专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

US20060188875A1 Human genomic polymorphisms 审中-公开
标题翻译：人类基因组多态性
公开(公告)号：US20060188875A1
公开(公告)日：2006-08-24
申请号：US10284444
申请日：2002-10-31
申请人： David Cox , Nila Patil , Anthony Berno , David Hinds
发明人： David Cox , Nila Patil , Anthony Berno , David Hinds
IPC分类号： C12Q1/68 , G06F19/00 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/172 , G16B20/00 , G16B40/00
摘要： The invention provides nucleic acid segments of the human genome including polymorphic sites, SNP haplotype blocks, SNP haplotype patterns for each block and informative SNPs for each pattern. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as association studies and other genetic analyses.
摘要翻译：本发明提供人类基因组的核酸片段，包括多态性位点，SNP单倍型区块，每个区块的SNP单倍型模式和每种模式的信息性SNP。还提供了与这些位点侧翼区域杂交的等位基因特异性引物和探针。核酸，引物和探针用于关联研究和其他遗传分析等应用。

72. 发明申请

US20060143771A1 BODY ARMOR 失效
标题翻译：身体护具
公开(公告)号：US20060143771A1
公开(公告)日：2006-07-06
申请号：US11027281
申请日：2004-12-30
申请人： Christopher Winkle , David Cox
发明人： Christopher Winkle , David Cox
IPC分类号： A41D13/00
CPC分类号： F41H1/02
摘要： A body armor accessory adds protection to unguarded areas of conventional body armor. The removable accessory comprises an axillary panel having a coverage area and is made of material that impedes the penetration of a foreign object. The accessory can be worn on either the left or right side of the wearer. The coverage area to the deltoid and flank areas of the wearer provided by the axillary panel is greater than that provided by the vest without the panel. A deltoid panel provides added protection to the deltoid area of the wearer.
摘要翻译：身体护甲附件为常规护甲的无保护区域增添保护。可移除附件包括具有覆盖区域的腋窝面板，并且由妨碍异物渗透的材料制成。附件可以穿在佩戴者的左侧或右侧。由腋窝面板提供的穿戴者的三角肌和侧腹区域的覆盖区域大于没有面板的背心提供的覆盖区域。三角形面板为佩戴者的三角肌区域提供了额外的保护。

73. 发明申请

US20060070036A1 Adapting the demonstration of a program execution without modifying the program code by providing application hooks in the program to display user selected images 审中-公开
标题翻译：通过在程序中提供应用程序钩子来显示用户选择的图像，适应程序执行的演示而不修改程序代码
公开(公告)号：US20060070036A1
公开(公告)日：2006-03-30
申请号：US10955185
申请日：2004-09-30
申请人： David Cox , Craig Lawton , Jonathan Lewis , Christopher Peters , Lorin Ullmann
发明人： David Cox , Craig Lawton , Jonathan Lewis , Christopher Peters , Lorin Ullmann
IPC分类号： G06F9/44
CPC分类号： G06F9/451
摘要： A method, computer program product and system for displaying images during the execution of an application. A developer of an application inserts application hooks at particular locations in the code of the application to be executed. An application hook could be a call to a function in a utility code where the call includes the passing of a “key name”. The called function may retrieve an image located at an image file name in a configuration file associated with the key name if such an image file exists. Presentations that demonstrate the execution of the application may be easily modified by adding, deleting or replacing images at these file names. These modifications may be made without modifying the code of the application being executed. In this manner, different images used in different presentations may be displayed to different targeted audiences without modifying the code of the executed application.
摘要翻译：一种用于在执行应用程序期间显示图像的方法，计算机程序产品和系统。应用程序的开发人员将应用程序钩子插入要执行的应用程序的代码中的特定位置。应用程序钩子可以是调用包含通过“密钥名称”的实用程序代码中的函数。如果存在这样的图像文件，被叫功能可以检索位于与密钥名称相关联的配置文件中的图像文件名的图像。通过添加，删除或替换这些文件名的图像可以轻松地修改演示应用程序执行的演示文稿。可以在不修改正在执行的应用的代码的情况下进行这些修改。以这种方式，不同的呈现中使用的不同的图像可以显示给不同的目标受众，而不修改所执行的应用的代码。

74. 发明授权

US06887871B2 Use of phenylheteroakylamine derivatives 失效
标题翻译：苯基鸟胺衍生物的用途
公开(公告)号：US06887871B2
公开(公告)日：2005-05-03
申请号：US10204742
申请日：2001-02-20
申请人： David Cheshire , Stephen Connolly , David Cox , Peter Hamley , Antonio Mete , Austen Pimm
发明人： David Cheshire , Stephen Connolly , David Cox , Peter Hamley , Antonio Mete , Austen Pimm
IPC分类号： C07D295/08 , A61K31/137 , A61K31/138 , A61K31/275 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4412 , A61K31/445 , A61K31/4453 , A61K31/4462 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K45/00 , A61P1/00 , A61P19/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07C209/68 , C07C217/48 , C07C253/30 , C07C255/54 , C07D207/12 , C07D211/22 , C07D211/46 , C07D213/38 , C07D213/50 , C07D213/61 , C07D213/64 , C07D233/24 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D295/092 , C07D307/14 , C07D307/52 , C07D333/20 , A61K31/535 , A01N43/50 , A01N43/76
CPC分类号： C07D213/64 , A61K31/137 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/4462 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C217/48 , C07C255/54 , C07C2601/02 , C07D207/12 , C07D211/22 , C07D211/46 , C07D213/38 , C07D213/61 , C07D233/24 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D295/088 , C07D307/14 , C07D333/20
摘要： There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease.
摘要翻译：公开了使用式（I）的化合物，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，及其药学上可接受的盐，对映异构体或外消旋物，用于制备药物，用于治疗或预防一氧化氮合酶活性抑制有益的疾病或病症。公开了某些新的式（Ia）化合物及其药学上可接受的盐及其对映异构体和外消旋体; 以及其制备方法，含有它们的组合物及其在治疗中的用途。式（I）和（Ia）的化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病。

75. 发明申请

US20050087898A1 Potting method 失效
标题翻译：灌封法
公开(公告)号：US20050087898A1
公开(公告)日：2005-04-28
申请号：US10676458
申请日：2003-09-30
申请人： David Cox , Georg Schnieder , Fufang Zha , Joachim Muller , Cinzia Lea
发明人： David Cox , Georg Schnieder , Fufang Zha , Joachim Muller , Cinzia Lea
IPC分类号： B01D63/00 , B01D63/02 , B29C70/84 , B29C31/00
CPC分类号： B01D63/022
摘要： A method of forming a pot for an array of hollow fibre membranes (7) is provided, including the steps of placing the ends (6) of the fibre membranes (7) in a mould (5); forming a first layer (20) of curable resin material in a non-cured state around the fibre membrane ends (6), applying a second layer (21) of a polyurethane resin material to the first layer (20) prior to full curing of the first layer, the polyurethane resin material layer being chemically reactive with the first layer material to form an adhesive bond therebetween; at least partially curing both layers and removing the pot formed from the mould (5), wherein the second layer material is of higher flexibility than the first layer material when each layer is fully cured. Apparatus for performing the method is also disclosed.
摘要翻译：提供一种形成中空纤维膜阵列（7）的罐的方法，包括将纤维膜（7）的端部（6）放置在模具（5）中的步骤; 在所述纤维膜端部（6）的周围形成处于非固化状态的可固化树脂材料的第一层（20），在完全固化之前，将聚氨酯树脂材料的第二层（21）施加至所述第一层（20）所述第一层，所述聚氨酯树脂材料层与所述第一层材料发生化学反应，以在其间形成粘结剂; 至少部分地固化两层并移除由模具（5）形成的罐，其中当每层完全固化时，第二层材料比第一层材料具有更高的柔韧性。还公开了用于执行该方法的装置。

76. 发明申请

US20050003410A1 Allele-specific expression patterns 审中-公开
标题翻译：等位基因特异性表达模式
公开(公告)号：US20050003410A1
公开(公告)日：2005-01-06
申请号：US10845316
申请日：2004-05-12
申请人： Kelly Frazer , David Cox , Heng Tao , Krishna Pant , Geoffrey Nilson
发明人： Kelly Frazer , David Cox , Heng Tao , Krishna Pant , Geoffrey Nilson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6827 , C12Q2531/113 , C12Q2565/501
摘要： The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.
摘要翻译：本发明提供了分析差异相对等位基因表达模式的基因的方法。分析个体基因组中的单倍型区域，以鉴定与特异性差异相对等位基因表达模式相关联的单倍型模式。可以进一步研究包含相关单体型模式的单倍型区域，以鉴定参与差异相对等位基因表达模式的基因的基因或变体。

77. 外观设计

USD478913S1 Manifold header 失效
标题翻译：歧管头
公开(公告)号：USD478913S1
公开(公告)日：2003-08-26
申请号：US29119130
申请日：2000-02-24
申请人： Warren Thomas Johnson , Robert James McMahon , David Cox , Leon Keith Ernst , Bruce Gregory Biltoft , Gary William Stollery , David Wood
设计人： Warren Thomas Johnson , Robert James McMahon , David Cox , Leon Keith Ernst , Bruce Gregory Biltoft , Gary William Stollery , David Wood

78. 发明授权

US06306159B1 Meniscal repair device 有权
标题翻译： Meniscal修复装置
公开(公告)号：US06306159B1
公开(公告)日：2001-10-23
申请号：US09464809
申请日：1999-12-17
申请人： Herbert E. Schwartz , Thomas C. May , Stuart Fromm , Robert-Jan Enzerink , Eric Hubbard , John Margetts , Keith Denlinger , David Cox
发明人： Herbert E. Schwartz , Thomas C. May , Stuart Fromm , Robert-Jan Enzerink , Eric Hubbard , John Margetts , Keith Denlinger , David Cox
IPC分类号： A61B1704
CPC分类号： A61B17/0401 , A61B17/0487 , A61B2017/0404 , A61B2017/0445 , A61B2017/0451 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0646
摘要： The invention disclosed is a device for repairing a soft tissue defect, particularly a defect in the meniscus of a knee. The device comprises an outer wall anchor for engaging against an outside wall of the meniscus on a first side of the defect, an inner meniscal anchor engaging an inner surface of the meniscus on a second side of the defect, the inner meniscal anchor having a locking mechanism, and a suture adjustably connecting the outer wall anchor to the inner meniscal anchor. Tension on the suture pulls the defect together and the locking mechanism then locks the suture in place.
摘要翻译：所公开的发明是用于修复软组织缺损的装置，特别是膝盖半月板的缺陷。所述装置包括用于在所述缺陷的第一侧与所述弯月面的外壁接合的外壁锚固件，在所述缺损的第二侧上接合所述弯液面的内表面的内半月板锚固件，所述内半月板锚具具有锁定机构，以及可调节地将外壁锚固件连接到内半月板锚杆的缝合线。缝合线上的张力将缺陷拉到一起，锁定机构将缝合线锁定在适当位置。

79. 发明授权

US06238418B1 Meniscal repair device 有权
公开(公告)号：US06238418B1
公开(公告)日：2001-05-29
申请号：US09464809
申请日：1999-12-17
申请人： Herbert E. Schwartz , Thomas C. May , Stuart Fromm , Robert-Jan Enzerink , Eric Hubbard , John Margetts , Keith Denlinger , David Cox
发明人： Herbert E. Schwartz , Thomas C. May , Stuart Fromm , Robert-Jan Enzerink , Eric Hubbard , John Margetts , Keith Denlinger , David Cox
IPC分类号： A61B1704
摘要： The invention disclosed is a device for repairing a soft tissue defect, particularly a defect in the meniscus of a knee. The device comprises an outer wall anchor for engaging against an outside wall of the meniscus on a first side of the defect, an inner meniscal anchor engaging an inner surface of the meniscus on a second side of the defect, the inner meniscal anchor having a locking mechanism, and a suture adjustably connecting the outer wall anchor to the inner meniscal anchor. Tension on the suture pulls the defect together and the locking mechanism then locks the suture in place.

80. 发明授权

US5650494A Process for refolding recombinantly produced TGF-.beta.-like proteins 失效
标题翻译：重组重组产生的TGF-β样蛋白的方法
公开(公告)号：US5650494A
公开(公告)日：1997-07-22
申请号：US486057
申请日：1995-06-07
申请人： Nico Cerletti , Gary Kent McMaster , David Cox , Albert Schmitz , Bernd Meyhack
发明人： Nico Cerletti , Gary Kent McMaster , David Cox , Albert Schmitz , Bernd Meyhack
IPC分类号： C12P21/02 , A61K38/00 , A61K38/18 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K1/113 , C07K1/20 , C07K1/36 , C07K14/00 , C07K14/495 , C07K14/51 , C07K14/52 , C12N15/09 , C12N15/16 , C12R1/19 , C12R1/865 , C07K1/14 , C12P21/04
CPC分类号： C07K1/1136 , A61K38/1841 , C07K1/1133 , C07K14/495
摘要： The process for the production of a dimeric, biologically active Transforming Growth Factor type .beta. (TGF-.beta.)-like protein or a salt thereof, comprising refolding the denatured monomeric form of the protein in the presence of a mild detergent that permits folding of the monomeric protein into a spatial conformation, which after dimerization, is the conformation associated with the biological activity, while retaining the monomeric protein in soluble form. Mild detergents include sulfobetaines, 3-(3-chlolamidopropyl)dimethylammonio-1-propanesulfonate, 3-(3-chlolamidopropyl)dimethylammonio-2-hydroxy-1-propane-sulfonate, digitonin, cholate and deoxycholate at a concentration of about 1 to 100 mM. Compositions containing a TGF-.beta.-like protein produced according the invention can be used for the promotion and acceleration of wound healing and bone and tissue repair, cancer treatment, bone marrow protective agent, as a mediator of cardio-protection, as an anti-inflammatory or immunosuppressive agent, or as a growth regulator in mammalian cell cultures.
摘要翻译：用于生产二聚体，生物活性的转化生长因子β（TGF-β）样蛋白或其盐的方法，包括在温和洗涤剂存在下重折叠变性单体形式的蛋白质，其允许折叠单体蛋白转化为空间构象，其在二聚后是与生物活性相关的构象，同时保留单体蛋白质的可溶形式。轻度洗涤剂包括浓度为约1至100的磺基甜菜碱，3-（3-氯丙酰氨基丙基）二甲基氨基-1-丙磺酸盐，3-（3-氯丙酰胺丙基）二甲基铵-2-羟基-1-丙磺酸盐，赤藓糖醇，胆酸和脱氧胆酸盐 mM。含有根据本发明生产的TGF-β样蛋白质的组合物可用于促进和加速伤口愈合和骨组织修复，癌症治疗，骨髓保护剂作为心脏保护的介质，作为抗 - 炎症或免疫抑制剂，或作为哺乳动物细胞培养物中的生长调节剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式