与氧的比例的增加和减少，这允许以下事实：从还原区进入氧化区的气体的热含量随炉渣的氧化铅含量而变化。

80. 发明授权

US4377951A Gear-change mechanism for a gear-change transmission consisting of a main drive and a two-range group drive 失效
标题翻译：用于由主驱动装置和两档组驱动组成的变速传动装置的换档机构
公开(公告)号：US4377951A
公开(公告)日：1983-03-29
申请号：US222643
申请日：1981-01-05
申请人： Alfred Magg , Peter Fischer , Gerold Bieber
发明人： Alfred Magg , Peter Fischer , Gerold Bieber
IPC分类号： F16H61/16 , F16H59/02 , F16H61/22 , F16H61/24 , F16H61/34 , F16H63/00 , F16H63/02 , F16H63/20 , F16H63/30 , F16H63/36 , F16H63/38 , F16H63/44 , G05G5/10
CPC分类号： F16H63/44 , F16H61/24 , F16H2063/208 , F16H63/3408 , F16H63/38 , Y10S74/90 , Y10T74/20128
摘要： A gear-change mechanism for a conventional two-range speed-selection transmission comprises a gear-shift lever which is coupled to a shaft in a housing, this shaft carrying a pair of strikers which engage elements connected to the shifting rod. According to the invention, the striker forms a packet with a plurality of check plates disposed between and in front of and behind the striker plates and held on the shaft for axial displacement therewith. The check plates are guided in the housing so that they cannot rotate with the shaft.
摘要翻译：用于传统的两档速度选择变速器的换档机构包括齿轮换档杆，该变速杆联接到壳体中的轴，该轴承载着一对撞击件，其接合连接到换档杆的元件。根据本发明，撞针形成具有设置在撞击板之间和之后的多个检查板的包装，并且保持在轴上以与其轴向位移。检查板在壳体中引导，使得它们不能与轴一起旋转。

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