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71. 发明申请

US20070239228A1 System and method using multiple timing channels for electrode adjustement during set up of an implanted stimulator device 有权
标题翻译：使用多个定时通道的系统和方法用于在植入的刺激器装置的设置期间进行电极调节
公开(公告)号：US20070239228A1
公开(公告)日：2007-10-11
申请号：US11399876
申请日：2006-04-07
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/0526 , A61N1/0551 , A61N1/36185
摘要： Methods using multiple timing channels for electrode adjustment during set up of an implanted stimulator device are disclosed. In one embodiment, at least two conditions of electrodes (i.e., electrode combinations, pulse widths, pulse frequencies, pulse amplitudes) can be “simultaneously” tested by providing each condition in its own timing channel. In a preferred embodiment, the pulses in each of the timing channels are interleaved and non-overlapping to preserve the ability of the patient to assess the therapeutic feel of both and to allow some time between pulses for recovery. As well as allowing two sets of electrode conditions to be gauged at the same time, the technique allows the electrode to be manipulated during set up with ease and with a reduced possibility of providing the patient with erroneous results. For example, the two conditions in the two timing channels can comprise initial and target final conditions, and transitioning between from one to the other during device set up is facilitated as compared to the prior art because concerns with electrodes having inconsistent properties in both conditions are alleviated.
摘要翻译：公开了在植入的刺激器装置的设置期间使用多个定时通道用于电极调节的方法。在一个实施例中，通过在其自己的定时通道中提供每个条件，可以“同时”测试电极的至少两个条件（即，电极组合，脉冲宽度，脉冲频率，脉冲幅度）。在优选实施例中，每个定时通道中的脉冲是交错的和不重叠的，以保持患者评估两者的治疗感觉并且允许用于恢复的脉冲之间的一些时间的能力。同时允许同时测量两组电极条件，该技术允许在设置期间容易地操作电极，并且降低为患者提供错误结果的可能性。例如，两个定时通道中的两个条件可以包括初始和目标最终条件，并且与现有技术相比，便于在设备设置期间从一个到另一个之间的转换，因为在两个条件下具有不一致特性的电极的关注是缓解

72. 发明申请

US20070213795A1 Implantable medical lead 审中-公开
标题翻译：可植入医用铅
公开(公告)号：US20070213795A1
公开(公告)日：2007-09-13
申请号：US10839518
申请日：2004-05-05
申请人： Kerry Bradley , B. Lauro
发明人： Kerry Bradley , B. Lauro
IPC分类号： A61N1/05
CPC分类号： A61N1/0558
摘要： An improved percutaneous lead is provided. The lead has a circumferential, concave neck located on the distal portion of the lead and a stylet lumen traversing through the lead including through the concave neck. The concave neck has a narrower circumference than the remainder of the lead. The concave neck is designed to bend up to 45 degrees with a pre-curved stylet inserted into the stylet lumen. The presence of a concave neck permits the ingrowth of tissue into and around the concave neck, thereby helping to anchor the lead post-implant. The concavity in the neck presents no sharp edges to disrupt the isodiametric lead profile.
摘要翻译：提供改进的经皮引线。引线具有位于引线的远端部分上的周向凹入的颈部，以及穿过引线的探针管，包括穿过凹入的颈部。凹颈的圆周比铅的剩余部分窄。凹入的颈部设计成可以弯曲45度，并将预弯曲的探针插入探针管腔中。凹入颈部的存在允许组织向凹入颈部和周围的向内生长，从而有助于固定植入后引线。颈部凹陷不会有尖锐的边缘破坏等参导线轮廓。

73. 发明授权

US07263402B2 System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
标题翻译：快速，舒适的脊髓刺激参数切换的系统和方法
公开(公告)号：US07263402B2
公开(公告)日：2007-08-28
申请号：US10212585
申请日：2002-08-05
申请人： James R Thacker , John D King , Kerry Bradley
发明人： James R Thacker , John D King , Kerry Bradley
IPC分类号： A61N1/18
CPC分类号： A61N1/36071 , A61N1/0551
摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.
摘要翻译：用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。估计的感知水平是基于以前的刺激结果。然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

74. 发明申请

US20070156207A1 Expanding single channel stimulator capability on multi-area stimulation programs 审中-公开
标题翻译：在多区域刺激计划中扩展单通道刺激器能力
公开(公告)号：US20070156207A1
公开(公告)日：2007-07-05
申请号：US11324811
申请日：2006-01-04
申请人： Sridhar Kothandaraman , Kerry Bradley
发明人： Sridhar Kothandaraman , Kerry Bradley
IPC分类号： A61N1/36
CPC分类号： A61N1/36071
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted lead including at least one electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. In tissue stimulation systems, two or more electrical stimulation combinations may be delivered to a patient simultaneously through a reduced number of channels. Systems and methods described herein may combine the two or more stimulation combinations into a reduced number of new stimulation combinations for delivery of the stimulation combinations over a reduced number of channels.
摘要翻译：组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，至少一个注入导线，包括至少一个用于传递由脉冲发生装置产生的电刺激脉冲的电极，以及能够与脉冲发生装置通信的编程器。在组织刺激系统中，可以通过减少数量的通道将两个或多个电刺激组合同时传送给患者。本文描述的系统和方法可以将两个或更多个刺激组合组合成减少数量的新刺激组合，以在减少数量的通道上递送刺激组合。

75. 发明申请

US20070142863A1 Apparatus and methods for stimulating tissue 审中-公开
标题翻译：用于刺激组织的装置和方法
公开(公告)号：US20070142863A1
公开(公告)日：2007-06-21
申请号：US11300963
申请日：2005-12-15
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/36125
摘要： Apparatus and methods for stimulating tissue employing local current imbalance to facilitate more effective stimulation regimens.
摘要翻译：使用局部电流不平衡刺激组织以促进更有效的刺激方案的装置和方法。

76. 发明授权

US07174215B2 Method for determining stimulation parameters 有权
标题翻译：确定刺激参数的方法
公开(公告)号：US07174215B2
公开(公告)日：2007-02-06
申请号：US10728455
申请日：2003-12-05
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/08
摘要： A method is provided for determining optimal stimulus pulsewidth and stimulus amplitude for stimulating nerves with at least one electrode (17). The method comprises: providing a predetermined calibration curve comprising a set of pulsewidth and amplitude values; and delivering sets of pulsewidths and amplitude values which are part of the calibration curve to the at least one electrode (17) to determine at least the optimal pulsewidth. A pulsewidth (70) and an amplitude can be efficiently selected that is efficacious and provides an ample clinical usage range (UR).
摘要翻译：提供一种用于确定用至少一个电极（17）刺激神经的最佳刺激脉冲宽度和刺激振幅的方法。该方法包括：提供包括一组脉冲宽度和振幅值的预定校准曲线; 以及将作为校准曲线的一部分的脉冲宽度和振幅值的集合传送到至少一个电极（17）以确定至少最佳脉冲宽度。脉冲宽度（70）和振幅可被有效地选择，这是有效的并且提供充足的临床使用范围（UR）。

77. 发明授权

US07006869B2 Method and device for enhanced capture tracking by discrimination of fusion beats 有权
公开(公告)号：US07006869B2
公开(公告)日：2006-02-28
申请号：US09952458
申请日：2001-09-10
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3716
摘要： An apparatus and a method for identifying fusion beats as part of an automatic capture routine in a cardiac stimulation device are disclosed. By requiring each post-pulse electrical response to be closely correlated with an expected morphology for either a capture condition or a loss-of-capture condition before classification of the post-pulse electrical response as either capture or loss-of-capture respectively, the present invention is able to identify fusion beats. In various embodiments, this fusion identification is performed using both template matching and assessment of particular detection features. Moreover, in one embodiment, a moving average and a standard deviation are maintained for each detection feature, thereby creating an automatically adjusting evoked response detection threshold.

78. 发明授权

US06961615B2 System and method for evaluating risk of mortality due to congestive heart failure using physiologic sensors 失效
标题翻译：使用生理传感器评估充血性心力衰竭死亡风险的系统和方法
公开(公告)号：US06961615B2
公开(公告)日：2005-11-01
申请号：US10071282
申请日：2002-02-07
申请人： Mark W. Kroll , Kerry Bradley
发明人： Mark W. Kroll , Kerry Bradley
IPC分类号： A61N1/365 , A61N1/368 , A61N1/39 , A61N1/18
CPC分类号： A61N1/36514 , A61B5/0205 , A61B5/7275 , A61N1/368 , A61N1/3956 , G06F19/00
摘要： A congestive heart failure (CHF) mortality risk metric is automatically generated using an implantable medical device and, if it exceeds a predetermined threshold, a warning signal is issued indicating a significant risk of mortality due to CHF, perhaps necessitating more aggressive medical therapy. The CHF mortality risk metric is calculated based on a combination of estimated ventilatory response values and the slope of heart rate reserve as a function of predicted heart rates. Ventilatory response is estimated based on detected values of actual heart rate, arterial oxygen saturation, right ventricular O2, stroke volume, tidal volume, and respiration rate. Heart rate reserve values are derived from the actual heart rate along with patient age and rest heart rate. The predicted heart rates, which represent the heart rates the patient would achieve if healthy, are derived from activity sensor signals. The CHF mortality risk metric is then calculated as a ratio of ventilatory response and the slope of the heart rate reserve. If the CHF mortality risk metric exceeds a critical threshold value, such as 90, the warning signal is generated. Also described herein are various techniques for estimating ventilatory response.
摘要翻译：充血性心力衰竭（CHF）死亡率风险度量使用可植入医疗设备自动生成，并且如果超过预定阈值，则发出警告信号，指示由于CHF引起的死亡风险显着，可能需要更积极的药物治疗。 CHF死亡率风险度量是基于估计的通气反应值和作为预测心率的函数的心率储备斜率的组合计算的。基于实际心率，动脉血氧饱和度，右心室O 2，行程体积，潮气量和呼吸速率的检测值估计通气反应。心率储备值来自实际心率以及患者年龄和休息心率。预测的心率，代表患者将如果健康实现的心率，则来自活动传感器信号。然后将CHF死亡率风险度量计算为通气反应与心率储备斜率的比值。如果CHF死亡率风险度量值超过临界阈值（如90），则会产生警告信号。本文还描述了用于估计通气反应的各种技术。

79. 发明授权

US06950704B1 Use of ER signal variability for fusion detection and response in ventricular and atrial autocapture algorithms 有权
标题翻译：使用ER信号变异性进行心室和心房自体捕获算法中的融合检测和反应
公开(公告)号：US06950704B1
公开(公告)日：2005-09-27
申请号：US10000052
申请日：2001-11-01
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/36 , A61N1/37
CPC分类号： A61N1/371
摘要： An implantable cardiac stimulation device is equipped to differentiate fusion beats, intrinsic activity, and evoked responses. The device optionally responds to improve cardiac activity.
摘要翻译：装有可植入的心脏刺激装置来区分融合节拍，内在活动和诱发反应。该装置可选地响应以改善心脏活动。

80. 发明授权

US06915164B2 Automatic capture using independent channels in bi-chamber stimulation 有权
标题翻译：在双室刺激中使用独立通道自动捕获
公开(公告)号：US06915164B2
公开(公告)日：2005-07-05
申请号：US10124164
申请日：2002-04-16
申请人： Kerry Bradley , Joseph J. Florio , Gene A. Bornzin , Euljoon Park
发明人： Kerry Bradley , Joseph J. Florio , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/368 , A61N1/37
CPC分类号： A61N1/371 , A61N1/3684
摘要： A cardiac stimulation device and method deliver independent stimulation pulses to right and left cardiac chambers, based on the capture thresholds of each chamber, and confirm capture in each chamber. A threshold test is performed in one chamber while stimulating the opposite chamber at increased pulse energy and adjusted interchamber delay.
摘要翻译：基于每个室的捕获阈值，心脏刺激装置和方法将独立的刺激脉冲输送到左心室和左心室，并确认每个腔室中的捕获。在一个腔室中执行阈值测试，同时以增加的脉冲能量和调节的车间延迟刺激相反的腔室。

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