专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US07364865B2 Antibodies to myeloid progenitor inhibitory factor-1 (MPIF-1) 失效
标题翻译：骨髓祖细胞抑制因子-1（MPIF-1）的抗体
公开(公告)号：US07364865B2
公开(公告)日：2008-04-29
申请号：US11381977
申请日：2006-05-05
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： C12N5/10 , C12N5/12 , G01N33/53 , C07K16/24
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

72. 发明授权

US07238667B2 Albumin fusion proteins 有权
标题翻译：白蛋白融合蛋白
公开(公告)号：US07238667B2
公开(公告)日：2007-07-03
申请号：US11429373
申请日：2006-05-08
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
IPC分类号： A61K38/38 , C07K14/76 , C07K14/765
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，紊乱或病症的方法。

73. 发明授权

US07208582B2 Vascular endothelial growth factor 2 有权
标题翻译：血管内皮生长因子2
公开(公告)号：US07208582B2
公开(公告)日：2007-04-24
申请号：US10120414
申请日：2002-04-12
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： C07K16/22 , C07K21/08
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

74. 发明授权

US07175988B2 Human G-protein Chemokine Receptor (CCR5) HDGNR10 失效
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US07175988B2
公开(公告)日：2007-02-13
申请号：US10067800
申请日：2002-02-08
申请人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号： G01N33/53 , C07K16/00 , A61K39/395
CPC分类号： C07K14/7158 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

75. 发明授权

US07169566B2 Metalloproteinases 失效
标题翻译：金属蛋白酶
公开(公告)号：US07169566B2
公开(公告)日：2007-01-30
申请号：US10979092
申请日：2004-11-02
申请人： Jian Ni , Steven M. Ruben , Laurie A. Brewer , Reiner L. Gentz , Craig A. Rosen
发明人： Jian Ni , Steven M. Ruben , Laurie A. Brewer , Reiner L. Gentz , Craig A. Rosen
IPC分类号： G01N33/53 , C12N5/06 , C12N5/16 , C12P21/08 , C07K16/00
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译：本发明涉及新型金属蛋白酶样蛋白质。特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

76. 发明授权

US07163797B2 50 human secreted proteins 失效
标题翻译： 50种人体分泌的蛋白质
公开(公告)号：US07163797B2
公开(公告)日：2007-01-16
申请号：US10970493
申请日：2004-10-22
申请人： Steven M. Ruben , Craig A. Rosen , Reinhard Ebner
发明人： Steven M. Ruben , Craig A. Rosen , Reinhard Ebner
IPC分类号： G01N33/53 , C12N5/00 , C12N5/02 , C12N1/20 , C12N5/06 , C12N5/16 , C12N5/12 , C12N5/22 , C07K16/00 , C07K16/18 , C12P21/08
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

77. 发明授权

US07064189B2 Antibodies that immunospecifically bind to trail receptors 有权
公开(公告)号：US07064189B2
公开(公告)日：2006-06-20
申请号：US10139785
申请日：2002-05-07
申请人： Theodora Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K31/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

78. 发明授权

US06844170B1 Cytokine receptor common gamma chain like 有权
标题翻译：细胞因子受体常见γ链
公开(公告)号：US06844170B1
公开(公告)日：2005-01-18
申请号：US09263626
申请日：1999-03-05
申请人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
发明人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/715 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C07K14/715
摘要： The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

79. 发明授权

US06824993B2 Antibodies that bind human prostate specific G-protein receptor HPRAJ70 失效
标题翻译：结合人前列腺特异性G蛋白受体HPRAJ70的抗体
公开(公告)号：US06824993B2
公开(公告)日：2004-11-30
申请号：US09968033
申请日：2001-10-02
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1618
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K2317/622
摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.
摘要翻译：本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

80. 发明授权

US06806351B2 Secreted protein HBJFE12 失效
标题翻译：分泌蛋白HBJFE12
公开(公告)号：US06806351B2
公开(公告)日：2004-10-19
申请号：US09774639
申请日：2001-02-01
申请人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
发明人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
IPC分类号： C07K14435
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式